Asclepiadoideae subfamily (Apocynaceae): ethnopharmacology, biological activities and chemophenetics based on pregnane glycosides

IF 7.3 2区生物学 Q1 PLANT SCIENCES

Phytochemistry Reviews Pub Date : 2024-03-22 DOI:10.1007/s11101-024-09914-2

Thalisson Amorim de Souza, Francisca Sabrina Vieira Lins, Jociano da Silva Lins, Alan Ferreira Alves, Samuel Paulo Cibulski, Brito Thiago de Araújo Medeiros, Lucas Silva Abreu, Luciana Scotti, Marcus Tullius Scotti, Marcelo Sobral da Silva, Josean Fechine Tavares

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引用次数: 0

Abstract

Apocynaceae, one of the largest plant families with over 5.100 widely distributed species, serves as a significant model for evolutionary and biochemical studies. Within this family, compounds such as alkaloids, flavonoids, and terpenoids with potential therapeutic activities have been isolated. Among its subfamilies, Asclepiadoideae is recognized as a rich source of C₂₁ pregnane derivatives. This paper presents a comprehensive review of pregnane glycosides (PG) obtained from Asclepiadoideae, employing an interdisciplinary approach that combines chemophenetics with neural network data analysis to identify promising species and bioactive compounds. A dataset comprising 660 unique PGs and 705 botanical occurrences was compiled for this purpose. The ethnopharmacological aspects, as well as the extraction, isolation, and biological activity of PGs, were analyzed and discussed. Chemophenetic analysis using Self-Organizing Maps (SOM) and phylogeny reconstruction revealed similarities between the Marsdenia-Ceropegiae tribes and highlighted the occurrence of seco and diseco pregnane types predominantly within the Asclepiadeae tribe. Both scaffolds exhibited intriguing structural features, and their derivatives have demonstrated anti-inflammatory and cytotoxic activities. These findings provide valuable insights for future research on these compounds and their medicinal plant sources.

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Asclepiadoideae 亚科（天胡荽科）：基于孕烷苷的民族药理学、生物活性和化学遗传学

天南星科（Apocynaceae）是最大的植物科之一，广泛分布着 5100 多个物种，是进化和生物化学研究的重要模型。在该科中，生物碱、黄酮类和萜类等具有潜在治疗活性的化合物已被分离出来。在其亚科中，Asclepiadoideae 被认为是 C21 孕烷衍生物的丰富来源。本文全面综述了从 Asclepiadoideae 中获得的孕烷苷 (PG)，采用了一种跨学科的方法，将化学表观遗传学与神经网络数据分析相结合，以确定有前景的物种和生物活性化合物。为此汇编了一个数据集，其中包括 660 种独特的 PG 和 705 种植物。分析和讨论了民族药理学方面以及 PGs 的提取、分离和生物活性。利用自组织结构图（SOM）和系统发育重建进行的化学遗传学分析揭示了马齿苋科-芹菜科之间的相似性，并强调了主要出现在 Asclepiadeae 科中的 seco 和 diseco 孕烷类型。这两种支架都表现出引人入胜的结构特征，其衍生物具有抗炎和细胞毒性活性。这些发现为今后研究这些化合物及其药用植物来源提供了有价值的见解。

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来源期刊

Phytochemistry Reviews PLANT SCIENCES-

CiteScore

16.30

自引率

2.60%

发文量

审稿时长

2 months

期刊介绍： Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.