Phytochemistry Reviews最新文献

{"title":"Insights to therapeutic potentials, pharmaceutical formulations, chemistry and analytical methods of catechin","authors":"Divya Shikha,&nbsp;Amandeep Singh,&nbsp;Naresh Kumar Rangra,&nbsp;Vikramdeep Monga,&nbsp;Rohit Bhatia","doi":"10.1007/s11101-024-09929-9","DOIUrl":"10.1007/s11101-024-09929-9","url":null,"abstract":"<div><p>Catechin is one of the prestigious phytoconstituent obtained from the divine wealth of nature. It is a polyphenolic constituent which is broadly distributed in plant kingdom and tea, legumes and rubeaceous plants are rich sources of it. Various research groups have extracted and isolated it by using different analytical techniques due to its diverse pharmacological profile. It is evident in nature that catechin possesses promising anti-inflammatory, neuroprotective, antioxidant, antibacterial, anticancer and anti-viral properties. There are several formulations reported which are intended for multiple uses where catechins are important ingredient. This review discusses the various analytical techniques employed for the extraction and isolation of catechins from various sources, as well as a summary of various reported formulations. The authors also discuss the various pharmacological activities exhibited by catechins, along with the significant outcomes and plausible mode of action. In addition, the review provides an insight into various synthetic and biosynthetic procedures for catechins, along with a description of various clinical trials and patents. In the lateral sections of this compilation, an insight to various synthetic/biosynthetic procedures for catechins has been provided along with description to various clinical trials and patents. Although a lot of progress has been made towards exploration of catechins, still these are associated with some issues of bioavailability and unclear modes of action, which need to be resolved in upcoming times. This review is more comprehensive on catechins, as it covers a wider range of topic includings; analytical techniques for the extraction and isolations of catechins, formulations containing catechins, pharmacological activities, synthetic and biosynthetic procedure, clinical trials as well as patents. The review also provide a more in-depth discussion of the pharmacological activities of catechins, including the significant outcomes and plausible mode of action. The article also highlights the need for the further research to address the issues of bioavailability and unclear modes of action associated with the catechin. This is an important area of research, as it is essential to understand the ADME to develop effective catechin-based therapies.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1557 - 1598"},"PeriodicalIF":7.3,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140097327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolites of Piper sarmentosum and their biological properties: a recent update","authors":"Adiana Mohamed Adib,&nbsp;Nursabrina Najwa Salmin,&nbsp;Noraini Kasim,&nbsp;Sui Kiong Ling,&nbsp;Geoffrey A. Cordell,&nbsp;Nor Hadiani Ismail","doi":"10.1007/s11101-024-09930-2","DOIUrl":"10.1007/s11101-024-09930-2","url":null,"abstract":"<div><p><i>Piper sarmentosum</i> (Piperaceae) is a well-recognized traditional medicinal plant and has attracted considerable attention due to its extensive range of pharmacological properties. This review aims to provide a comprehensive overview of the traditional uses, phytochemical constituents, and biological and pharmacological activities associated with <i>P. sarmentosum</i>, focusing on the scientific literature appearing in the period 2012–2023. Published articles were selected from databases including Science Direct, Google Scholar, and those with a digital object identifier (DOI). The traditional uses of <i>P. sarmentosum</i> encompass a wide spectrum of biological activities, including anticancer, anti-osteoporotic, antibacterial, antioxidant, anti-hypertensive, anti-inflammatory, and anti-diabetic characteristics. The leaf part has been utilized in various forms, including crude extracts or standardized extracts, either alone or in combination with other pharmacological agents, for the treatment of diverse ailments in humans. This review highlights the phytochemical constituents of <i>P. sarmentosum</i> and their contributions to its pharmacological activities. Furthermore, it emphasizes the importance of identifying, determining, and standardizing the active constituents to examine the full biological potential of the plant in a reproducible manner. <i>P. sarmentosum</i> emerges as a rich plant source that holds promise for the development of potential standardized medication candidates. However, further research is needed to assess its safety and therapeutic efficacy beyond the existing data based on a standardized preparation. Preserving this valuable medicinal plant asset is crucial for the health benefits of future generations. This review serves as a comprehensive reference for researchers, medicinal plant practitioners, and healthcare professionals, and encourages further investigation into the multifaceted properties of <i>P. sarmentosum</i> paving the way for its optimal and sustainable utilization in contemporary healthcare.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1443 - 1475"},"PeriodicalIF":7.3,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140097331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of the skin use of bakuchiol: physicochemical properties, sources, bioactivities, nanotechnology delivery systems, regulatory and toxicological concerns","authors":"Filipa Mascarenhas-Melo,&nbsp;Mariana Marques Ribeiro,&nbsp;Kaveh Hatami Kahkesh,&nbsp;Sagarika Parida,&nbsp;Kiran D. Pawar,&nbsp;K. Velsankar,&nbsp;Niraj Kumar Jha,&nbsp;Fouad Damiri,&nbsp;Gustavo Costa,&nbsp;Francisco Veiga,&nbsp;Ana Cláudia Paiva-Santos","doi":"10.1007/s11101-024-09926-y","DOIUrl":"10.1007/s11101-024-09926-y","url":null,"abstract":"<div><p>Bakuchiol is a meroterpene that has recently aroused great interest in the cosmetic and pharmaceutical industries. Its main source is the seeds of <i>Psoralea corylifolia,</i> a medicinal plant native to Asia, despite having a wide geographical distribution. However, this medicinal herb faces endangerment due to low seed germination rates and high seedling mortality. In this context, this review article highlights studies that have focused on describing plant regeneration from root fragments. Subsequently, given its morphological similarity to other species, a technique that can be used to verify the authenticity of the plant and prevent counterfeiting is also mentioned and explored. Additionally, a “green” extraction method for obtaining bakuchiol is presented, and the possibility of obtaining bakuchiol through chemical synthesis routes is also explored. Furthermore, we provide an exhaustive description of bakuchiol's wide range of biological activities, with particular relevance to the skin. The main skin bioactivities of bakuchiol include antifungal, antibacterial, antioxidant, anti-inflammatory, antiaging, depigmenting, and anticancer. However, the particular physicochemical properties of bakuchiol require and benefit from the development of innovative skin delivery systems that allow its encapsulation. These include micro- and nano-sized systems for therapeutic and cosmetic applications, which are also carefully described in this review article. Finally, regulatory issues, metabolic considerations, and toxicological concerns related to the use of bakuchiol in cosmetic and dermopharmaceutical formulations will be addressed, relating not only to the user but also to the environment.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1377 - 1413"},"PeriodicalIF":7.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09926-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140010652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of natural plant-derived seco-triterpenoids and derived saponins from 2020 to 2023: new compounds, distributions, diverse activities and structure–activity relationships","authors":"Xi-Fan Wei,&nbsp;Yi-Kun Wang,&nbsp;Ruo-Tong Liu,&nbsp;Jian-Ping Wu,&nbsp;Kang-Ping Xu","doi":"10.1007/s11101-024-09917-z","DOIUrl":"10.1007/s11101-024-09917-z","url":null,"abstract":"<div><p><i>Seco-</i>triterpenoids are a unique class of triterpenoids possessing distinct structural features. Based on the differences in their parent nucleus, they can be divided into two categories: tetracyclic triterpenes and pentacyclic triterpenes, which are widely distributed across various plant species. Previous studies indicate that natural <i>seco</i>-triterpenoids have diverse chemical structures and exhibit extensive biological activities, including anti-tumor, anti-inflammatory, hypoglycemic, and neuroprotective effects. This review comprehensively summarizes recent research (2020–2023) on <i>seco</i>-triterpenoids and derived saponins, encompassing their chemical structures, plant distributions, pharmacological activities, structure–activity relationships, and future development trends. Furthermore, we utilized the latest bibliometric tool, VOSviewer, to conduct a keyword cluster analysis, enabling us to identify current research hotspots and patterns. Besides, we have cataloged and analyzed 351 compounds, inclusive of 298 tetracyclic triterpenoids and 53 pentacyclic triterpenoids, in order to provide valuable references for activity mining and structural modification of <i>seco</i>-triterpenoids, facilitating further clinical applications and developments. Collectively, <i>seco</i>-triterpenoids represent an important class of natural products with significant potential for pharmacological use. By summarizing recent research achievements, this review provides a beneficial resource for scientists in the field, promoting the exploration and development of <i>seco</i>-triterpenoid-based drugs.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1117 - 1166"},"PeriodicalIF":7.3,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent insights on pharmacological potential of lycopene and its nanoformulations: an emerging paradigm towards improvement of human health","authors":"Amit Kumar Tripathi,&nbsp;Richa Das,&nbsp;Anup Kumar Ray,&nbsp;Sunil Kumar Mishra,&nbsp;Santosh Anand","doi":"10.1007/s11101-024-09922-2","DOIUrl":"10.1007/s11101-024-09922-2","url":null,"abstract":"<div><p>Nutritional antioxidants derived from phytochemicals have been shown to have multifaceted health benefits via the pleiotropic molecular mechanisms. Lycopene is one such aliphatic hydrocarbon carotenoid with no beta-ionone and imparts red coloration to watermelon, tomatoes, and papayas. It is a potent antioxidant and free radical scavenger owing to the presence of 13 carbon–carbon double bonds, out of which 11 are conjugated and the remaining 2 are non-conjugated. It has many biological effects on different types of cancers like prostate, breast, skin, and oral cancer by targeting the Keap1-NF-kB, Keap1-Nrf 2 and PI3K/AKT/m-TOR signalling pathway. In addition to cancer, lycopene also has the ability to modify the gut microbiome, and also work against SARS-CoV-2. This review focuses on the sources, isomers, metabolites, therapeutic targets, mechanistic action, nanoformulations, pharmacokinetics, completed and ongoing clinical trials. In addition to above we are adding the potential ability of lycopene in obesity, infertility, metabolic disorder, gut microbiome, and COVID-19 treatment.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1091 - 1118"},"PeriodicalIF":7.3,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139979508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: “It is not just artemisinin: Artemisia sp. for treating diseases including malaria and schistosomiasis","authors":"B. M. Gruessner,&nbsp;L. Cornet-Vernet,&nbsp;M. R. Desrosiers,&nbsp;P. Lutgen,&nbsp;M. J. Towler,&nbsp;P. J. Weathers","doi":"10.1007/s11101-024-09915-1","DOIUrl":"10.1007/s11101-024-09915-1","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 2","pages":"281 - 282"},"PeriodicalIF":7.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142413276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytopharmacological aspects of Mimosa tenuiflora (Willd.) poir.: a systematic review of preclinical data","authors":"Emerson de Oliveira Silva,&nbsp;Myla Lôbo de Souza,&nbsp;Nathália Andrezza Carvalho de Souza,&nbsp;Demis Ferreira de Melo,&nbsp;Lucas Amadeu Gonzaga da Costa,&nbsp;Bruna Fernanda de Lima Arruda Holanda,&nbsp;Rodolfo Hideki Vicente Nishimura,&nbsp;Larissa Araújo Rolim,&nbsp;Pedro José Rolim Neto","doi":"10.1007/s11101-024-09919-x","DOIUrl":"10.1007/s11101-024-09919-x","url":null,"abstract":"<div><p><i>Mimosa tenuiflora</i> (Willd.) Poir. is a native species of tropical regions with a diverse therapeutic potential due to the presence of various metabolites in its botanical composition. This review provides updated information on the phytochemistry and pharmacological activities of <i>M. tenuiflora</i>. The studies used in this review were obtained from specialized databases (PubMed, Scielo, Science Direct, Web of Science, Springer, and Scopus) using the keywords: <i>Mimosa tenuiflora</i>, phytochemistry, and pharmacological activity. The selected articles were analyzed by year of publication, country where the research was conducted, isolated chemical compounds reported, and biological activities evaluated. The selected articles were peer-reviewed in the following order: title, abstract, and full text. While the majority of studies involving <i>M. tenuiflora</i> are still situated in Brazil and Mexico, some research is being conducted outside of Latin America. In vitro and in vivo studies report various pharmacological activities for <i>M. tenuiflora</i>, such as antimicrobial, antiparasitic, antioxidant, anti-inflammatory, antinociceptive, and antidepressant effects. These diverse activities are attributed to the presence of flavonoids and alkaloids, identified as the main classes of secondary metabolites in <i>M. tenuiflora</i>. The effective doses for biological activities vary according to the plant part used and the type of extracting solvent. Additionally, the isolation and concentration of the bioactive compound optimizes and reduces the potential effective therapeutic dose. The arsenal of bioactive compounds provides versatility for potential therapeutic uses of <i>M. tenuiflora</i>. Despite its therapeutic potential, clinical trials are still lacking, and preclinical studies remain limited and heterogeneous, representing an opportunity for further pharmacological investigation.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1183 - 1203"},"PeriodicalIF":7.3,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal therapies for pain management: a scoping review of the current evidence","authors":"Md. Kamrul Hasan,&nbsp;Khwaja Zohura Zanzabil,&nbsp;Iffat Ara,&nbsp;Tania Rahman,&nbsp;Alexander Kieu,&nbsp;Linda Östlundh,&nbsp;Sameeha Junaidi,&nbsp;Moien AB Khan","doi":"10.1007/s11101-024-09916-0","DOIUrl":"10.1007/s11101-024-09916-0","url":null,"abstract":"<div><p>Pain is a common symptom which can result in disability and lower quality of life. The current review covers the use of medicinal plants as an alternative therapy for pain relief, as traditional painkillers like NSAIDs, opioids, and antidepressants can have serious side effects. Medicinal plants are effective, easily available, low-cost, and have fewer side effects. The review examines commonly used medicinal plants, their active components, their pharmacological activity, and their mechanism of action for different types of pain in humans and animal models. The review also discusses the use of herbal therapies for pain in various conditions, such as rheumatoid arthritis, neuropathies, osteoarthritis, dysmenorrhea, headache, migraine, wounds, low back pain, and chest pain, and weighs the advantages and disadvantages of using herbal therapies in light of recent research.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1065 - 1116"},"PeriodicalIF":7.3,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karanjin: a potential furanoflavonoid for neuroprotection","authors":"Charles Gnanaraj,&nbsp;Mogana Govendan,&nbsp;Ching-Yee Loo,&nbsp;Yoong Soon Yong,&nbsp;Mahendran Sekar,&nbsp;Che Norma Mat Taib,&nbsp;Shamala Devi Subramaniam,&nbsp;Muhammad Dawood Shah,&nbsp;Wing-Hin Lee","doi":"10.1007/s11101-024-09925-z","DOIUrl":"10.1007/s11101-024-09925-z","url":null,"abstract":"<div><p>Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from <i>Millettia pinnata</i> L., emerging in the field of pharmacology and exerting potential therapeutic values in pre-clinical studies. The review aims to highlight the potential of karanjin as a neuroprotective agent with the significance of modulating the underlying molecular mechanistic pathways. Common neurodegenerative diseases reported globally include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. The main problem in the treatment of neurodegenerative diseases is the effect of the prescribed drugs for the underlying conditions is only momentary whereby a permanent solution is unavailable. Bioactive compounds under the class of flavonoids have largely been acknowledged for neuroprotection in pre-clinical studies and partial clinical trials through various mechanism of action such as modulation of NF-kB pathway, inhibition of oxidative stress, modulation of PI3K/Akt, and more. Molecular docking results of karanjin have proven the potential against Alzheimer’s and Parkinson’s disease through modulation of molecular targets adenosine A2A receptor, α-synuclein, catechol-<i>O</i>-methyltransferase, monoamine oxidase B, angiotensin converting enzyme, β-site APP cleaving enzyme, glycogen synthase kinase-3, TNF-α converting enzyme, and acetylcholinesterase involved in the disease progression, compared to commercial standard drugs. The review emphasizes the optimization method for the isolation of karanjin and the various impending mechanistic effects of karanjin in modulating neurodegenerative diseases.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1351 - 1375"},"PeriodicalIF":7.3,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New dawn of ginsenosides: regulating gut microbiota to treat metabolic syndrome","authors":"Xue Bai,&nbsp;Rongzhan Fu,&nbsp;Jianjun Deng,&nbsp;Haixia Yang,&nbsp;Chenhui Zhu,&nbsp;Daidi Fan","doi":"10.1007/s11101-024-09920-4","DOIUrl":"10.1007/s11101-024-09920-4","url":null,"abstract":"<div><p>Metabolic Syndrome (MS) is an amalgamation of symptoms encompassing insulin resistance, obesity, dyslipidemia, elevated fasting blood glucose levels, and hepatic steatosis. Emerging evidence suggests that the hallmark of MS lies in alterations in the composition of the gut microbiota and its metabolites. These alterations traverse a compromised intestinal barrier, exerting an impact on various metabolic organs, thereby precipitating the onset of MS. In recent years, the rapid advancement of sequencing methodologies, bioinformatics, and metagenomic technologies has rendered the exploration of the composition and functionality of the gut microbiota feasible. The manipulation of the gut microbiota is now considered a highly promising novel strategy for the treatment of MS. Ginsenosides, serving as the principal bioactive constituents of the esteemed herb ginseng, have been unequivocally validated to possess a diverse array of pharmacological activities, encompassing anti-inflammatory, antidiabetic, and cardiovascular protective properties. Nevertheless, the intricacies of the therapeutic mechanisms underlying ginsenosides in the treatment of MS remain unclear, owing to the challenge posed by their inherently low absorption rates. Recent studies indicate that when ginsenosides enters the gastrointestinal tract, ginsenosides can interact with the gut microbiota. The gut microbiota may represent a potential mechanism for the therapeutic effects of ginsenosides in treating MS. Based on this, this review aims to summarize the latest research progress of ginsenosides targeting the gut microbiota and its metabolites for the treatment of MS, and provide evidence to confirm that ginsenosides have the potential to become modulators of gut microbiota for the treatment of MS.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 4","pages":"1247 - 1269"},"PeriodicalIF":7.3,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}