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The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity 海桐属:关于传统用途、植物化学和药理活性的现有知识
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-27 DOI: 10.1007/s11101-024-09990-4
Nguyen Thi Thuy Linh, Nguyen Van Tuyen, Ty Viet Pham, Suresh Awale, Ninh The Son
{"title":"The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity","authors":"Nguyen Thi Thuy Linh, Nguyen Van Tuyen, Ty Viet Pham, Suresh Awale, Ninh The Son","doi":"10.1007/s11101-024-09990-4","DOIUrl":"https://doi.org/10.1007/s11101-024-09990-4","url":null,"abstract":"<p>Background: <i>Pittosporum</i> (the family Pittosporaceae) contains flowering plants, which was used as folk medicines in some countries of Asia, Europe, and Africa. Traditional use and pharmacological values of plants in this genus were deduced from a great role of their secondary metabolites. Objective: The ultimate goal of the review fully provides significant information on traditional use, phytochemistry, and pharmacology of <i>Pittosporum</i> plants. Methods: The search for reference data is mostly based on electronic resources, such as Google Scholar, Sci-Finder, and Web of Science. “<i>Pittosporum</i>” is the most important keyword, in which it was used alone or combined with other words to seek literature documents. Results: Traditionally, <i>Pittosporum</i> species are on the recommended list for medicinal purposes and fragrance preparation. From the 1960s to the present, more than 270 metabolites have been isolated with the derivatives type terpenoids, saponins, and lignans being the main phytochemical classes. Essential oils derived from <i>Pittosporum</i> species were dominated by terpenoids and fatty acids. Accumulating evidence has firmly revealed that <i>Pittosporum</i> constituents generated a wide variety of pharmacological activities, including cytotoxic, anti-inflammatory, antioxidative, antimicrobial, antiparasitic, antiarrhythmic, antinociceptive, antimalarial, enzyme inhibitory, and hepatoprotective activities. <i>Conclusion</i>: Technological advances in the chromatographic isolation of huge amounts are desirable. Toxicological assessments are needed. In vivo pharmacological experiments, molecular mechanisms of action, and clinical evaluations are warranted.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"4 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry Zephyranthes Herb.属的特殊代谢物:分类学和植物化学评论
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-26 DOI: 10.1007/s11101-024-09931-1
Marcela Šafratová, Rudolf Vrabec, Gerald Blunden, Lucie Cahlíková, Jana Křoustková
{"title":"Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry","authors":"Marcela Šafratová, Rudolf Vrabec, Gerald Blunden, Lucie Cahlíková, Jana Křoustková","doi":"10.1007/s11101-024-09931-1","DOIUrl":"https://doi.org/10.1007/s11101-024-09931-1","url":null,"abstract":"<p>This article is a critical review of the taxonomy and phytochemistry of the genus <i>Zephyranthes</i> Herb., a group of plants known for their beautiful flowers and traditional medicinal uses. The present review summarizes the occurrence, isolation, and identification of specialized metabolites, which have recently been frequently studied because of their important biological activities. Among the accepted 203 species, only 27 have been phytochemically investigated. This paper provides an overview of the different types of specialized metabolites identified in these plants and considers problematic taxonomic evolution within this species. The differences between two internationally recognized databases, which classify only 41% of the species in the same way, are briefly summarized. In addition, there are many reports on their metabolites, especially alkaloids, but some of the data in the literature are occasionally inaccurate and sometimes even erroneous. This critical review aims to discuss, summarize, and evaluate up-to-date (up to July of 2023) information about metabolites of the genus <i>Zephyranthes,</i> focusing on phytochemistry and taxonomy.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"45 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action 治疗糖尿病的植物药方法:概述经科学证实具有降血糖作用的药用植物及其可能的作用机制
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-22 DOI: 10.1007/s11101-024-09984-2
Stanley I. R. Okoduwa, Daniel H. Mhya, Ibrahim Abdulwaliyu, Bernard E. Igiri, Ugochi J. Okoduwa, David E. Arthur, Aderinsola O. Laleye, Gerrard J. Osang, Oluwatimilehin L. Onaleye, Emmanuella Nathyns-Pepple
{"title":"Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action","authors":"Stanley I. R. Okoduwa, Daniel H. Mhya, Ibrahim Abdulwaliyu, Bernard E. Igiri, Ugochi J. Okoduwa, David E. Arthur, Aderinsola O. Laleye, Gerrard J. Osang, Oluwatimilehin L. Onaleye, Emmanuella Nathyns-Pepple","doi":"10.1007/s11101-024-09984-2","DOIUrl":"https://doi.org/10.1007/s11101-024-09984-2","url":null,"abstract":"<p>Diabetes mellitus is a metabolic disorder that can lead to various complications affecting the heart, kidney, and eye. Several synthetic and natural products have been used for disease management, but the disease still remains a global challenge. The use of plants as an alternative management for diabetes has been on the rise. Regrettably, the comprehensive repository is not available to guide future research in the area of plants with a related mechanism of action for the development of an effective drug. To identify and compile medicinal plants frequently used with proven scientific hypoglycaemic properties and their possible modes of action. This was done through a literature search of scientific databases using search tools like DOAJ, EMBASE, Europe PMC, FSTA, Google Scholar, HubMed, Indian Citation Index, Medline Plus, Merck Index, PubMed, ScienceDirect, Science3open, Science Open, SciFinder, Scirus, Core, Scopus, Semantic Scholar, Shodhganga, and World Wide Science. Search keywords included: medicinal plants, antidiabetics, hypoglycaemic, alpha-amylases/glucosidase inhibition, glucose metabolic enzymes, antihyperglycaemia, insulin secretion/surrogate, β-cell amelioration, phytochemicals, diabetes management, anti-oxidant, and enhance glucose transporters. The study excludes plants used in the management of diseases other than diabetes mellitus. From the search, 611 authenticated medicinal plants with anti-diabetic properties were eligible and grouped according to their reported probable mode of action. Precisely 20.6% of the plants exhibited their anti-diabetic effect via prevention of oxidative stress; 11.6% acted through stimulation of insulin secretion, inhibition of insulin degradation, and reduction of insulin resistance. Also, 10.8% inhibited enzymes of carbohydrate gastrointestinal digestion, 2.8% were postulated to regulate enzymes of glucose metabolism, and 54.2% acted via nonspecific or multiple means, as well as those whose anti-diabetic mode of action was yet to be identified. This study has shown that the exact mechanisms or mode of action of the majority of plants with hypoglycaemic properties are yet to be explored. Scientists would therefore find this paper useful in their future research. This paper may also serve as a potential lead for the easy harmonization of plants with a related mode of action in the drug discovery process targeted at the management of diabetes mellitus.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"93 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The current status on secondary metabolites produced by fungi of the genus Diplodia associated with plants 与植物有关的 Diplodia 属真菌产生的次级代谢物的现状
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-21 DOI: 10.1007/s11101-024-09979-z
Maria Michela Salvatore, Marco Masi, Anna Andolfi
{"title":"The current status on secondary metabolites produced by fungi of the genus Diplodia associated with plants","authors":"Maria Michela Salvatore, Marco Masi, Anna Andolfi","doi":"10.1007/s11101-024-09979-z","DOIUrl":"https://doi.org/10.1007/s11101-024-09979-z","url":null,"abstract":"<p>Fungi of the genus <i>Diplodia</i> have a worldwide distribution and are typically associated with plants. <i>Diplodia</i> is well‐known for the diseases it causes on economically and ecologically relevant plants. In particular, this fungal genus is responsible of various symptoms of plant diseases, including shoot blights, dieback, cankers and fruit rots. In the last decades, literature concerning metabolites produced by <i>Diplodia</i> species has been significantly enriched by many reports dealing with the biosynthetic potential of this fungal genus. Several polyketide- and terpenoid-derived compounds have been reported, demonstrating the biosynthetic arsenal of this fungal genus. Investigations on the biological properties of compounds isolated from in vitro cultures of these fungi have proved a broad spectrum of biological functions. In particular, bioassays disclosed that antimicrobial and phytotoxic activities are the most notable bioactivities of secondary metabolites isolated from this genus. Hence, the present review is intended as reference guide to metabolites produced by fungi currently belong to the genus <i>Diplodia</i>, emphasizing the implication of their occurrence, absolute configuration determinations and the structure–activity relationships.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"32 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What goes underground comes around: the molecular basis of crosstalk between plants and soil microorganisms 地下有知:植物与土壤微生物之间相互联系的分子基础
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-21 DOI: 10.1007/s11101-024-09989-x
Manuela Tadrosova, Ondrej Uhlik, Jachym Suman
{"title":"What goes underground comes around: the molecular basis of crosstalk between plants and soil microorganisms","authors":"Manuela Tadrosova, Ondrej Uhlik, Jachym Suman","doi":"10.1007/s11101-024-09989-x","DOIUrl":"https://doi.org/10.1007/s11101-024-09989-x","url":null,"abstract":"<p>The co-existence of plants and microorganisms throughout their evolution resulted in an intertwined ecological network that serves as the basis for the functioning of today’s terrestrial ecosystems. The interactions between plants, bacteria, and fungi are often multipartite and occur both within and among kingdoms. Apart from the textbook examples of tight mutualistic associations such as root nodule symbiosis or mycorrhizas, there are also looser interactions, e.g., those between plants and plant growth-promoting bacteria and fungi. Additionally, plants are also targets of microbial pathogens. Thus, intricate mechanisms of how plants and microorganisms recognize each other have evolved, mediated by chemical signals resulting in a differential gene expression and, eventually, a physiological response. This paper aims to review the molecular basis of such signaling, the apparatus of signal sensing and transduction in bacteria and plants are outlined and exemplified. Moreover, examples of recent discoveries in the field of plant–microbe signaling are presented, i.e., quorum quenching and the involvement of small RNAs. Last but not least, suggestions are provided for the potential exploitation of plant–microbe communication networks for human benefit, e.g., in the field of sustainable agriculture, aiming at crop growth promotion and protection against pathogens.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"162 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties 荨麻科植物化学和抗炎特性综述
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-20 DOI: 10.1007/s11101-024-09980-6
Rui Parente, Ana Cláudia Paiva-Santos, Célia Cabral, Gustavo Costa
{"title":"Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties","authors":"Rui Parente, Ana Cláudia Paiva-Santos, Célia Cabral, Gustavo Costa","doi":"10.1007/s11101-024-09980-6","DOIUrl":"https://doi.org/10.1007/s11101-024-09980-6","url":null,"abstract":"<p>Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. <i>Urtica dioica</i> L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of <i>Urtica</i> species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"17 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Lamiaceae-derived bioactive compounds as nature’s arsenal for sustainable pest management 探索源自灯盏花属植物的生物活性化合物,将其作为可持续害虫管理的大自然武器库
IF 7.7 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-17 DOI: 10.1007/s11101-024-09987-z
Muhammad Ali, Abrar Muhammad, Zemian Lin, Hai He, Yu Zhang
{"title":"Exploring Lamiaceae-derived bioactive compounds as nature’s arsenal for sustainable pest management","authors":"Muhammad Ali, Abrar Muhammad, Zemian Lin, Hai He, Yu Zhang","doi":"10.1007/s11101-024-09987-z","DOIUrl":"https://doi.org/10.1007/s11101-024-09987-z","url":null,"abstract":"<p>Intensive agriculture has long been associated with the excessive use of synthetic pesticides, leading to environmental pollution, health risks, and the development of pesticide-resistant insect populations. In response, significant scientific efforts are underway to seek safer alternatives for eco-friendly pest management, such as utilizing natural compounds, including essential oils derived from plants in the Lamiaceae family. This review explores the existing literature on Lamiaceae-derived bioactive compounds and their efficacy as alternative biopesticides. It delves into their chemical composition, mechanism of action, and practical application in pest management strategies. The multifaceted impact of these oils on insect pests is profound, with components like monoterpene, monoterpenoid, sesquiterpenoid, and aliphatic phenylpropanoids exhibiting diverse modes of action. These mechanisms may involve rupturing cell membranes, neurotoxic effects, antifeedant effects, repellent properties, and growth regulatory effects that make them effective natural alternatives to synthetic pesticides. However, their development as alternative biopesticides is often hindered by challenges such as standardization and formulation, regulatory approval, resistance development in insects, cost-effectiveness, as well as knowledge and awareness gaps. This synthesis of knowledge contributes to the evolving landscape of sustainable pest management practices, reducing the ecological footprint of intensive agriculture, and mitigating risks associated with conventional insecticides.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"27 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eleutherococcus giraldii (Harms) Nakai: a review of botany, traditional uses, phytochemistry, pharmacology and quality control Eleutherococcus giraldii (Harms) Nakai:植物学、传统用途、植物化学、药理学和质量控制综述
IF 7.3 2区 生物学
Phytochemistry Reviews Pub Date : 2024-06-07 DOI: 10.1007/s11101-024-09982-4
Ling Li, Jie Zhang, Li-wen Zhong, Rui Gu, Shi-hong Zhong
{"title":"Eleutherococcus giraldii (Harms) Nakai: a review of botany, traditional uses, phytochemistry, pharmacology and quality control","authors":"Ling Li,&nbsp;Jie Zhang,&nbsp;Li-wen Zhong,&nbsp;Rui Gu,&nbsp;Shi-hong Zhong","doi":"10.1007/s11101-024-09982-4","DOIUrl":"10.1007/s11101-024-09982-4","url":null,"abstract":"<div><p><i>Eleutherococcus giraldii</i> (Harms) Nakai (EG, thereafter) is a perennial shrub, widely recognized for its medicinal properties. The stem bark of this plant is a widely used traditional Chinese herb with the effects of dispelling dampness, strengthening sinews and invigorating bones. Native to the upper reaches of the Minjiang River, EG is a prevalent Qiang medicine. It was included in the 2010 Edition of the Standard of Traditional Chinese Medicines of Sichuan Province. In the 1990s, numerous phytochemistry was carried out. Several chemical constituents have been identified, including saponins, lignans, alkali nucleosides, polysaccharides, alkanes, organic acids, and other compounds. Notably, glycosides and their glycosides with ivy saponins as ligands stand out among these constituents. Modern pharmacological studies have shown that the stem bark of <i>Eleutherococcus giraldii</i> (Harms) Nakai (EGSB, thereafter) has anti-inflammatory, immunomodulatory, anti-tumour, anti-oxidant, anti-ischemic and hepatoprotective effects. In addition to its stem bark being used in medicine, the young leaves of EG are the traditional food of the Qiang people, which has been developed into a tea product and pushed to the market. The prospect of industrialisation is good. This comprehensive review aims to explore the taxonomic status, botanical characteristics, traditional applications, phytochemistry, pharmacology, and quality control of EG. The primary focus is placed on phytochemical and pharmacological investigations.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"1027 - 1055"},"PeriodicalIF":7.3,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The different parts of Dendrobium officinale Kimura et Migo: traditional uses, phytochemistry, pharmacological activities, and product development status and potential Dendrobium officinale Kimura et Migo 的不同部分:传统用途、植物化学、药理活性以及产品开发现状和潜力
IF 7.3 2区 生物学
Phytochemistry Reviews Pub Date : 2024-05-31 DOI: 10.1007/s11101-024-09973-5
Yuan Li, Qin-Xiang Chang, Peng-Guo Xia, Zong-Suo Liang
{"title":"The different parts of Dendrobium officinale Kimura et Migo: traditional uses, phytochemistry, pharmacological activities, and product development status and potential","authors":"Yuan Li,&nbsp;Qin-Xiang Chang,&nbsp;Peng-Guo Xia,&nbsp;Zong-Suo Liang","doi":"10.1007/s11101-024-09973-5","DOIUrl":"10.1007/s11101-024-09973-5","url":null,"abstract":"<div><p><i>Dendrobium officinale</i> Kimura et Migo (<i>D. officinale</i>), a valuable medicinal and edible homologous plant, is a synonym of <i>Dendrobium catenatum</i> Lindl. <i>D. officinale</i> has been used for thousands of years in daily health care and treatment of diabetes, gastrointestinal diseases, and various cancers. During the cultivation and harvesting of <i>D. officinale</i>, its non-medicinal parts (leaves and flowers) are often discarded as waste, resulting in a huge waste of resources. Approximately 244 chemical constituents have been isolated from the stems, leaves, and flowers of <i>D. officinale</i>, mainly polysaccharides, bibenzyls, phenanthrenes, flavonoids, phenolic acids, and other constituents. Among these substances, polysaccharides are the most abundant and main bioactive components. The stems, leaves, and flowers of <i>D. officinale</i> can all be used for food, medicine, cosmetic, or health care purposes. Among these, the flowers play many roles, such as antioxidant, neuroprotection, anti-depression, and learning and memory improvement functions, and can be used as a natural nutritional supplement to prevent neurologic disorders like depression and Alzheimer’s disease. Simultaneously, the leaves of <i>D. officinale</i> exhibit beneficial effects on metabolic and cardiovascular diseases and can used as a functional food for the prevention and treatment of hyperglycemia, hypertension, and hyperuricemia. To the best of our knowledge, this paper is the first systematic and comparative review of the traditional uses, bioactive compounds, pharmacological effects, and applications of different parts of <i>D. officinale</i>. We hope this review will provide a scientific reference for the development and utilization of this plant.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"985 - 1026"},"PeriodicalIF":7.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141191046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of secondary metabolites in plant defense mechanisms: a molecular and biotechnological insights 次生代谢物在植物防御机制中的作用:分子和生物技术的启示
IF 7.3 2区 生物学
Phytochemistry Reviews Pub Date : 2024-05-24 DOI: 10.1007/s11101-024-09976-2
R. Upadhyay, R. Saini, P. K. Shukla, K. N. Tiwari
{"title":"Role of secondary metabolites in plant defense mechanisms: a molecular and biotechnological insights","authors":"R. Upadhyay,&nbsp;R. Saini,&nbsp;P. K. Shukla,&nbsp;K. N. Tiwari","doi":"10.1007/s11101-024-09976-2","DOIUrl":"10.1007/s11101-024-09976-2","url":null,"abstract":"<div><p>The plants produce secondary metabolites (SMs) as defence compounds against both abiotic and biotic stresses. These stresses instigate the secretion and release of SMs by up or down-regulating the concerned genes involved in their synthesis. The secretion of SMs varies with the plant's genetic constitution and accordingly-they are susceptible or resistant. These metabolites mostly act as deterrents or antifeedants, allelochemicals, toxins or precursors of other metabolites that defend plants from stresses. However, some pathogens use these metabolites as a signal for host recognition or nutrition rather than using them as toxins or deterrents. The SMs activate different signalling pathways e.g. terpenoids modulate the calcineurin pathway, sesquiterpenoids modulate the jasmonic acid and salicylic acid pathway, polyphenols activate the jasmonic acid and phenylpropanoid pathway, and alkaloids activate the salicylic acid pathway to protect against pathogens and herbivores. Polyphenolic compounds provide resistance to different microbes by expressing different pathogenesis-proteins and hypersensitive reaction-mediated cell death and eliminate pathogens by altering the membrane permeability (inhibiting efflux pump), cell wall integrity, suppressing enzyme activity, free radicals’ generation, inhibiting protein biosynthesis, damaging DNA and reducing the expression of virulent genes. Flavonoids help plants sustain pathogen stresses through the changes in the auxin transport process. The pathogen exposure upregulate genes of alkaloid synthesis pathways such as tyrosine decarboxylase (TyDC), S-norcoclurine synthase (NCS), codeinone reductase 2-like (COR-2), and StWRKY8 transcription factors which in turn accumulate alkaloids in large amounts. Plant exposure to pathogens leads to hypersensitivity reactions and phytoalexin accumulation. The plant's treatment of salicylic acid and jasmonic acid upregulated downstream transcription factors, increased the expression of defence proteins, triggered the synthesis of SMs, and provided resistance against multiple pathogens. Pathogens and herbivores have also coevolved to cope with defence metabolites by detoxifying the toxic metabolites, converting toxins into useful products, evolving their food choice, fast digestive system, expulsion of toxins, and down-regulation of the gene-producing secondary metabolites. This review article gives a molecular insight into the genes and regulatory proteins controlling the synthesis of SMs, which may help decipher the role of the biosynthetic pathway intermediates and thereby scoring genes providing resistance to various stresses. The article comprehensively describes the roles of different SMs in plant defence and their molecular mechanisms of action.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"953 - 983"},"PeriodicalIF":7.3,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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