Phytochemistry Reviews最新文献

{"title":"An updated and comprehensive review of traditional uses, phytochemistry, and pharmacological progress on the Hypecoum genus","authors":"Hai-Lian Yuan,&nbsp;Li Zhang,&nbsp;Wen-Hao Huang,&nbsp;Chang-Gang Sun,&nbsp;Xiao-Dong Luo","doi":"10.1007/s11101-024-09985-1","DOIUrl":"10.1007/s11101-024-09985-1","url":null,"abstract":"<div><p>The <i>Hypecoum</i> genus belongs to the family Papaveraceae, consists of roughly 16 accepted species, and is extensively distributed from the Mediterranean to Central Asia and Northern China. It was used widely for the treatment of sore throat, tracheitis, cough, hepatitis, bronchitis, bacterial dysentery, and conjunctive congestion with swelling and pain disease in traditional Chinese and other countries’ medicine, especially in Tibetan or Mongolian medicine. Based on “<i>Hypecoum</i>”, a total of 163 relevant papers published since 1924 were meticulously selected through comprehensive searches of the American Chemical Society (ACS), PubMed, Web of Science, and Science Direct databases. Modern pharmacological researches have evaluated its various biological activities, such as analgesic, anti-inflammatory, antibacterial, hepatoprotective, and antiproliferative activities, even the assessment of its potential for mitigating the impact of corona virus disease 2019 (COVID-19). Approximately 100 alkaloids have been obtained and identified from the <i>Hypecoum</i> species, as well as flavonoid, volatile oil, phenolic, and aromatic compounds. Additionally, the <i>Hypecoum</i> species is widely used in traditional Chinese medicine (TCM) formulae, partial efficacies of which have been verified via numerous pharmacological and clinical investigations, particularly in the treatment of inflammatory and pain diseases. This reviews performed an exhaustive literature review to bridge the knowledge gap that there has yet to be a comprehensive and systematic review addressing the botany, traditional uses, phytochemicals, pharmacological effects, and underlying mechanisms associated with <i>Hypecoum</i> genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of <i>Hypecoum</i> spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1843 - 1921"},"PeriodicalIF":7.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141570582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on essential oils and extracts from Iris rhizomes","authors":"Carlo Bicchi,&nbsp;Daniel Joulain","doi":"10.1007/s11101-024-09981-5","DOIUrl":"10.1007/s11101-024-09981-5","url":null,"abstract":"<div><p><i>Iris</i> spp. rhizomes (commonly known as orris rhizomes) are a precious raw material used in perfumery, as sources of high-value violet odorant substances, mainly consisting of irones. The review comprehensively and critically presents the techniques for the optimized production of irones from orris rhizomes and their formation from their triterpene precursors (the iridals). It also thoroughly discusses the qualitative and quantitative techniques to analyze both iridals and irones, the chemical structures and stereochemistry of irones and their olfactory properties. It also describes a detailed composition of the orris extracts intended for applications in fragrance and flavor fields. This unprecedented survey also includes patent applications, granted or not.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1629 - 1665"},"PeriodicalIF":7.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry","authors":"Marcela Šafratová, Rudolf Vrabec, Gerald Blunden, Lucie Cahlíková, Jana Křoustková","doi":"10.1007/s11101-024-09931-1","DOIUrl":"https://doi.org/10.1007/s11101-024-09931-1","url":null,"abstract":"<p>This article is a critical review of the taxonomy and phytochemistry of the genus <i>Zephyranthes</i> Herb., a group of plants known for their beautiful flowers and traditional medicinal uses. The present review summarizes the occurrence, isolation, and identification of specialized metabolites, which have recently been frequently studied because of their important biological activities. Among the accepted 203 species, only 27 have been phytochemically investigated. This paper provides an overview of the different types of specialized metabolites identified in these plants and considers problematic taxonomic evolution within this species. The differences between two internationally recognized databases, which classify only 41% of the species in the same way, are briefly summarized. In addition, there are many reports on their metabolites, especially alkaloids, but some of the data in the literature are occasionally inaccurate and sometimes even erroneous. This critical review aims to discuss, summarize, and evaluate up-to-date (up to July of 2023) information about metabolites of the genus <i>Zephyranthes,</i> focusing on phytochemistry and taxonomy.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"45 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action","authors":"Stanley I. R. Okoduwa,&nbsp;Daniel H. Mhya,&nbsp;Ibrahim Abdulwaliyu,&nbsp;Bernard E. Igiri,&nbsp;Ugochi J. Okoduwa,&nbsp;David E. Arthur,&nbsp;Aderinsola O. Laleye,&nbsp;Gerrard J. Osang,&nbsp;Oluwatimilehin L. Onaleye,&nbsp;Emmanuella Nathyns-Pepple","doi":"10.1007/s11101-024-09984-2","DOIUrl":"10.1007/s11101-024-09984-2","url":null,"abstract":"<div><p>Diabetes mellitus is a metabolic disorder that can lead to various complications affecting the heart, kidney, and eye. Several synthetic and natural products have been used for disease management, but the disease still remains a global challenge. The use of plants as an alternative management for diabetes has been on the rise. Regrettably, the comprehensive repository is not available to guide future research in the area of plants with a related mechanism of action for the development of an effective drug. To identify and compile medicinal plants frequently used with proven scientific hypoglycaemic properties and their possible modes of action. This was done through a literature search of scientific databases using search tools like DOAJ, EMBASE, Europe PMC, FSTA, Google Scholar, HubMed, Indian Citation Index, Medline Plus, Merck Index, PubMed, ScienceDirect, Science3open, Science Open, SciFinder, Scirus, Core, Scopus, Semantic Scholar, Shodhganga, and World Wide Science. Search keywords included: medicinal plants, antidiabetics, hypoglycaemic, alpha-amylases/glucosidase inhibition, glucose metabolic enzymes, antihyperglycaemia, insulin secretion/surrogate, β-cell amelioration, phytochemicals, diabetes management, anti-oxidant, and enhance glucose transporters. The study excludes plants used in the management of diseases other than diabetes mellitus. From the search, 611 authenticated medicinal plants with anti-diabetic properties were eligible and grouped according to their reported probable mode of action. Precisely 20.6% of the plants exhibited their anti-diabetic effect via prevention of oxidative stress; 11.6% acted through stimulation of insulin secretion, inhibition of insulin degradation, and reduction of insulin resistance. Also, 10.8% inhibited enzymes of carbohydrate gastrointestinal digestion, 2.8% were postulated to regulate enzymes of glucose metabolism, and 54.2% acted via nonspecific or multiple means, as well as those whose anti-diabetic mode of action was yet to be identified. This study has shown that the exact mechanisms or mode of action of the majority of plants with hypoglycaemic properties are yet to be explored. Scientists would therefore find this paper useful in their future research. This paper may also serve as a potential lead for the easy harmonization of plants with a related mode of action in the drug discovery process targeted at the management of diabetes mellitus.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1691 - 1751"},"PeriodicalIF":7.3,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties","authors":"Rui Parente,&nbsp;Ana Cláudia Paiva-Santos,&nbsp;Célia Cabral,&nbsp;Gustavo Costa","doi":"10.1007/s11101-024-09980-6","DOIUrl":"10.1007/s11101-024-09980-6","url":null,"abstract":"<div><p>Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. <i>Urtica dioica</i> L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of <i>Urtica</i> species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1591 - 1628"},"PeriodicalIF":7.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09980-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Lamiaceae-derived bioactive compounds as nature’s arsenal for sustainable pest management","authors":"Muhammad Ali,&nbsp;Abrar Muhammad,&nbsp;Zemian Lin,&nbsp;Hai He,&nbsp;Yu Zhang","doi":"10.1007/s11101-024-09987-z","DOIUrl":"10.1007/s11101-024-09987-z","url":null,"abstract":"<div><p>Intensive agriculture has long been associated with the excessive use of synthetic pesticides, leading to environmental pollution, health risks, and the development of pesticide-resistant insect populations. In response, significant scientific efforts are underway to seek safer alternatives for eco-friendly pest management, such as utilizing natural compounds, including essential oils derived from plants in the Lamiaceae family. This review explores the existing literature on Lamiaceae-derived bioactive compounds and their efficacy as alternative biopesticides. It delves into their chemical composition, mechanism of action, and practical application in pest management strategies. The multifaceted impact of these oils on insect pests is profound, with components like monoterpene, monoterpenoid, sesquiterpenoid, and aliphatic phenylpropanoids exhibiting diverse modes of action. These mechanisms may involve rupturing cell membranes, neurotoxic effects, antifeedant effects, repellent properties, and growth regulatory effects that make them effective natural alternatives to synthetic pesticides. However, their development as alternative biopesticides is often hindered by challenges such as standardization and formulation, regulatory approval, resistance development in insects, cost-effectiveness, as well as knowledge and awareness gaps. This synthesis of knowledge contributes to the evolving landscape of sustainable pest management practices, reducing the ecological footprint of intensive agriculture, and mitigating risks associated with conventional insecticides.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1989 - 2013"},"PeriodicalIF":7.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical diversity and pharmacological effects of sesquiterpenes from Artemisia spp.","authors":"Amin Rezaei Do,&nbsp;Seyed Ahmad Emami,&nbsp;Maryam Akaberi","doi":"10.1007/s11101-024-09962-8","DOIUrl":"10.1007/s11101-024-09962-8","url":null,"abstract":"<div><p><i>Artemisia</i> L., belonging to the Asteraceae family, consists of 498 species worldwide. Studies show that sesquiterpenes, as the main bioactive compounds from the genus, have exhibited a wide range of pharmacological activities. In this updated review paper, we aimed to discuss the phytochemistry of the sesquiterpenes isolated from <i>Artemisia</i> species from 2015 to December 2023 and their pharmacological activities. We searched the scientific databases “Scopus”, “PubMed”, and “ISI Web of Science” with the keywords “<i>Artemisia</i>” AND “Sesquiterpene” OR “Sesquiterpenoid” OR “Eudesmanolide” OR “Guaianolide” OR “Germacranolide” OR “Eudesmane” OR “Guaiane” OR “Germacrane”, OR “Chemical”. A total of 914 sesquiterpenes with various skeletons mainly belonging to eudesmane, guaiane, germacrene, and cadinane subtypes were reported from 53 different <i>Artemisia</i> species. Additionally, the dimeric sesquiterpenes constituted one of the most reported classes of compounds. Based on the literature survey, sesquiterpenes from <i>Artemisia</i> can be potent anti-inflammatory and cytotoxic compounds, of which guaiane and dimeric sesquiterpenes showed the best anti-inflammatory and cytotoxic effects. However, antimicrobial, immunosuppressant, and neuroprotective effects, as well as antifeedant, and nematocidal activities, have been reported for the <i>Artemisia</i> sesquiterpenes. Overall, this review shows that the sesquiterpenes of <i>Artemisia</i> can be promising lead compounds for drug discovery programs, particularly as anti-inflammatory and cytotoxic agents. Besides, more phytochemical, pharmacological, and clinical studies are necessary to discover more compounds that are potent and to assess their safety and efficacy.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1365 - 1502"},"PeriodicalIF":7.3,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eleutherococcus giraldii (Harms) Nakai: a review of botany, traditional uses, phytochemistry, pharmacology and quality control","authors":"Ling Li,&nbsp;Jie Zhang,&nbsp;Li-wen Zhong,&nbsp;Rui Gu,&nbsp;Shi-hong Zhong","doi":"10.1007/s11101-024-09982-4","DOIUrl":"10.1007/s11101-024-09982-4","url":null,"abstract":"<div><p><i>Eleutherococcus giraldii</i> (Harms) Nakai (EG, thereafter) is a perennial shrub, widely recognized for its medicinal properties. The stem bark of this plant is a widely used traditional Chinese herb with the effects of dispelling dampness, strengthening sinews and invigorating bones. Native to the upper reaches of the Minjiang River, EG is a prevalent Qiang medicine. It was included in the 2010 Edition of the Standard of Traditional Chinese Medicines of Sichuan Province. In the 1990s, numerous phytochemistry was carried out. Several chemical constituents have been identified, including saponins, lignans, alkali nucleosides, polysaccharides, alkanes, organic acids, and other compounds. Notably, glycosides and their glycosides with ivy saponins as ligands stand out among these constituents. Modern pharmacological studies have shown that the stem bark of <i>Eleutherococcus giraldii</i> (Harms) Nakai (EGSB, thereafter) has anti-inflammatory, immunomodulatory, anti-tumour, anti-oxidant, anti-ischemic and hepatoprotective effects. In addition to its stem bark being used in medicine, the young leaves of EG are the traditional food of the Qiang people, which has been developed into a tea product and pushed to the market. The prospect of industrialisation is good. This comprehensive review aims to explore the taxonomic status, botanical characteristics, traditional applications, phytochemistry, pharmacology, and quality control of EG. The primary focus is placed on phytochemical and pharmacological investigations.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"1027 - 1055"},"PeriodicalIF":7.3,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vigna mungo (Linn.) Hepper: ethnobotanical, pharmacological, phytochemical, and nutritious profile","authors":"Fazal Hadi,&nbsp;Haseeba Sardar,&nbsp;Waqas Alam,&nbsp;Michael Aschner,&nbsp;Fuad M. Alzahrani,&nbsp;Ibrahim F. Halawani,&nbsp;Jianbo Xiao,&nbsp;Haroon Khan","doi":"10.1007/s11101-024-09972-6","DOIUrl":"10.1007/s11101-024-09972-6","url":null,"abstract":"<div><p><i>Vigna mungo</i> is a member of the family <i>Fabaceae</i> and important medicinal plant that is widely consumed as food in South Asia. It is commonly referred as Black Gram, Urad daal and Maash. It is traditionally used for strangulated bowel syndrome, dyspepsia, constipation, neuropathy, hepatopathy, gastritis, diarrhea, rheumatism, diabetes, etc. This review article provides up-to-date information on <i>V. mungo,</i> including its reported ethnopharmacology, pharmacological activities, phytochemistry and nutritious composition. Articles were screened from databases such as Web of Science, SpringerLink, Google Scholar, PubMed, Medline Plus, Elsevier, and Science Direct. <i>V. mungo</i> contains phytochemical including alkaloids, flavonoids, saponins, steroids, tannins, phenolic compounds, fatty acids, carbohydrates, amino acids, vitamins, and carotenoids. These compounds exert pharmacological activities both in-vitro and in-vivo including antioxidant, antidiabetic, anti-hyperlipidemic, immunostimulatory, hepatoprotective, nephroprotective, antibacterial, anthelmintic, thrombolytic, anti-inflammatory, analgesic, ulcerogenic, anticonvulsant, nootropic, anti-osteoarthritic, aphrodisiac, spermatogenic and anticancer activities. Currently, scientific data in supports of the biological activities are scarce. We suggest more in-depth to determine its clinical efficacy.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1119 - 1142"},"PeriodicalIF":7.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The botanical details, pharmacological activities and industrial applications of date seed (Phoenix dactylifera L.)","authors":"Susan Chinedu Nwachukwu,&nbsp;Great Iruoghene Edo,&nbsp;Princess Oghenekeno Samuel,&nbsp;Agatha Ngukuran Jikah,&nbsp;Gift Onyinyechi Oloni,&nbsp;Gracious Okeoghene Ezekiel,&nbsp;Joy Johnson Agbo","doi":"10.1007/s11101-024-09967-3","DOIUrl":"10.1007/s11101-024-09967-3","url":null,"abstract":"<div><p>Date palm (<i>Phoenix dactylifera</i> L.) is a very vital crop tree in many Middle Eastern countries and also, its fruits called dates are consumed worldwide by thousands of people. Date seeds which are the by-product of date fruits, are usually regarded as wastes and at most, only used as feed for farm animals. Unbeknownst to many however, date seeds are embedded with numerous amounts of fiber, carbohydrates, protein, oil, and dietary additionally, date seeds also contain phytochemicals that may elicit biological effects. Moreover, the abundant chemical composition of date seeds makes them apposite for use in medical supplements, food product formulation and cosmetics. It is the aim of the authors to review to the latest data on the pharmacological properties of date seeds discussing the botanical properties and industrial applications as well.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"927 - 951"},"PeriodicalIF":7.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}