Phytochemistry Reviews最新文献

{"title":"Bio revolution of green polymers: advancing the circular bioeconomy via bio-sourced biopolymers, from extraction to diverse applications and sustainability assessment","authors":"Afaf Moufaddel,&nbsp;Badr Eddine Kartah,&nbsp;Hanae El Monfalouti,&nbsp;Khalid Bougrin","doi":"10.1007/s11101-025-10204-8","DOIUrl":"10.1007/s11101-025-10204-8","url":null,"abstract":"<div><p>The biodegradability, biocompatibility, and sustainability of the biopolymers have created a new wave of innovation in the biosciences field and have become today an important component in the circular economy as green biotechnology, which could have a significant impact on scientific, engineering, and industrial sectors. Recent developments in the green economy, focusing on protecting the environment, have increased the demand for biopolymers derived from renewable resources as viable alternatives to petroleum-derived polymers, emphasizing sustainability and value-adding. Adopting a suitable extraction process is the main obstacle and challenge to producing biopolymers at low-cost, economical manufacturing plants, and continues to influence industrial research. This review describes the potential scale of alternative sources of biopolymers from renewable biomass waste as an energy-efficient and low-carbon process. Biopolymers exhibit significant variability depending on their origin, pretreatment methods, and extraction techniques, each with unique benefits and challenges in production. The study categorizes these biopolymers into various forms, such as films, membranes, scaffolds, sponges, hydrogels, fibers, and encapsulations, each with distinct advantages and diverse applications across multiple industries, including textiles, medical devices, biodegradable packaging, pharmaceuticals, cosmetics, agriculture, water treatment, bio composites, and biosensors. Furthermore, we evaluate the sustainability and durability of biopolymers throughout their life cycles, with particular attention to their environmental impacts at the end of life. </p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2489 - 2544"},"PeriodicalIF":7.6,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auraptene: a survey of the last three years of intense research","authors":"Chiara Collevecchio,&nbsp;Lorenzo Marchetti,&nbsp;Francesco Epifano,&nbsp;Salvatore Genovese,&nbsp;Serena Fiorito","doi":"10.1007/s11101-025-10210-w","DOIUrl":"10.1007/s11101-025-10210-w","url":null,"abstract":"<div><p>Auraptene (7-geranyloxycoumarin) a naturally occurring bioactive coumarin geranyl ether is widely distributed across a limited number of plant families, including Rutaceae, Apiaceae, and a few others. Notably, this oxyprenylated coumarin has been extracted from several edible fruits, vegetables, and medicinal plants consumed worldwide. There is growing evidence supporting the therapeutic benefits of this molecule. Auraptene is highly pleiotropic, modulating intracellular signaling pathways that regulate inflammation, cell growth, and apoptosis. It holds potential for preventing and treating various diseases due to its anti-inflammatory and antioxidant activities, along with an excellent safety profile. Particularly in the last three years, this secondary metabolite has been the subject of intense research, with more than 50 articles published during this period. These studies have explored various aspects of auraptene’s pharmacological activities and, for the first time, included clinical trials involving phytopreparations containing this biologically active coumarin. This review aims to provide a comprehensive overview of the data published in the last three years, offering insights into the therapeutic and chemopreventive potential of auraptene.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 7","pages":"4879 - 4896"},"PeriodicalIF":6.3,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of Annona species: a systematic review","authors":"Patricia Luciana Carriel Corrêa,&nbsp;Mariano Martínez-Vázquez,&nbsp;Iván De-la-Cruz-Chacón,&nbsp;Carolina Ovile Mimi,&nbsp;Gisela Ferreira","doi":"10.1007/s11101-025-10205-7","DOIUrl":"10.1007/s11101-025-10205-7","url":null,"abstract":"<div><p>The genus <i>Annona</i>, which belongs to the Annonaceae family, has several biological activities, including anticancer activity. Cancer is one of the leading causes of death worldwide, requiring investigation of new alternatives to combat it. This systematic review aims to analyze the chemodiversity of plant organs of the genus <i>Annona</i> and their anticancer activity. A systematic search was performed in the Scopus, PubMed and Web of Science databases, using the search terms: “<i>Annona</i>” AND “antitumor OR anticancer OR cytotoxic OR antitumoral OR cancer”. The review only included studies that mentioned the compounds present in extracts of <i>Annona</i> species that have shown activity against cancer cells. Of the 166 species of the genus <i>Annona</i>, 29 have been studied for their anticancer activity in their extracts or compounds. Specialized metabolites of <i>Annona</i> species with anticancer activity include alkaloids, acetogenins, terpenes, flavonoids, coumarins, cyclopeptides and saponins, with distinct mechanisms of action. The most studied plant organs are leaves and seeds. Acetogenins isolated from seeds are the metabolites most evaluated against several cancer cell lines, reflecting the interest in their high inhibitory potential. The chemodiversity of plant organs of <i>Annona</i> species has high cytotoxic potential, especially with the presence of acetogenins.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2545 - 2582"},"PeriodicalIF":7.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147558781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytotherapeutic insights into wound healing: unveiling the potential of Agrimonia eupatoria L.","authors":"Matúš Čoma,&nbsp;Silvia Bittner Fialová,&nbsp;Pavel Mučaji,&nbsp;Peter Gál","doi":"10.1007/s11101-025-10203-9","DOIUrl":"10.1007/s11101-025-10203-9","url":null,"abstract":"<div><p><i>Agrimonia eupatoria</i> L., a perennial herbaceous plant long utilized in traditional European and Asian medicine, has recently attracted significant scientific attention for its wound healing properties. This review synthesizes current evidence on pharmacological activity of <i>A. eupatoria</i> in the context of cutaneous wound repair. Rich in polyphenols, flavonoids, tannins, and triterpenoids, <i>A. eupatoria</i> exhibits a broad range of bioactivities relevant to each phase of wound healing. These include antioxidant effects that mitigate oxidative stress, anti-inflammatory actions that regulate immune responses, and stimulatory effects on keratinocyte proliferation, fibroblast activation, and angiogenesis. Experimental models reveal enhanced re-epithelialization, extracellular matrix remodeling, and improved collagen maturation in wounds treated with <i>A. eupatoria</i> extracts. Moreover, the plant demonstrates antimicrobial and antibiofilm activities against both Gram-positive and Gram-negative pathogens, including <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, further supporting its use in chronic and infected wounds. While promising, variability in extract composition and limited clinical data highlight the need for further standardization and translational research. Collectively, this review positions <i>A. eupatoria</i> as a potent botanical candidate for future development in phytotherapeutic wound management, offering a multi-targeted approach that integrates traditional knowledge with modern biomedical science.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 7","pages":"4857 - 4878"},"PeriodicalIF":6.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10203-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical complexity, pharmacological significance and developed products of Pelargonium sidoides DC","authors":"Kundani Khameli,&nbsp;Muinat Nike Lewu,&nbsp;Takalani Mulaudzi,&nbsp;Oluwafemi Ayodeji Adebo,&nbsp;Oluwatobi Samuel Oluwafemi","doi":"10.1007/s11101-025-10201-x","DOIUrl":"10.1007/s11101-025-10201-x","url":null,"abstract":"<div><p><i>Pelargonium sidoides</i> DC. is a plant of significant medicinal value that grows naturally in Southern Africa, particularly in Lesotho and South Africa. This plant has been utilised for decades as a traditional medicine by different tribes to treat gastrointestinal and respiratory infections. It has also been widely studied, which has led to its local and international commercial success. This review provides a comprehensive analysis of the plant’s phytochemistry, its pharmacological significance and the products produced from the plant’s roots. Different classes of phytochemicals that have been reported from the plant’s extract, such as coumarins and flavonoids, are presented. Extraction techniques and solvents to exploit valuable phytochemicals in <i>P. sidoides</i> are also addressed. The aqueous ethanolic extract of <i>P. sidoides,</i> commercially known as EPs 7630, is evaluated for the clinical treatment of ailments such as acute bronchitis and acute tonsillopharyngitis. In addition, various phytochemical products such as Linctagon and Umckaloabo produced from <i>P. sidoides</i> are discussed. The review also provides information on products currently available in the market and their respective uses. As a result of the significant demand for this plant in the market, this review will further give an insight into the possibility of commercially cultivating <i>P. sidoides</i> to meet market needs, to avoid depleting the naturally occurring plants.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2411 - 2438"},"PeriodicalIF":7.6,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147561516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diospyrin: biosynthesis, distribution in the plant kingdom, and therapeutic potential","authors":"Lutfun Nahar,&nbsp;Satyajit D. Sarker","doi":"10.1007/s11101-025-10200-y","DOIUrl":"10.1007/s11101-025-10200-y","url":null,"abstract":"<div><p>Diospyrin, a naturally occurring bisnaphthoquinone, is chemically known as 5-hydroxy-6-(5-hydroxy-7-methyl-1,4-dioxonaphthalen-2-yl)-7-methylnaphthalene-1,4-dione. It was first isolated from the heartwood of <i>Diospyros montana</i> Roxb. (Ebenaceae) and later was found in several species of the genera <i>Diospyros</i> and <i>Euclea</i>. This bisnaphthoquinone is biosynthesized through the dimerization of 7-methyljuglone, a 1,4-naphthoquinone, via C-2 and C-6’ coupling. Previous <i>in vitro</i>, <i>in vivo</i> and <i>in silico</i> studies have established diospyrin as a bioactive compound with therapeutic potentials; the most prominent therapeutically relevant bioactivities include its antibacterial (especially against <i>Mycobacterium</i> and <i>Staphylococcus</i> species), anticancer/antitumour (mainly against Ehrlich ascites carcinoma, blood, breast, cervical, colon, lung, prostate and skin cancer cell lines), and antiparasitic (particularly against <i>Leishmania</i>, <i>Plasmodium</i> and <i>Trypanosoma</i> parasites) properties. In addition to three major activities, diospyrin was found to possess antiallergic, antidiabetic, antifungal, anti-inflammatory, antinociceptive, antioxidant, antiviral, neuroprotective, and sedative properties. Some information on the plausible mechanisms of action of diospyrin for its major bioactivities is also available in the literature. Diospyrin was shown to produce a certain level of cytotoxicity in normal cells, hepatotoxicity and mutagenicity. Overall, diospyrin could be considered a structural lead for developing new therapeutics for cancers and bacterial and parasitic infections, albeit further preclinical and clinical studies with diospyrin and its structural analogues are still needed. This review presents a comprehensive and updated overview, and a critical appraisal of published information until February 2025 on diospyrin (<b>1</b>), including its occurrence in the plant kingdom, biosynthesis, therapeutic potential, mechanisms of action and toxicity.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 7","pages":"4829 - 4856"},"PeriodicalIF":6.3,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10200-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in dietary bioactives: Unlocking chromatin accessibility","authors":"Wenqi Huang,&nbsp;Shiye Lin,&nbsp;Yi Yuan,&nbsp;Mohamed A. Farag,&nbsp;Hui Wang,&nbsp;Jianbo Xiao","doi":"10.1007/s11101-025-10196-5","DOIUrl":"10.1007/s11101-025-10196-5","url":null,"abstract":"<div><p>The DNA and chromatin within the nucleus of eukaryotic cells form a highly dynamic system, where the balance of RNA dynamics critically depends on access to DNA. Such access is regulated by <i>cis</i>-regulatory elements such as non-coding RNAs, transcription factors, histone modifications, and ATP-dependent chromatin remodelers, all of which play crucial roles in health and disease. Nucleosome organization and occupancy further influence chromatin states. Dietary bioactives have emerged as key modulators of chromatin accessibility, contributing to cellular homeostasis and disease outcomes. This review summarizes recent advancements in DNA-seq methods for mapping chromatin accessibility landscapes. Additionally, the interplay between nutritional modulation of chromatin accessibility and disease progression is presented for the first time in literature providing insights into genome-wide regulatory mechanisms in diseased populations. The alteration of nuclear metabolism by dietary flavonoids is an important driving factor to modulate chromatin landscapes.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 6","pages":"3555 - 3581"},"PeriodicalIF":6.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148782378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of chemical diversity of Kappaphycus alvarezii: biological properties, health benefits, and food applications","authors":"Bahrun Bahrun,&nbsp;Hakiki Melanie,&nbsp;Nina Artanti,&nbsp;Yulia Anita,&nbsp;Endar Marraskuranto,&nbsp;Ambo Tuwo,&nbsp;Yusaku Miyamae","doi":"10.1007/s11101-025-10197-4","DOIUrl":"10.1007/s11101-025-10197-4","url":null,"abstract":"<div><p>Macroalgae are considered highly nutritious organism and are potentially used as a functional food. Additionally, macroalgae are rich in secondary metabolites that can be used to treat various diseases. Macroalgae can be regarded as one of the options for resolving numerous global health issues that have become increasingly concerning. <i>Kappaphycus alvarezii</i>, also known as <i>Eucheuma cottonii</i>, is considered for various applications. This potential arises from its high content of both primary and secondary metabolites. This review will highlight the metabolites and their implications for biological properties, health benefits, and food applications of <i>K. alvarezii</i>. This marine red algae species contains secondary metabolites, including terpenoids, chlorinated C20-cyclooctene and C23-cyclooctenyl, heptalenecarbolactone, and heptalenecarboxylate derivatives, along with various N-containing and other compounds. Additionally, it has primary metabolites such as fatty acids, lipids, amino acids, proteins, sugars, and polysaccharides. These metabolites contribute to various biological properties, including antibacterial, antioxidant, anticancer, antifungal, antiviral, anti-inflammatory, and antidiabetic effects, rendering them valuable for health applications. Moreover, <i>K. alvarezii</i> holds promise in the food industry due to its nutritional content, which includes essential minerals, amino acids, proteins, ω-3, ω-6, and ω-9 fatty acids. Recognizing this potential is crucial for maximizing the future use of <i>K. alvarezii</i> as a source of beneficial metabolites. Efforts should focus on isolating and characterizing these diverse yet underexplored compounds, which could provide valuable insights for applications in pharmaceuticals, nutraceuticals, and biotechnology.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2367 - 2388"},"PeriodicalIF":7.6,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the chemical space of natural products from diverse sources: a chemoinformatics perspective","authors":"Yi Liu,&nbsp;Zhen Tian,&nbsp;Bohong Xu,&nbsp;De-Xin Kong","doi":"10.1007/s11101-025-10198-3","DOIUrl":"10.1007/s11101-025-10198-3","url":null,"abstract":"<div><p>Natural products (NPs) have been pivotal in drug discovery, with over half of approved small-molecule drugs originating directly or indirectly from NPs. With continuous practice, a significant amount of NP-related data has been accumulated, leading to the booming of various NP databases and chemoinformatics analysis. This review aims to examine chemoinformatics studies of the chemical space of NPs, emphasizing their structural characteristics and bioactivities across different source species, chemotypes, environments, and geographical regions. Current databases document over 1.1 million NPs, which display high structural diversity and complexity, frequently with glycosylation and halogenation. NPs exhibit distinct features based on their origins. Marine NPs are larger and more hydrophobic than terrestrial counterparts, while deep-sea and extremophile-derived NPs show novel scaffolds and bioactivities. NPs occupy broader chemical spaces than synthetic compounds, yet discovery rates of novel structures are declining. The limited availability of NPs (only ~ 10% purchasable) and the redundancy in known scaffolds pose major challenges in NP research. Future strategies highlight integrating multidimensional databases, leveraging artificial intelligence for target prediction, and exploring untapped species and extreme environments to uncover unique bioactive compounds. The key findings of chemoinformatics analysis on NPs to date were summarized. This article presents a comprehensive, multidimensional perspective on NP chemical space, contributing to a deeper understanding of NPs and valuable theoretical insights into natural drug discovery.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 3","pages":"2389 - 2410"},"PeriodicalIF":7.6,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147558842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective on yeast-3-hybrid assays for target identification of bioactive natural products","authors":"Jonas A. Stehlin,&nbsp;Claudia Ascher,&nbsp;Simone Moser","doi":"10.1007/s11101-025-10199-2","DOIUrl":"10.1007/s11101-025-10199-2","url":null,"abstract":"<div><p>While an immense number of natural products have been screened for bioactivity using a variety of phenotypic assays, elucidation of their protein targets remains a significant bottleneck limiting further clinical research. Next to conventional pulldown assays and modern developments, such as cellular thermal shift assays (CETSA), yeast three-hybrid (Y3H) has emerged as a powerful yet underutilized tool that provides a low-barrier avenue for target identification of the challenging natural products space. Still, adoption of Y3H in natural products research has been slow in spite of successful target identification of a diverse range of small molecules reported in literature. In this perspective, we present the underlying methodology and its limitations as well as possible future developments and how it may accelerate and complement the target ID of natural compounds. We encourage natural product researchers to increase efforts on target elucidation of their lead compounds and propose Y3H as an approach, which could be integrated into existing workflows.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"25 4","pages":"2623 - 2629"},"PeriodicalIF":7.6,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-025-10199-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}