Phytochemistry Reviews最新文献

{"title":"Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties","authors":"Rui Parente,&nbsp;Ana Cláudia Paiva-Santos,&nbsp;Célia Cabral,&nbsp;Gustavo Costa","doi":"10.1007/s11101-024-09980-6","DOIUrl":"10.1007/s11101-024-09980-6","url":null,"abstract":"<div><p>Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. <i>Urtica dioica</i> L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of <i>Urtica</i> species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1591 - 1628"},"PeriodicalIF":7.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09980-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Lamiaceae-derived bioactive compounds as nature’s arsenal for sustainable pest management","authors":"Muhammad Ali,&nbsp;Abrar Muhammad,&nbsp;Zemian Lin,&nbsp;Hai He,&nbsp;Yu Zhang","doi":"10.1007/s11101-024-09987-z","DOIUrl":"10.1007/s11101-024-09987-z","url":null,"abstract":"<div><p>Intensive agriculture has long been associated with the excessive use of synthetic pesticides, leading to environmental pollution, health risks, and the development of pesticide-resistant insect populations. In response, significant scientific efforts are underway to seek safer alternatives for eco-friendly pest management, such as utilizing natural compounds, including essential oils derived from plants in the Lamiaceae family. This review explores the existing literature on Lamiaceae-derived bioactive compounds and their efficacy as alternative biopesticides. It delves into their chemical composition, mechanism of action, and practical application in pest management strategies. The multifaceted impact of these oils on insect pests is profound, with components like monoterpene, monoterpenoid, sesquiterpenoid, and aliphatic phenylpropanoids exhibiting diverse modes of action. These mechanisms may involve rupturing cell membranes, neurotoxic effects, antifeedant effects, repellent properties, and growth regulatory effects that make them effective natural alternatives to synthetic pesticides. However, their development as alternative biopesticides is often hindered by challenges such as standardization and formulation, regulatory approval, resistance development in insects, cost-effectiveness, as well as knowledge and awareness gaps. This synthesis of knowledge contributes to the evolving landscape of sustainable pest management practices, reducing the ecological footprint of intensive agriculture, and mitigating risks associated with conventional insecticides.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1989 - 2013"},"PeriodicalIF":7.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical diversity and pharmacological effects of sesquiterpenes from Artemisia spp.","authors":"Amin Rezaei Do,&nbsp;Seyed Ahmad Emami,&nbsp;Maryam Akaberi","doi":"10.1007/s11101-024-09962-8","DOIUrl":"10.1007/s11101-024-09962-8","url":null,"abstract":"<div><p><i>Artemisia</i> L., belonging to the Asteraceae family, consists of 498 species worldwide. Studies show that sesquiterpenes, as the main bioactive compounds from the genus, have exhibited a wide range of pharmacological activities. In this updated review paper, we aimed to discuss the phytochemistry of the sesquiterpenes isolated from <i>Artemisia</i> species from 2015 to December 2023 and their pharmacological activities. We searched the scientific databases “Scopus”, “PubMed”, and “ISI Web of Science” with the keywords “<i>Artemisia</i>” AND “Sesquiterpene” OR “Sesquiterpenoid” OR “Eudesmanolide” OR “Guaianolide” OR “Germacranolide” OR “Eudesmane” OR “Guaiane” OR “Germacrane”, OR “Chemical”. A total of 914 sesquiterpenes with various skeletons mainly belonging to eudesmane, guaiane, germacrene, and cadinane subtypes were reported from 53 different <i>Artemisia</i> species. Additionally, the dimeric sesquiterpenes constituted one of the most reported classes of compounds. Based on the literature survey, sesquiterpenes from <i>Artemisia</i> can be potent anti-inflammatory and cytotoxic compounds, of which guaiane and dimeric sesquiterpenes showed the best anti-inflammatory and cytotoxic effects. However, antimicrobial, immunosuppressant, and neuroprotective effects, as well as antifeedant, and nematocidal activities, have been reported for the <i>Artemisia</i> sesquiterpenes. Overall, this review shows that the sesquiterpenes of <i>Artemisia</i> can be promising lead compounds for drug discovery programs, particularly as anti-inflammatory and cytotoxic agents. Besides, more phytochemical, pharmacological, and clinical studies are necessary to discover more compounds that are potent and to assess their safety and efficacy.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1365 - 1502"},"PeriodicalIF":7.3,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eleutherococcus giraldii (Harms) Nakai: a review of botany, traditional uses, phytochemistry, pharmacology and quality control","authors":"Ling Li,&nbsp;Jie Zhang,&nbsp;Li-wen Zhong,&nbsp;Rui Gu,&nbsp;Shi-hong Zhong","doi":"10.1007/s11101-024-09982-4","DOIUrl":"10.1007/s11101-024-09982-4","url":null,"abstract":"<div><p><i>Eleutherococcus giraldii</i> (Harms) Nakai (EG, thereafter) is a perennial shrub, widely recognized for its medicinal properties. The stem bark of this plant is a widely used traditional Chinese herb with the effects of dispelling dampness, strengthening sinews and invigorating bones. Native to the upper reaches of the Minjiang River, EG is a prevalent Qiang medicine. It was included in the 2010 Edition of the Standard of Traditional Chinese Medicines of Sichuan Province. In the 1990s, numerous phytochemistry was carried out. Several chemical constituents have been identified, including saponins, lignans, alkali nucleosides, polysaccharides, alkanes, organic acids, and other compounds. Notably, glycosides and their glycosides with ivy saponins as ligands stand out among these constituents. Modern pharmacological studies have shown that the stem bark of <i>Eleutherococcus giraldii</i> (Harms) Nakai (EGSB, thereafter) has anti-inflammatory, immunomodulatory, anti-tumour, anti-oxidant, anti-ischemic and hepatoprotective effects. In addition to its stem bark being used in medicine, the young leaves of EG are the traditional food of the Qiang people, which has been developed into a tea product and pushed to the market. The prospect of industrialisation is good. This comprehensive review aims to explore the taxonomic status, botanical characteristics, traditional applications, phytochemistry, pharmacology, and quality control of EG. The primary focus is placed on phytochemical and pharmacological investigations.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"1027 - 1055"},"PeriodicalIF":7.3,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The different parts of Dendrobium officinale Kimura et Migo: traditional uses, phytochemistry, pharmacological activities, and product development status and potential","authors":"Yuan Li,&nbsp;Qin-Xiang Chang,&nbsp;Peng-Guo Xia,&nbsp;Zong-Suo Liang","doi":"10.1007/s11101-024-09973-5","DOIUrl":"10.1007/s11101-024-09973-5","url":null,"abstract":"<div><p><i>Dendrobium officinale</i> Kimura et Migo (<i>D. officinale</i>), a valuable medicinal and edible homologous plant, is a synonym of <i>Dendrobium catenatum</i> Lindl. <i>D. officinale</i> has been used for thousands of years in daily health care and treatment of diabetes, gastrointestinal diseases, and various cancers. During the cultivation and harvesting of <i>D. officinale</i>, its non-medicinal parts (leaves and flowers) are often discarded as waste, resulting in a huge waste of resources. Approximately 244 chemical constituents have been isolated from the stems, leaves, and flowers of <i>D. officinale</i>, mainly polysaccharides, bibenzyls, phenanthrenes, flavonoids, phenolic acids, and other constituents. Among these substances, polysaccharides are the most abundant and main bioactive components. The stems, leaves, and flowers of <i>D. officinale</i> can all be used for food, medicine, cosmetic, or health care purposes. Among these, the flowers play many roles, such as antioxidant, neuroprotection, anti-depression, and learning and memory improvement functions, and can be used as a natural nutritional supplement to prevent neurologic disorders like depression and Alzheimer’s disease. Simultaneously, the leaves of <i>D. officinale</i> exhibit beneficial effects on metabolic and cardiovascular diseases and can used as a functional food for the prevention and treatment of hyperglycemia, hypertension, and hyperuricemia. To the best of our knowledge, this paper is the first systematic and comparative review of the traditional uses, bioactive compounds, pharmacological effects, and applications of different parts of <i>D. officinale</i>. We hope this review will provide a scientific reference for the development and utilization of this plant.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"985 - 1026"},"PeriodicalIF":7.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141191046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of secondary metabolites in plant defense mechanisms: a molecular and biotechnological insights","authors":"R. Upadhyay,&nbsp;R. Saini,&nbsp;P. K. Shukla,&nbsp;K. N. Tiwari","doi":"10.1007/s11101-024-09976-2","DOIUrl":"10.1007/s11101-024-09976-2","url":null,"abstract":"<div><p>The plants produce secondary metabolites (SMs) as defence compounds against both abiotic and biotic stresses. These stresses instigate the secretion and release of SMs by up or down-regulating the concerned genes involved in their synthesis. The secretion of SMs varies with the plant's genetic constitution and accordingly-they are susceptible or resistant. These metabolites mostly act as deterrents or antifeedants, allelochemicals, toxins or precursors of other metabolites that defend plants from stresses. However, some pathogens use these metabolites as a signal for host recognition or nutrition rather than using them as toxins or deterrents. The SMs activate different signalling pathways e.g. terpenoids modulate the calcineurin pathway, sesquiterpenoids modulate the jasmonic acid and salicylic acid pathway, polyphenols activate the jasmonic acid and phenylpropanoid pathway, and alkaloids activate the salicylic acid pathway to protect against pathogens and herbivores. Polyphenolic compounds provide resistance to different microbes by expressing different pathogenesis-proteins and hypersensitive reaction-mediated cell death and eliminate pathogens by altering the membrane permeability (inhibiting efflux pump), cell wall integrity, suppressing enzyme activity, free radicals’ generation, inhibiting protein biosynthesis, damaging DNA and reducing the expression of virulent genes. Flavonoids help plants sustain pathogen stresses through the changes in the auxin transport process. The pathogen exposure upregulate genes of alkaloid synthesis pathways such as tyrosine decarboxylase (TyDC), S-norcoclurine synthase (NCS), codeinone reductase 2-like (COR-2), and StWRKY8 transcription factors which in turn accumulate alkaloids in large amounts. Plant exposure to pathogens leads to hypersensitivity reactions and phytoalexin accumulation. The plant's treatment of salicylic acid and jasmonic acid upregulated downstream transcription factors, increased the expression of defence proteins, triggered the synthesis of SMs, and provided resistance against multiple pathogens. Pathogens and herbivores have also coevolved to cope with defence metabolites by detoxifying the toxic metabolites, converting toxins into useful products, evolving their food choice, fast digestive system, expulsion of toxins, and down-regulation of the gene-producing secondary metabolites. This review article gives a molecular insight into the genes and regulatory proteins controlling the synthesis of SMs, which may help decipher the role of the biosynthetic pathway intermediates and thereby scoring genes providing resistance to various stresses. The article comprehensively describes the roles of different SMs in plant defence and their molecular mechanisms of action.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"953 - 983"},"PeriodicalIF":7.3,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vigna mungo (Linn.) Hepper: ethnobotanical, pharmacological, phytochemical, and nutritious profile","authors":"Fazal Hadi,&nbsp;Haseeba Sardar,&nbsp;Waqas Alam,&nbsp;Michael Aschner,&nbsp;Fuad M. Alzahrani,&nbsp;Ibrahim F. Halawani,&nbsp;Jianbo Xiao,&nbsp;Haroon Khan","doi":"10.1007/s11101-024-09972-6","DOIUrl":"10.1007/s11101-024-09972-6","url":null,"abstract":"<div><p><i>Vigna mungo</i> is a member of the family <i>Fabaceae</i> and important medicinal plant that is widely consumed as food in South Asia. It is commonly referred as Black Gram, Urad daal and Maash. It is traditionally used for strangulated bowel syndrome, dyspepsia, constipation, neuropathy, hepatopathy, gastritis, diarrhea, rheumatism, diabetes, etc. This review article provides up-to-date information on <i>V. mungo,</i> including its reported ethnopharmacology, pharmacological activities, phytochemistry and nutritious composition. Articles were screened from databases such as Web of Science, SpringerLink, Google Scholar, PubMed, Medline Plus, Elsevier, and Science Direct. <i>V. mungo</i> contains phytochemical including alkaloids, flavonoids, saponins, steroids, tannins, phenolic compounds, fatty acids, carbohydrates, amino acids, vitamins, and carotenoids. These compounds exert pharmacological activities both in-vitro and in-vivo including antioxidant, antidiabetic, anti-hyperlipidemic, immunostimulatory, hepatoprotective, nephroprotective, antibacterial, anthelmintic, thrombolytic, anti-inflammatory, analgesic, ulcerogenic, anticonvulsant, nootropic, anti-osteoarthritic, aphrodisiac, spermatogenic and anticancer activities. Currently, scientific data in supports of the biological activities are scarce. We suggest more in-depth to determine its clinical efficacy.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 2","pages":"1119 - 1142"},"PeriodicalIF":7.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The botanical details, pharmacological activities and industrial applications of date seed (Phoenix dactylifera L.)","authors":"Susan Chinedu Nwachukwu,&nbsp;Great Iruoghene Edo,&nbsp;Princess Oghenekeno Samuel,&nbsp;Agatha Ngukuran Jikah,&nbsp;Gift Onyinyechi Oloni,&nbsp;Gracious Okeoghene Ezekiel,&nbsp;Joy Johnson Agbo","doi":"10.1007/s11101-024-09967-3","DOIUrl":"10.1007/s11101-024-09967-3","url":null,"abstract":"<div><p>Date palm (<i>Phoenix dactylifera</i> L.) is a very vital crop tree in many Middle Eastern countries and also, its fruits called dates are consumed worldwide by thousands of people. Date seeds which are the by-product of date fruits, are usually regarded as wastes and at most, only used as feed for farm animals. Unbeknownst to many however, date seeds are embedded with numerous amounts of fiber, carbohydrates, protein, oil, and dietary additionally, date seeds also contain phytochemicals that may elicit biological effects. Moreover, the abundant chemical composition of date seeds makes them apposite for use in medical supplements, food product formulation and cosmetics. It is the aim of the authors to review to the latest data on the pharmacological properties of date seeds discussing the botanical properties and industrial applications as well.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"927 - 951"},"PeriodicalIF":7.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive approach to phytochemical analysis of macromolecular composites that protect tubers: case studies in suberized potato periderm tissues","authors":"Keyvan Dastmalchi,&nbsp;Van Chanh Phan,&nbsp;Subhasish Chatterjee,&nbsp;Bingwu Yu,&nbsp;Mercè Figueras,&nbsp;Olga Serra,&nbsp;Ruth E. Stark","doi":"10.1007/s11101-024-09974-4","DOIUrl":"10.1007/s11101-024-09974-4","url":null,"abstract":"<div><p>Terrestrial plants rely on protection conferred by their outer coverings to defend against desiccation, bruising, and microbial invasion. For food staples such as potato tubers, the periderm contains the phellem (tuber skin) which creates a hydrophobic barrier by depositing macromolecular composites comprised of waxes, soluble phenolics, and a complex aliphatic suberin polyester (or suberin aliphatic domain) and lignin-like biopolymer (or suberin polyphenolic domain) within the previously formed polysaccharide cell wall. The antibacterial activity of both the soluble chemical constituents and their solid polymeric assemblies provides essential plant defense; their antioxidant and waterproofing properties also offer practical potential for sustainable food preservation and packaging applications. To characterize these phytochemical composites comprehensively and in molecular detail, we developed an approach that coordinates ‘bottom-up’ analysis of extracted metabolites that include suberin precursors, solid-state NMR spectroscopy of the polymers in intact skins or solid suspensions, and ‘top-down’ analysis of chemical breakdown products of suberin. The usefulness of analytical methods that include LC–MS, GC–MS, multivariate analysis, solid-state NMR, SEM, and TEM is illustrated for studies of molecular and supramolecular structures that underlie protective function in three potato periderm systems: (1) native tuber periderms versus suberized wound-healing tissues including closing layer and wound periderm; (2) metabolites unleashed in rapid response to wounding prior to formation of suberized tissues; (3) wild type versus genetically modified potato varieties with altered suberin deposition. We also demonstrate how enrichment with stable ¹³C and ¹⁵N isotopes can improve our understanding of how the suberin biopolymer molecular structure develops, increasing the reach of MS, 2D solid-state NMR, and dynamic nuclear polarization spectroscopic methods and revealing phenolic amide constituents that could represent an underappreciated part of the plant’s defensive arsenal.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"909 - 925"},"PeriodicalIF":7.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140925060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of the Desmodium genus: An innovative exploration of its phytopharmacological characteristics, hepatoprotective capabilities, underlying mechanisms of action and possible applications","authors":"Anju Rani George,&nbsp;Aarthi Jeganathan,&nbsp;Anju Byju,&nbsp;Sradha Sajeev,&nbsp;Kavimani Thangasamy,&nbsp;Paulpandi Manickam,&nbsp;Geetha Natesan","doi":"10.1007/s11101-024-09963-7","DOIUrl":"10.1007/s11101-024-09963-7","url":null,"abstract":"<div><p>Liver disease is a significant global health concern, leading to around two million fatalities annually. This disorder encompasses a broad range of causes, including both well-established factors such as lifestyle choices, as well as less understood origins such as pre-existing medical diseases. In the present scenario, liver cancer poses a significant worldwide health concern, with projections indicating that the number of cases is expected to exceed one million by the year 2025. According to the World Health Organization, numerous developing nations, such as India, continue to rely on the utilization of plants and plant-derived substances for the treatment of diverse ailments. <i>Desmodium Desv</i>., a genus within the Fabaceae family, encompasses about 350 species that are primarily found in tropical and subtropical regions worldwide. These plants have a long-standing history of traditional medicinal use in India, Thailand, and China, particularly for the treatment of liver diseases. The objective of this review is to provide a comprehensive overview of the ethnobotanical applications, phytoconstituents, and hepatoprotective properties associated with all species of <i>Desmodium</i>. The research employed various methodologies. Data on the <i>Desmodium</i> genus was collected up until the year 2022 through the examination of research articles, patents, and diverse online bibliographic databases such as PubMed, Research Gate, PubChem, Science Direct, Scopus, Wiley Online Library, Web of Science, eOL, POWO, and IUCN. The online search was conducted using the following keywords: <i>Desmodium</i> species, review articles, ethnobotanical uses, phytochemical constituents, and hepatoprotective property. In conclusion, it can be inferred that Ethnobotanical research has revealed that these particular species possess diverse pharmacological attributes, including anti-oxidant, anti-inflammatory, anti-bacterial, cytotoxic, and hepatoprotective activities. The analysis of phytochemistry reveals the presence of various compounds such as flavonoids, alkaloids, terpenoids, steroids, phenols, and other constituents inside these species. Out of a total of 350 species, it has been observed that 18 possess hepatoprotective properties. In order to substantiate the hepatoprotective applications and advance the development of prominent pharmaceuticals, additional pharmacological investigations including animal models and phytochemical explorations are necessary.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"24 1","pages":"879 - 908"},"PeriodicalIF":7.3,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140925162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}