Phytochemistry Reviews最新文献

{"title":"Bioactive plant compounds and exercise: from molecular mechanisms to clinical applications","authors":"Sen Lin,&nbsp;Jiayu Jiang,&nbsp;Jingjing Ren,&nbsp;Mohammad J. Rezaei","doi":"10.1007/s11101-025-10192-9","DOIUrl":"10.1007/s11101-025-10192-9","url":null,"abstract":"<div><p>Intense physical exercise induces oxidative stress, inflammation, and muscle damage, which can impair athletic performance and recovery. This comprehensive review synthesizes the current evidence on the molecular mechanisms and clinical efficacy of bioactive plant compounds in mitigating these physiological stressors. Analysis of the literature reveals that these compounds primarily exert protective effects by modulating key signaling pathways, such as activating the Nrf2 antioxidant response and inhibiting NF-κB-mediated inflammation. In human trials, specific compounds demonstrate clear benefits: bioavailable curcumin formulations (e.g., ~ 400 mg/day) and tart cherry anthocyanins are effective at reducing key markers of muscle damage (such as creatine kinase) and soreness, while beetroot juice (providing ~ 5–8 mmol of nitrate) consistently improves exercise efficiency and performance via the nitrate-nitric oxide pathway. In contrast, promising compounds like quercetin and resveratrol have yielded inconsistent results, a discrepancy largely attributed to poor oral bioavailability. The clinical utility of these compounds is therefore critically dependent on formulation and delivery methods. While plant-based bioactives represent a promising nutritional strategy for athletes, future research must prioritize large-scale, standardized trials to translate these findings into reliable, evidence-based recommendations.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2183 - 2231"},"PeriodicalIF":7.6,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants and human health: a comprehensive review of bioactive compounds, therapeutic effects, and applications","authors":"Riffat Latif,&nbsp;Taufiq Nawaz","doi":"10.1007/s11101-025-10194-7","DOIUrl":"10.1007/s11101-025-10194-7","url":null,"abstract":"<div><p>Medicinal plants continue to serve as a vital source of structurally diverse bioactive compounds with broad therapeutic potential. This review synthesizes recent advances in the field, emphasizing how modern technologies are reshaping natural product research and translational applications. Omics platforms—including genomics, metabolomics, proteomics, and spatial omics—enable comprehensive mapping of biosynthetic pathways, regulatory networks, and spatial chemical distributions, accelerating the discovery and characterization of bioactive compounds. Artificial intelligence-driven approaches in predictive modeling, automated metabolite annotation, and optimized cultivation strategies are examined as transformative tools for improving research efficiency and reproducibility. In parallel, nanotechnology-based drug delivery systems are highlighted for their ability to enhance bioavailability, target specificity, and therapeutic efficacy, particularly against complex diseases such as cancer and neurodegeneration. The review also addresses critical challenges, including biodiversity conservation, contamination and adulteration of herbal products, and gaps in regulatory oversight. Finally, we discuss future perspectives where integrative, multidisciplinary strategies are poised to advance personalized medicine, promote sustainable harvesting, and drive innovative phytopharmaceutical development. By bridging traditional knowledge with state-of-the-art technologies, this review underscores the evolving role of medicinal plants in next-generation healthcare solutions and their transformative potential for global health.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2299 - 2342"},"PeriodicalIF":7.6,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10194-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into therapeutic potential of Centella asiatica (L.) Urb.in diabetes mellitus and its chronic health complexities: from botany, medicinal chemistry to clinical trials approach","authors":"Harshita Singh,&nbsp;Navneeta Bharadvaja","doi":"10.1007/s11101-025-10195-6","DOIUrl":"10.1007/s11101-025-10195-6","url":null,"abstract":"<div><p>Herbal drugs are gaining spectacular attention nowadays due to immense therapeutic potential known since time immemorial. The remarkable increase in herbal drugs in different disease such as cardiovascular, neurodegenerative, diabetes, leprosy etc. is indeed creating a pavement to exploit the traditional ancient wisdom through scientific lens of modern era. Diabetic patients are upsurging day by day and is becoming a matter of concern. The surge in number of illnesses associated with diabetes is presenting the cartographic scenario of diabetes worldwide. The present review is an attempt to elucidate the anti-diabetic potential of Centelloids and others phytoconstituents from <i>Centella asiatica.</i> The significance of <i>C. asiatica</i> phytocompounds, their pharmacology and phytochemistry are  also highlighted. The study was conducted via surfing of different databases such as Google scholar databases, PubMed, Scopus, science direct and few articles from the concerned publications website using different keywords like <i>C. asiatica</i>, compounds, diabetes mellitus etc. This review consists of many relevant papers with their valuable citations. A diverse range of phytocompounds such as asiatic acid, madecassic acid etc. in <i>C. asiatica</i> has contributed to its therapeutic potential in diabetes mellitus. <i>C. asiatica</i> is enriched with many secondary metabolites. Different molecular and pharmacological mechanism based on clinical trials has been reported to elucidate the mode of action of <i>C. asiatica</i> phytoconstituents via different signaling pathway namely, protein kinase B, glycogen synthase kinase B, TGFb1/Samd AMPK, SIRT1, TGF etc. in diabetes mellitus, thus making it a miraculous medicinal herb. This review insights into possible therapeutic potential of <i>C. asiatica</i> compounds in diabetes mellitus via different mechanism and mode of action, its description, phytochemistry, ethnobotany which could further pave a pathway for development of significant drugs for diabetes mellitus.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2343 - 2366"},"PeriodicalIF":7.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147558848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scratching the surface: The diversity and roles of triterpenoids in plant cuticular waxes","authors":"Priyanka Trivedi,&nbsp;Gang-Shuai Liu,&nbsp;Linards Klavins,&nbsp;Raktim Bhattacharya,&nbsp;Soile Jokipii-Lukkari,&nbsp;Adinpunya Mitra,&nbsp;Maris Klavins,&nbsp;Da-qi Fu,&nbsp;Laura Jaakola,&nbsp;Anna Szakiel,&nbsp;Katja Karppinen","doi":"10.1007/s11101-025-10191-w","DOIUrl":"10.1007/s11101-025-10191-w","url":null,"abstract":"<div><p>The cuticle and cuticular waxes play vital roles as the interface between a plant and its environment. Cuticular waxes are composed of very long-chain fatty acids (VLCFAs) and their derivatives as well as triterpenoids, which are specialized metabolites. Although triterpenoids constitute a major fraction of cuticular waxes, their functions remain poorly understood. In this review, we provide an overview of the chemical diversity of triterpenoids in the cuticular waxes of leaves and fruits of angiosperms and discuss changes in triterpenoid content during their development. The methods and challenges for the analysis of cuticular wax triterpenoids are summarized. The biosynthesis of triterpenoids is also reviewed along with recent knowledge of the potential mechanisms of triterpenoid transportation and secretion from the site of biosynthesis to the plant surface. Considering ongoing climate change, the current understanding of the effects of environmental conditions and abiotic stress factors on cuticular wax triterpenoids is reviewed. We also present an overview of the current knowledge on the roles of triterpenoids in cuticular waxes in transpiration and defense against biotic stressors and their possible role in cuticle stabilization. Moreover, owing to the generally high levels of triterpenoids in fruit cuticular waxes, the provided information on the variation and role of cuticular wax triterpenoids during postharvest fruit storage might help in the development of strategies for better fruit quality maintenance and preservation.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2149 - 2182"},"PeriodicalIF":7.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10191-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147558847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The green antidote: phytochemical defense as a natural shield against chemical warfare","authors":"Nabil Zakaria,&nbsp;Mostafa G. Ali,&nbsp;Zhongyu Zhou","doi":"10.1007/s11101-025-10189-4","DOIUrl":"10.1007/s11101-025-10189-4","url":null,"abstract":"&lt;div&gt;&lt;p&gt;Chemical warfare agents (CWAs), including nerve agents, blister agents, choking agents, and blood agents, pose severe threats to human health and environmental security due to their neurotoxic, immunosuppressive, and oxidative stress-inducing properties. Although conventional antidotes, including atropine, pralidoxime, and various oximes and chelators, have proven effective, they are often associated with significant toxicity, limited availability, and high costs. These limitations necessitate the development of alternative, sustainable countermeasures. Phytochemicals, a diverse group of plant-derived bioactive compounds—including alkaloids, polyphenols, flavonoids, and terpenoids—are emerging as promising natural defenses against CWAs. Their multifaceted biological activities, such as antioxidative, anti-inflammatory, metal-chelating, immune-modulating, and tissue-regenerative properties, offer an eco-friendly and effective alternative countermeasure against CWAs. This review comprehensively explores the potential of phytochemical-based antidotes as a revolutionary natural shield against CWAs. Among phytochemicals, flavonoids and polyphenols play pivotal roles in detoxification mechanisms by upregulating antioxidant enzymes, including Glutathione S-Transferase (GST), NAD(P)H Quinone Dehydrogenase 1 (NQO1), and Superoxide Dismutase (SOD), while simultaneously suppressing pro-inflammatory pathways. Notably, phytochemicals such as quercetin, resveratrol, curcumin, and silymarin not only contribute to detoxification but also enhance adaptive immune responses by promoting T-cell and B-cell activation, thereby offering a multifaceted defense strategy against CWA-induced toxicity. Terpenoids, including ginsenosides, geniposides, and andrographolide, bolster hepatoprotective and neuroprotective mechanisms through the activation of phase I/II detoxification enzymes and neutralization of reactive oxygen species (ROS). Similarly, alkaloids such as galantamine and berberine activate the Nrf2/ARE signaling pathway, strengthening cellular defense mechanisms and offering protection against oxidative and inflammatory damage caused by CWAs. Furthermore, phytochemicals exhibit strong metal-chelating properties, mitigating neurotoxicity and multi-organ damage linked to toxic metals present in CWAs. Their ability to counteract nerve agent toxicity through acetylcholinesterase (AChE) modulation, suppression of neuroinflammation, and enhancement of neuronal survival further highlights their therapeutic potential. Recent advances in nanophytochemistry have significantly improved the bioavailability, targeted delivery, and controlled release of these bioactive compounds, optimizing their efficacy in CWAs defense. Moreover, the integration of phytochemicals into functional textiles, protective formulations, and nutraceutical-based countermeasures represents a paradigm shift in biodefense strategies. By bridging phytochemistry with pharmacology and nanotechnology","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 2","pages":"2027 - 2064"},"PeriodicalIF":7.6,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147342930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive compounds of Piper chaba and their pharmacological relevance: a phytochemistry-focused review","authors":"Vibha Joshi,&nbsp;Vishwajeet Bachhar,&nbsp;Rajesh Haldhar,&nbsp;Ravi K. Shukla,&nbsp;Shashank Shekher Mishra,&nbsp;Seong-Cheol Kim,&nbsp;Manisha Duseja","doi":"10.1007/s11101-025-10193-8","DOIUrl":"10.1007/s11101-025-10193-8","url":null,"abstract":"<div><p>Despite the ethnobotanical significance and widespread therapeutic applications, <i>Piper chaba</i> (Chui Jhal) phytochemical composition and pharmacological mechanisms remain underexplored in modern medicinal research. Therefore, the present systematic review comprehensively examines the current scientific literature on the phytoconstituents and biological activities of <i>Piper chaba</i>, highlighting over 100 identified bioactive compounds, including alkaloids, amides, terpenoids, and flavonoids. <i>Piper</i> species extracts and essential oils have been proven to exhibit many medicinal potentials, which makes them promising therapeutic and health-improving medications due to the presence of various bioactive components in the plant. Several isolated molecules, including piperine, chabamides, and e-piplartine, demonstrate promising therapeutic properties, notably through modulation of cellular redox balance, enzyme inhibition, mitochondrial pathways, and apoptosis induction in cancer models. Additionally, the plant’s favourable toxicity profile and emerging applications in green nanotechnology and drug delivery systems further underscore its medicinal potential. This review highlights <i>P. chaba</i> as a viable source of natural lead chemicals for drug discovery and development by combining old knowledge with new mechanistic insights. It provides a path for next preclinical and translational research while also highlighting important gaps in pharmacokinetics, clinical validation, and molecular targeting.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2233 - 2298"},"PeriodicalIF":7.6,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147561451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals as potential therapeutic agents for inflammatory bowel disease: a comprehensive review","authors":"Sidhartha Jyoti Bora,&nbsp;Soubhik Bhattacharyya,&nbsp;Soumya Deb,&nbsp;Dhrubajyoti Sarkar","doi":"10.1007/s11101-025-10188-5","DOIUrl":"10.1007/s11101-025-10188-5","url":null,"abstract":"<div><p>Inflammatory Bowel Disease is a chronic gastrointestinal inflammatory condition that affects millions of individuals worldwide. There are various therapy options for Inflammatory Bowel Disease, including synthetic medicines such as aminosalicylates, oral corticosteroids, immunomodulators, and biologics. However, these drugs have limitations, including potential side effects, immunogenicity, susceptibility to infections, and high costs. Phytochemicals may serve as an alternative treatment for Inflammatory Bowel Disease due to their numerous health benefits and fewer side effects compared to traditional pharmaceuticals. This study summarised 16 bioactive phytochemicals and 31 medicinal plants shown to impact IBD. Phytochemicals such as hydroxycinnamic acids, natural alkaloids, fatty acids, coumarins, anthraquinones, and terpenoids are useful in treating Inflammatory Bowel Disease. They can target multiple aspects of the disease, making them a promising and effective alternative or supplementary therapy for inflammatory bowel disease. This study conducted a comprehensive review of recent research on the molecular mechanisms of phytochemicals and provided evidence for novel therapeutic agents for Inflammatory Bowel Disease, opening new possibilities for developing treatment regimens.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 2","pages":"1985 - 2026"},"PeriodicalIF":7.6,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147338785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products for the treatment of Chagas disease: a review of plant-derived compounds and related synthetic derivatives as potential trypanocidal drugs","authors":"Antonio Martín-Martín,&nbsp;Alicia Gómez-Barrio,&nbsp;Cristina Fonseca-Berzal","doi":"10.1007/s11101-025-10190-x","DOIUrl":"10.1007/s11101-025-10190-x","url":null,"abstract":"<div><p>Chagas disease (CD), caused by the hemoflagellate protozoan <i>Trypanosoma cruzi</i>, is one of the current 23 Neglected Tropical Diseases and, mainly, affects the less economically developed areas of Central and South America. Benznidazole and nifurtimox are the only two drugs available for the specific treatment of the infection; however, both show many drawbacks, such as their limited effectiveness, the induction of numerous adverse effects in patients and the existence of natural resistant strains of the parasite, among others. Given the urgent need to identify new antichagasic therapies, the search of bioactive natural compounds stands out as one of the main strategies for improving the therapeutic arsenal of the disease. In this framework, the present work reviews different families of secondary metabolites (e.g., alkaloids, flavonoids, quinones and terpenes) obtained from diverse plant sources, with reported anti-<i>T. cruzi</i> activity. Furthermore, some of their synthetic derivatives, which show interesting activity towards the parasite, are also revisited. In certain cases, the structure–activity relationship of the molecules is also remarked, contributing this way to the development and improvement of promising scaffolds, as well as to elucidate the mechanism of action triggered in the parasite, focusing on the mitochondrion as a crucial drug target. Accordingly, the aim of this work is to provide an overview of the most relevant plant-derived compounds and related derivatives, which have been investigated for the development of more effective CD treatments.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2123 - 2148"},"PeriodicalIF":7.6,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanopharmacological relevance of Cuscuta reflexa Roxb. and its role as a hepato-protective agent: a comprehensive review","authors":"Nighat Gull,&nbsp;Arif Ahmad,&nbsp;Sumbul Rehman","doi":"10.1007/s11101-025-10187-6","DOIUrl":"10.1007/s11101-025-10187-6","url":null,"abstract":"<div><p><i>Cuscuta reflexa</i> Roxb is a widespread parasitic perennial herb used therapeutically since time immemorial. Various parts of the plant have been utilized for its medicinal value. It is encumbered with several biologically active compounds like amarbelin, cuscutin, and cuscutalin, having inbuilt therapeutic potential with anticancer, antitumor, antibacterial, analgesic, antihelmintic, anti-inflammatory and laxative activities. This review aims to endow with a critical evaluation of the botanical, chemical, therapeutic aspects of <i>Cuscuta reflexa</i> herb with a particular focus on its hepatoprotective properties. Given the ongoing various in vivo and in vitro studies was conducted to specifically evaluate the hepatoprotective properties of traditional herbal preparations derived from this plant and demonstrated its efficacy in mitigating chemically induced liver damage by modulating hepato specific enzymes, oxidative stress, and restores the histo-architecture of liver tissue. The <i>Cuscuta reflexa</i> extracts exhibit a protective effect on hepatic cells and thus could be potentially used in the management of hepatic impairments. Despite encouraging preclinical evidence, further research, including well-structured clinical trials, is crucial to confirm its therapeutic potential and safety profile in human populations. This review underscores the necessity for more in-depth pharmacological and mechanistic studies to validate <i>Cuscuta reflexa</i> as a promising natural hepatoprotective agent.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 2","pages":"1965 - 1984"},"PeriodicalIF":7.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147338436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anti-tumor mechanism and epigenetic effects of bioactive components in saffron","authors":"Xiao-Nan Chen,&nbsp;Ze-Juan Li,&nbsp;Yan Zhang,&nbsp;Andy T. Y. Lau,&nbsp;Yan-Ming Xu","doi":"10.1007/s11101-025-10183-w","DOIUrl":"10.1007/s11101-025-10183-w","url":null,"abstract":"<div><p>Cancer is one of the most important causes of mortality worldwide, and its incidence is increasing annually in both developed and developing countries. Up to now, chemotherapy has been a commonly used treatment for cancer. However, due to its significant side effects, other complementary or alternative treatments are needed as adjunctive therapies. The active chemical components extracted from herbal medicine are characterized by lower toxicity and fewer side effects compared to traditional anti-cancer drugs. Recently, the anti-tumor effects of saffron (<i>Crocus sativus</i> L.) and its bioactive components crocins, crocetin, safranal, and picrocrocin (isolated from the stigma of saffron) have been extensively explored. The biological activities of saffron include the inhibition of DNA, RNA, and protein synthesis, induction of cytotoxic effects, inhibition of inflammatory responses, epigenetic regulation, etc. Thus, this review aims to provide an overview of the anti-cancer properties and epigenetic effects of saffron, as well as theoretical foundations for its bioactive components as effective synergistic agents for cancer therapy.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 2","pages":"1857 - 1880"},"PeriodicalIF":7.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147338359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}