Phytochemistry Reviews最新文献

Phytochemistry and therapeutic potential of the genus Asphodelus L.: an update Asphodelus L.属的植物化学和治疗潜力：最新进展

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-09-06 DOI: 10.1007/s11101-024-10004-6

Lutfun Nahar, Afaf Al Groshi, Lakshmi Thangavelu, Fyaz M. D. Ismail, Andrew R. Evans, Satyajit D. Sarker

{"title":"Phytochemistry and therapeutic potential of the genus Asphodelus L.: an update","authors":"Lutfun Nahar, Afaf Al Groshi, Lakshmi Thangavelu, Fyaz M. D. Ismail, Andrew R. Evans, Satyajit D. Sarker","doi":"10.1007/s11101-024-10004-6","DOIUrl":"https://doi.org/10.1007/s11101-024-10004-6","url":null,"abstract":"The genus Asphodelus L. (family: Asphodelaceae) comprises ca. 20 hardy herbaceous, perennial flowering plant species, and is native to Africa, the Indian subcontinent, the Mediterranean region, and temperate Europe, and naturalized in Australia, Mexico, New Zealand, and some parts of the USA. The Asphodelus species have long been used as traditional medicines for the treatment of acne, alopecia, burns, earache, eczema, local inflammation, psoriasis, and toothache. Since the publication of the last review in 2019, which essentially covered the published literature until the end of 2018, several articles have been published reporting the identification of various secondary metabolites including anthraquinones, flavonoids and phenolic acids and demonstrating the therapeutic potential of the genus Asphodelus. This review article critically appraises the literature on this genus published during 2019–2023 on therapeutic potential and phytochemistry. During this period, among the identified compounds from various Asphodelus species, including A. aestivus Brot., A. albus Mill., A. bento-rainhae P. Silva, A. fistulosus L., A. macrocarpus Salzm. Viv., A. ramosus L. and A. tenuifolius Cav., the phytochemicals of the classes of anthraquinones, flavonoids and phenolic acids were the most dominating ones. Numerous studies established the therapeutic potential of the Asphodelus species mainly against cancer, diabetes, microbial infections, and various ailments caused by oxidative stress. None or negligible toxicity could be observed in the toxicological studies, suggesting an acceptable level of safety of Asphodelus products for potential therapeutic applications.","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural products against gram-negative bacteria: promising antimicrobials in future complementary medicine 抗革兰氏阴性菌的天然产品：未来补充医学中大有可为的抗菌剂

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-09-06 DOI: 10.1007/s11101-024-10012-6

Fahimeh Nourbakhsh, Marziyeh Esmaeilzadeh Kashi, Abolfazl Shakeri

引用次数: 0

Fruit juices: chemical compositions and health benefits 果汁：化学成分和健康益处

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-09-05 DOI: 10.1007/s11101-024-10013-5

Gülin Renda, Didem Şöhretoğlu

{"title":"Fruit juices: chemical compositions and health benefits","authors":"Gülin Renda, Didem Şöhretoğlu","doi":"10.1007/s11101-024-10013-5","DOIUrl":"https://doi.org/10.1007/s11101-024-10013-5","url":null,"abstract":"Polyphenols are known to have positive effects on health. Consuming fruits rich in polyphenols can reduce the risk of chronic diseases. Drinking fruit juices or other fruit-derived beverages can be an enjoyable way to incorporate fruit’s nutritional benefits and flavor into the diet. However, concerns have been raised that drinking fruit juices and contain too little fiber compared to whole fruit, can lead to weight gain. Despite the differences in chemical composition and health effects, fruit-derived beverages are still a healthy option. This article summarizes the chemical composition and health benefits of commonly consumed fruit juices and beverages made from polyphenol-rich fruits. Based on the reviewed papers, apple, blackberry, cherry, Citrus, cranberry, grape and pomegranate juices have preventive effects on degenerative diseases like cardiovascular and neurological illness and diabetes. Furthermore, some juice has also different favourable effects ie. cranberry juice is important for the prevention of mainly urinary tract infections and Helicobacter infections, Citrus juices have antimicrobial action against a wide range of pathogens. In view of their use as food, increasing studies on fruit drinks are extremely important for health.","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chalcone and derived natural products: versatile scaffolds for multiple targets in treatment of Type 2 diabetes 查耳酮及其衍生天然产品：治疗 2 型糖尿病多靶点的多功能支架

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-09-02 DOI: 10.1007/s11101-024-10007-3

Vinayak S. Marulkar, Neela M. Bhatia

{"title":"Chalcone and derived natural products: versatile scaffolds for multiple targets in treatment of Type 2 diabetes","authors":"Vinayak S. Marulkar, Neela M. Bhatia","doi":"10.1007/s11101-024-10007-3","DOIUrl":"https://doi.org/10.1007/s11101-024-10007-3","url":null,"abstract":"Type 2 diabetes is characterized by insulin resistance, elevated blood sugar levels, oxidative stress, chronic inflammation, dyslipidemia, increased angiogenesis, and a multitude of associated complications. The use of herbs in the treatment of diabetes has been a longstanding practice, proving effective in preventing and treating diabetic symptoms. However, the specific molecular mechanisms underlying their effectiveness remain largely unexplored. A versatile class of phytochemicals, the chalcone, serves as precursor to a wide range of flavonoids, obtained naturally and derived synthetically as well as semi synthetically found effective in treating Type 2 diabetes mellitus. Natural chalcones and its plant metabolites were reported effective in treating diabetes and related complications by virtue of their interaction with diverse metabolic targets involved in glucose homeostasis. This review specifically explores studies on such natural chalcones, its plant metabolites and phyto-complexes conducted within the last decade on drug targets of Type 2 diabetes mellitus like α-glucosidase, PTP1B, α-amylase, DPP-IV, aldose reductase, PPARγ.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances on anti-diabetic potential of pigmented phytochemicals in foods and medicinal plants 食品和药用植物中色素植物化学物质抗糖尿病潜力的最新研究进展

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-08-30 DOI: 10.1007/s11101-024-10014-4

Senem Kamiloglu, Deniz Günal-Köroğlu, Tugba Ozdal, Merve Tomas, Esra Capanoglu

{"title":"Recent advances on anti-diabetic potential of pigmented phytochemicals in foods and medicinal plants","authors":"Senem Kamiloglu, Deniz Günal-Köroğlu, Tugba Ozdal, Merve Tomas, Esra Capanoglu","doi":"10.1007/s11101-024-10014-4","DOIUrl":"https://doi.org/10.1007/s11101-024-10014-4","url":null,"abstract":"Type 2 diabetes is marked by elevated blood sugar levels and linked to impaired insulin secretion and resistance to insulin. Researchers are continuously investigating different classes of phytochemicals including natural pigments for their potential direct or indirect advantages in the prevention and/or control of diabetes. In this review, clinical trials, animal studies, and cell culture models, as well as in vitro enzyme inhibition assays and in silico molecular docking studies were covered for pigmented phytochemicals including anthocyanins, carotenoids, betalains, chlorophylls, curcumin, and phycocyanins. Recent research has shown that the anti-diabetic effects of pigments include (1) inhibition of ROS formation, (2) downregulation of inflammatory response like inhibiting COX, or regulation of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), (3) regulation of multiple signal pathways such as NF-κB, AMPK, MAPK, (4) inhibition of cell apoptosis, according to the ratio of Bcl-2/Bax; and cell proliferation via PI3K/Akt pathways, and (5) digestive enzyme inhibition, such as α-amylase and α-glucosidase, among others.","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bergamottin a bioactive compound unveiled: exploring its potential in disease managments and in-silico insights 揭开生物活性化合物佛手柑素的神秘面纱：探索其在疾病治疗中的潜力并进行分子内研究

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-08-29 DOI: 10.1007/s11101-024-10016-2

Iqra Farzeen, Muhammad Muzammil Nazir, Saima Muzammil, Saima Zafar, Derya karatas Yeni, Asma Ashraf

{"title":"Bergamottin a bioactive compound unveiled: exploring its potential in disease managments and in-silico insights","authors":"Iqra Farzeen, Muhammad Muzammil Nazir, Saima Muzammil, Saima Zafar, Derya karatas Yeni, Asma Ashraf","doi":"10.1007/s11101-024-10016-2","DOIUrl":"https://doi.org/10.1007/s11101-024-10016-2","url":null,"abstract":"Bergamottin (BGM), major furanocoumarins present in citrus fruits such as grapefruit. BGM is found in both the skin and flesh of grapefruit and has been reported in flavedo at concentrations as high as 666.54 μg g−1 dry weight.BGM has been reported to induce elevated bioavailability of drugs via the inhibition of multiple cytochrome P450 enzymes, such as CYPs3A4. The present review will focus on anti-cancer, ant-inflammatory, anti-obesity potential of bergamottin through literature review and in silico study. Thorough literature search was carried out utilizing specialized and dedicated search platforms.In different types of cancer BGM has anticancer effect. NF-κB inhibition by BGM is a desirable way to manage inflammation.In diabetes treatment, it increased glucose uptake by 41.6% after a 24-h period. In obese patients, BGM affected the expression of adipogenic factors during 3T3-L1 differentiation and ampK signalling activation.Role of bioactive compound against inflammation, cancer and diabetes analyzed through network pharmacology (ADME, Networking and Docking). Gene ontology and Kegg analysis showed BGM is effective through dfferent cancer and immune system pathways. Docking analysis performed by receptor protein 6Y3C (Human COX-1) and 6DWM that have best fit with the compound: Bergamottin having docking scores of −8.46 and −11.1 respectively. In conclusion, BGM can be characterized as novel compound in drug development.","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using protein–metabolite interactions to identify novel plant metabolite receptors 利用蛋白质与代谢物的相互作用识别新型植物代谢物受体

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-08-27 DOI: 10.1007/s11101-024-10005-5

Hillary D. Fischer, Alisdair Fernie, Aleksandra Skirycz

引用次数: 0

A review of Juniperus rigida Sieb. et Zucc.: a potential supplier of bioactive compounds and medical outcomes 审查杜松：生物活性化合物和医疗效果的潜在供应商

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-08-24 DOI: 10.1007/s11101-024-10010-8

Duozhen Zhong, Dengwu Li

{"title":"A review of Juniperus rigida Sieb. et Zucc.: a potential supplier of bioactive compounds and medical outcomes","authors":"Duozhen Zhong, Dengwu Li","doi":"10.1007/s11101-024-10010-8","DOIUrl":"https://doi.org/10.1007/s11101-024-10010-8","url":null,"abstract":"Juniperus rigida Sieb. et Zucc. has been long used as a traditional medicine in China, Korea, and Japan. Diseases like neuralgia, dropsy, gout, brucellosis, dermatitis, nephritis, and rheumatoid arthritis have been treated by J. rigida. According to most studies of the plant, these uses above are mainly attributed to its phytochemical composition, which turns out rich in phenolics, terpenoids, organic acids, alkaloids, and volatile compounds. In recent years, more and more reports are pointing out the bioactive potential of this evergreen shrub in a wide range of different biomedical fields, namely antioxidant, anti-wrinkling, anti-bacterial, anti-inflammatory, cytotoxic, anti-cancer, anti-tumor, anti-mutagenicity, anti-obesity, anti-cholinesterase, anti-fungal activities. Despite these promising results, more in vivo and in vitro studies are needed to provide more evidence and methods for its application in cosmetics and pharmacology. Therefore, we conducted the first review on J. rigida, a recalcitrant plant and a promising source of bioactive compounds and medical outcomes, to outline and summarize all the bioactive compounds and biomedical activities reported so far.","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hesperidin: a flavanone with multifaceted applications in the food, animal feed, and environmental fields 橙皮甙：一种在食品、动物饲料和环境领域具有多方面用途的黄酮类化合物

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-08-21 DOI: 10.1007/s11101-024-10008-2

Verónica Pereira, Onofre Figueira, Paula C. Castilho

{"title":"Hesperidin: a flavanone with multifaceted applications in the food, animal feed, and environmental fields","authors":"Verónica Pereira, Onofre Figueira, Paula C. Castilho","doi":"10.1007/s11101-024-10008-2","DOIUrl":"https://doi.org/10.1007/s11101-024-10008-2","url":null,"abstract":"Hesperidin, a glycosylated flavanone abundant in nature, is an antioxidant widely researched in the pharmaceutical industry for its anti-inflammatory, anticancer, antiviral, anti-aging, cardioprotective and neuroprotective effects. Despite the extensive literature highlighting these therapeutic activities, there remains a significant gap in understanding hesperidin role across other fields. This review aims at demonstrating hesperidin applications beyond pharmaceutical applications, particularly in the food, feed, and environmental fields. For this purpose, a brief description of the biosynthesis pathway of hesperidin in citrus plants is provided as well as its main chemical derivatives. In the food industry, hesperidin and its derivatives are commercialized as dietetic supplements and have been studied as food additives and active ingredients in edible food packaging. Within the feed industry, meat and/or eggs from animals supplemented with hesperidin show higher oxidative stability and prolonged shelf life. Moreover, in the environment research, hesperidin induces plant tolerance against abiotic factors and shows biopesticide activity.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insight into pharmacological effects of secondary metabolites from Bidens pilosa Bidens pilosa 次生代谢物药理作用的机理研究

IF 7.7 2区生物学

Phytochemistry Reviews Pub Date : 2024-08-21 DOI: 10.1007/s11101-024-10011-7

Aaron Mwesigwa, Shariff Ssempijja, Ashishkumar Kyada

{"title":"Mechanistic insight into pharmacological effects of secondary metabolites from Bidens pilosa","authors":"Aaron Mwesigwa, Shariff Ssempijja, Ashishkumar Kyada","doi":"10.1007/s11101-024-10011-7","DOIUrl":"https://doi.org/10.1007/s11101-024-10011-7","url":null,"abstract":"Bidens pilosa also known as blackjack, Spanish needles, or beggar’s ticks, is native to central and southern America but has drastically spread to other parts of the world including Europe, Asia, and Africa. Its folklore use as a traditional herb and food supplement has been noted for many years, which triggered research interest in its phytochemistry and possible pharmacological actions. Phytochemical screening of different solvent extracts of B. pilosa has revealed the presence of many phytocompounds of pharmacological importance. In the present review paper, some of the phytochemicals belonging to polyacetylenes, flavonoids, terpenes, steroids, alkaloids, phenolics, and coumarins present in the different solvent extracts of the plant parts or whole plant have been considered to exert a range of therapeutic actions such as analgesic, antipyretic, anti-inflammatory, anti-hemorrhoid, anti-bacterial, antioxidant, anti-diabetic, anti-cancer, anti-ulcer, anti-malarial, hepatoprotective, diuretic, anti-allergy, anti-angiogenic and anti-fungal effects. This review discusses the pharmacological actions of active secondary metabolites in B. pilosa and their potential mechanisms contributing to specific pharmacological actions.<h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0