Phytochemistry Reviews最新文献

{"title":"Anthocyanins: a comprehensive review on biosynthesis, structural diversity, and industrial applications","authors":"Nitisha Sendri,&nbsp;Pamita Bhandari","doi":"10.1007/s11101-024-09945-9","DOIUrl":"10.1007/s11101-024-09945-9","url":null,"abstract":"<div><p>Anthocyanins, a sub-class of polyphenolic secondary metabolites, are the subject of research in numerous pharmacological chemical studies and food industries. These molecules exhibit a wide array of pharmacological benefits own fascinating different molecular architectures and reflect colorful hues, which have made them popular targets for their studies. The potential application of anthocyanins (natural pigment) has attracted numerous widespread industrial interest. The beautiful colorant unveiled by anthocyanins has widened the scope of anthocyanin applications in food. This review summarizes the isolation of more than 200 new anthocyanins during 2010–2023 along with a discussion of their structural diversities, structural elucidation, biosynthetic pathway and more importantly, their industrial relevance in food. These molecules are classified into acylated anthocyanins and non-acylated anthocyanins, which are further divided according to their substitution pattern i.e. <i>O</i>-methylated anthocyanins, 3-deoxyanthocyanins. These are systematized into their derivative viz. pyranoanthocyanins, pyranoanthocyanins dimers, and metalloanthocyanins. The present review also focuses on the structural characterization of anthocyanins by nuclear magnetic resonance spectroscopy.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 6","pages":"1913 - 1974"},"PeriodicalIF":7.3,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycorine as a lead molecule in the treatment of cancer and strategies for its biosynthesis using the in vitro culture technique","authors":"Saikat Sena,&nbsp;Harmeet Kaur,&nbsp;Vijay Kumar","doi":"10.1007/s11101-024-09941-z","DOIUrl":"10.1007/s11101-024-09941-z","url":null,"abstract":"<div><p>Medicinal plants are used by many of the global population because they are safe and effective alternative to other treatments. Over the last few decades, using plant cells to produce natural or recombinant chemicals of economic interest has become a great intention. Secondary metabolites are recognized to have a significant role in plant adaptation to their environment and are also a valuable source of medication. The increasing economic importance of secondary metabolites has recently sparked a lot of interest in biotransformation, particularly in using tissue culture techniques to modify the production of bioactive plant metabolites. Plants of the family Amaryllidaceae have been used to extract several different alkaloids, each of which has the potential to be involved in a variety of pharmacological processes. Due to its multiple biological functions and divergent structure, lycorine has received significant interest in the medicinal field. Lycorine and other alkaloids from the Amaryllidaceae family have limited bioavailability by nature. In vitro culture provides an alternate method for producing lycorine sustainably due to the pharmaceutical industries dramatically increasing demand for it and the insufficient availability of natural resources. Many medicinal plants have been reported to produce lycorine in vitro in plant cell suspension cultures, and bioreactors play an effective role in their commercial production. This article focuses on the production of lycorine in in vitro systems from plants and its potential in the treatment of cancer. This study  also aims  to provide different biotechnological strategies  for the  production of this important alkaloid using in vitro system.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 6","pages":"1861 - 1888"},"PeriodicalIF":7.3,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the therapeutic potential of cinchonains: a comprehensive review","authors":"Nidal Fahsi,&nbsp;Ismail Mahdi,&nbsp;Hassan Annaz,&nbsp;Gabin Thierry M. Bitchagno,&nbsp;Mona F. Mahmoud,&nbsp;Mansour Sobeh","doi":"10.1007/s11101-024-09949-5","DOIUrl":"10.1007/s11101-024-09949-5","url":null,"abstract":"<div><p>Cinchonains are a group of naturally occurring flavonolignans that exhibit a plethora of biological activities. This comprehensive review provides a critical analysis of the research on cinchonains and their related compounds, aiming to describe their various biological activities, including but not limited to, cytotoxicity, antioxidant, anti-inflammatory, antimicrobial, neuroprotective, antidiabetic, and anticancer activities. The occurrence and distribution of cinchonains in plants, their biosynthesis pathways, bioavailability, toxicity, and clinical investigations are also discussed. By synthesizing information from scientific literature, we present an informative and accessible overview of cinchonains' potential as a source of new therapeutics and highlight the importance of continued research on cinchonains and their related compounds to unlock their possible therapeutic merits.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"197 - 233"},"PeriodicalIF":7.3,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products: protective effects against sensorineural hearing loss","authors":"Wenqi Xu,&nbsp;Mao Huang,&nbsp;Minyan Liao,&nbsp;Shuangshuang Mao,&nbsp;Lei Yang,&nbsp;Rong Chen","doi":"10.1007/s11101-024-09924-0","DOIUrl":"10.1007/s11101-024-09924-0","url":null,"abstract":"<div><p>Hearing loss is one of the major public health problems in the world, which brings huge adverse effects to individuals and society. Sensorineural hearing loss (SNHL) is responsible for the majority of hearing loss. Mechanisms contributing to SNHL include excessive accumulation of reactive oxygen species; over-activation of inflammatory factors; impaired blood micro-circulation in the inner ear or Ca²⁺ homeostasis imbalance, etc. Natural products (NPs), which have a long history of use in traditional medicine and a favorable safety profile, can be developed into a library of drug candidates for the treatment or prevention of SNHL. In this paper, we summarized 24 NPs to exhibit their preventive or therapeutic effects on cellular and animal models of SNHL in terms of their anti-apoptotic, anti-inflammatory, microcirculation-improving, and calcium antagonist effects, as well as 5 NPs in current clinical application. Further, combination with advanced technologies such as drug delivery systems and network pharmacology are applied to improve the research of NPs in the prevention of SNHL. Overall, this review provides a strong reference for the mining and development of NPs in the prevention and treatment of SNHL.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1323 - 1349"},"PeriodicalIF":7.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosomes: a critical tool for delivery of herbal drugs for cancer","authors":"Kajal Chaudhary,&nbsp;Anjali Rajora","doi":"10.1007/s11101-024-09947-7","DOIUrl":"10.1007/s11101-024-09947-7","url":null,"abstract":"<div><p>Phytosomes represent specialized vesicular structures akin to liposomes, encapsulating active phytoconstituents within a lipid core. Many phytoconstituents, such as glycosides and flavonoids, exhibit hydrophilic properties and encounter challenges traversing lipid-based cellular membranes. Nevertheless, the lipid core of phytosomes enhances their permeability across these barriers, thereby augmenting the bioavailability and efficacy of enclosed plant components. Cancer remains a prominent global cause of mortality, posing significant challenges for existing treatments, which often entail serious side effects associated with conventional approaches like surgery, radiation therapy, and chemotherapy. In exploring alternative strategies, the utilization of herbal active compounds in cancer treatment shows considerable promise in synergizing with conventional methods. While natural plant-derived active components demonstrate robust in vitro pharmacological activity, their in vivo absorption is often limited. Addressing this constraint, phytosomes emerge as a burgeoning nanotechnology offering a solution by enhancing the adaptability of bioactive phytoconstituents within lipid-rich barriers. This study delves into a meta-analysis of the physicochemical attributes of phytosomes, elucidating their structural intricacies. Furthermore, the review discusses the advantages and disadvantages of phytosomes as carriers for herbal drugs, shedding light on patented phytosome technologies and associated clinical trials. Additionally, it examines several prominent phytosome-based herbal constituents showcasing notable anticancer properties. Lastly, the review addresses the challenges and potential future directions regarding the use of phytosomes in cancer therapy.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"165 - 195"},"PeriodicalIF":7.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme-mediated adaptation of herbivorous\u0000 insects to host phytochemicals","authors":"Showket Ahmad Dar,&nbsp;Wajid Hasan,&nbsp;Yendrembam K. Devi,&nbsp;Ivana Tlak Gajger,&nbsp;James John","doi":"10.1007/s11101-024-09933-z","DOIUrl":"10.1007/s11101-024-09933-z","url":null,"abstract":"<p>The review comprehensively explores factors influencing enzyme\u0000 activities in insects and their implications in defense against toxicants. It\u0000 encompasses a diverse array of enzymes involved in metabolizing synthetic chemicals,\u0000 emphasizing their dynamic regulation. Key factors affecting enzyme activities, such\u0000 as external and internal influences, are discussed, shedding light on the intricate\u0000 regulatory mechanisms. The inhibitory effects of various compounds on insect GST\u0000 activity are thoroughly examined, providing insights into potential avenues for\u0000 insect control. The implications of insect defenses against toxicants are elucidated,\u0000 emphasizing the complexity of plant–insect interactions. The review delves into the\u0000 evolutionary adaptations of insects to plant defense mechanisms, highlighting the\u0000 role of enzymes like thioglucosidase and myrosinase in detoxifying glucosinolates.\u0000 The co-evolutionary dynamics between insects and plants, particularly in the\u0000 Brassicaceae family, are explored, underscoring the intricate biochemical strategies\u0000 employed by both parties. Additionally, the review addresses the challenges\u0000 associated with developing pest-resistant crop plants through traditional breeding or\u0000 genetic engineering. It discusses the need for a nuanced approach, considering the\u0000 adaptability of insects to various toxicants and the potential drawbacks of repeated\u0000 exposures. The success of chemical plant defenses, particularly monoterpene synthesis\u0000 in pine trees, is noted, along with the distinctive biodegradability of plant\u0000 metabolites. The review provides a thorough examination of the mechanisms underlying\u0000 insect responses to toxic plant metabolites, offering valuable insights into the\u0000 dynamic interplay between insects and plants. It suggests potential targets for\u0000 insect control programs and highlights the importance of understanding the\u0000 co-evolutionary processes that shape these interactions.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1 - 24"},"PeriodicalIF":7.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uneven molecular distribution: a connection with plant functioning and stress resilience","authors":"Saumya Jaiswal,&nbsp;Durgesh Kumar Tripathi,&nbsp;Ravi Gupta,&nbsp;Francisco J. Corpas,&nbsp;Vijay Pratap Singh","doi":"10.1007/s11101-024-09953-9","DOIUrl":"10.1007/s11101-024-09953-9","url":null,"abstract":"<div><p>The current global population is approximately 8 billion. So from a socio-economic point of view, governmental policies are intended to secure at least a minimum of the natural resources like food to the global population to minimize their uneven distribution. However, in the case of plants, the scenario seems different where an uneven distribution of resources seems to be required for the optimized growth. Therefore, a better understanding of this uneven distribution in plants is needed to generate stress-resilient plants with improved yield. It is known that all necessary functions in plants are governed by the efflux and influx of molecules/chemical species and their distribution make plants capable of performing crucial physiological processes as well as acclimating under stress conditions. In this review, we have discussed the role of uneven distribution of different molecules/chemical species in sustaining plant life in the surrounding environment with a few examples of physiological processes.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"151 - 163"},"PeriodicalIF":7.3,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clerodendrum inerme (L.) Gaertn.: a critical review on current progress in traditional uses, phytochemistry, pharmacological aspects and toxicity","authors":"Manabendu Barman,&nbsp;Anuva Barman,&nbsp;Sanjib Ray","doi":"10.1007/s11101-024-09934-y","DOIUrl":"10.1007/s11101-024-09934-y","url":null,"abstract":"<div><p><i>Clerodendrum inerme</i> (L.) Gaertn., commonly known as garden quinine, is a perennial shrub that belongs to the <i>Lamiaceae</i> family. It has been extensively used in various traditional medicinal practices to treat ailments such as rheumatic pain, arthritis, scrofulous, venereal disease, skin diseases, wounds, fever, cough, dysentery, and more. This review aims to critically examine a comprehensive compilation of recent research on <i>C. inerme</i>, encompassing its botanical characteristics, ethnomedical applications, phytochemicals, pharmacological activity, and toxicological data, in order to provide insights and inspiration for future research, promote further development, and facilitate the rational application of <i>C. inerme.</i> Nearly 95 chemical constituents belonging to different classes have been isolated from <i>C. inerme</i>, including diterpenoids, triterpenoids, steroids, flavonoids, phenolic glycosides, lignans, iridoid and megastigmane glycosides. Notably, diterpenoids, triterpenoids, steroids, and flavonoids are the main bioactive substances that have been extensively studied and demonstrated the most significant bioactivity. Pharmacological studies demonstrated that the extract of <i>C. inerme</i> exhibits a wide range of biological activities, such as antioxidant, antimicrobial, anticancer, antiinflammatory, insecticidal, antifeedant, neuroprotective, anti-motor tic, and so on, which are closely connected to its numerous ethnomedicinal applications. Nevertheless, some literature have reported the toxicity of <i>C. inerme</i>. Therefore, it is imperative to conduct further in-depth studies encompassing toxicology, as well as preclinical and clinical research, to ascertain the safety and efficacy of <i>C. inerme</i> for medicinal purposes.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 6","pages":"1675 - 1736"},"PeriodicalIF":7.3,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular approaches to prevent UV-induced premature skin aging: focus on phytochemicals as photo-protectants","authors":"Iva D. Stoykova,&nbsp;Ivanka K. Koycheva,&nbsp;Biser K. Binev,&nbsp;Liliya V. Mihaylova,&nbsp;Milen I. Georgiev","doi":"10.1007/s11101-024-09952-w","DOIUrl":"10.1007/s11101-024-09952-w","url":null,"abstract":"<div><p>Chronic exposure to ultraviolet radiation (UVR) leads to premature aging of the skin, with external manifestations of unsightly scars and internal molecular dysregulations that significantly reduce the protective function of the skin and increase the risk of cancer development. Photoprotection through daily application of sunscreen product is widely recommended to avoid UV-induced skin photodamage and to minimaze the risk for dermal malignancies. However, the environmental hazard that is a consequence of the use of traditional sunscreen products drives the increased interest in the investigation of alternative UVR blockers. Due to their structural diversity, modulation of multiple molecular mechanisms, and favorable safety profile, natural plant-derived compounds have become attractive candidates for skin photoaging prevention. This review summarizes the critical aspects of skin photoaging, from its pathological characteristics and current photoprotective options to the specific molecular players that emerge as therapeutic targets. Special emphasis has been placed on phytochemicals targeting the molecular hallmarks of UV-induced skin aging. The potential of plant molecules to control oxidative stress, inflammation, photo-senescence, DNA damage, extracellular matrix components degradation, and to manage different types of UV-trigerred cell death has been highlighted. Summarizing the molecular signalling pathways responsible for the photoprotective action of plant-derived molecules may provide meaningful outlook for development of new effective therapeutics options for prevention of skin photoaging.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"119 - 150"},"PeriodicalIF":7.3,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the chemotherapeutic potential and therapeutic insight of phloretin against human malignancies: a systematic review","authors":"Md. Sohel,&nbsp;Nishat Ulfat Nity,&nbsp;Md. Rifat Sarker,&nbsp;Md. Rezoan Hossain,&nbsp;K. M. Tanjida Islam,&nbsp;Ahona Rahman,&nbsp;Partha Biswas,&nbsp;Mohammad Nurul Amin,&nbsp;Zitu Barman,&nbsp;Md. Mahmudul Hasan,&nbsp;Abdullah Al Mamun","doi":"10.1007/s11101-024-09938-8","DOIUrl":"10.1007/s11101-024-09938-8","url":null,"abstract":"<div><p><b>T</b>he search of alternative therapeutic agents for the use  of cancer patients has dramatically expanded. Natural products are especially in focus since their structures already function in nature and are more likely to be potent with fewer side effects. Phloretin is a natural product that has been studied for a wide variety of pharmacological actions against human malignancies. This systematic review aims to present up-to-date critical and comprehensive information on the anti-cancer ability of Phloretin with all associated molecular and cellular mechanisms in various forms of cancers. Data retrieved according to PRISMA guidelines from Science Direct, PubMed, and Scopus searching servers by using keywords including Phloretin, cancer name, synergistic, resistance and Pharmacokinetics property was analyzed via some in silico tools. This systematic review comprised 127 articles from different types of study, where Phloretin is hypothesized to be effective against 20 various forms of cancer. Phloretin has been found to inhibit cancer initiation and progression by modulating many imbalanced signalling pathways, including apoptosis, autophagy, necrosis, metastasis, angiogenesis, cell proliferation, glucose absorption, oxidative stress, inflammation, DNA damage, and many other pathways. This wide range of activity may be due to the structural targeting of numerous proteins including, Bcl-2, Bax, Bak, Bad, caspase, cyclins (B1, D1, E) and CDKs (4, 6,7) p18, p21, p27, p53, MMP-2, MMP- 8, MMP-9, Wnt/-catenin, PARP, TNF-α, NF-κB, IκB kinase, IL-1β, TNF-α, phospho-Akt, phosphor-p65, NF-κB, PI3K/Akt, MAPK/ERK, p-mTOR. The introduction of nano-technology-based strategies can improve the efficacy of Phloretin for cancer treatment. Existing evidence shows that Phloretin has synergistic effects with other natural compounds and conventional drugs, and this mechanism assists in reversing the resistance of anticancer drugs by regulating resistance-related proteins. However, Phloretin possesses favorable pharmacokinetic properties with  low toxicity in the human body by in silico methods. Therefore, Phloretin could be a potential anti-cancer drug against numerous cancer treatment by mitigating it's toxic effect and enhancing efficacy using nano-technology-based strategies. </p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 6","pages":"1775 - 1803"},"PeriodicalIF":7.3,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}