Phytochemistry Reviews最新文献

{"title":"Chimaphila umbellata; a biotechnological perspective on the coming-of-age prince’s pine","authors":"Urooj Ali,&nbsp;Muhammad Mustajab Khan,&nbsp;Naveera Khan,&nbsp;Rida tul Haya,&nbsp;Muhammad Usama Asghar,&nbsp;Bilal Haider Abbasi","doi":"10.1007/s11101-023-09880-1","DOIUrl":"10.1007/s11101-023-09880-1","url":null,"abstract":"<div><p><i>Chimaphila umbellata</i> has been studied for almost two centuries now, with the first paper exploring the phytochemistry of the plant published in 1860. Almost all contemporary studies focus on the biotechnological advances of <i>C. umbellata</i> including its utilization as a natural alternative in the cosmetic, food, biofuel, and healthcare industry, with a special focus on its therapeutic uses. This literature review critically investigates the significance and applications of secondary metabolites extracted from the plant and presses on the biotechnological approaches to improve its utilization. <i>C. umbellata</i> is home to many industrially and medicinally important phytochemicals, the majority of which belong to phenolics, sterols, and triterpenoids. Other important compounds include 5-hydroxymethylfurfural, isohomoarbutin, and methyl salicylate (the only essential oil of the plant). <i>Chimaphilin</i> is the characteristic phytochemical of the plant. This review focuses on the phytochemistry of <i>C. umbellata</i> and digs into their chemical structures and attributes. It further discusses the challenges of working with <i>C. umbellata</i> including its alarming conservation status, problems with <i>in-vitro</i> cultivation, and research and development issues. This review concludes with recommendations based on biotechnology, bioinformatics, and their crucial interface.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 1","pages":"229 - 244"},"PeriodicalIF":7.3,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the ethno-medicinal and pharmacological properties of Terminalia chebula fruit","authors":"Mansi Tiwari,&nbsp;Mridula S. Barooah","doi":"10.1007/s11101-023-09878-9","DOIUrl":"10.1007/s11101-023-09878-9","url":null,"abstract":"<div><p><i>Terminalia chebula</i>, commonly known as <i>black myrobalan, ink tree</i> and <i>Chebulic myrobalan</i> is a deciduous tree belonging to the family Combretaceae. It is native to the tropical region with the highest occurrence in the South East Asian regions. The plant exhibits a wide spectrum of biological activity due to its phytochemicals such as polyphenols, flavonoids, terpenes, anthocyanins and glycosides. The fruit of <i>T. chebula</i> has been used in several traditional medicinal practices such as Ayurveda, Unani and Siddha for the treatment of different diseases and ailments including chronic diarrhoea, gastroenteritis, constipation, asthma, ulcer, haemorrhoids, cold and cough. The plant has been well reported in the current literature to possess anti-oxidant, anti-bacterial, anti-arthritic, anti-cancerous, anti-diabetic, anti-viral, anti-bacterial, hypo-cholesterolemic, anti-plasmodial, antinociceptive, antiulcerogenic and anti-spermatogenic properties. However, comprehensive reviews on the broad spectrum of bioactivity of this plant are limited in literature. Therefore, this review was designed to critically analyse and summarise the current ethno-medicinal and pharmacological evidence on <i>T. chebula.</i> Owing to its bioactivity, <i>T. chebula</i> possesses great potential to include in modern drug discovery. However, further pre-clinical and clinical studies are warranted for its prospective pharmaceutical applications.\u0000</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 1","pages":"125 - 145"},"PeriodicalIF":7.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49437975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids in major cereal grasses: distribution, functions, biosynthesis, and applications","authors":"Lydia Pui Ying Lam,&nbsp;Lanxiang Wang,&nbsp;Andy C. W. Lui,&nbsp;Hongjia Liu,&nbsp;Toshiaki Umezawa,&nbsp;Yuki Tobimatsu,&nbsp;Clive Lo","doi":"10.1007/s11101-023-09873-0","DOIUrl":"10.1007/s11101-023-09873-0","url":null,"abstract":"<div><p>Cereal food crops like maize (<i>Zea mays</i>), rice (<i>Oryza sativa</i>), sorghum (<i>Sorghum bicolor</i>) and wheat (<i>Triticum aestivum</i>) are members of the grass family (Poaceae). Together with bioenergy grasses, they play essential roles in agriculture and biorefinery, comprising an important component of bio-economy. Grasses accumulate a unique range of flavonoids (a class of plant-specific specialized metabolites) that contribute to defense responses, fertility, pigmentation and cell wall lignification. This review summarizes the distribution, functions, biosynthesis and regulation of flavonoids, including flavanones, tricin and flavone <i>O</i>-conjugates, flavone <i>C</i>-glycosides, 3-deoxyanthocyanidins, phlobaphenes, anthocyanins, proanthocyanidins (condensed tannins) and flavonols, in grasses focusing on model cereal grasses. In particular, the constitutive, predominant and widespread tricin-lignin, flavone <i>O</i>-conjugates and flavone <i>C</i>-glycosides as well as the inducible and/or lineage-specific sakuranetin (a flavanone), maysin (a flavone <i>C</i>-glycoside), 3-deoxyanthocyanidins and phlobaphenes, are highlighted. Finally, the impacts and importance of cereal grass flavonoids on scientific research, agricultural production, food and health, and biorefinery are discussed.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"22 5","pages":"1399 - 1438"},"PeriodicalIF":7.7,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41083965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition, biological activities and traditional uses of plants from the segregated genus Caesalpinia sensu lato","authors":"Bruna Oliveira do Nascimento,&nbsp;Jorge Mauricio David","doi":"10.1007/s11101-023-09874-z","DOIUrl":"10.1007/s11101-023-09874-z","url":null,"abstract":"<div><p>The species <i>Caesalpinia</i> s.l. (Leguminosae: Caesalpinioideae) are widely distributed over all continents and content a large amount of unusual secondary metabolites with vast biological potential. Traditionally, this genus includes more than 150 species, but currently, in an attempt to group the species by similar phylogenetic characteristics, <i>Caesalpinia</i> s.l. was categorized into the following nine different genera: <i>Caesalpinia</i> s.s., <i>Coulteria, Erythrostemon, Guilandina, Libidibia, Mezoneuron, Poincianella, Pomaria</i> and <i>Tara.</i> Recently, some taxonomic groups were relocated to genera from the informal <i>Caesalpinia</i> Group, such as <i>Cenostigma</i>, <i>Moullava, Biancaea</i> and <i>Hultholia</i>. However, pharmacological and chemical studies continue to use the original genera in their research. Eight hundred thirty-one compounds, including 479 new occurrences in natural products, have been identified and described in the literature in the last decade. Despite the large number of studies, the main species remain scientifically unexplored. Of the more than 140 species belonging to the segregated genera, only 30 species were analysed in chemical studies, all of which are described in this work. A review of the taxonomy of the genus <i>Caesalpinia</i> s.l. revealed that the reclassification, which led to the union of species based on morphological characteristics related to chemical composition, divided species with unusual chemical constituents into distinct genera. In addition, this revision reflects on the taxonomic reclassification of the genus to update the scenario of structures already isolated in the genera and the biological and pharmacological properties of constituents obtained from <i>Caesalpinia</i> and the other segregated genera, considering an updated nomenclature and a previous reclassification covering the available data in the literature published from 2010 to 2022.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 1","pages":"1 - 93"},"PeriodicalIF":7.3,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47546996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant","authors":"Jan Tauchen,&nbsp;Adela Frankova,&nbsp;Anna Manourova,&nbsp;Irena Valterova,&nbsp;Bohdan Lojka,&nbsp;Olga Leuner","doi":"10.1007/s11101-023-09869-w","DOIUrl":"10.1007/s11101-023-09869-w","url":null,"abstract":"<div><p><i>Garcinia kola</i> Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. <i>Garcinia kola</i> is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Several different classes of compounds such as biflavonoids, benzophenones, benzofurans, benzopyran, vitamin E derivatives, xanthones, and phytosterols, have been isolated from <i>G. kola</i>, of which many appears to be found only in this species, such as garcinianin (found in seeds and roots), kolanone (fruit pulp, seeds, roots), gakolanone (stem bark), garcinoic acid, garcinal (both in seeds), garcifuran A and B, and garcipyran (all in roots). They showed a wide range of pharmacological activities (e.g. analgesic, anticancer, antidiabetic, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective and neuroprotective effects), though this has only been confirmed in animal models. Kolaviron is the most studied compound and is perceived by many studies as the active principle of <i>G. kola</i>. However, its research is associated with significant flaws (e.g. too high doses tested, inappropriate positive control). Garcinol has been tested under better conditions and is perhaps showing more promising results and should attract deeper research interest (especially in the area of anticancer, antimicrobial, and neuroprotective activity). Human clinical trials and mechanism-of-action studies must be carried out to verify whether any of the compounds present in <i>G. kola</i> may be used as a lead in the drug development.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"22 5","pages":"1305 - 1351"},"PeriodicalIF":7.7,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-023-09869-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41084226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant peptides from plants: a review","authors":"Ana P. C. César,&nbsp;Francisco E. S. Lopes,&nbsp;Francisca F. N. Azevedo,&nbsp;Yago O. Pinto,&nbsp;Claudia R. Andrade,&nbsp;Felipe P. Mesquita,&nbsp;Gabrielly O. Silva,&nbsp;Cleverson D. T. Freitas,&nbsp;Pedro F. N. Souza","doi":"10.1007/s11101-023-09875-y","DOIUrl":"10.1007/s11101-023-09875-y","url":null,"abstract":"<div><p>Bioactive peptides derived from plant protein sequences have a broad spectrum of biotechnological applications, including treating oxidation-related diseases. In this way, these molecules can interact with specific receptors in human cells, modulating several metabolic functions, such as fatty acid catabolism and blood glucose regulation. Several databases contribute to the strengthening of studies in the area since plant proteins and antioxidant peptides derived from them can slow down some oxidative processes in the body, thus improving global public health. Peptides from various food sources have bioactivities, including antihypertensive, antioxidant, anticancer, antimicrobial, and immunomodulatory effects and cholesterol-reducing effects, essential for human health. However, further studies are still needed to explore the mechanisms of action, bioavailability, and possible physiological or functional properties. Thus, scientific reviews are needed to improve further scientific knowledge in plant antioxidant peptides, an area with significant exponential growth supported by bioinformatics. Therefore, this review may provide a significant reference for the construction and development of new antioxidant peptides.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 1","pages":"95 - 104"},"PeriodicalIF":7.3,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45440101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review","authors":"Bian-Xia Xue,&nbsp;Ru-Shang He,&nbsp;Jia-Xin Lai,&nbsp;Nana Ama Mireku-Gyimah,&nbsp;Li-Hua Zhang,&nbsp;Hong-Hua Wu","doi":"10.1007/s11101-023-09870-3","DOIUrl":"10.1007/s11101-023-09870-3","url":null,"abstract":"<div><p><i>Cyperus rotundus</i> L. has been widely used in the treatment and prevention of numerous diseases in traditional systems of medicine around the world, such as nervous, gastrointestinal systems diseases and inflammation. In traditional Chinese medicine (TCM), its rhizomes are frequently used to treat liver disease, stomach pain, breast tenderness, dysmenorrheal and menstrual irregularities. The review is conducted to summarize comprehensively the plant’s vernacular names, distribution, phytochemistry, pharmacology, toxicology and analytical methods, along with the data mining for TCM prescriptions containing <i>C. rotundus</i>. Herein, 552 compounds isolated or identified from <i>C. rotundus</i> were systematically collated and classified, concerning monoterpenoids, sesquiterpenoids, flavonoids, phenylpropanoids, phenolics and phenolic glycosides, triterpenoids and steroids, diterpenoids, quinonoids, alkaloids, saccharides and others. Their pharmacological effects on the digestive system, nervous system, gynecological diseases, and other bioactivities like antioxidant, anti-inflammatory, anti-cancer, insect repellent, anti-microbial activity, etc. were summarized accordingly. Moreover, except for the data mining on the compatibility of <i>C. rotundus</i> in TCM, the separation, identification and analytical methods of <i>C. rotundus</i> compositions were also systematically summarized, and constituents of the essential oils from different regions were re-analyzed using multivariate statistical analysis. In addition, the toxicological study progresses on <i>C. rotundus</i> revealed the safety property of this herb. This review is designed to serve as a scientific basis and theoretical reference for further exploration into the clinical use and scientific research of <i>C. rotundus</i>.\u0000</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"22 5","pages":"1353 - 1398"},"PeriodicalIF":7.7,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41083927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the genus Melodinus: traditional uses, phytochemical diversity and pharmacological activities of indole alkaloids","authors":"Si-Fan Teng, Fang-Ru Li, Qimin Cui, Afsar Khan, Ting He, Xiao-Dong Luo, Ya-Ping Liu, Guiguang Cheng","doi":"10.1007/s11101-023-09871-2","DOIUrl":"https://doi.org/10.1007/s11101-023-09871-2","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"1 1","pages":"1-54"},"PeriodicalIF":7.7,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43473638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-chain variable fragment-based immunoassay for bioactive natural products","authors":"Xiping Cui, Jian Lu, Jinchao Wei, Suqing Zhao, Yiyong Yan, Guo Yin, Bing Wang, Y. Mu, Peng Li","doi":"10.1007/s11101-023-09867-y","DOIUrl":"https://doi.org/10.1007/s11101-023-09867-y","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"1 1","pages":"1-21"},"PeriodicalIF":7.7,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49362130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal chemical defence allocation in roots: where, why and how?","authors":"A. Touw, N. V. van Dam","doi":"10.1007/s11101-023-09872-1","DOIUrl":"https://doi.org/10.1007/s11101-023-09872-1","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"1 1","pages":"1-10"},"PeriodicalIF":7.7,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46984106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}