Effects of ginger supplementation on quality of life in patients with functional dyspepsia: An open-label, clinical trial

IF 1.7 Q2 Medicine
Lemlem Gebremariam Aregawi , Csiki Zoltan
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引用次数: 0

Abstract

Background and purpose

Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, often marked by persistent discomfort and negatively impacting patients' quality of life. Despite various treatment approaches, many patients continue to experience symptoms. Ginger has been suggested as a potential natural remedy for dyspepsia due to its anti-inflammatory and prokinetic properties. While previous studies have focused on ginger’s ability to alleviate dyspeptic symptoms, its impact on QoL in FD patients remains unclear. This study aimed to assess the effects of ginger supplementation on QoL in patients with FD.

Materials and methods

This open-label clinical trial enrolled adult FD patients who met the Rome IV criteria. A total of 62 patients were enrolled, and 51 completed the study. Participants received a standardized ginger supplement of 540 mg twice daily for eight weeks. Quality of life was assessed at baseline and post-intervention using a validated questionnaire, Nepean Dyspepsia Index (NDI). Secondary outcomes were also evaluated.

Results

After eight weeks of ginger supplementation, there was a significant improvement in QoL, as indicated by a decrease in NDI scores (mean change ± SD: 9.97 ± 16.20, p = 0.039). This demonstrates a notable enhancement in the participants' QoL, particularly in terms of interference, eating and improved day-to-day activity. Secondary outcomes also showed favorable changes.

Conclusion

Ginger supplementation may offer a beneficial adjunct therapy for patients with FD, improving both symptom management and overall QoL. Future studies with larger sample sizes and randomized controls are warranted to confirm these findings and explore the mechanisms involved.
补充生姜对功能性消化不良患者生活质量的影响:一项开放标签的临床试验
背景和目的功能性消化不良(FD)是一种常见的胃肠道疾病,通常以持续不适为特征,并对患者的生活质量产生负面影响。尽管有各种治疗方法,但许多患者仍会出现症状。生姜因其抗炎和促进运动的特性而被认为是治疗消化不良的潜在天然药物。虽然以前的研究集中在生姜缓解消化不良症状的能力上,但它对FD患者生活质量的影响尚不清楚。本研究旨在评估补充生姜对FD患者生活质量的影响。材料和方法本开放标签临床试验招募符合Rome IV标准的成年FD患者。共有62名患者入组,其中51人完成了研究。参与者每天服用两次540 毫克的标准生姜补充剂,持续8周。使用有效的Nepean消化不良指数(NDI)问卷在基线和干预后评估生活质量。次要结果也进行了评估。结果补充生姜8周后,患者的生活质量有显著改善,NDI评分下降(平均变化± SD: 9.97 ± 16.20,p = 0.039)。这表明参与者的生活质量显著提高,特别是在干扰、饮食和改善日常活动方面。次要结果也显示出有利的变化。结论补充生姜可为FD患者提供有益的辅助治疗,改善症状管理和总体生活质量。未来有必要进行更大样本量和随机对照的研究,以证实这些发现并探索其中的机制。
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来源期刊
Advances in integrative medicine
Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.20
自引率
11.80%
发文量
0
审稿时长
15 weeks
期刊介绍: Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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