Sweet violet syrup reduces restlessness and improves appetite in children with fever: A double-blind randomized controlled trial

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-03-07 DOI:10.1016/j.aimed.2025.03.003

Ali Akbar Safari , Meysam Shirzad , Mohammad Sadegh Adel Mehraban , Leila Mohammad Taghizadeh Kashani , Hamid Shams-Baghbanan , Kumars Pourrostami , Mohammad Mahdi Ahmadian-Attari

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引用次数: 0

Abstract

Objectives

Viola odorata L. (sweet violet) has been mentioned in Iranian traditional medicine as an herb with antifebrile, antitussive, anti-headache, and sedative activities. In this study, we tried to evaluate the effect of this medicinal plant on fever, sleep, restlessness, and appetite of children with fever.

Designs

This double-blind randomized controlled trial was conducted on 100 febrile children (body core temperature <39°C) aged between 3 and 7 years with the clinical diagnosis of a viral common cold. These children visiting a university pediatric clinic in Karaj, Iran were divided into two equal groups (sweet violet syrup vs placebo).

Interventions

One group received sweet violet syrup (2 ml for children<15 kg; 3 ml for children>15 kg TID) + acetaminophen syrup (15 mg/kg QID) and another group received placebo syrup + acetaminophen syrup with similar doses.

Outcome measures

To evaluate the status of fever, sleep, restlessness, and appetite, a self-reported form was filled out by one of the parents and finally submitted to the clinic.

Results

The results showed that sweet violet syrup can significantly reduce restlessness (P = 0.03) and improve appetite (P = 0.05). However, this syrup had no effect on sleep. Surprisingly, concomitant intake of the first dose of acetaminophen and sweet violet syrup weakened the antifebrile activity of acetaminophen (P = 0.04).

Conclusion

Sweet violet syrup can reduce restlessness and improve the appetite of febrile children. Due to probable chemical or physical interactions between this syrup with acetaminophen, it is suggested that these syrups be taken separately.

Trial Registration

This trial was registered at the Iranian Registry of Clinical Trials (IRCT20190409043215N1).

查看原文本刊更多论文

甜紫罗兰糖浆减少发烧儿童的躁动和改善食欲：一项双盲随机对照试验

目的在伊朗传统医学中，堇菜是一种具有解热、止咳、抗头痛和镇静作用的草药。在本研究中，我们试图评估这种药用植物对发烧儿童的发烧，睡眠，躁动和食欲的影响。设计：本双盲随机对照试验对100名临床诊断为病毒性普通感冒的3 - 7岁发热儿童（体温39°C）进行研究。这些在伊朗卡拉杰一所大学儿科诊所就诊的儿童被分成两组（甜紫罗兰糖浆组和安慰剂组）。干预措施：一组给予紫罗兰糖浆(儿童2 ml；15 kg；儿童3 ml(15 kg TID) + 对乙酰氨基酚糖浆（15 mg/kg QID），另一组服用安慰剂糖浆+ 对乙酰氨基酚糖浆，剂量相似。为了评估发烧、睡眠、躁动和食欲的状况，其中一位家长填写了一份自我报告表格，最后提交给诊所。结果紫甜糖浆能显著降低烦躁不安（P = 0.03），改善食欲（P = 0.05）。然而，这种糖浆对睡眠没有影响。令人惊讶的是，同时服用第一剂量的对乙酰氨基酚和甜紫罗兰糖浆削弱了对乙酰氨基酚的解热活性（P = 0.04）。结论紫甜糖浆能减少发热儿童躁动，改善食欲。由于这种糖浆与对乙酰氨基酚之间可能存在化学或物理相互作用，建议将这些糖浆分开服用。试验注册本试验已在伊朗临床试验注册中心注册（IRCT20190409043215N1）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.