Phytochemistry Reviews最新文献

{"title":"Diterpenes of Salvia (2016–2024): phytochemistry and pharmacology","authors":"Alireza Rahimi,&nbsp;Seyed Ahmad Emami,&nbsp;Maryam Akaberi","doi":"10.1007/s11101-024-10060-y","DOIUrl":"10.1007/s11101-024-10060-y","url":null,"abstract":"<div><p><i>Salvia</i> L. (Sage) is a therapeutically important plant genus with over 1000 species worldwide. They are a rich source of novel diterpenes. In this present study, we tried to review the chemistry and pharmacology of the <i>Salvia</i> diterpenes between 2016 and 2024. Therefore, we collected information from various scientific databases, including Scopus and PubMed, using key words “<i>Salvia</i>” AND “Diterpene” OR “Diterpenoid”. This updated review article discussed the phytochemistry and pharmacology of 258 undescribed diterpenes isolated from the <i>Salvia</i> genus between 2016 and October 2024. Studies showed that these diterpenes could be structurally divided into subclasses such as abietanes, clerodanes, icetexanes, labdanes, and fusicoccanes. The reported diterpenes have exhibited various pharmacological effects such as anticancer, antibacterial, antiviral, antiparasitic, anti-inflammatory, analgesic, anti-oxidant, antidiabetic, and neurotrophic activities. According to the results, these diterpenes of <i>Salvia</i> can be the lead compounds for drug discovery, especially for cancer and microbial diseases.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 6","pages":"4939 - 5017"},"PeriodicalIF":7.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145561058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical insights into terpene cyclases as biocatalysts in cancer treatment: unraveling nature’s chemistry for therapeutic innovation","authors":"Mostafa G. Ali,&nbsp;Fahmy Attia,&nbsp;Nabil Zakaria","doi":"10.1007/s11101-025-10105-w","DOIUrl":"10.1007/s11101-025-10105-w","url":null,"abstract":"<div><p>Terpene cyclases (TCs) are pivotal enzymes in nature, orchestrating the intricate synthesis of terpenes, a diverse group of natural compounds with profound biological activities. This review delves into the multifaceted roles of terpene cyclases, which serve as nature’s biochemical architects, sculpting the chemical landscape of plants, fungi, and bacteria. Understanding the catalytic mechanisms of TCs unveils the astounding diversity of terpenes and their vital functions in plant defense, pollination, and growth regulation. Moreover, this review examines the classification of TCs, shedding light on their distinct classes and the array of terpenoids they produce, each with unique biological activities. Exploration of terpenes in cancer therapy uncovers their promising anti-cancer properties, targeting key hallmarks of cancer progression such as proliferation, survival, and metastasis. This review elaborates on various mechanisms through which terpenes induce apoptosis, inhibit tumor growth, modulate immune responses, and enhance chemotherapy efficacy. Additionally, it includes case studies and ongoing clinical trials showcasing the efficacy of terpene-based treatments across different cancer types. Challenges in utilizing terpenes for cancer therapy, such as stability, specificity, and drug resistance, are outlined, alongside strategies to overcome these hurdles. A significant highlight of this review is the potential of engineered terpene cyclases for tailored therapies. Directed evolution and rational enzyme design strategies offer avenues to create designer terpenes optimized for anti-cancer properties. This review culminates in a comprehensive exploration of synergistic approaches, combining terpenes with chemotherapy, immunotherapy, and targeted therapies to enhance treatment efficacy and minimize side effects. Through the lens of terpene cyclases, it provides a broad overview of the diverse landscape of terpenes in nature, their potential in cancer therapy, and the exciting frontier of engineered terpene-based therapies.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 6","pages":"6045 - 6063"},"PeriodicalIF":7.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145561059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharides, saponins and flavonoids in Astragali Radix: a review of phytochemistry and pharmacology for future therapeutic applications","authors":"Xiaolin Huang,&nbsp;Ziyuan Guo,&nbsp;Zihan Wang,&nbsp;Chen Ma,&nbsp;Li Dong,&nbsp;Xiaosong Hu,&nbsp;Fang Chen,&nbsp;Yinghua Luo,&nbsp;Daotong Li","doi":"10.1007/s11101-025-10120-x","DOIUrl":"10.1007/s11101-025-10120-x","url":null,"abstract":"<div><p><i>Astragali Radix</i> (<i>A. Radix</i>) is a medicine and food homologous plant that has been used as an ethnomedicine in China for a long history. Due to its affordability and safety, it has been widely studied by medical researchers and accumulating evidence has showed that it has enormous potential in treating human diseases. Polysaccharides, saponins and flavonoids are the major active ingredients in <i>A. Radix</i>. Modern pharmacological studies show that these compounds exhibit promising properties in immunomodulation, antioxidant, anti-inflammatory, diabetes treatment, neuroprotection and anticancer. Nevertheless, few studies are available reviewing the phytochemical and biological properties of the main active components in <i>A. Radix</i>. In this study, we first provide an overview of the botany, morphological features and nutritional properties of <i>A. Radix</i>. In addition, the structure, extraction, separation, and purification of polysaccharides, saponins and flavonoids in <i>A. Radix</i> are introduced. Finally, the up-to-date progress of studies on the pharmacological effects of these bioactive compounds were summarized in order to provide valuable implications for its further development and application in modern medicine.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 1","pages":"123 - 155"},"PeriodicalIF":7.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147337987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An extensive analysis of the biochemical dimensions of phytochemicals in the treatment or prevention of breast cancer","authors":"Monika Kumari,&nbsp;Kapil Vashisht,&nbsp;Manoj Kumar,&nbsp;Priyamvada Singh,&nbsp;Dhruv Kumar,&nbsp;Ashok Kumar Balaraman,&nbsp;Geeta Singh,&nbsp;Brijesh Rathi","doi":"10.1007/s11101-025-10111-y","DOIUrl":"10.1007/s11101-025-10111-y","url":null,"abstract":"<div><p>Breast cancer ranks as the second most frequently diagnosed cancer in women worldwide. Despite advances in treatment and diagnostic technologies, it has become a growing global health concern in recent decades. The currently used treatment approaches for breast cancer include radiation therapy, the use of several chemotherapeutic drugs, and surgical exclusion. These strategies pose certain limitations like drug resistance, local tumor recurrence, metastasis, etc., which necessitates safer alternatives for breast cancer treatment or prevention. Phytochemicals are naturally occurring, bioactive, non–nutrient compounds that are capable of modulating different genes, gene products, and multiple signalling pathways, causing inhibition of the proliferative ability of the breast cancerous cells, angiogenesis, metastatic ability, tumor incursion, and induction of apoptosis. Phytochemicals can also be used as adjuvant cancer therapy because of their capability to modulate immune regulation in the tumor microenvironment. Thus, phytochemicals offer a potent and safer alternative for breast cancer treatment or prevention, with no or fewer side effects. This review article provides an extensive analysis of the biochemical dimension of various phytochemicals belonging to different chemical classes (such as curcumin, apigenin, resveratrol, berberine, gallic acid, genistein, epigallocatechin gallate, sulforaphane, etc.), and the underlying molecular mechanisms involved in breast cancer treatment or prevention. Further, a brief description of phytochemicals in breast cancer combinatorial therapies and clinical trials is also provided in this article.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 6","pages":"6223 - 6253"},"PeriodicalIF":7.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145561341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Espinheira-santa phytochemical, pharmacological, and technological aspects: a scoping review","authors":"Ahmad Kassem El Zein,&nbsp;Joel Toribio Espinoza,&nbsp;Lazo Raul Edison Luna,&nbsp;Jane Manfron,&nbsp;Luana Mota Ferreira,&nbsp;Roberto Pontarolo","doi":"10.1007/s11101-025-10072-2","DOIUrl":"10.1007/s11101-025-10072-2","url":null,"abstract":"<div><p>Although frequently used for anti-ulcerogenic and analgesic purposes, the <i>Monteverdia ilicifolia</i> (Mart. ex Reissek) Biral, popularly known as espinheira-santa, demonstrates scarcity of scientific evidence to confirm its efficacy. This study sought to answer the question \"What is the scientific evidence on M<i>. ilicifolia</i> in relation to phytochemical, clinical, and technological development aspects?\" by filling the information gaps regarding pre-clinical, clinical, and technological development perspectives through a scoping review involving articles and patents. Following the guidelines of the Joanna Briggs Institute and recommendations of PRISMA-ScR, the articles searches were carried out in the PubMed, Scopus, and Web of Science databases, while patents were searched on Google Patents, Espacenet, Derwent Innovations Index, and The Lens. All the studies found were checked for suitability to the topic. Approved studies went on a data extraction step, while the ones that did not fit the inclusion criteria had their exclusion reasoning recorded. 13 articles and three patents fitted the inclusion criteria and underwent data extraction. Studies showed that <i>M. ilicifolia</i> can be used in the form of aqueous, alcoholic, hydroalcoholic extracts, gels, creams, gel-creams, parenteral solutions, with doses of 0.1 to 500 mg/kg, one to five times a day, and showed safety up to 3000 mg/kg. Therapeutic properties included antimicrobial, antiulcer, spasmolytic, antidiarrheal, anti-inflammatory, natriuretic, diuretic, hypotensive and antimutagenic, with no observed toxicity or teratogenicity. Those effects were attributed to polyphenolic compounds, triterpenes, tannins, flavonoids, gallic and caffeic acids, exhibiting a variety of modes of action. Espinheira-santa shown promising evidence about its biological activities.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 6","pages":"5287 - 5315"},"PeriodicalIF":7.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145561340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agarwood as a neuroprotective agent: a comprehensive review of existing evidence and potential avenues for future research","authors":"Ankur Das,&nbsp;Khaleda Begum,&nbsp;Raja Ahmed,&nbsp;Suraiya Akhtar,&nbsp;Tanisha Neog,&nbsp;Abhijit Sarma,&nbsp;Amartya Chakraborty,&nbsp;Sofia Banu","doi":"10.1007/s11101-025-10117-6","DOIUrl":"10.1007/s11101-025-10117-6","url":null,"abstract":"<div><p>Neurodegenerative diseases (NDDs), characterized by the loss of neural cells, present a significant public health challenge due to their increasing prevalence and the limited treatment options available. In this context, plant-based natural products rich in bioactive compounds have gained attention as safe and alternative remedies. Recent evidences have highlighted that agarwood has the potential to alleviate symptoms such as anxiety, depression, and cognitive decline associated with NDDs, and exhibits significant neuroprotective potential. The bioactive compounds, particularly sesquiterpenoids, flavonoids, and chromones, modulate neurotransmitter balance, regulate the excitatory/inhibitory (E/I) system via GABAergic modulation, and suppress neuroinflammation. Additionally, it lowers hypothalamic–pituitary–adrenal (HPA) axis activity which reduces stress-mediated neural damage and promotes neurite outgrowth in neurotoxic cells. Studies demonstrate agarwood’s ability to enhance cell viability, lower oxidative stress, and prevent apoptosis by modulating multiple pathways. This review discusses the current scientific findings, emphasizing agarwood’s ability to mitigate neurotoxicity, and managing anxiety, depression, and sleep disorders in experimental models which are implicated in NDDs. Furthermore, it highlights the various mechanisms through which agarwood extracts impart beneficial effects on the brain. Despite its therapeutic potential, the review acknowledges several challenges and scope for further research, including clinical trials and pharmacokinetic studies in utilizing agarwood for clinical applications. Addressing the existing challenges is expected to enable the development of standardized, safe, and effective agarwood-based treatments for NDDs.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 1","pages":"1 - 22"},"PeriodicalIF":7.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147337610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The call of the wild hops: chemical diversity of Humulus species and their use in brewing","authors":"Augustin Bildstein,&nbsp;Gabriel Lefèvre,&nbsp;Anne-Sophie Paguet,&nbsp;Mathilde Vandenberghe,&nbsp;Sylvie Chollet,&nbsp;Céline Rivière","doi":"10.1007/s11101-025-10104-x","DOIUrl":"10.1007/s11101-025-10104-x","url":null,"abstract":"<div><p>The genus <i>Humulus</i> currently includes 7 listed species that have common but also differentiating chemical characteristics. Due in particular to their richness in original specialized metabolites, the female infructescences of hop are widely used as a bittering, aromatic and stabilizing ingredient in beer. Wild hops are chemically more diverse than cultivars that come from a common gene pool. Initially oriented towards the study of disease resistance and productivity potential, research on wild hops has exploded in recent decades and in various countries to focus on the search for organoleptic qualities. Wild hops have been hybridized with cultivars, intentionally or spontaneously, giving rise to new original varieties thanks to the heritability of their chemical characteristics transmitted to their descendants. This research has proven itself with the development of cultivars with interesting organoleptic qualities for hopping beer. Depending on the hopping technique used, which has diversified considerably in recent decades, hop compounds undergo numerous chemical reactions during the brewing process, offering the brewer a wide organoleptic spectrum in terms of bitterness and aromas. The volatile compounds of hops, from the more classic terpenes to polyfunctional thiols, have been particularly studied in recent years due to the search for new varieties rich in original aromas.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 5","pages":"3757 - 3795"},"PeriodicalIF":7.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145384910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural antioxidants in the preservation of omega-3-rich oils: applications in bulk, emulsified, and microencapsulated chia, flaxseed, and Sacha inchi oils","authors":"Estefania N. Guiotto,&nbsp;Luciana M. Julio,&nbsp;Vanesa Y. Ixtaina","doi":"10.1007/s11101-025-10109-6","DOIUrl":"10.1007/s11101-025-10109-6","url":null,"abstract":"<div><p>Antioxidants are widely used in the food industry to protect polyunsaturated lipids from oxidative degradation. In recent years, interest in natural antioxidants has increased due to concerns about the toxicity of synthetic alternatives. Plant-derived compounds such as tocopherols, vitamin C, and flavonoids provide antioxidant benefits in foods and may help to prevent chronic diseases. Spices and aromatic plants, valued for their antimicrobial properties, are increasingly used in food preservation, pharmaceuticals, and natural therapies due to their biologically active and antioxidant compounds. The health benefits of omega-3 fatty acids and the imbalance between omega-3 and omega-6 in Western diets have driven efforts to increase their intake through unconventional oils. Oils from plant sources with very high omega-3 levels (&gt; 45%), such as chia (<i>Salvia hispanica</i> L.), flaxseed (<i>Linum usitatisimum</i> L.), and Sacha inchi (<i>Plukenetia volubilis</i> L.), are excellent for enhancing omega-3 intake. However, these oils are highly prone to oxidative degradation, necessitating effective stabilization strategies. This review provides novel insights into the application of natural antioxidants across diverse systems—bulk oils, blends, emulsions, and microencapsulated oils—highlighting their potential to enhance oxidative stability and extend the shelf life of omega-3-rich oils. By integrating natural antioxidants with advanced stabilization techniques, this review underscores promising approaches to preserving the quality and functionality of chia, flaxseed, and Sacha inchi oils, thereby facilitating their industrial and nutritional applications.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 6","pages":"6139 - 6167"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145560870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroidal saponins: a treasure trove of natural resources that require urgent development","authors":"Zhiqiang Sun,&nbsp;Chunmei Zhong,&nbsp;Hongdan Zhang,&nbsp;Yunle Liu,&nbsp;Yitong Wang,&nbsp;Chunyan Zhang,&nbsp;Cheng Cai,&nbsp;Jun Xie","doi":"10.1007/s11101-025-10107-8","DOIUrl":"10.1007/s11101-025-10107-8","url":null,"abstract":"<div><p>Steroidal saponins, prominent bioactive constituents present in monocot plants, primarily comprise sugars and glycosides. They significantly contribute to the domain of natural product chemistry due to their profound pharmacological attributes and demonstrated efficacy in treating a plethora of disease. The complex and multifaceted synthetic pathways of steroidal saponins stem from the diversity within spirostane structures and glycosyl ligands. This provides a material basis for the diversity of physiological activities of steroidal saponins and enriches the resource pool of steroidal saponins. However, it comes with the substantial challenge of refining and separating total steroidal saponins in plants, exacerbating difficulties in deciphering the mechanism of action for total steroidal saponin extracts as physiologically active constituents. Presently, the main utilization of steroidal saponins is to hydrolyze them into diosgenin as simple drug precursors, but the intrinsic value of these highly active natural compounds has not been fully utilized. To maximize their medicinal potential and bolster their contribution to human health, recent advancements in the biosynthesis, extraction, separation, and application of steroidal saponins were summarized here. Potential challenges faced at different stages with plausible suggestions are discussed for future exploration, adoption, and development of steroidal saponins.</p><h3>Graphical abstract</h3><p>To enhance comprehension of its pharmacological properties and unleash its medicinal potential, this article reviews the latest progress in the biosynthesis, extraction, separation, and application of steroidal saponins.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 6","pages":"6095 - 6121"},"PeriodicalIF":7.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145561800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review","authors":"Rudolf Vrabec,&nbsp;Pavel Drašar,&nbsp;Lubomír Opletal,&nbsp;Štefan Kosturko,&nbsp;Gerald Blunden,&nbsp;Lucie Cahlíková","doi":"10.1007/s11101-025-10102-z","DOIUrl":"10.1007/s11101-025-10102-z","url":null,"abstract":"<div><p>This review provides a comprehensive overview of the alkaloids in the genus <i>Vinca</i> L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest Africa, and southwest Asia. By consolidating extensive phytochemical and pharmacological research in five phytochemically investigated species within the genus <i>Vinca</i> L., it highlights 202 identified alkaloids—categorized into 20 structural groups—and emphasizes their structural diversity and biological activities. These alkaloids, including notable compounds such as vincamine and reserpine, exhibit a range of biological activities, including antitumor, anti-Alzheimer, antibacterial, and antihypertensive effects. The review also explores biosynthetic pathways, key structural classes (aspidosperma, corynanthe, iboga, yohimbe, strychnos), and the structural and biological complexities surrounding these alkaloids. Additionally, it provides a botanical perspective on <i>Vinca</i> species, underscoring both their historical and current medicinal uses. Overall, the genus <i>Vinca</i> emerges as a valuable source of bioactive compounds, with significant potential for future pharmacognostic and drug development research, particularly in oncology and neurodegenerative diseases.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 5","pages":"3665 - 3735"},"PeriodicalIF":7.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10102-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145384909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}