植物化学、药理学、毒性和药用加工综述

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Jin Li, Shi-Jun Liu, Zai-Long Huang, Jia Yu
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引用次数: 0

摘要

Physochlainae Radix [中文名称为华山参],是 Physochlaina infundibularis Kuang.(在中国被用作传统药物。在传统中医药中,华参山(HSS)传统上用于治疗喘咳、心悸和失眠。通过互联网(ScienceDirect、CNKI、万方数据、谷歌学术和百度学术)和图书馆搜索,收集了与华蟾素相关的信息。自 1965 年至 2023 年 9 月,已从人参中分离鉴定出 99 种化合物。这项工作系统地梳理了恒河沙数中结构清晰的 99 个化合物。在此基础上,结合花生皂苷的化学成分,对其功能功效进行了阐述。本综述旨在研究这种植物的植物学、植物化学、药理作用、毒性、药用加工和质量控制。花椒的主要化学成分包括生物碱,尤其是托烷生物碱,次要化合物包括挥发油、脂肪酸和酚酸、酰胺及其他小分子化合物。这些活性物质赋予了人参抗哮喘活性、中枢神经系统活性、心血管活性、保肝活性、肾脏保护活性、增强免疫力、改善胃肠功能等药理活性,并在体内和体外实验中得到了多次验证。中药使用人参,包括温肺化痰、止咳平喘、宁心安神等,都是基于它的平喘活性、中枢神经系统活性、心血管活性、保肝活性、肾脏保护活性。此外,HSS 的毒性与托烷生物碱密切相关。考虑到临床应用中兼顾疗效和安全性的要求,人参皂苷的质量标准需要依靠现代分析技术和药理学方法进行更深入的研究。人参皂苷的医疗需求与资源保护之间存在矛盾,如何解决人参皂苷自然资源短缺的问题是一个重要课题。资源保护与药用成分开发的现代研究也是今后的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Physochlainae Radix, a review of its phytochemistry, pharmacology, toxicity and medica processing

Physochlainae Radix, a review of its phytochemistry, pharmacology, toxicity and medica processing

Physochlainae Radix [called Huashanshen (华山参)in Chinese], the root of Physochlaina infundibularis Kuang. (PI), is utilized as traditional medicine in China. In Traditional Chinese Medicine (TCM) use, Huashanshen (HSS) is traditionally used to treat wheezing and coughing, palpitation and insomnia. The information related to HSS was gathered by searching the internet (ScienceDirect, CNKI, WANFANG DATA, Google Scholar and Baidu Scholar) and libraries. From 1965 to September 2023, 99 compounds have been isolated and identified from HSS. This work systematically sorted out 99 compounds with clear structures in HSS. On this basis, combined with the chemical composition of HSS, its functional efficacy was expounded. The aim of this review was to examine this plant’s botany, phytochemistry, pharmacological effects, toxicity, medica processing and quality control. The main chemical constituents of HSS include alkaloids, especially tropane alkaloids and the secondary compounds include volatile oils, fatty acids and phenolic acids, amides and other small molecules. These active substances endowed HSS antiasthmatic activity, central nervous system activity, cardiovascular activity, hepatoprotective activity, renal protective activity, enhance immune system, improve gastrointestinal function and other pharmacological activities, which has been verified many times in vivo and in vitro experiments. The TCM use of HSS, including warming lung to eliminate sputum, relieving cough and asthma and tranquilizing mind, is based on its antiasthmatic activity, central nervous system activity, cardiovascular activity, hepatoprotective activity, renal protective activity. In addition, the toxicity of HSS is closely related to tropane alkaloids. Considering the requirement of balancing efficacy and safety in clinical applications, the quality standards of HSS need to rely on modern analytical techniques and pharmacological methods for more in-depth research. There is a conflict between the medical needs and resource protection of HSS, and how to solve the shortage of natural resources of HSS is an important issue. Modern research on resource protection and development of medicinal ingredients is also the direction of future research.

Graphical abstract

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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