Phytochemistry Reviews最新文献

{"title":"Phytochemicals in medicine and food: potential to the development of health products in medicine and food industries","authors":"Aline Priscilla Gomes da Silva, Jianbo Xiao, Haiyan Gao","doi":"10.1007/s11101-025-10082-0","DOIUrl":"10.1007/s11101-025-10082-0","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1057 - 1060"},"PeriodicalIF":7.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond traditional uses: the multifaceted bioactivities of steroidal saponins from the genus Trillium and their modern applications","authors":"Dong-Sheng Fan,&nbsp;Lu Yu,&nbsp;Xiao-Gang Zhou,&nbsp;Yue Zhang,&nbsp;Dong Yi,&nbsp;Qi-Bing Mei,&nbsp;Da-Lian Qin,&nbsp;Jian-Ming Wu,&nbsp;An-Guo Wu","doi":"10.1007/s11101-024-09954-8","DOIUrl":"10.1007/s11101-024-09954-8","url":null,"abstract":"<div><p>Steroidal saponins with diverse bioactivities have gained considerable attention. The genus <i>Trillium</i>, a group of perennial flowering plants, is a prominent source of these compounds, historically esteemed in both Native American and East Asian medicinal traditions. This review integrates traditional knowledge with modern scientific findings to explore the phytochemical, pharmacological, and toxicological properties of <i>Trillium</i>-derived steroidal saponins. Through an exhaustive literature review utilizing databases such as PubMed, Science Direct, CNKI, and Google Scholar, 134 pivotal papers up to October 17, 2023, were selected for analysis. This emphasizes the medicinal importance of the <i>Trillium</i> genus, particularly highlighting <i>Trillium Tschonoskii</i>, and identifies steroidal saponins as the primary bioactive components among various compounds. The pharmacological activities of <i>Trillium</i> species reveals that steroidal saponins exhibit various bioactivities, including anticancer, antidiabetic, neuroprotective, anti-aging, and anti-inflammatory effects. Specifically, these saponins have shown potential in inhibiting tumor growth, enhancing insulin sensitivity, protecting neuronal cells from oxidative stress, slowing the aging process, and reducing inflammation through various cellular and molecular mechanisms. Such findings underscore the therapeutic potential of steroidal saponins in addressing a multitude of health conditions, suggesting their role in developing innovative therapeutic solutions. However, despite these promising bioactivities, there remains a crucial need for in-depth clinical studies to validate the therapeutic efficacy of <i>Trillium</i>-derived steroidal saponins fully. Looking forward, the multifarious bioactivities of these compounds present a compelling case for continued scientific exploration, with the potential to revolutionize the realm of natural medicine by offering new avenues for the treatment and management of various diseases.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1283 - 1344"},"PeriodicalIF":7.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring plant-derived bisindole alkaloids: a comprehensive review of sources, phytochemistry and cytotoxicity","authors":"Zilong Zhang,&nbsp;Yuze Li,&nbsp;Yiming Li,&nbsp;Xiaomei Song,&nbsp;Rui Wang,&nbsp;Dongdong Zhang","doi":"10.1007/s11101-024-10015-3","DOIUrl":"10.1007/s11101-024-10015-3","url":null,"abstract":"<div><p>Bisindole alkaloids represent a notable class of natural compounds distinguished by their characteristic bisindole structure and recognized for their anticancer potential. Over the past nine decades, a plethora of bisindole alkaloids have been isolated from plants. The chemical compositions and cytotoxicity of these plant-derived bisindole alkaloids (PDBAs) have been elucidated. Currently, 735 PDBAs have been documented. Predominantly sourced from plants within the Apocynaceae family, these compounds demonstrate formidable cytotoxicity against various tumor types, such as colorectal cancer, breast cancer and lung cancer. This review comprehensively examines the sources, phytochemistry, and cytotoxicity of these compounds. Furthermore, it provides a summary of the structure–activity relationship (SAR) and the mechanisms through which PDBAs exert their cytotoxicity. In summary, the aim of this paper is to offer a comprehensive overview of the advancements in the investigation of PDBAs for their continued development and utilization.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1753 - 1841"},"PeriodicalIF":7.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review on Abrus precatorius Linn. since 1871: ethnobotanical uses, phytochemistry and pharmacological properties","authors":"Sukanya Vijayan,&nbsp;M. Thirumal","doi":"10.1007/s11101-024-09988-y","DOIUrl":"10.1007/s11101-024-09988-y","url":null,"abstract":"<div><p><i>Abrus precatorius</i> also known <i>as Abrus pauciflorus</i> or <i>Abrus minor</i> is a medicinal plant that has been widely used in indigenous medicine, belonging to the family Fabaceae, widely distributed in tropical and sub-tropical regions like India and China, commonly Known as Rosary pea, Crabs eye, Gunja, Indian Liquorice etc. It has been extensively used to cure diseases like Cancer, Diabetes, inflammation, malaria, tuberculosis etc. Since the 1870s multiple studies on different parts of the plant has been performed. The presence of various secondary metabolites like Flavonoids, Terpenoids, Alkaloids, Steroids have developed interest among researchers for this plant. It has been reported for various pharmacological activities like Anticancer, antidiabetic, antiulcer, antimicrobial, anti-inflammatory, insecticidal, antitubercular, hair growth promoting etc. This review, aim to systematically summarize the traditional uses, phytoconstituents and activity reported. All the articles from databases like Scopus, PubMed, ScienceDirect, and Google Scholar have been considered since 1871. Articles are collected from these databases until October 2022. Articles in English is only considered. Publications from peer-reviewed journals were only selected. Keywords used for the search are <i>Abrus precatorius</i>, Pharmacology, Phytochemistry, Ethnobotany, Rosary pea, and Crabs eye. This review aims to provide references for further studies by finding the research gaps.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1941 - 1970"},"PeriodicalIF":7.3,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles as new elicitors for the production of bioactive and phytochemicals in vitro and in vivo plant culture","authors":"Mahsa Darbahani, Mohammad Rasoul Ghiyasi, Mahdi Rahaie","doi":"10.1007/s11101-024-10022-4","DOIUrl":"https://doi.org/10.1007/s11101-024-10022-4","url":null,"abstract":"<p>Plants have been used for their beneficial compounds especially therapeutic and medicinal properties over the centuries. Various applications of plants in industry and medicine are related to their distinct phytochemical molecules called secondary metabolites (bioactive chemicals). In reaction to stress, plants produce secondary metabolites that serve numerous physiological functions. Their complex chemical compositions make them valuable across various industries, including food, agriculture, cosmetics, and pharmaceuticals. The chemicals are efficacious and have been deemed an optimal candidate for commercialization. From several decades ago, studies have suggested that elicitation is an effective strategy to increase the production of secondary metabolites in plants. This could help overcome the limitations of plant cell technology for commercial use. An external stimulus may enhance the synthesis of secondary metabolites by triggering various biosynthetic pathways, activating specific genes associated with defense or non-defense functions, stimulating distinct enzymes, and modifying proteins via phosphorylation or dephosphorylation. Upon new findings, it has found that nanoparticles (NPs) might stimulate the production of bioactive molecules, particularly secondary metabolites in plants. This review will highlight in vivo and in vitro studies using different carbon and metal nanoparticles as nano-elicitors to stimulate secondary metabolite production in various plants.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"18 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mint (Mentha spp.) essential oil extraction: from conventional to emerging technologies","authors":"Sara Hedayati, Mohammad Tarahi, Vahid Baeghbali, Zahra Tahsiri, Mohammad Hashem Hashempur","doi":"10.1007/s11101-024-10020-6","DOIUrl":"https://doi.org/10.1007/s11101-024-10020-6","url":null,"abstract":"<p>Mint essential oil (MEO) is an economically appreciated natural product with significant importance in the cosmetics, pharmaceutics, foods, and healthcare products due to its biological activities. Extraction is a critical step in the production of essential oils from aromatic plants, such as mint. Conventional extraction approaches, such as steam distillation and solvent extraction are commonly used for the extraction of MEO. However, they are energy and time-consuming processes with relatively low extraction yields. Consequently, emerging techniques, such as microwave-assisted, ohmic-assisted, ultrasound-assisted, pulsed electric field, and super and sub-critical fluid extraction methods have been developed to overcome these shortcomings. This review aims to investigate the influence of different extraction methods and conditions on the extraction yield, composition, physicochemical properties, and bioactivity of MEO. Overall, selection of appropriate extraction method and conditions is a crucial step in the extraction of MEO that can have significant effects on the quality and quantity of the isolated EOs. Inappropriate extraction of MEO may reduce the extraction yield, prolong the extraction duration, and increase the energy consumption. Additionally, it may deteriorate the physicochemical properties and bioactivity of the extracted MEO.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"42 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anticancer properties of harmine and its derivatives","authors":"Abdul Aziz Timbilla,&nbsp;Rudolf Vrabec,&nbsp;Radim Havelek,&nbsp;Martina Rezacova,&nbsp;Jakub Chlebek,&nbsp;Gerald Blunden,&nbsp;Lucie Cahlikova","doi":"10.1007/s11101-024-09978-0","DOIUrl":"10.1007/s11101-024-09978-0","url":null,"abstract":"<div><p>This review aims to provide information about the anticancer potential of harmine, a β-carboline alkaloid that was initially isolated in 1847 from the seeds and roots of <i>Peganum harmala</i> L. Various studies have revealed that it possesses a wide range of therapeutic qualities, including anti-inflammatory, antibacterial, antiviral, antidiabetic, and, most notably, anticancer effects. This review discusses the anticancer capabilities of harmine and its derivatives against malignancies such as breast cancer, lung cancer, gastric cancer, colon cancer, glioblastoma, neuroblastoma, liver cancer, pancreatic cancer and thyroid cancer. Harmine uses mechanisms such as apoptosis and angiogenesis inhibition to fight cancer cells. It also influences the cell cycle by inhibiting specific cyclin-dependent kinases and slowing tumor cell proliferation. Synergistic effects have also been observed when harmine is used in combination with other anticancer medications. Harmine has the potential to be a potent anticancer medication that can help in the fight against cancer.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1535 - 1564"},"PeriodicalIF":7.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09978-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elicitation as a tool to improve the accumulation of secondary metabolites in Cannabis sativa","authors":"Daniela Trono","doi":"10.1007/s11101-024-10019-z","DOIUrl":"https://doi.org/10.1007/s11101-024-10019-z","url":null,"abstract":"<p><i>Cannabis sativa</i> L. is an annual dioecious species native from Central Asia, which has mainly been used for medical purposes by many ancient cultures and is currently used for the treatment of several diseases. The pharmacological properties of <i>C. sativa</i> are related to cannabinoids, a class of secondary metabolites entirely unique to this crop that are produced and stored at high levels in the inflorescences and leaves. In addition to cannabinoids, <i>C. sativa</i> plants also produce a large number of non-cannabinoid secondary metabolites including terpenes, phenolic compounds and others, which have also been associated with health-promoting activities. In recent decades, the interest in secondary metabolites from <i>C. sativa</i> has been increasing due to their potential applications not only as pharmaceuticals, but also as nutraceuticals, food additives, drugs, fragrances, and biopesticides. This has generated a significant increase in the development of effective strategies for improving the production of such bioactive compounds. In this context, elicitation has emerged as an effective tool based on the application of abiotic or biotic factors that induce physiological changes and stimulate defense or stress-related responses in plants, including the biosynthesis of secondary metabolites. The current review gives a comprehensive overview of the available studies on the different elicitation approaches used to enhance the accumulation of the major bioactive compounds in <i>C. sativa</i>, and highlights challenges and opportunities related to the use of external elicitors for improving the added value of this crop.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"14 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry and therapeutic potential of the genus Asphodelus L.: an update","authors":"Lutfun Nahar, Afaf Al Groshi, Lakshmi Thangavelu, Fyaz M. D. Ismail, Andrew R. Evans, Satyajit D. Sarker","doi":"10.1007/s11101-024-10004-6","DOIUrl":"https://doi.org/10.1007/s11101-024-10004-6","url":null,"abstract":"<p>The genus <i>Asphodelus</i> L. (family: Asphodelaceae) comprises <i>ca.</i> 20 hardy herbaceous, perennial flowering plant species, and is native to Africa, the Indian subcontinent, the Mediterranean region, and temperate Europe, and naturalized in Australia, Mexico, New Zealand, and some parts of the USA. The <i>Asphodelus</i> species have long been used as traditional medicines for the treatment of acne, alopecia, burns, earache, eczema, local inflammation, psoriasis, and toothache. Since the publication of the last review in 2019, which essentially covered the published literature until the end of 2018, several articles have been published reporting the identification of various secondary metabolites including anthraquinones, flavonoids and phenolic acids and demonstrating the therapeutic potential of the genus <i>Asphodelus</i>. This review article critically appraises the literature on this genus published during 2019–2023 on therapeutic potential and phytochemistry. During this period, among the identified compounds from various <i>Asphodelus</i> species, including <i>A. aestivus</i> Brot., <i>A. albus</i> Mill., <i>A. bento-rainhae</i> P. Silva, <i>A. fistulosus</i> L., <i>A. macrocarpus</i> Salzm. Viv., <i>A. ramosus</i> L. and <i>A. tenuifolius</i> Cav., the phytochemicals of the classes of anthraquinones, flavonoids and phenolic acids were the most dominating ones. Numerous studies established the therapeutic potential of the <i>Asphodelus</i> species mainly against cancer, diabetes, microbial infections, and various ailments caused by oxidative stress. None or negligible toxicity could be observed in the toxicological studies, suggesting an acceptable level of safety of <i>Asphodelus</i> products for potential therapeutic applications.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"141 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products against gram-negative bacteria: promising antimicrobials in future complementary medicine","authors":"Fahimeh Nourbakhsh, Marziyeh Esmaeilzadeh Kashi, Abolfazl Shakeri","doi":"10.1007/s11101-024-10012-6","DOIUrl":"https://doi.org/10.1007/s11101-024-10012-6","url":null,"abstract":"<p>Gram-negative bacteria are nonfermentative and opportunistic and are among the most important causes of nosocomial infections. These bacteria, especially <i>Pseudomonas aeruginosa</i>, <i>Acinetobacter baumannii</i> and <i>Escherichia coli</i>, are resistant to various antibiotics worldwide. This level of antibiotic resistance as well as the overuse of drugs can be among the most important reasons for the tendency toward naturally occurring products. Although the majority of natural products have much greater antibacterial activity against gram-positive bacteria than gram-negative ones, in this review, we presented natural products with anti-gram-negative bacteria and their mechanisms of action. Phenolic compounds, terpenoids, alkaloids and organosulfur compounds are among the most important classes of antimicrobial natural products and are briefly discussed.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"8 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}