{"title":"探索植物衍生的双吲哚生物碱：来源、植物化学和细胞毒性的综合综述","authors":"Zilong Zhang, Yuze Li, Yiming Li, Xiaomei Song, Rui Wang, Dongdong Zhang","doi":"10.1007/s11101-024-10015-3","DOIUrl":null,"url":null,"abstract":"<div><p>Bisindole alkaloids represent a notable class of natural compounds distinguished by their characteristic bisindole structure and recognized for their anticancer potential. Over the past nine decades, a plethora of bisindole alkaloids have been isolated from plants. The chemical compositions and cytotoxicity of these plant-derived bisindole alkaloids (PDBAs) have been elucidated. Currently, 735 PDBAs have been documented. Predominantly sourced from plants within the Apocynaceae family, these compounds demonstrate formidable cytotoxicity against various tumor types, such as colorectal cancer, breast cancer and lung cancer. This review comprehensively examines the sources, phytochemistry, and cytotoxicity of these compounds. Furthermore, it provides a summary of the structure–activity relationship (SAR) and the mechanisms through which PDBAs exert their cytotoxicity. In summary, the aim of this paper is to offer a comprehensive overview of the advancements in the investigation of PDBAs for their continued development and utilization.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1753 - 1841"},"PeriodicalIF":7.3000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring plant-derived bisindole alkaloids: a comprehensive review of sources, phytochemistry and cytotoxicity\",\"authors\":\"Zilong Zhang, Yuze Li, Yiming Li, Xiaomei Song, Rui Wang, Dongdong Zhang\",\"doi\":\"10.1007/s11101-024-10015-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bisindole alkaloids represent a notable class of natural compounds distinguished by their characteristic bisindole structure and recognized for their anticancer potential. Over the past nine decades, a plethora of bisindole alkaloids have been isolated from plants. The chemical compositions and cytotoxicity of these plant-derived bisindole alkaloids (PDBAs) have been elucidated. Currently, 735 PDBAs have been documented. Predominantly sourced from plants within the Apocynaceae family, these compounds demonstrate formidable cytotoxicity against various tumor types, such as colorectal cancer, breast cancer and lung cancer. This review comprehensively examines the sources, phytochemistry, and cytotoxicity of these compounds. Furthermore, it provides a summary of the structure–activity relationship (SAR) and the mechanisms through which PDBAs exert their cytotoxicity. In summary, the aim of this paper is to offer a comprehensive overview of the advancements in the investigation of PDBAs for their continued development and utilization.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":733,\"journal\":{\"name\":\"Phytochemistry Reviews\",\"volume\":\"24 2\",\"pages\":\"1753 - 1841\"},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Reviews\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11101-024-10015-3\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s11101-024-10015-3","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Exploring plant-derived bisindole alkaloids: a comprehensive review of sources, phytochemistry and cytotoxicity
Bisindole alkaloids represent a notable class of natural compounds distinguished by their characteristic bisindole structure and recognized for their anticancer potential. Over the past nine decades, a plethora of bisindole alkaloids have been isolated from plants. The chemical compositions and cytotoxicity of these plant-derived bisindole alkaloids (PDBAs) have been elucidated. Currently, 735 PDBAs have been documented. Predominantly sourced from plants within the Apocynaceae family, these compounds demonstrate formidable cytotoxicity against various tumor types, such as colorectal cancer, breast cancer and lung cancer. This review comprehensively examines the sources, phytochemistry, and cytotoxicity of these compounds. Furthermore, it provides a summary of the structure–activity relationship (SAR) and the mechanisms through which PDBAs exert their cytotoxicity. In summary, the aim of this paper is to offer a comprehensive overview of the advancements in the investigation of PDBAs for their continued development and utilization.
期刊介绍：
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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