卡拉金:一种潜在的神经保护呋喃黄酮类化合物

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Charles Gnanaraj, Mogana Govendan, Ching-Yee Loo, Yoong Soon Yong, Mahendran Sekar, Che Norma Mat Taib, Shamala Devi Subramaniam, Muhammad Dawood Shah, Wing-Hin Lee
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引用次数: 0

摘要

摘要 植物化学物质因其在治疗各种人体疾病方面的药理作用而广为人知,近年来,不断有新的化合物被发现,对健康大有裨益。卡兰金是一种呋喃黄酮类化合物,主要从小米草中分离出来,在药理学领域崭露头角,在临床前研究中具有潜在的治疗价值。本综述旨在强调卡朗金作为神经保护剂的潜力,以及调节潜在分子机理途径的意义。全球报告的常见神经退行性疾病包括阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症。治疗神经退行性疾病的主要问题是,治疗潜在疾病的处方药只能起到暂时的作用,无法找到永久性的解决方案。在临床前研究和部分临床试验中,黄酮类生物活性化合物通过调节 NF-kB 通路、抑制氧化应激、调节 PI3K/Akt 等各种作用机制,在很大程度上被认为具有神经保护作用。与商业标准药物相比,卡朗金的分子对接结果证明了其通过调节参与疾病进展的分子靶点腺苷 A2A 受体、α-突触核蛋白、儿茶酚-O-甲基转移酶、单胺氧化酶 B、血管紧张素转换酶、β-位点 APP 裂解酶、糖原合酶激酶-3、TNF-α 转换酶和乙酰胆碱酯酶,具有防治阿尔茨海默病和帕金森病的潜力。综述强调了分离卡朗金的优化方法,以及卡朗金在调节神经退行性疾病方面即将产生的各种机理作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Karanjin: a potential furanoflavonoid for neuroprotection

Karanjin: a potential furanoflavonoid for neuroprotection

Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from Millettia pinnata L., emerging in the field of pharmacology and exerting potential therapeutic values in pre-clinical studies. The review aims to highlight the potential of karanjin as a neuroprotective agent with the significance of modulating the underlying molecular mechanistic pathways. Common neurodegenerative diseases reported globally include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. The main problem in the treatment of neurodegenerative diseases is the effect of the prescribed drugs for the underlying conditions is only momentary whereby a permanent solution is unavailable. Bioactive compounds under the class of flavonoids have largely been acknowledged for neuroprotection in pre-clinical studies and partial clinical trials through various mechanism of action such as modulation of NF-kB pathway, inhibition of oxidative stress, modulation of PI3K/Akt, and more. Molecular docking results of karanjin have proven the potential against Alzheimer’s and Parkinson’s disease through modulation of molecular targets adenosine A2A receptor, α-synuclein, catechol-O-methyltransferase, monoamine oxidase B, angiotensin converting enzyme, β-site APP cleaving enzyme, glycogen synthase kinase-3, TNF-α converting enzyme, and acetylcholinesterase involved in the disease progression, compared to commercial standard drugs. The review emphasizes the optimization method for the isolation of karanjin and the various impending mechanistic effects of karanjin in modulating neurodegenerative diseases.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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