Phytochemistry Reviews最新文献

{"title":"Biological activities of hydroxyanthracene derivatives (HADs) from Aloe species and their potential uses","authors":"Juan J. Merino,&nbsp;Alexandra G. Durán,&nbsp;Nuria Chinchilla,&nbsp;Francisco A. Macías","doi":"10.1007/s11101-025-10089-7","DOIUrl":"10.1007/s11101-025-10089-7","url":null,"abstract":"<div><p>Hydroxyanthracene derivatives (HADs) are a class of naturally occurring organic compounds known for their diverse biological activities and applications. Due to their pharmacological versatility, hydroxyanthracene derivatives represent a major area of interest in natural products research and drug development. They are found in a wide variety of organisms including bacteria, fungi, plants and some animals. One of the most important sources of HADs is the plant <i>Aloe vera</i>, which is particularly rich in these compounds. HADs can be divided into several types based on their chemical structure and the presence of functional groups: anthraquinones, anthrones, anthranols, anthracenols and dianthrones, with anthraquinones being the most abundant. Plants are a particularly rich source, with around 200 known anthraquinones found in roots, rhizomes, flowers and fruits. These compounds are known for their diverse biological activities, including anticancer, anti-inflammatory, diuretic, antiarthritic, antifungal, antibacterial and antimalarial properties. Some anthraquinones are already in clinical use and commercially available. In addition to their medicinal applications, these molecules are valuable in analytical chemistry and industrial processes such as cellulose production, and serve as dyes, agrochemicals and prototypes for the development of new bioactive molecules. Various techniques are used to extract anthraquinones from natural sources to maximize yield and preserve the integrity of the compounds. Common methods include maceration, soxhlet extraction, supercritical fluid extraction, green processes and ultrasound-assisted extraction. This chapter focuses on the key properties and applications of anthraquinone from <i>Aloe vera</i>. Through a comprehensive review of these aspects, this chapter aims to provide a thorough understanding of the potential of anthraquinones and their diverse roles in both natural and applied sciences.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 3","pages":"2387 - 2415"},"PeriodicalIF":7.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10089-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals in medicine and food: potential to the development of health products in medicine and food industries","authors":"Aline Priscilla Gomes da Silva,&nbsp;Jianbo Xiao,&nbsp;Haiyan Gao","doi":"10.1007/s11101-025-10082-0","DOIUrl":"10.1007/s11101-025-10082-0","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1057 - 1060"},"PeriodicalIF":7.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond traditional uses: the multifaceted bioactivities of steroidal saponins from the genus Trillium and their modern applications","authors":"Dong-Sheng Fan,&nbsp;Lu Yu,&nbsp;Xiao-Gang Zhou,&nbsp;Yue Zhang,&nbsp;Dong Yi,&nbsp;Qi-Bing Mei,&nbsp;Da-Lian Qin,&nbsp;Jian-Ming Wu,&nbsp;An-Guo Wu","doi":"10.1007/s11101-024-09954-8","DOIUrl":"10.1007/s11101-024-09954-8","url":null,"abstract":"<div><p>Steroidal saponins with diverse bioactivities have gained considerable attention. The genus <i>Trillium</i>, a group of perennial flowering plants, is a prominent source of these compounds, historically esteemed in both Native American and East Asian medicinal traditions. This review integrates traditional knowledge with modern scientific findings to explore the phytochemical, pharmacological, and toxicological properties of <i>Trillium</i>-derived steroidal saponins. Through an exhaustive literature review utilizing databases such as PubMed, Science Direct, CNKI, and Google Scholar, 134 pivotal papers up to October 17, 2023, were selected for analysis. This emphasizes the medicinal importance of the <i>Trillium</i> genus, particularly highlighting <i>Trillium Tschonoskii</i>, and identifies steroidal saponins as the primary bioactive components among various compounds. The pharmacological activities of <i>Trillium</i> species reveals that steroidal saponins exhibit various bioactivities, including anticancer, antidiabetic, neuroprotective, anti-aging, and anti-inflammatory effects. Specifically, these saponins have shown potential in inhibiting tumor growth, enhancing insulin sensitivity, protecting neuronal cells from oxidative stress, slowing the aging process, and reducing inflammation through various cellular and molecular mechanisms. Such findings underscore the therapeutic potential of steroidal saponins in addressing a multitude of health conditions, suggesting their role in developing innovative therapeutic solutions. However, despite these promising bioactivities, there remains a crucial need for in-depth clinical studies to validate the therapeutic efficacy of <i>Trillium</i>-derived steroidal saponins fully. Looking forward, the multifarious bioactivities of these compounds present a compelling case for continued scientific exploration, with the potential to revolutionize the realm of natural medicine by offering new avenues for the treatment and management of various diseases.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1283 - 1344"},"PeriodicalIF":7.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A comprehensive review on various carcinogenic aspects of N-nitrosopiperidine (NPIP)","authors":"Priya Chaudhary,&nbsp;Devendra Singh,&nbsp;Pracheta Janmeda","doi":"10.1007/s11101-024-10026-0","DOIUrl":"10.1007/s11101-024-10026-0","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3289 - 3289"},"PeriodicalIF":7.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untangling the rhizosphere specialized metabolome","authors":"Genesiska,&nbsp;Joana Falcao Salles,&nbsp;Kira Juliane Tiedge","doi":"10.1007/s11101-024-10036-y","DOIUrl":"10.1007/s11101-024-10036-y","url":null,"abstract":"<div><p>The importance of microbes in helping plants deal with unfavorable environmental conditions is currently receiving a lot of attention. Still, how plants and microbes communicate on a chemical level warrants a deeper understanding. Both plants and microbes exude specialized metabolites (SMs) into the rhizosphere, and the exudate profiles drastically change under sub-optimal conditions such as drought. Yet, it remains unclear what the ecophysiological functions of these exuded compounds are and whether common underlying patterns exist across different plant species. The complexity of chemical mixtures in the rhizosphere, the diversity of microbial communities, and dissimilar experimental conditions are impeding progress in this field. With this article, we aim to link plant-derived SMs under normal and stressful conditions to their signaling effect on soil microbial communities and vice versa while pointing out the newest developments and bottlenecks of getting to the function of root exudate composition. Additionally, we provide some best practices for increasing comparability and reproducibility among experiments.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"2527 - 2537"},"PeriodicalIF":7.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-10036-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the molecular mechanisms of melon fruit firmness: insights into cell wall gene expression and regulation","authors":"Flávia Maria Gustani,&nbsp;Cristiane Colodel,&nbsp;Ricardo Antonio Ayub","doi":"10.1007/s11101-024-10023-3","DOIUrl":"10.1007/s11101-024-10023-3","url":null,"abstract":"<div><p>Melons exhibit broad phenotypic variation, with fruits undergoing both climacteric and non-climacteric maturation patterns that directly impact the texture of the endocarp. The loss of fruit firmness is intricately linked to the degradation of cell wall components, mainly cellulose, hemicelluloses, and pectins. The cell wall serves multiple functions, including providing mechanical resistance, regulating osmotic pressure, acting as a diffusion barrier, controlling cell adhesion and expansion, and protecting the plasma membrane from damage and pathogens. The biochemical changes influencing the physical properties of the wall are orchestrated by gene expression and interactions with epigenetic and hormonal factors. Establishing knowledge of these interactions and understanding the structural changes that occur during maturation are essential for elucidating the primary causes of firmness loss in melon fruits. In this review we summarize knowledge on the expression of cell wall genes in melon and how they contribute to the synthesis, loosening, and depolymerization of the cell wall during maturation. Such information provides a valuable foundation for advanced postharvest management strategies and future physiological and molecular studies to enhance fruit quality and extend shelf life.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3205 - 3220"},"PeriodicalIF":7.6,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC–MS analysis, HPLC–UV analysis, antimicrobial and antioxidant activities of extracts of wild-growing anabasis salsa native to kazakhstan desert iands","authors":"Ubaidilla Datkhayev,&nbsp;Zhanibek Shegebayev,&nbsp;Aknur Turgumbayeva,&nbsp;Ahmet Beyatli,&nbsp;Myrzakozha Diyas,&nbsp;Kairat Zhakipbekov,&nbsp;Abay Shepetov,&nbsp;Gulmira Datkayeva,&nbsp;Almat Kodasbaev,&nbsp;Sabit Pazilov,&nbsp;Abay Kussainov,&nbsp;Assem Kalykova,&nbsp;Zaure Datkhayeva,&nbsp;Zhanserik Shynykul","doi":"10.1007/s11101-024-09999-9","DOIUrl":"10.1007/s11101-024-09999-9","url":null,"abstract":"<div><p><i>Anabasis salsa</i> has been used to treat various diseases in kazakh folk medicine. Petroleum ether and dichloromethane extracts were subjected to GC–MS analysis, and valuable bioactive compounds were identified from the chromatograms. Additionally, butanol extract was subjected to HPLC–UV analysis and it was confirmed the presence of gallic acid. Overall, results confirmed the presence of overall 108 various compounds from different chemical classes: fatty acids and derivatives, steroidal compounds, phenolic compounds and minor group compounds. In this study, <i>A. salsa</i> was preliminarily subjected to extraction, and the resultant extracts were then evaluated for their antimicrobial and antioxidant potentials. The antioxidant activity results of <i>A. salsa</i> demonstrated that the dichloromethane extract exhibited higher activity compared to the butanol and petroleum ether extracts in both methods (DPPH: 503.12 ± 8.34 mg/g and ABTS: 119.51 ± 6.23 mg/g). Moreover, the dichloromethane extract of <i>A. salsa</i> was found to be more effective against all tested microorganisms, with minimum inhibitory concentrations (MICs) of 1.250 mg/ml for <i>S. aureus</i>, 0.312 mg/ml for <i>E. faecalis</i>, 0.156 mg/ml for <i>E. coli</i>, 0.039 mg/ml for <i>P. aeruginosa</i>, and 0.009 mg/ml for <i>C. albicans</i>. As a result, <i>A. salsa</i> shows promise as a therapeutic alternative and deserves additional investigation for its possible biological advantages. Beyond its use in separating pure responsible components, this plant may hold additional applications in the field of medicine and research. For example, chemical composition analysis has shown the presence of different biologically active compounds with a broad spectrum of applications in pharmacology. Hence, further investigations are needed to uncover its full range of biological potentials.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"2651 - 2675"},"PeriodicalIF":7.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and physiological function of lignin in the reproductive structures of angiosperms","authors":"Monica Borghi,&nbsp;Yuri Takeda-Kimura","doi":"10.1007/s11101-024-10043-z","DOIUrl":"10.1007/s11101-024-10043-z","url":null,"abstract":"<div><p>Lignin, a polymer of hydroxycinnamyl alcohols and related monomers, is found in great abundance in the plant vasculature, where it confers mechanical strength and facilitates water transport. Lignin is also found in many other plant organs, including roots, flowers, fruits, and abscission zones. While in these organs impregnation of lignin is usually limited to a thin layer of cells, or just a few cells, this thin lignin linin often fulfills important physiological functions related to reproduction and plant fitness. In this perspective review, we focused on the lignin of flowers and fruits. After a brief introduction on the anatomy and morphology of these organs, we provided an overview of the molecular mechanisms governing the spatial and temporal regulation of lignin synthesis. We further described the consequences that perturbations of these processes have on the biochemical structure of lignin polymers, plant reproduction, and fitness. Recent discoveries on the chemical composition of seed coat lignin and the formation of the petal abscission zone are also discussed. With this Perspective review, we hope to bring the topic of lignin in reproductive organs to a wider audience, while highlighting the impact that future research could have on breeding and agriculture.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"2539 - 2551"},"PeriodicalIF":7.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145162748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring plant-derived bisindole alkaloids: a comprehensive review of sources, phytochemistry and cytotoxicity","authors":"Zilong Zhang,&nbsp;Yuze Li,&nbsp;Yiming Li,&nbsp;Xiaomei Song,&nbsp;Rui Wang,&nbsp;Dongdong Zhang","doi":"10.1007/s11101-024-10015-3","DOIUrl":"10.1007/s11101-024-10015-3","url":null,"abstract":"<div><p>Bisindole alkaloids represent a notable class of natural compounds distinguished by their characteristic bisindole structure and recognized for their anticancer potential. Over the past nine decades, a plethora of bisindole alkaloids have been isolated from plants. The chemical compositions and cytotoxicity of these plant-derived bisindole alkaloids (PDBAs) have been elucidated. Currently, 735 PDBAs have been documented. Predominantly sourced from plants within the Apocynaceae family, these compounds demonstrate formidable cytotoxicity against various tumor types, such as colorectal cancer, breast cancer and lung cancer. This review comprehensively examines the sources, phytochemistry, and cytotoxicity of these compounds. Furthermore, it provides a summary of the structure–activity relationship (SAR) and the mechanisms through which PDBAs exert their cytotoxicity. In summary, the aim of this paper is to offer a comprehensive overview of the advancements in the investigation of PDBAs for their continued development and utilization.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1753 - 1841"},"PeriodicalIF":7.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling promising bioactives for breast cancer: a novel approach for herbal-based drug discovery","authors":"Aditya Arvindekar,&nbsp;Snehal Arvindekar,&nbsp;Suraj N. Mali,&nbsp;Sachin Mali","doi":"10.1007/s11101-024-10024-2","DOIUrl":"10.1007/s11101-024-10024-2","url":null,"abstract":"<div><p>Breast cancer (BC) is a complex disease that manifests with a malignancy of the mammary gland. Globally, the year 2020 witnessed 2.3 million diagnosis cases and 685,000 deaths due to breast cancer. Therefore, there is a dire need for the development of new anticancer drugs for BC. Traditional herbal medicine offers a rich source in the prospect of new drug discovery. In this pursuit, this review covers the discovery of compounds against breast cancer with the possible mechanisms of action, which can assist the development of novel phytomedicines in the drug discovery process. Specifically, the bioactives against breast cancer developed from 1999 to 2023 were categorized based on their chemical class based on a systematic search on PubMed and Embase. Over 70 + natural products belonging to different chemical classes and their mechanisms of action for anticancer activity with commonly used drugs in clinical practice are summarized for a simple understanding of the experimental data. The review draws attention to the vital need to isolate novel bioactive constituents and to develop new drugs based on these isolated bioactives using novel drug delivery systems, so as to increase the target specificity and thereby reduce the adverse effects.Finally, we highlighted the natural bioactives undergoing preclinical and clinical trials to determine their potential for use in the treatment of BC, which could pave the way towards new target-specific drugs against breast cancer.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3221 - 3264"},"PeriodicalIF":7.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}