Phytochemistry Reviews最新文献

{"title":"An updated and comprehensive review of traditional uses, phytochemistry, and pharmacological progress on the Hypecoum genus","authors":"Hai-Lian Yuan,&nbsp;Li Zhang,&nbsp;Wen-Hao Huang,&nbsp;Chang-Gang Sun,&nbsp;Xiao-Dong Luo","doi":"10.1007/s11101-024-09985-1","DOIUrl":"10.1007/s11101-024-09985-1","url":null,"abstract":"<div><p>The <i>Hypecoum</i> genus belongs to the family Papaveraceae, consists of roughly 16 accepted species, and is extensively distributed from the Mediterranean to Central Asia and Northern China. It was used widely for the treatment of sore throat, tracheitis, cough, hepatitis, bronchitis, bacterial dysentery, and conjunctive congestion with swelling and pain disease in traditional Chinese and other countries’ medicine, especially in Tibetan or Mongolian medicine. Based on “<i>Hypecoum</i>”, a total of 163 relevant papers published since 1924 were meticulously selected through comprehensive searches of the American Chemical Society (ACS), PubMed, Web of Science, and Science Direct databases. Modern pharmacological researches have evaluated its various biological activities, such as analgesic, anti-inflammatory, antibacterial, hepatoprotective, and antiproliferative activities, even the assessment of its potential for mitigating the impact of corona virus disease 2019 (COVID-19). Approximately 100 alkaloids have been obtained and identified from the <i>Hypecoum</i> species, as well as flavonoid, volatile oil, phenolic, and aromatic compounds. Additionally, the <i>Hypecoum</i> species is widely used in traditional Chinese medicine (TCM) formulae, partial efficacies of which have been verified via numerous pharmacological and clinical investigations, particularly in the treatment of inflammatory and pain diseases. This reviews performed an exhaustive literature review to bridge the knowledge gap that there has yet to be a comprehensive and systematic review addressing the botany, traditional uses, phytochemicals, pharmacological effects, and underlying mechanisms associated with <i>Hypecoum</i> genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of <i>Hypecoum</i> spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1843 - 1921"},"PeriodicalIF":7.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141570582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable extraction methods for the recovery of polyphenolic compounds from grape pomace and its biological properties: a comprehensive review","authors":"Luiz Eduardo Nochi Castro,&nbsp;William Gustavo Sganzerla,&nbsp;Aline Priscilla Gomes Silva,&nbsp;Oliver Dean John,&nbsp;Tiago Linhares Cruz Tabosa Barroso,&nbsp;Mauricio A. Rostagno,&nbsp;Tânia Forster-Carneiro","doi":"10.1007/s11101-024-09991-3","DOIUrl":"10.1007/s11101-024-09991-3","url":null,"abstract":"<div><p>Grape pomace (seeds, skin, and stalks) holds promise as a feedstock for various industrial applications. This comprehensive review describes advancements in sustainable and novel extraction processes for recovering polyphenolic compounds and their biological properties. In contrast to traditional methods, sustainable extraction techniques such as microwave-assisted, ultrasound-assisted, pressurized liquid, enzyme-assisted, and hydrothermal processes have been applied to produce high-quality and safe extracts. These methods utilize non-toxic solvents, maintain moderate temperatures, achieve fast extraction times, and require low energy input. The polyphenolic compounds, particularly flavan-3-ols, anthocyanins, and proanthocyanidins extracted from grape pomace, exhibit a wide range of biological properties, including anti-inflammatory, anti-obesity, antioxidant, antidiabetic, hepatoprotective, anticancer, antimicrobial, and heart health-promoting effects. They also contribute to enhancing the gut microbiota population, promoting health. In conclusion, emerging extraction methods offer a sustainable approach to producing bioactive compounds from grape pomace for use in the cosmetic, pharmaceutical, and food industries.\u0000</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"2059 - 2086"},"PeriodicalIF":7.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symphytum genus—from traditional medicine to modern uses: an update on phytochemistry, pharmacological activity, and safety","authors":"Adriana Trifan, Evelyn Wolfram, Krystyna Skalicka-Woźniak, Simon Vlad Luca","doi":"10.1007/s11101-024-09977-1","DOIUrl":"https://doi.org/10.1007/s11101-024-09977-1","url":null,"abstract":"<p>With around 34 recognized species, <i>Symphytum</i> genus (comfrey) has a noteworthy position within the Boraginaceae family. Comfrey species have been empirically used since ancient times as wound-healing and skin-regenerating agents in ulcers, wounds, bone fractures, and rheumatic complaints. This review aims to provide a thorough examination of recent scientific advances and challenges within the <i>Symphytum</i> genus, covering data published between 2013 and 2023. It delivers an updated overview of the taxonomy, ethnopharmacological uses, chemical composition, and pharmacological activities of the genus. Special emphasis is put on molecular identification methods for species taxonomy, emerging extraction technologies for comfrey phytochemicals, metabolomics techniques for mapping chemical complexity, modern bioassay platforms revealing its poly-pharmacology, formulation strategies, and remediation approaches for removal of toxic pyrrolizidine alkaloids (PAs). For instance, recent metabolomic studies employing advanced spectro-chromatographic techniques have revealed a diverse chemical composition of comfrey plants, including polysaccharides, allantoin, benzoic and cinnamic acid derivatives, flavonoids, fatty acids, and unsaturated necine-structure-based PAs. The mechanisms underlying their anti-inflammatory, analgesic, wound-healing, anti-irritant, and osteo-regenerative properties were targeted in modern pharmacological setups. Thus, key compounds like allantoin, rosmarinic acid, globoidnans A and B, rabdosiin, and comfreyn A, have been identified as significant contributors to the anti-inflammatory and wound-healing effects of <i>Symphytum</i>-derived preparations. Despite their well-established clinical use, concerns about PAs-induced toxicity have prompted the development of novel PA remediation strategies, enabling the production of comfrey extracts with enhanced safety profiles that can meet the regulatory standards imposed by authorities.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on essential oils and extracts from Iris rhizomes","authors":"Carlo Bicchi,&nbsp;Daniel Joulain","doi":"10.1007/s11101-024-09981-5","DOIUrl":"10.1007/s11101-024-09981-5","url":null,"abstract":"<div><p><i>Iris</i> spp. rhizomes (commonly known as orris rhizomes) are a precious raw material used in perfumery, as sources of high-value violet odorant substances, mainly consisting of irones. The review comprehensively and critically presents the techniques for the optimized production of irones from orris rhizomes and their formation from their triterpene precursors (the iridals). It also thoroughly discusses the qualitative and quantitative techniques to analyze both iridals and irones, the chemical structures and stereochemistry of irones and their olfactory properties. It also describes a detailed composition of the orris extracts intended for applications in fragrance and flavor fields. This unprecedented survey also includes patent applications, granted or not.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1629 - 1665"},"PeriodicalIF":7.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral potential of essential oils and their plant sources, delivery methods, and drug development strategies with special focus on their mechanisms: a comprehensive review","authors":"Anjie Feng,&nbsp;Tiantian Si,&nbsp;Baoxiang Du,&nbsp;Qihui Sun,&nbsp;Yong Yang,&nbsp;Rong Rong","doi":"10.1007/s11101-024-09983-3","DOIUrl":"10.1007/s11101-024-09983-3","url":null,"abstract":"<div><p>The rise in viral infections has presented a multitude of public health concerns on a global scale, including the emergence of influenza and SARS-CoV-2. The emergence of drug-resistant virus strains has underscored the paramount importance of expedited research in the development of novel antiviral therapeutics. It has led to a surge in interest in the potential application of essential oils (EOs) as antiviral agents, owing to their noteworthy antiviral efficacy. A considerable number of EOs and their components have demonstrated promising antiviral activities in vitro and in vivo research. This review provided an overview of the various aspects of EOs inhibiting viruses, including plant sources, the different delivery methods, current challenges and strategies for developing drugs, and in-depth discussions on the relevant mechanisms. It concisely explores the antiviral mechanisms of EOs, ranging from molecular docking simulations to in-depth cellular, animal, and human studies. EOs demonstrate antiviral potential by inhibiting viral proteins, disrupting replication, and modulating host cellular functions, immune responses, and nervous system interactions. This review serves as a valuable resource for researchers and pharmaceutical entities, offering insights and references that advance the antiviral research and innovative drug development utilizing plant-derived essential oils.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1667 - 1689"},"PeriodicalIF":7.3,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity","authors":"Nguyen Thi Thuy Linh,&nbsp;Nguyen Van Tuyen,&nbsp;Ty Viet Pham,&nbsp;Suresh Awale,&nbsp;Ninh The Son","doi":"10.1007/s11101-024-09990-4","DOIUrl":"10.1007/s11101-024-09990-4","url":null,"abstract":"<div><p>Background: <i>Pittosporum</i> (the family Pittosporaceae) contains flowering plants, which was used as folk medicines in some countries of Asia, Europe, and Africa. Traditional use and pharmacological values of plants in this genus were deduced from a great role of their secondary metabolites. Objective: The ultimate goal of the review fully provides significant information on traditional use, phytochemistry, and pharmacology of <i>Pittosporum</i> plants. Methods: The search for reference data is mostly based on electronic resources, such as Google Scholar, Sci-Finder, and Web of Science. “<i>Pittosporum</i>” is the most important keyword, in which it was used alone or combined with other words to seek literature documents. Results: Traditionally, <i>Pittosporum</i> species are on the recommended list for medicinal purposes and fragrance preparation. From the 1960s to the present, more than 270 metabolites have been isolated with the derivatives type terpenoids, saponins, and lignans being the main phytochemical classes. Essential oils derived from <i>Pittosporum</i> species were dominated by terpenoids and fatty acids. Accumulating evidence has firmly revealed that <i>Pittosporum</i> constituents generated a wide variety of pharmacological activities, including cytotoxic, anti-inflammatory, antioxidative, antimicrobial, antiparasitic, antiarrhythmic, antinociceptive, antimalarial, enzyme inhibitory, and hepatoprotective activities. <i>Conclusion</i>: Technological advances in the chromatographic isolation of huge amounts are desirable. Toxicological assessments are needed. In vivo pharmacological experiments, molecular mechanisms of action, and clinical evaluations are warranted.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"2015 - 2058"},"PeriodicalIF":7.3,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry","authors":"Marcela Šafratová, Rudolf Vrabec, Gerald Blunden, Lucie Cahlíková, Jana Křoustková","doi":"10.1007/s11101-024-09931-1","DOIUrl":"https://doi.org/10.1007/s11101-024-09931-1","url":null,"abstract":"<p>This article is a critical review of the taxonomy and phytochemistry of the genus <i>Zephyranthes</i> Herb., a group of plants known for their beautiful flowers and traditional medicinal uses. The present review summarizes the occurrence, isolation, and identification of specialized metabolites, which have recently been frequently studied because of their important biological activities. Among the accepted 203 species, only 27 have been phytochemically investigated. This paper provides an overview of the different types of specialized metabolites identified in these plants and considers problematic taxonomic evolution within this species. The differences between two internationally recognized databases, which classify only 41% of the species in the same way, are briefly summarized. In addition, there are many reports on their metabolites, especially alkaloids, but some of the data in the literature are occasionally inaccurate and sometimes even erroneous. This critical review aims to discuss, summarize, and evaluate up-to-date (up to July of 2023) information about metabolites of the genus <i>Zephyranthes,</i> focusing on phytochemistry and taxonomy.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"45 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action","authors":"Stanley I. R. Okoduwa,&nbsp;Daniel H. Mhya,&nbsp;Ibrahim Abdulwaliyu,&nbsp;Bernard E. Igiri,&nbsp;Ugochi J. Okoduwa,&nbsp;David E. Arthur,&nbsp;Aderinsola O. Laleye,&nbsp;Gerrard J. Osang,&nbsp;Oluwatimilehin L. Onaleye,&nbsp;Emmanuella Nathyns-Pepple","doi":"10.1007/s11101-024-09984-2","DOIUrl":"10.1007/s11101-024-09984-2","url":null,"abstract":"<div><p>Diabetes mellitus is a metabolic disorder that can lead to various complications affecting the heart, kidney, and eye. Several synthetic and natural products have been used for disease management, but the disease still remains a global challenge. The use of plants as an alternative management for diabetes has been on the rise. Regrettably, the comprehensive repository is not available to guide future research in the area of plants with a related mechanism of action for the development of an effective drug. To identify and compile medicinal plants frequently used with proven scientific hypoglycaemic properties and their possible modes of action. This was done through a literature search of scientific databases using search tools like DOAJ, EMBASE, Europe PMC, FSTA, Google Scholar, HubMed, Indian Citation Index, Medline Plus, Merck Index, PubMed, ScienceDirect, Science3open, Science Open, SciFinder, Scirus, Core, Scopus, Semantic Scholar, Shodhganga, and World Wide Science. Search keywords included: medicinal plants, antidiabetics, hypoglycaemic, alpha-amylases/glucosidase inhibition, glucose metabolic enzymes, antihyperglycaemia, insulin secretion/surrogate, β-cell amelioration, phytochemicals, diabetes management, anti-oxidant, and enhance glucose transporters. The study excludes plants used in the management of diseases other than diabetes mellitus. From the search, 611 authenticated medicinal plants with anti-diabetic properties were eligible and grouped according to their reported probable mode of action. Precisely 20.6% of the plants exhibited their anti-diabetic effect via prevention of oxidative stress; 11.6% acted through stimulation of insulin secretion, inhibition of insulin degradation, and reduction of insulin resistance. Also, 10.8% inhibited enzymes of carbohydrate gastrointestinal digestion, 2.8% were postulated to regulate enzymes of glucose metabolism, and 54.2% acted via nonspecific or multiple means, as well as those whose anti-diabetic mode of action was yet to be identified. This study has shown that the exact mechanisms or mode of action of the majority of plants with hypoglycaemic properties are yet to be explored. Scientists would therefore find this paper useful in their future research. This paper may also serve as a potential lead for the easy harmonization of plants with a related mode of action in the drug discovery process targeted at the management of diabetes mellitus.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1691 - 1751"},"PeriodicalIF":7.3,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current status on secondary metabolites produced by fungi of the genus Diplodia associated with plants","authors":"Maria Michela Salvatore,&nbsp;Marco Masi,&nbsp;Anna Andolfi","doi":"10.1007/s11101-024-09979-z","DOIUrl":"10.1007/s11101-024-09979-z","url":null,"abstract":"<div><p>Fungi of the genus <i>Diplodia</i> have a worldwide distribution and are typically associated with plants. <i>Diplodia</i> is well‐known for the diseases it causes on economically and ecologically relevant plants. In particular, this fungal genus is responsible of various symptoms of plant diseases, including shoot blights, dieback, cankers and fruit rots. In the last decades, literature concerning metabolites produced by <i>Diplodia</i> species has been significantly enriched by many reports dealing with the biosynthetic potential of this fungal genus. Several polyketide- and terpenoid-derived compounds have been reported, demonstrating the biosynthetic arsenal of this fungal genus. Investigations on the biological properties of compounds isolated from in vitro cultures of these fungi have proved a broad spectrum of biological functions. In particular, bioassays disclosed that antimicrobial and phytotoxic activities are the most notable bioactivities of secondary metabolites isolated from this genus. Hence, the present review is intended as reference guide to metabolites produced by fungi currently belong to the genus <i>Diplodia</i>, emphasizing the implication of their occurrence, absolute configuration determinations and the structure–activity relationships.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1565 - 1589"},"PeriodicalIF":7.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09979-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What goes underground comes around: the molecular basis of crosstalk between plants and soil microorganisms","authors":"Manuela Tadrosova,&nbsp;Ondrej Uhlik,&nbsp;Jachym Suman","doi":"10.1007/s11101-024-09989-x","DOIUrl":"10.1007/s11101-024-09989-x","url":null,"abstract":"<div><p>The co-existence of plants and microorganisms throughout their evolution resulted in an intertwined ecological network that serves as the basis for the functioning of today’s terrestrial ecosystems. The interactions between plants, bacteria, and fungi are often multipartite and occur both within and among kingdoms. Apart from the textbook examples of tight mutualistic associations such as root nodule symbiosis or mycorrhizas, there are also looser interactions, e.g., those between plants and plant growth-promoting bacteria and fungi. Additionally, plants are also targets of microbial pathogens. Thus, intricate mechanisms of how plants and microorganisms recognize each other have evolved, mediated by chemical signals resulting in a differential gene expression and, eventually, a physiological response. This paper aims to review the molecular basis of such signaling, the apparatus of signal sensing and transduction in bacteria and plants are outlined and exemplified. Moreover, examples of recent discoveries in the field of plant–microbe signaling are presented, i.e., quorum quenching and the involvement of small RNAs. Last but not least, suggestions are provided for the potential exploitation of plant–microbe communication networks for human benefit, e.g., in the field of sustainable agriculture, aiming at crop growth promotion and protection against pathogens.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1971 - 1987"},"PeriodicalIF":7.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09989-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}