Phytochemistry Reviews最新文献

{"title":"Herbal therapies for pain management: a scoping review of the current evidence","authors":"Md. Kamrul Hasan,&nbsp;Khwaja Zohura Zanzabil,&nbsp;Iffat Ara,&nbsp;Tania Rahman,&nbsp;Alexander Kieu,&nbsp;Linda Östlundh,&nbsp;Sameeha Junaidi,&nbsp;Moien AB Khan","doi":"10.1007/s11101-024-09916-0","DOIUrl":"10.1007/s11101-024-09916-0","url":null,"abstract":"<div><p>Pain is a common symptom which can result in disability and lower quality of life. The current review covers the use of medicinal plants as an alternative therapy for pain relief, as traditional painkillers like NSAIDs, opioids, and antidepressants can have serious side effects. Medicinal plants are effective, easily available, low-cost, and have fewer side effects. The review examines commonly used medicinal plants, their active components, their pharmacological activity, and their mechanism of action for different types of pain in humans and animal models. The review also discusses the use of herbal therapies for pain in various conditions, such as rheumatoid arthritis, neuropathies, osteoarthritis, dysmenorrhea, headache, migraine, wounds, low back pain, and chest pain, and weighs the advantages and disadvantages of using herbal therapies in light of recent research.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1065 - 1116"},"PeriodicalIF":7.3,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karanjin: a potential furanoflavonoid for neuroprotection","authors":"Charles Gnanaraj,&nbsp;Mogana Govendan,&nbsp;Ching-Yee Loo,&nbsp;Yoong Soon Yong,&nbsp;Mahendran Sekar,&nbsp;Che Norma Mat Taib,&nbsp;Shamala Devi Subramaniam,&nbsp;Muhammad Dawood Shah,&nbsp;Wing-Hin Lee","doi":"10.1007/s11101-024-09925-z","DOIUrl":"10.1007/s11101-024-09925-z","url":null,"abstract":"<div><p>Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from <i>Millettia pinnata</i> L., emerging in the field of pharmacology and exerting potential therapeutic values in pre-clinical studies. The review aims to highlight the potential of karanjin as a neuroprotective agent with the significance of modulating the underlying molecular mechanistic pathways. Common neurodegenerative diseases reported globally include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. The main problem in the treatment of neurodegenerative diseases is the effect of the prescribed drugs for the underlying conditions is only momentary whereby a permanent solution is unavailable. Bioactive compounds under the class of flavonoids have largely been acknowledged for neuroprotection in pre-clinical studies and partial clinical trials through various mechanism of action such as modulation of NF-kB pathway, inhibition of oxidative stress, modulation of PI3K/Akt, and more. Molecular docking results of karanjin have proven the potential against Alzheimer’s and Parkinson’s disease through modulation of molecular targets adenosine A2A receptor, α-synuclein, catechol-<i>O</i>-methyltransferase, monoamine oxidase B, angiotensin converting enzyme, β-site APP cleaving enzyme, glycogen synthase kinase-3, TNF-α converting enzyme, and acetylcholinesterase involved in the disease progression, compared to commercial standard drugs. The review emphasizes the optimization method for the isolation of karanjin and the various impending mechanistic effects of karanjin in modulating neurodegenerative diseases.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1351 - 1375"},"PeriodicalIF":7.3,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New dawn of ginsenosides: regulating gut microbiota to treat metabolic syndrome","authors":"Xue Bai,&nbsp;Rongzhan Fu,&nbsp;Jianjun Deng,&nbsp;Haixia Yang,&nbsp;Chenhui Zhu,&nbsp;Daidi Fan","doi":"10.1007/s11101-024-09920-4","DOIUrl":"10.1007/s11101-024-09920-4","url":null,"abstract":"<div><p>Metabolic Syndrome (MS) is an amalgamation of symptoms encompassing insulin resistance, obesity, dyslipidemia, elevated fasting blood glucose levels, and hepatic steatosis. Emerging evidence suggests that the hallmark of MS lies in alterations in the composition of the gut microbiota and its metabolites. These alterations traverse a compromised intestinal barrier, exerting an impact on various metabolic organs, thereby precipitating the onset of MS. In recent years, the rapid advancement of sequencing methodologies, bioinformatics, and metagenomic technologies has rendered the exploration of the composition and functionality of the gut microbiota feasible. The manipulation of the gut microbiota is now considered a highly promising novel strategy for the treatment of MS. Ginsenosides, serving as the principal bioactive constituents of the esteemed herb ginseng, have been unequivocally validated to possess a diverse array of pharmacological activities, encompassing anti-inflammatory, antidiabetic, and cardiovascular protective properties. Nevertheless, the intricacies of the therapeutic mechanisms underlying ginsenosides in the treatment of MS remain unclear, owing to the challenge posed by their inherently low absorption rates. Recent studies indicate that when ginsenosides enters the gastrointestinal tract, ginsenosides can interact with the gut microbiota. The gut microbiota may represent a potential mechanism for the therapeutic effects of ginsenosides in treating MS. Based on this, this review aims to summarize the latest research progress of ginsenosides targeting the gut microbiota and its metabolites for the treatment of MS, and provide evidence to confirm that ginsenosides have the potential to become modulators of gut microbiota for the treatment of MS.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1247 - 1269"},"PeriodicalIF":7.3,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Himalayan weeds as potential bioresources for bioactive agents: toxic compounds to valuable scaffolds","authors":"Ekta Bala,&nbsp;Varun Aggarwal,&nbsp;Pawan Kumar,&nbsp;Rohit Sharma,&nbsp; Saima,&nbsp;Manickam Selvaraj,&nbsp;Mohammed A. Assiri,&nbsp;Praveen Kumar Verma","doi":"10.1007/s11101-024-09921-3","DOIUrl":"10.1007/s11101-024-09921-3","url":null,"abstract":"<div><p>Natural products are highly prevalent in Himalayan region clustered in medicinal and aromatic plants including weeds. Toxic weed plants are of serious concerns due to their hazardous effects to humans, environment, and animals. The cause of toxicity of these toxic weed plants is due to the presence of toxic secondary metabolites. Several toxic secondary metabolites have been reported and characterised in these weed plants. There are several functionalities (toxicophores) in these secondary metabolites which have been identified responsible for the toxic effects of these naturally occurring molecules. The eradication of these toxic weed plants is the major strategy to minimize the hazardous effects. Albeit, there are possibilities for the utilization of these abundantly available toxic secondary metabolites as the valuable scaffolds by their synthetic modification to alter their toxicophores. Herein, we have compiled the reports based on the synthetic modification of the toxicophores present in these secondary metabolites and evaluated for their various pharmacological potential. Several molecules have been illustrated which are present in good amount in the toxic weeds and utilised as valuable bioactive scaffolds through intervention of synthetic modifications. The current review will be highly beneficial for the future developments utilising the abundantly available toxic molecules isolated from toxic weed plants and will also provide the alternative and effective strategy for the utilization of these toxic weeds.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1205 - 1246"},"PeriodicalIF":7.3,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyamines metabolism and their biological role in plant cells: what do we really know?","authors":"Yaroslav S. Kolesnikov,&nbsp;Serhii V. Kretynin,&nbsp;Roberta Filepova,&nbsp;Peter I. Dobrev,&nbsp;Jan Martinec,&nbsp;Volodymyr S. Kravets","doi":"10.1007/s11101-024-09913-3","DOIUrl":"10.1007/s11101-024-09913-3","url":null,"abstract":"<div><p>In the present review, we concentrated on primary signaling and regulatory events in plant cells that are rapidly evoked in response to extracellular polyamines in vivo and induce cellular and biochemical responses. Downstream pathways that allow polyamines to regulate plant growth, development, and stress tolerance are analyzed. The results of the recent studies on polyamine metabolism and its regulatory mechanisms are also discussed. Taken together, the data suggest that endogenously and exogenously regulated polyamines by activating ion transport, calcium dynamics, lipid, protein kinase, protein conjugation, and nucleic acid regulation mechanisms modulate downstream transcriptomic, proteomic, metabolomic, and hormonal pathways affecting growth, development, and stress tolerance.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"997 - 1026"},"PeriodicalIF":7.3,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances of sesquiterpenoid dimers from Compositae: distribution, chemistry and biological activities","authors":"FanCheng Meng,&nbsp;Zhe Wang,&nbsp;SiJie Peng,&nbsp;GangGang Zhou,&nbsp;Ammara Khalid,&nbsp;JingXin Mao,&nbsp;GuoWei Wang,&nbsp;ZhiHua Liao,&nbsp;Min Chen","doi":"10.1007/s11101-023-09911-x","DOIUrl":"10.1007/s11101-023-09911-x","url":null,"abstract":"<div><p>Composite family contains a wide variety of plants and many of them possess high medicinal value. Various constituents have been isolated from members of Composite family. Sesquiterpenoids prove to be the characteristic constituents. In recent years, phytochemical studies on natural sesquiterpenoids, especially the sesquiterpenoid dimers from Composite have been a hot spot. As an important class of bioactive natural products, about 260 novel sesquiterpenoid dimers were isolated from plants of Compositae family since 2018 till date and most of them displayed significant therapeutic potential including anti-inflammatory, anti-tumor, neuroprotective, and other effects. In this review, the structural features, plant resources, and biological activities of these newly discovered sesquiterpenoid dimers were summarized.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 3","pages":"625 - 655"},"PeriodicalIF":7.3,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Argemone mexicana L. (Papaveraceae): chemistry, pharmacology, and toxicology","authors":"Jiri Patocka,&nbsp;Maribel Ovando-Martinez,&nbsp;Zdenka Navratilova,&nbsp;Patrik Oleksak,&nbsp;Matthew Chidozie Ogwu,&nbsp;Eugenie Nepovimova,&nbsp;Kamil Kuca","doi":"10.1007/s11101-024-09918-y","DOIUrl":"10.1007/s11101-024-09918-y","url":null,"abstract":"<div><p>This mini-review is a compilation of research data on the phytochemistry, pharmacology, and various therapeutic potentials of <i>Argemone mexicana</i>. <i>A. mexicana</i> is a well-known medicinal plant that is used in several ethnomedicinal treatments including for the treatment and management of skin diseases, inflammations, warts, tumors, malaria, jaundice, rheumatism, leprosy, and microbial infections. The plant consists of alkaloids, flavonoids, terpenoids, long-chain aliphatic alcohol, amino acids, carboxylic acid, steroids, carbohydrates, and phenols. The ethnopharmacological relevance of the plant includes the application of the plant extract in Ayurveda and other traditional healthcare as an antioxidant, antimicrobial, anti-inflammatory, anticancer, and larvicidal, as well as for wound healing, hepatoprotection, and sterilizing activities. It can be concluded from this mini-review that <i>A. mexicana</i> has broad applications that are connected to various pharmacological and phytochemical properties of the plant. This work provides some detailed evidence and suggestions for the medicinal application of this plant to improve the condition of mankind.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1167 - 1182"},"PeriodicalIF":7.3,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artemisia argyi H. Lév. & Vaniot: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities","authors":"Wen-Jun Wei,&nbsp;Tao Guo,&nbsp;Gui-Min Xue,&nbsp;Rui Ma,&nbsp;Yuefei Wang,&nbsp;Zhe-Sheng Chen","doi":"10.1007/s11101-023-09910-y","DOIUrl":"10.1007/s11101-023-09910-y","url":null,"abstract":"<div><p><i>Artemisia argyi</i>, a perennial herb of the genus <i>Artemisia</i>, is recorded as medicine for the treatment of various diseases, such as metrorrhagia, menorrhagia, irregular menstruation, hemorrhage, dysmenorrhea, eczema and skinitch. The dried leaves of <i>A. argyi</i> can be made into moxa floss, which is the raw material of moxibustion. In addition, <i>A. argyi</i> is also one of the symbols of the Dragon Boat Festival in China and its shoots and seedlings can be used as tea and vegetables. Therefore, <i>A. argyi</i> has attracted extensive attentions due to its various chemical constituents and biological activities, as well as its extensive clinical and folk applications. Phytochemical investigation of <i>A. argyi</i> has led to the isolation of sesquiterpenoids, flavonoids, triterpeniods, volatile oils, and others, especially sesquiterpenoids, which are the most characteristic components. The crude extracts and the isolated compounds from <i>A. argyi</i> reveal diverse biological activities, including antibacterial, anti-tumor, anti-inflammatory, antioxidant, etc. Although most biological activities are only the results of in vitro experiments. The aim of this review is to provide a summary on the traditional efficacy, folk application, phytochemistry and modern pharmacological research of <i>A. argyi</i>, which will bring more attention to other researchers for further study.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 3","pages":"821 - 862"},"PeriodicalIF":7.3,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139645235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulated phenolic compounds: clinical efficacy of a novel delivery method","authors":"Gulay Ozkan,&nbsp;Tuğçe Ceyhan,&nbsp;Gizem Çatalkaya,&nbsp;Logesh Rajan,&nbsp;Hammad Ullah,&nbsp;Maria Daglia,&nbsp;Esra Capanoglu","doi":"10.1007/s11101-023-09909-5","DOIUrl":"10.1007/s11101-023-09909-5","url":null,"abstract":"<div><p>Encapsulation is a drug or food ingredient loaded-delivery system that entraps active components, protecting them from decomposition/degradation throughout the processing and storage stages and facilitates their delivery to the target tissue/organ, improving their bioactivities. The application of this technology is expanding gradually from pharmaceuticals to the food industry, since dietary bioactive ingredients, including polyphenols, are susceptible to environmental and/or gastrointestinal conditions. Polyphenols are the largest group of plants' secondary metabolites, with a wide range of biological effects. Literature data have indicated their potential in the prevention of several disorders and pathologies, ranging from simpler allergic conditions to more complex metabolic syndrome and cardiovascular and neurodegenerative diseases. Despite the promising health effects in preclinical studies, the clinical use of dietary polyphenols is still very limited due to their low bioaccessibility and/or bioavailability. Encapsulation can be successfully employed in the development of polyphenol-based functional foods, which may improve their bioaccessibility and/or bioavailability. Moreover, encapsulation can also aid in the targeted delivery of polyphenols and may prevent any possible adverse events. For the encapsulation of bioactive ingredients, several techniques are applied such as emulsion phase separation, emulsification/internal gelation, film formation, spray drying, spray-bed-drying, fluid-bed coating, spray-chilling, spray-cooling, and melt injection. The present review aims to throw light on the existing literature highlighting the possibility and clinical benefits of encapsulated polyphenols in health and disease. However, the clinical data is still very scarce and randomized clinical trials are needed before any conclusion is drawn.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 3","pages":"781 - 819"},"PeriodicalIF":7.3,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-023-09909-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139590535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sources, extraction techniques and food applications: a review on biocolors as next-generation colorants","authors":"Iqra Bashir,&nbsp;Vinay Kumar Pandey,&nbsp;Aamir Hussain Dar,&nbsp;Kshirod Kumar Dash,&nbsp;Rafeeya Shams,&nbsp;Shabir Ahmad Mir,&nbsp;Ufaq Fayaz,&nbsp;Shafat Ahmad Khan,&nbsp;Rahul Singh,&nbsp;Insha Zahoor","doi":"10.1007/s11101-023-09908-6","DOIUrl":"10.1007/s11101-023-09908-6","url":null,"abstract":"<div><p>A large number of food additives are used to enhance their marketable quality. Similarly, for increasing the aesthetic value of food, different synthetic food colors are incorporated that are believed to cause severe problems to humans and the environment. Thus, to overcome these issues, biocolors have been utilized sharply due to their potential therapeutic and medicinal benefits. A wide variety of industries, including medicines, textiles, food, and beverage, have used biocolor additives. Biocolors are deployed in the food sector ranging from beverages to confectionary to processed meals to bakery goods to dairy products to pet treats to colored sugar. Considering the stability and sensitivity of biocolors towards the extraction process and environment, new emerging non-thermal or mild technologies are gaining popularity in order to preserve the biocolors from degradation. This comprehensive review focuses on recent advances in knowledge and understanding of the extraction techniques of biocolors, their sources, and their applications.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1 - 26"},"PeriodicalIF":7.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}