{"title":"揭示牛黄素在治疗阿尔茨海默氏症和帕金森氏症中的作用:从食品到纳米药物的旅程","authors":"Harmanpreet Kaur, Bushra Bashir, Amandeep Kaur, Navneet Singh, Sukriti Vishwas, Puneet Kumar, Harish Dureja, Motamarri Venkata Naga Lalitha Chaitanya, Thakur Gurjeet Singh, Gaurav Gupta, Aftab Alam, Francisco Veiga, Ana Cláudia Paiva-Santos, Kamal Dua, Sachin Kumar Singh","doi":"10.1007/s11101-024-09936-w","DOIUrl":null,"url":null,"abstract":"<p>Flavonoids have a longstanding tradition of being employed in traditional medicine to improve human health. Crocin has been suggested as a potential candidate for addressing a range of ailments, including neurodegenerative diseases (NDs). In the modern era, diverse pharmacological activities of crocin have been explored due to its bioactive constituents like kaempferol, picrocrocin, safranal, and crocetin. It demonstrates pharmacological and therapeutic efficacy against various diseases such as cancer, kidney diseases, NDs, and measles, attributable to several mechanisms. Various studies evidence that it exerts a neuroprotective effect in conditions like Alzheimer’s disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and others, by modulating relevant parameters. Despite harboring numerous pharmacological benefits, it exhibits low bioavailability due to poor solubility and limited ability to cross the blood–brain barrier (BBB). To address this issue, diverse approaches involving nanoformulations have been developed to enhance their bioavailability, aqueous solubility, and BBB permeability. Various types of studies have been conducted on crocin-loaded nanoparticles against NDs, which are discussed in this paper.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unravelling role of crocin for the treatment of Alzheimer’s and Parkinson’s disease: sojourn from food to nanomedicine\",\"authors\":\"Harmanpreet Kaur, Bushra Bashir, Amandeep Kaur, Navneet Singh, Sukriti Vishwas, Puneet Kumar, Harish Dureja, Motamarri Venkata Naga Lalitha Chaitanya, Thakur Gurjeet Singh, Gaurav Gupta, Aftab Alam, Francisco Veiga, Ana Cláudia Paiva-Santos, Kamal Dua, Sachin Kumar Singh\",\"doi\":\"10.1007/s11101-024-09936-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Flavonoids have a longstanding tradition of being employed in traditional medicine to improve human health. Crocin has been suggested as a potential candidate for addressing a range of ailments, including neurodegenerative diseases (NDs). In the modern era, diverse pharmacological activities of crocin have been explored due to its bioactive constituents like kaempferol, picrocrocin, safranal, and crocetin. It demonstrates pharmacological and therapeutic efficacy against various diseases such as cancer, kidney diseases, NDs, and measles, attributable to several mechanisms. Various studies evidence that it exerts a neuroprotective effect in conditions like Alzheimer’s disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and others, by modulating relevant parameters. Despite harboring numerous pharmacological benefits, it exhibits low bioavailability due to poor solubility and limited ability to cross the blood–brain barrier (BBB). To address this issue, diverse approaches involving nanoformulations have been developed to enhance their bioavailability, aqueous solubility, and BBB permeability. Various types of studies have been conducted on crocin-loaded nanoparticles against NDs, which are discussed in this paper.</p>\",\"PeriodicalId\":733,\"journal\":{\"name\":\"Phytochemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Reviews\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11101-024-09936-w\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11101-024-09936-w","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Unravelling role of crocin for the treatment of Alzheimer’s and Parkinson’s disease: sojourn from food to nanomedicine
Flavonoids have a longstanding tradition of being employed in traditional medicine to improve human health. Crocin has been suggested as a potential candidate for addressing a range of ailments, including neurodegenerative diseases (NDs). In the modern era, diverse pharmacological activities of crocin have been explored due to its bioactive constituents like kaempferol, picrocrocin, safranal, and crocetin. It demonstrates pharmacological and therapeutic efficacy against various diseases such as cancer, kidney diseases, NDs, and measles, attributable to several mechanisms. Various studies evidence that it exerts a neuroprotective effect in conditions like Alzheimer’s disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and others, by modulating relevant parameters. Despite harboring numerous pharmacological benefits, it exhibits low bioavailability due to poor solubility and limited ability to cross the blood–brain barrier (BBB). To address this issue, diverse approaches involving nanoformulations have been developed to enhance their bioavailability, aqueous solubility, and BBB permeability. Various types of studies have been conducted on crocin-loaded nanoparticles against NDs, which are discussed in this paper.
期刊介绍:
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.