揭示牛黄素在治疗阿尔茨海默氏症和帕金森氏症中的作用:从食品到纳米药物的旅程

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Harmanpreet Kaur, Bushra Bashir, Amandeep Kaur, Navneet Singh, Sukriti Vishwas, Puneet Kumar, Harish Dureja, Motamarri Venkata Naga Lalitha Chaitanya, Thakur Gurjeet Singh, Gaurav Gupta, Aftab Alam, Francisco Veiga, Ana Cláudia Paiva-Santos, Kamal Dua, Sachin Kumar Singh
{"title":"揭示牛黄素在治疗阿尔茨海默氏症和帕金森氏症中的作用:从食品到纳米药物的旅程","authors":"Harmanpreet Kaur, Bushra Bashir, Amandeep Kaur, Navneet Singh, Sukriti Vishwas, Puneet Kumar, Harish Dureja, Motamarri Venkata Naga Lalitha Chaitanya, Thakur Gurjeet Singh, Gaurav Gupta, Aftab Alam, Francisco Veiga, Ana Cláudia Paiva-Santos, Kamal Dua, Sachin Kumar Singh","doi":"10.1007/s11101-024-09936-w","DOIUrl":null,"url":null,"abstract":"<p>Flavonoids have a longstanding tradition of being employed in traditional medicine to improve human health. Crocin has been suggested as a potential candidate for addressing a range of ailments, including neurodegenerative diseases (NDs). In the modern era, diverse pharmacological activities of crocin have been explored due to its bioactive constituents like kaempferol, picrocrocin, safranal, and crocetin. It demonstrates pharmacological and therapeutic efficacy against various diseases such as cancer, kidney diseases, NDs, and measles, attributable to several mechanisms. Various studies evidence that it exerts a neuroprotective effect in conditions like Alzheimer’s disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and others, by modulating relevant parameters. Despite harboring numerous pharmacological benefits, it exhibits low bioavailability due to poor solubility and limited ability to cross the blood–brain barrier (BBB). To address this issue, diverse approaches involving nanoformulations have been developed to enhance their bioavailability, aqueous solubility, and BBB permeability. Various types of studies have been conducted on crocin-loaded nanoparticles against NDs, which are discussed in this paper.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unravelling role of crocin for the treatment of Alzheimer’s and Parkinson’s disease: sojourn from food to nanomedicine\",\"authors\":\"Harmanpreet Kaur, Bushra Bashir, Amandeep Kaur, Navneet Singh, Sukriti Vishwas, Puneet Kumar, Harish Dureja, Motamarri Venkata Naga Lalitha Chaitanya, Thakur Gurjeet Singh, Gaurav Gupta, Aftab Alam, Francisco Veiga, Ana Cláudia Paiva-Santos, Kamal Dua, Sachin Kumar Singh\",\"doi\":\"10.1007/s11101-024-09936-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Flavonoids have a longstanding tradition of being employed in traditional medicine to improve human health. Crocin has been suggested as a potential candidate for addressing a range of ailments, including neurodegenerative diseases (NDs). In the modern era, diverse pharmacological activities of crocin have been explored due to its bioactive constituents like kaempferol, picrocrocin, safranal, and crocetin. It demonstrates pharmacological and therapeutic efficacy against various diseases such as cancer, kidney diseases, NDs, and measles, attributable to several mechanisms. Various studies evidence that it exerts a neuroprotective effect in conditions like Alzheimer’s disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and others, by modulating relevant parameters. Despite harboring numerous pharmacological benefits, it exhibits low bioavailability due to poor solubility and limited ability to cross the blood–brain barrier (BBB). To address this issue, diverse approaches involving nanoformulations have been developed to enhance their bioavailability, aqueous solubility, and BBB permeability. Various types of studies have been conducted on crocin-loaded nanoparticles against NDs, which are discussed in this paper.</p>\",\"PeriodicalId\":733,\"journal\":{\"name\":\"Phytochemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Reviews\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11101-024-09936-w\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11101-024-09936-w","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

传统医学中使用黄酮类化合物改善人类健康的传统由来已久。黄花苷被认为是治疗包括神经退行性疾病(NDs)在内的一系列疾病的潜在候选药物。在现代,人们探索了巴豆素的多种药理活性,因为它含有山奈酚、苦参碱、黄蓍醇和巴豆素等生物活性成分。它对癌症、肾病、非传染性疾病和麻疹等多种疾病具有药理和治疗功效,这归功于多种机制。多项研究证明,它通过调节相关参数,对阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩性脊髓侧索硬化症等疾病具有神经保护作用。尽管具有众多药理作用,但由于溶解度低和穿越血脑屏障(BBB)的能力有限,它的生物利用度较低。为解决这一问题,人们开发了多种涉及纳米制剂的方法,以提高其生物利用度、水溶性和血脑屏障渗透性。本文讨论了针对 NDs 的各种类型的牛黄素负载纳米颗粒研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Unravelling role of crocin for the treatment of Alzheimer’s and Parkinson’s disease: sojourn from food to nanomedicine

Unravelling role of crocin for the treatment of Alzheimer’s and Parkinson’s disease: sojourn from food to nanomedicine

Flavonoids have a longstanding tradition of being employed in traditional medicine to improve human health. Crocin has been suggested as a potential candidate for addressing a range of ailments, including neurodegenerative diseases (NDs). In the modern era, diverse pharmacological activities of crocin have been explored due to its bioactive constituents like kaempferol, picrocrocin, safranal, and crocetin. It demonstrates pharmacological and therapeutic efficacy against various diseases such as cancer, kidney diseases, NDs, and measles, attributable to several mechanisms. Various studies evidence that it exerts a neuroprotective effect in conditions like Alzheimer’s disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and others, by modulating relevant parameters. Despite harboring numerous pharmacological benefits, it exhibits low bioavailability due to poor solubility and limited ability to cross the blood–brain barrier (BBB). To address this issue, diverse approaches involving nanoformulations have been developed to enhance their bioavailability, aqueous solubility, and BBB permeability. Various types of studies have been conducted on crocin-loaded nanoparticles against NDs, which are discussed in this paper.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信