Phytochemistry Reviews最新文献

{"title":"A comprehensive review on essential oils and extracts from Iris rhizomes","authors":"Carlo Bicchi, Daniel Joulain","doi":"10.1007/s11101-024-09981-5","DOIUrl":"https://doi.org/10.1007/s11101-024-09981-5","url":null,"abstract":"<p><i>Iris</i> spp. rhizomes (commonly known as orris rhizomes) are a precious raw material used in perfumery, as sources of high-value violet odorant substances, mainly consisting of irones. The review comprehensively and critically presents the techniques for the optimized production of irones from orris rhizomes and their formation from their triterpene precursors (the iridals). It also thoroughly discusses the qualitative and quantitative techniques to analyze both iridals and irones, the chemical structures and stereochemistry of irones and their olfactory properties. It also describes a detailed composition of the orris extracts intended for applications in fragrance and flavor fields. This unprecedented survey also includes patent applications, granted or not.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral potential of essential oils and their plant sources, delivery methods, and drug development strategies with special focus on their mechanisms: a comprehensive review","authors":"Anjie Feng, Tiantian Si, Baoxiang Du, Qihui Sun, Yong Yang, Rong Rong","doi":"10.1007/s11101-024-09983-3","DOIUrl":"https://doi.org/10.1007/s11101-024-09983-3","url":null,"abstract":"<p>The rise in viral infections has presented a multitude of public health concerns on a global scale, including the emergence of influenza and SARS-CoV-2. The emergence of drug-resistant virus strains has underscored the paramount importance of expedited research in the development of novel antiviral therapeutics. It has led to a surge in interest in the potential application of essential oils (EOs) as antiviral agents, owing to their noteworthy antiviral efficacy. A considerable number of EOs and their components have demonstrated promising antiviral activities in vitro and in vivo research. This review provided an overview of the various aspects of EOs inhibiting viruses, including plant sources, the different delivery methods, current challenges and strategies for developing drugs, and in-depth discussions on the relevant mechanisms. It concisely explores the antiviral mechanisms of EOs, ranging from molecular docking simulations to in-depth cellular, animal, and human studies. EOs demonstrate antiviral potential by inhibiting viral proteins, disrupting replication, and modulating host cellular functions, immune responses, and nervous system interactions. This review serves as a valuable resource for researchers and pharmaceutical entities, offering insights and references that advance the antiviral research and innovative drug development utilizing plant-derived essential oils.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity","authors":"Nguyen Thi Thuy Linh, Nguyen Van Tuyen, Ty Viet Pham, Suresh Awale, Ninh The Son","doi":"10.1007/s11101-024-09990-4","DOIUrl":"https://doi.org/10.1007/s11101-024-09990-4","url":null,"abstract":"<p>Background: <i>Pittosporum</i> (the family Pittosporaceae) contains flowering plants, which was used as folk medicines in some countries of Asia, Europe, and Africa. Traditional use and pharmacological values of plants in this genus were deduced from a great role of their secondary metabolites. Objective: The ultimate goal of the review fully provides significant information on traditional use, phytochemistry, and pharmacology of <i>Pittosporum</i> plants. Methods: The search for reference data is mostly based on electronic resources, such as Google Scholar, Sci-Finder, and Web of Science. “<i>Pittosporum</i>” is the most important keyword, in which it was used alone or combined with other words to seek literature documents. Results: Traditionally, <i>Pittosporum</i> species are on the recommended list for medicinal purposes and fragrance preparation. From the 1960s to the present, more than 270 metabolites have been isolated with the derivatives type terpenoids, saponins, and lignans being the main phytochemical classes. Essential oils derived from <i>Pittosporum</i> species were dominated by terpenoids and fatty acids. Accumulating evidence has firmly revealed that <i>Pittosporum</i> constituents generated a wide variety of pharmacological activities, including cytotoxic, anti-inflammatory, antioxidative, antimicrobial, antiparasitic, antiarrhythmic, antinociceptive, antimalarial, enzyme inhibitory, and hepatoprotective activities. <i>Conclusion</i>: Technological advances in the chromatographic isolation of huge amounts are desirable. Toxicological assessments are needed. In vivo pharmacological experiments, molecular mechanisms of action, and clinical evaluations are warranted.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry","authors":"Marcela Šafratová, Rudolf Vrabec, Gerald Blunden, Lucie Cahlíková, Jana Křoustková","doi":"10.1007/s11101-024-09931-1","DOIUrl":"https://doi.org/10.1007/s11101-024-09931-1","url":null,"abstract":"<p>This article is a critical review of the taxonomy and phytochemistry of the genus <i>Zephyranthes</i> Herb., a group of plants known for their beautiful flowers and traditional medicinal uses. The present review summarizes the occurrence, isolation, and identification of specialized metabolites, which have recently been frequently studied because of their important biological activities. Among the accepted 203 species, only 27 have been phytochemically investigated. This paper provides an overview of the different types of specialized metabolites identified in these plants and considers problematic taxonomic evolution within this species. The differences between two internationally recognized databases, which classify only 41% of the species in the same way, are briefly summarized. In addition, there are many reports on their metabolites, especially alkaloids, but some of the data in the literature are occasionally inaccurate and sometimes even erroneous. This critical review aims to discuss, summarize, and evaluate up-to-date (up to July of 2023) information about metabolites of the genus <i>Zephyranthes,</i> focusing on phytochemistry and taxonomy.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action","authors":"Stanley I. R. Okoduwa, Daniel H. Mhya, Ibrahim Abdulwaliyu, Bernard E. Igiri, Ugochi J. Okoduwa, David E. Arthur, Aderinsola O. Laleye, Gerrard J. Osang, Oluwatimilehin L. Onaleye, Emmanuella Nathyns-Pepple","doi":"10.1007/s11101-024-09984-2","DOIUrl":"https://doi.org/10.1007/s11101-024-09984-2","url":null,"abstract":"<p>Diabetes mellitus is a metabolic disorder that can lead to various complications affecting the heart, kidney, and eye. Several synthetic and natural products have been used for disease management, but the disease still remains a global challenge. The use of plants as an alternative management for diabetes has been on the rise. Regrettably, the comprehensive repository is not available to guide future research in the area of plants with a related mechanism of action for the development of an effective drug. To identify and compile medicinal plants frequently used with proven scientific hypoglycaemic properties and their possible modes of action. This was done through a literature search of scientific databases using search tools like DOAJ, EMBASE, Europe PMC, FSTA, Google Scholar, HubMed, Indian Citation Index, Medline Plus, Merck Index, PubMed, ScienceDirect, Science3open, Science Open, SciFinder, Scirus, Core, Scopus, Semantic Scholar, Shodhganga, and World Wide Science. Search keywords included: medicinal plants, antidiabetics, hypoglycaemic, alpha-amylases/glucosidase inhibition, glucose metabolic enzymes, antihyperglycaemia, insulin secretion/surrogate, β-cell amelioration, phytochemicals, diabetes management, anti-oxidant, and enhance glucose transporters. The study excludes plants used in the management of diseases other than diabetes mellitus. From the search, 611 authenticated medicinal plants with anti-diabetic properties were eligible and grouped according to their reported probable mode of action. Precisely 20.6% of the plants exhibited their anti-diabetic effect via prevention of oxidative stress; 11.6% acted through stimulation of insulin secretion, inhibition of insulin degradation, and reduction of insulin resistance. Also, 10.8% inhibited enzymes of carbohydrate gastrointestinal digestion, 2.8% were postulated to regulate enzymes of glucose metabolism, and 54.2% acted via nonspecific or multiple means, as well as those whose anti-diabetic mode of action was yet to be identified. This study has shown that the exact mechanisms or mode of action of the majority of plants with hypoglycaemic properties are yet to be explored. Scientists would therefore find this paper useful in their future research. This paper may also serve as a potential lead for the easy harmonization of plants with a related mode of action in the drug discovery process targeted at the management of diabetes mellitus.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current status on secondary metabolites produced by fungi of the genus Diplodia associated with plants","authors":"Maria Michela Salvatore, Marco Masi, Anna Andolfi","doi":"10.1007/s11101-024-09979-z","DOIUrl":"https://doi.org/10.1007/s11101-024-09979-z","url":null,"abstract":"<p>Fungi of the genus <i>Diplodia</i> have a worldwide distribution and are typically associated with plants. <i>Diplodia</i> is well‐known for the diseases it causes on economically and ecologically relevant plants. In particular, this fungal genus is responsible of various symptoms of plant diseases, including shoot blights, dieback, cankers and fruit rots. In the last decades, literature concerning metabolites produced by <i>Diplodia</i> species has been significantly enriched by many reports dealing with the biosynthetic potential of this fungal genus. Several polyketide- and terpenoid-derived compounds have been reported, demonstrating the biosynthetic arsenal of this fungal genus. Investigations on the biological properties of compounds isolated from in vitro cultures of these fungi have proved a broad spectrum of biological functions. In particular, bioassays disclosed that antimicrobial and phytotoxic activities are the most notable bioactivities of secondary metabolites isolated from this genus. Hence, the present review is intended as reference guide to metabolites produced by fungi currently belong to the genus <i>Diplodia</i>, emphasizing the implication of their occurrence, absolute configuration determinations and the structure–activity relationships.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What goes underground comes around: the molecular basis of crosstalk between plants and soil microorganisms","authors":"Manuela Tadrosova, Ondrej Uhlik, Jachym Suman","doi":"10.1007/s11101-024-09989-x","DOIUrl":"https://doi.org/10.1007/s11101-024-09989-x","url":null,"abstract":"<p>The co-existence of plants and microorganisms throughout their evolution resulted in an intertwined ecological network that serves as the basis for the functioning of today’s terrestrial ecosystems. The interactions between plants, bacteria, and fungi are often multipartite and occur both within and among kingdoms. Apart from the textbook examples of tight mutualistic associations such as root nodule symbiosis or mycorrhizas, there are also looser interactions, e.g., those between plants and plant growth-promoting bacteria and fungi. Additionally, plants are also targets of microbial pathogens. Thus, intricate mechanisms of how plants and microorganisms recognize each other have evolved, mediated by chemical signals resulting in a differential gene expression and, eventually, a physiological response. This paper aims to review the molecular basis of such signaling, the apparatus of signal sensing and transduction in bacteria and plants are outlined and exemplified. Moreover, examples of recent discoveries in the field of plant–microbe signaling are presented, i.e., quorum quenching and the involvement of small RNAs. Last but not least, suggestions are provided for the potential exploitation of plant–microbe communication networks for human benefit, e.g., in the field of sustainable agriculture, aiming at crop growth promotion and protection against pathogens.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties","authors":"Rui Parente, Ana Cláudia Paiva-Santos, Célia Cabral, Gustavo Costa","doi":"10.1007/s11101-024-09980-6","DOIUrl":"https://doi.org/10.1007/s11101-024-09980-6","url":null,"abstract":"<p>Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. <i>Urtica dioica</i> L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of <i>Urtica</i> species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Lamiaceae-derived bioactive compounds as nature’s arsenal for sustainable pest management","authors":"Muhammad Ali, Abrar Muhammad, Zemian Lin, Hai He, Yu Zhang","doi":"10.1007/s11101-024-09987-z","DOIUrl":"https://doi.org/10.1007/s11101-024-09987-z","url":null,"abstract":"<p>Intensive agriculture has long been associated with the excessive use of synthetic pesticides, leading to environmental pollution, health risks, and the development of pesticide-resistant insect populations. In response, significant scientific efforts are underway to seek safer alternatives for eco-friendly pest management, such as utilizing natural compounds, including essential oils derived from plants in the Lamiaceae family. This review explores the existing literature on Lamiaceae-derived bioactive compounds and their efficacy as alternative biopesticides. It delves into their chemical composition, mechanism of action, and practical application in pest management strategies. The multifaceted impact of these oils on insect pests is profound, with components like monoterpene, monoterpenoid, sesquiterpenoid, and aliphatic phenylpropanoids exhibiting diverse modes of action. These mechanisms may involve rupturing cell membranes, neurotoxic effects, antifeedant effects, repellent properties, and growth regulatory effects that make them effective natural alternatives to synthetic pesticides. However, their development as alternative biopesticides is often hindered by challenges such as standardization and formulation, regulatory approval, resistance development in insects, cost-effectiveness, as well as knowledge and awareness gaps. This synthesis of knowledge contributes to the evolving landscape of sustainable pest management practices, reducing the ecological footprint of intensive agriculture, and mitigating risks associated with conventional insecticides.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical diversity and pharmacological effects of sesquiterpenes from Artemisia spp.","authors":"Amin Rezaei Do, Seyed Ahmad Emami, M. Akaberi","doi":"10.1007/s11101-024-09962-8","DOIUrl":"https://doi.org/10.1007/s11101-024-09962-8","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}