Phytochemistry Reviews最新文献

{"title":"Exploring AI-enhanced NMR dereplication analysis for complex mixtures and its potential use in adulterant detection","authors":"Xiao-Nan Du,&nbsp;You-Wen Chen,&nbsp;Qing Wang,&nbsp;Hui-Ying Yang,&nbsp;Yong Lu,&nbsp;Xian-Fu Wu","doi":"10.1007/s11101-024-10006-4","DOIUrl":"10.1007/s11101-024-10006-4","url":null,"abstract":"<div><p>Identifying chemical entities in complex mixtures is crucial for advancing research in natural products and metabolomics. This enables the discovery of unique structures and bioactive compounds. Dereplication analysis streamlines this process by rapidly identifying known compounds, reducing redundant efforts, and accelerating the exploration of bioactive entities. NMR is the most effective technique for the identification of small organic molecules due to its robust structural elucidation capabilities. However, challenges such as low sensitivity and complex sample matrices often lead to overlapping NMR signals and spectral ambiguities. Artificial intelligence (AI), especially deep learning, has revolutionized dereplication by significantly enhancing pattern recognition in applications ranging from regression and classification to clustering. This review explores the origins, development, and principles of dereplication techniques, as well as the features of mass spectrometry and NMR. It also delves into the advancements in AI-enhanced NMR dereplication, elucidating the principles for various models and the key issues they address during the dereplication process. Furthermore, it covers the methods for constructing reference databases, and the usability and accessibility of these models. These insights can assist researchers, including those new to AI algorithms, in rapidly adopting and implementing these advanced methods. Moreover, this review highlights the broader utility of dereplication methods in fields such as the detection of illegal additives in cosmetics, emphasizing their potential applications in a wider range of fields.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"2833 - 2868"},"PeriodicalIF":7.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review on Abrus precatorius Linn. since 1871: ethnobotanical uses, phytochemistry and pharmacological properties","authors":"Sukanya Vijayan,&nbsp;M. Thirumal","doi":"10.1007/s11101-024-09988-y","DOIUrl":"10.1007/s11101-024-09988-y","url":null,"abstract":"<div><p><i>Abrus precatorius</i> also known <i>as Abrus pauciflorus</i> or <i>Abrus minor</i> is a medicinal plant that has been widely used in indigenous medicine, belonging to the family Fabaceae, widely distributed in tropical and sub-tropical regions like India and China, commonly Known as Rosary pea, Crabs eye, Gunja, Indian Liquorice etc. It has been extensively used to cure diseases like Cancer, Diabetes, inflammation, malaria, tuberculosis etc. Since the 1870s multiple studies on different parts of the plant has been performed. The presence of various secondary metabolites like Flavonoids, Terpenoids, Alkaloids, Steroids have developed interest among researchers for this plant. It has been reported for various pharmacological activities like Anticancer, antidiabetic, antiulcer, antimicrobial, anti-inflammatory, insecticidal, antitubercular, hair growth promoting etc. This review, aim to systematically summarize the traditional uses, phytoconstituents and activity reported. All the articles from databases like Scopus, PubMed, ScienceDirect, and Google Scholar have been considered since 1871. Articles are collected from these databases until October 2022. Articles in English is only considered. Publications from peer-reviewed journals were only selected. Keywords used for the search are <i>Abrus precatorius</i>, Pharmacology, Phytochemistry, Ethnobotany, Rosary pea, and Crabs eye. This review aims to provide references for further studies by finding the research gaps.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1941 - 1970"},"PeriodicalIF":7.3,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals with anticancer activity from poisonous plants: potential leads for cancer therapy","authors":"Eun Seo Jang,&nbsp;Youngsang Nam,&nbsp;Yeo Jin Lee,&nbsp;Chanhee Jang,&nbsp;Seoung Rak Lee","doi":"10.1007/s11101-024-10025-1","DOIUrl":"10.1007/s11101-024-10025-1","url":null,"abstract":"<div><p>Despite advances in cancer treatment, the disease remains a major global health challenge, requiring innovative approaches for prevention and therapy. Phytochemicals, encompassing a vast array of secondary metabolites with therapeutic potential, have been integral to traditional medicines globally and continue to serve as sources of modern pharmaceuticals. Anticancer phytochemicals derived from poisonous plants have offered promising avenues in cancer treatment, characterized by their ability to inhibit tumor growth, induce apoptosis, and modulate critical cancer pathways. This review focuses on cytotoxic phytochemicals identified from poisonous plants, highlighting their potential as novel anticancer agents. We also discuss the chemical structures and cytotoxic activities of representative phytochemicals from poisonous plants. Future research should focus on thorough phytochemical studies to discover new anticancer phytochemicals and investigate their synergistic effects with existing therapies, thereby enhancing the range of cancer treatment options available.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3265 - 3287"},"PeriodicalIF":7.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive overview of glucosinolates in crucifers: occurrence, roles, metabolism, and transport mechanisms—a review","authors":"Sanjula Sharma,&nbsp;Heena Rani,&nbsp;Gurpreet Kaur,&nbsp;Sarwan Kumar,&nbsp;Salma Sheikh,&nbsp;Mahesh Kumar Samota","doi":"10.1007/s11101-024-10021-5","DOIUrl":"10.1007/s11101-024-10021-5","url":null,"abstract":"<div><p>Plants of the Brassicaceae family exhibit a sophisticated defense mechanism against plant pathogens and insect herbivores, leading to the production of diverse hydrolytic derivatives such as thiocyanates, isothiocyanates, nitriles, and epithionitriles. These chemical transformations are catalyzed through the enzymatic action of myrosinase on glucosinolates (GSLs), which are otherwise inactive in the intact plant. The hydrolytic products of GSLs are incredibly effective at protecting plants from pests, weeds, herbivores, bacterial and fungal attack. The impact of GSLs on animal health is multifaceted, with nutritional attributes varying based on chemical structure and concentration. While certain GSLs and their derivatives in Brassica plants are associated with health benefits and cancer prevention, others have been linked to goitrogenic effects in ruminants, with concentrations ranging from 50 to 120 μmol g⁻¹. This variability has implications for the use of rapeseed–mustard meal in food and feed. Despite considerable efforts to modify the chemical profile of GSLs in Brassica species, a comprehensive understanding of their composition and metabolism is still essential for achieving effective and targeted manipulation. This review aims to consolidate both foundational and recent advancements in GSLs research, with a focus on their biological properties, role in plant-pathogen interactions, transport and strategies for managing their accumulation in Brassica seeds. Our goal is to enhance the utilization of this crop by maximizing its potential benefits. This information could be pivotal in developing new varieties with tailored GSLs content and profile, resulting in improved crop yields, enhanced nutritional quality, and greater biofumigation efficacy, thereby benefiting both agriculture and human health.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 3","pages":"2417 - 2444"},"PeriodicalIF":7.6,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern research progress on extraction and purification, pharmacological activity, toxicology, pharmacokinetics and carrier new dosage forms of ophiopogonin","authors":"Qingquan Wang,&nbsp;Yanan Li,&nbsp;Peng Gao,&nbsp;Long Dai","doi":"10.1007/s11101-024-09995-z","DOIUrl":"10.1007/s11101-024-09995-z","url":null,"abstract":"<div><p><i>Ophiopogon japonicus</i> (Thunb.) Ker Gawl. (OJ, called <i>Maidong</i> in China) is a traditional medicinal plant utilized as a tonic agent in various ethnomedical systems across East Asia, especially in China. With the advancement of research on OJ, the pharmacological activity of its primary active ingredient saponins has been increasingly recognized. Due to their different chemical structures, these saponins exhibit varying chemical properties and pharmacological activities. Ophiopogonin (OP), one of these saponins, demonstrates a range of pharmacological activities, including cardioprotection, anti-cancer effects, anti-inflammatory properties, antioxidant activity, bone damage repair, and regulation of intestinal flora. Furthermore, OP can be incorporated into drug carriers to enhance their potential efficacy. This paper reviews the research progress of extraction and purification methods, pharmacological activity, toxicology, pharmacokinetics, and new carrier formulations of OP, providing a foundation for further research into ophiopogonin.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"2553 - 2586"},"PeriodicalIF":7.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the biomedical applications of Campsis radicans (woody vine): integrating traditional wisdom and contemporary insights","authors":"Uday Kumar Killi,&nbsp;Matěj Malík,&nbsp;Zdeňka Navrátilová,&nbsp;Radoslav Patočka,&nbsp;Patrik Olekšák,&nbsp;Sireesha Uday Killi,&nbsp;Kamil Kuca,&nbsp;Pavel Tlustoš,&nbsp;Jiří Patočka","doi":"10.1007/s11101-024-10018-0","DOIUrl":"10.1007/s11101-024-10018-0","url":null,"abstract":"<div><p>The utilization of natural resources in traditional medicine has long served as a wellspring of inspiration for modern biomedical research. <i>Campsis radicans</i> (L.) Bureau, commonly known as trumpet creeper, occupies a significant place in traditional healing practices across various cultures. This review study, conducted in the early part of 2024, aims to synthesize traditional knowledge with contemporary scientific advancements to explore the biomedical potential of <i>C. radicans</i>. The relevant literary references were comprehensively reviewed and examined using various databases, including Web of Science, PubMed, Scopus, and Google Scholar. Data and information were synthesized from original research articles, meta-analyses, systematic reviews, and pertinent animal studies. By drawing upon historical uses, phytochemical analysis, pharmacological investigations, and recent research findings, this article provides an overview of the therapeutic applications of <i>C. radicans</i> in wound healing, anti-inflammatory interventions, cancer management, and potential prospects in neurology and cardiology. Furthermore, it delves into the challenges and prospects associated with unlocking the full potential of this woody vine in biomedicine.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3101 - 3117"},"PeriodicalIF":7.6,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral mechanisms of dietary polyphenols: recent developments as antiviral agents and future prospects in combating Nipah virus","authors":"S. Prabhu,&nbsp;K. Kalaimathi,&nbsp;M. Thiruvengadam,&nbsp;M. Ayyanar,&nbsp;K. Shine,&nbsp;S. Amalraj,&nbsp;S. Antony Ceasar,&nbsp;S. Padma Priya,&nbsp;N. Prakash","doi":"10.1007/s11101-024-10017-1","DOIUrl":"10.1007/s11101-024-10017-1","url":null,"abstract":"<div><p>Polyphenols are ubiquitous secondary metabolites found in plants that have attracted considerable attention owing to their diverse applications in various industries, including food, cosmetics, and pharmaceuticals. Particularly, the curcumin, rosmarinic acid, and catechins are known for their therapeutic potential and offer a range of benefits, including antioxidant, neuroprotective, anti-inflammatory, anti-cancer and antimicrobial properties. Most importantly, they have shown promise for combating viral infections. The effectiveness of these pharmacological properties has been demonstrated through rigorous in silico, in vitro, and in vivo studies. There are evidence that dietary and pharmaceutical polyphenols exert protective effects against viral infections. Therefore, this review aims to investigate the mechanisms of action of curcumin, rosmarinic acid, and catechins against serious viral diseases in the human race. According to the research report of previous results, we believe that the proposed molecules have various roles in preventing infection and supporting the healing process in cases of viral invasion by blocking viral entry, inhibiting virus replication, protecting blood vessels, and preventing superinfection. On the other hand, these act effectively as antioxidants by activating Nrf-2 and inhibiting the overexpression of epithelial proteins. To determine the anti-Nipah virus potential, these molecules were tested against fusion protein, glycoprotein, membrane protein, nucleoprotein and phosphoprotein of Nipah virus (NiV). Eventually, they were discovered to have greater inhibitory activity by exhibiting binding affinities with specific protein residues of the Nipah virus. Based on the results of the review and in silico validation, the present review suggests that curcumin, rosmarinic acid, ( −)-epicatechin and ( +)-gallocatechin may act as an effective inhibitor for the complications caused by Nipah virus.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3063 - 3099"},"PeriodicalIF":7.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles as new elicitors for the production of bioactive and phytochemicals in vitro and in vivo plant culture","authors":"Mahsa Darbahani,&nbsp;Mohammad Rasoul Ghiyasi,&nbsp;Mahdi Rahaie","doi":"10.1007/s11101-024-10022-4","DOIUrl":"10.1007/s11101-024-10022-4","url":null,"abstract":"<div><p>Plants have been used for their beneficial compounds especially therapeutic and medicinal properties over the centuries. Various applications of plants in industry and medicine are related to their distinct phytochemical molecules called secondary metabolites (bioactive chemicals). In reaction to stress, plants produce secondary metabolites that serve numerous physiological functions. Their complex chemical compositions make them valuable across various industries, including food, agriculture, cosmetics, and pharmaceuticals. The chemicals are efficacious and have been deemed an optimal candidate for commercialization. From several decades ago, studies have suggested that elicitation is an effective strategy to increase the production of secondary metabolites in plants. This could help overcome the limitations of plant cell technology for commercial use. An external stimulus may enhance the synthesis of secondary metabolites by triggering various biosynthetic pathways, activating specific genes associated with defense or non-defense functions, stimulating distinct enzymes, and modifying proteins via phosphorylation or dephosphorylation. Upon new findings, it has found that nanoparticles (NPs) might stimulate the production of bioactive molecules, particularly secondary metabolites in plants. This review will highlight in vivo and in vitro studies using different carbon and metal nanoparticles as nano-elicitors to stimulate secondary metabolite production in various plants.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3179 - 3203"},"PeriodicalIF":7.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mint (Mentha spp.) essential oil extraction: from conventional to emerging technologies","authors":"Sara Hedayati,&nbsp;Mohammad Tarahi,&nbsp;Vahid Baeghbali,&nbsp;Zahra Tahsiri,&nbsp;Mohammad Hashem Hashempur","doi":"10.1007/s11101-024-10020-6","DOIUrl":"10.1007/s11101-024-10020-6","url":null,"abstract":"<div><p>Mint essential oil (MEO) is an economically appreciated natural product with significant importance in the cosmetics, pharmaceutics, foods, and healthcare products due to its biological activities. Extraction is a critical step in the production of essential oils from aromatic plants, such as mint. Conventional extraction approaches, such as steam distillation and solvent extraction are commonly used for the extraction of MEO. However, they are energy and time-consuming processes with relatively low extraction yields. Consequently, emerging techniques, such as microwave-assisted, ohmic-assisted, ultrasound-assisted, pulsed electric field, and super and sub-critical fluid extraction methods have been developed to overcome these shortcomings. This review aims to investigate the influence of different extraction methods and conditions on the extraction yield, composition, physicochemical properties, and bioactivity of MEO. Overall, selection of appropriate extraction method and conditions is a crucial step in the extraction of MEO that can have significant effects on the quality and quantity of the isolated EOs. Inappropriate extraction of MEO may reduce the extraction yield, prolong the extraction duration, and increase the energy consumption. Additionally, it may deteriorate the physicochemical properties and bioactivity of the extracted MEO.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 4","pages":"3157 - 3178"},"PeriodicalIF":7.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anticancer properties of harmine and its derivatives","authors":"Abdul Aziz Timbilla,&nbsp;Rudolf Vrabec,&nbsp;Radim Havelek,&nbsp;Martina Rezacova,&nbsp;Jakub Chlebek,&nbsp;Gerald Blunden,&nbsp;Lucie Cahlikova","doi":"10.1007/s11101-024-09978-0","DOIUrl":"10.1007/s11101-024-09978-0","url":null,"abstract":"<div><p>This review aims to provide information about the anticancer potential of harmine, a β-carboline alkaloid that was initially isolated in 1847 from the seeds and roots of <i>Peganum harmala</i> L. Various studies have revealed that it possesses a wide range of therapeutic qualities, including anti-inflammatory, antibacterial, antiviral, antidiabetic, and, most notably, anticancer effects. This review discusses the anticancer capabilities of harmine and its derivatives against malignancies such as breast cancer, lung cancer, gastric cancer, colon cancer, glioblastoma, neuroblastoma, liver cancer, pancreatic cancer and thyroid cancer. Harmine uses mechanisms such as apoptosis and angiogenesis inhibition to fight cancer cells. It also influences the cell cycle by inhibiting specific cyclin-dependent kinases and slowing tumor cell proliferation. Synergistic effects have also been observed when harmine is used in combination with other anticancer medications. Harmine has the potential to be a potent anticancer medication that can help in the fight against cancer.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1535 - 1564"},"PeriodicalIF":7.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09978-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}