Phytochemistry Reviews最新文献

{"title":"Key-enzymes involved in the biosynthesis of resveratrol-based stilbenes in Vitis spp.: a review","authors":"Blandine Marant, Jérôme Crouzet, Amandine L. Flourat, Philippe Jeandet, Aziz Aziz, Eric Courot","doi":"10.1007/s11101-024-09958-4","DOIUrl":"https://doi.org/10.1007/s11101-024-09958-4","url":null,"abstract":"<p>Polyphenols are a large class of plant specialized metabolites with interesting biological properties. Among them, the stilbene phytoalexins are particularly abundant in grapevine gaining considerable applications in the cosmetic and nutraceutical industry. The well-studied stilbene biosynthetic pathway uses phenylalanine to generate resveratrol, the primary stilbene core synthetized in grapevine. A set of enzymes further metabolize resveratrol producing a diversity of stilbenes with different properties, activities and stabilities. In grapevine, 13 enzymes have been identified with the ability to use resveratrol as a substrate, including ten peroxidases, two glycosyltransferases and one <i>O</i>-methyltransferase. Peroxidases and methyltransferases are the most studied enzymes in grapevine, especially under stress conditions while the role of plant laccases and hydroxylases in stilbene metabolism is still poorly described. This article provides an overview of the key enzymes involved in the synthesis of resveratrol-based derivatives in <i>Vitis</i> spp. Perspectives to identify new enzymes are discussed, which could be further used for stilbene bioproduction using biotechnologies.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"102 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technological insights into lutein isolation from marigold flower and their diverse applications: a compendious review","authors":"Surbhi Sharma, Aushmita Das, Abha Kumari, Manju M. Gupta","doi":"10.1007/s11101-024-09959-3","DOIUrl":"https://doi.org/10.1007/s11101-024-09959-3","url":null,"abstract":"<p>In our comprehensive review, we delve into the critical steps of isolation of lutein and zeaxanthin from marigold flowers focusing on several pre-treatment technologies for marigold flower hydrolysis, non-green and green solvent-based extraction techniques of hydrolyzed solid biomass, and saponification of oleoresin while addressing the associated challenges and limitations. The review highlights the varying effects of different pre-treatments on the degradation of pectin, lignin, cellulose, and hemicellulose as well as on lutein and zeaxanthin ester yield. Notably, the enzymatic pre-treatment emerges as the most efficacious approach, despite its reliance on costly commercial enzymes. Based on the literature review, it is determined that supercritical fluid extraction, combined with ultrasound and various co-solvents gives off better yields of lutein as compared to the other extraction methods. This review also covers the saponification, purification, and recovery process. The applications of marigold flowers and lutein are also summarized.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"48 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hordatines, dimerised hydroxycinnamoylagmatine conjugates of barley (Hordeum vulgare L.): an appraisal of the biosynthesis, chemistry, identification and bioactivities","authors":"Claude Y. Hamany Djande, Ian A. Dubery","doi":"10.1007/s11101-024-09961-9","DOIUrl":"https://doi.org/10.1007/s11101-024-09961-9","url":null,"abstract":"<p>Hydroxycinnamoylamides are specialised metabolites widely distributed in the plant kingdom. These are phenolic moieties covalently linked to mono- or polyamines through amide bonds. Their oxidative coupling (dimerisation) leads to neolignanamides, a group of compounds showing high chemical, structural and functional diversity. Typical to barley, dehydro dimers of hydroxycinnamoylagmatines, hordatines are primarily found in germinated seeds and at the seedling stage. The first step in the biosynthesis of hordatines is catalysed by acyl-coenzyme A-dependent N-hydroxycinnamoyltransferases, and lead to the formation of hydroxycinnamoylagmatines (HCAgms). The oxidative homo- or hetero-dimerisation of the latter results in different hordatines (A, B, C or D). Hordatines can also undergo various types of conjugation and form hydroxylated, methylated or glycosylated derivatives. Although the research on the bioactivities of the hordatines is still nascent, the <i>in planta</i> antifungal properties have long been recognised. While hordatines are naturally and uniquely synthesised in barley plants, these molecules or lead compounds derived therefrom, also exhibit medicinal and pharmaceutical uses important for human health, stimulating research into the utilisation of biotechnology in alternative production hosts and to enhance agricultural yields and value-added production. This review summarises the older and recent knowledge about hordatines and derivatives and may serve as a springboard for future research on this intriguing class of secondary plant metabolites.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"55 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genus Quercus: metabolites, biological activity and mechanisms of action","authors":"Lulu Jiang, Shuanghui Yin, Guangyue Wang, Xinting Shao, Ye Wang, Yong Li, Yuling Ding","doi":"10.1007/s11101-024-09935-x","DOIUrl":"https://doi.org/10.1007/s11101-024-09935-x","url":null,"abstract":"<p><i>Quercus</i>, an essential genus within the Fagaceae family, comprises roughly 500 plant species. Over the past 5 years (2019–2023), there has been a noticeable increase in the production of high-quality research papers focusing on this genus, marking it as an emerging research area of interest. However, despite this growing body of work, there has yet to be a comprehensive and systematic review addressing the metabolites, pharmacological effects, and underlying mechanisms associated with <i>Quercus</i>. To bridge this knowledge gap, the current study performed an exhaustive literature review. A total of 64 relevant papers published in high-impact journals (classified as JCR Q1–Q3) between January 2019 and April 2023 were meticulously selected through comprehensive searches of the ACS, PubMed, Web of Science, and Science Direct databases. The chemical analysis encompassed the identification of 217 compounds, spanning categories like terpenoids, flavonoids, tannins, and phenols, among others. Within this set, 11 previously undisclosed compounds emerged, comprising 6 terpenoids and 5 esters. The study primarily delved into the internal and external pharmacological properties of 23 distinct plant species, including antioxidant, antibacterial, anti-inflammatory, antidiabetic effects, and even the assessment of its potential for mitigating the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This paper offers a comprehensive evaluation of the findings and provides insightful recommendations for guiding future research on this plant genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of <i>Quercus</i> spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"48 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review on Pulicaria species occurring in Qatar: traditional uses, phytochemistry and biological activities","authors":"Deepak M. Kasote, Malik Adil Nawaz, Kamal Usman, Najeeb Ullah, Mohammed Alsafran","doi":"10.1007/s11101-024-09932-0","DOIUrl":"https://doi.org/10.1007/s11101-024-09932-0","url":null,"abstract":"<p>In Qatar, three main species of <i>Pulicaria</i> (from Asteraceae) such as <i>Pulicaria undulata</i> (L.) C.A.Mey, <i>Pulicaria gnaphalodes</i> (Vent.) Boiss. and <i>Pulicaria sicula</i> (L.) Moris are reported. Traditionally, these species have almost the same ethnomedical uses, including their use as herbal tea. This could be because of morphological similarities among some of these species, which also results in taxonomic ambiguity. Altogether, this indicates that these species need to be reviewed comparatively, to understand the phytochemical uniqueness and therapeutic significance of each species individually, including species differentiation at the subspecies level. Hence, this review aims to comparatively review the available literature about traditional uses, phytochemistry, and bio-activities of these species. Being aromatic plants, the chemical composition of essential oils of these species has been extensively studied and reported over 300 volatile organic compounds. Among these, oxygenated monoterpenes and sesquiterpenes are dominant. The diverse and distinguishable composition of essential oils can differentiate <i>P. undulata</i> and <i>Pulicaria crispa</i> (Forssk.) Oliv. (Synonyme: <i>Pulicaria undulata</i> subsp. <i>undulata</i>). Likewise, flavonoids and sesquiterpenes are the most reported classes of compounds in non-essential oil fractions. Various biological and pharmacological activities are reported to the essential oils, crude extracts, and their fractions, or isolated compounds of these species. Among these, antimicrobial, anticancer, and anti-oxidant activities were mostly investigated, mainly under in vitro conditions. Several distinguishable compounds are listed for each species that can potentially be used as chemical markers while characterizing these species. Most of the traditional claims of these species are validated in recent scientific studies. However, further detailed in vivo clinical interventions are needed for their potential use as therapeutic agents.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"31 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allelopathy research on the continuous cropping problem of poplar (populus)","authors":"Tao Song,&nbsp;Jia-Xu Chen,&nbsp;Lin-Miao Shan,&nbsp;Yu-Chen Qian,&nbsp;Mo-Xian Chen,&nbsp;Jian-Gang Han,&nbsp;Fu-Yuan Zhu","doi":"10.1007/s11101-024-09948-6","DOIUrl":"10.1007/s11101-024-09948-6","url":null,"abstract":"<div><p>The mechanism of decline in continuous plantations is currently a popular research topic in forestry. Continuous cropping is a common obstacle in poplar production and management, and maintaining productivity is a technical challenge. Recent studies have shown that continuous cropping of poplars leads to a reduction in biomass, but there is a lack of information summarizing the effects of plant secondary compounds on belowground interactions. This paper explores the allelopathic phenomenon, which refers to the inhibitory or promoting effects of poplar tissue extracts on plants. The paper also considers the environmental behaviors of allelochemicals derived from poplars, including their secretion, degradation, adsorption, retention, and phytotoxicity. A conceptual model of the autotoxicity mechanism of continuous cropping poplar is proposed from three aspects: microorganisms, soil enzymes, and nutrient changes, with the goal of overcoming poplar autotoxicity. Finally, the research results and potential application prospects of biotechnological methods related to the allelopathic effects of poplar are presented.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1477 - 1495"},"PeriodicalIF":7.3,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gmelina asiatica: exploring traditional uses, pharmacological insights, and phytoconstituents—a comprehensive review (1961–2023)","authors":"","doi":"10.1007/s11101-024-09951-x","DOIUrl":"https://doi.org/10.1007/s11101-024-09951-x","url":null,"abstract":"<h3>Abstract</h3> <p><em>Gmelina asiatica</em> is one of medicinal plants that is famous in traditional medicines. It is known as Asian bushbeech under the family Lamiaceae. <em>Gmelina asiatica</em> is widely used in Indian folklore to treat many illnesses and disorders, such as treatment of jaundice, hemorrhoids, dysuria, arthritis, edema, liver diseases, neurological disorders, fever, heart diseases, dandruff, skin infections, acne, diabetes mellitus, catarrh of the bladder, syphilis, as antiseptic, astringent, demulcent, contraceptive and blood purifier. As well as, there are various reports on the pharmacological activities of this plant that scientifically support some of its traditional uses. These activities have been shown to include anticancer, anti-inflammatory, antioxidant, antihyperglycemic, antipyretic, nematicidal, anxiolytic, neuroprotective, anti-microbial, hepatoprotective, nephroprotective and analgesic activity. <em>Gmelina asiatica</em> is rich in furofuran lignans and flavonoids and contains many other secondary and primary metabolites, but only a few studies have been conducted to identify and isolate its phytoconstituents. The current review aims to provide the published information on <em>Gmelina asiatica</em>, its features, traditional uses, ethnobotanical uses by different tribes, pharmacological activities, and reported phytoconstituents, from 1961 to September 2023, which was collected from books and online databases such as Scopus, Google Scholar, PubMed, Science Direct, SpringerLink, and Wiley Online Library.</p> <span> <h3>Graphical Abstract</h3> <p><span> <span> <img alt=\"\" src=\"https://static-content.springer.com/image/MediaObjects/11101_2024_9951_Figa_HTML.png\"/> </span> </span></p> </span>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"18 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal phthalimidines-chemodiversity, bioactivity and biosynthesis of a unique class of natural products","authors":"Fayrouz El Maddah,&nbsp;Mamona Nazir,&nbsp;Rabbia Ahmad,&nbsp;Sobia Khurshid,&nbsp;Muhammad Saleem,&nbsp;Benjamin Libor","doi":"10.1007/s11101-024-09923-1","DOIUrl":"10.1007/s11101-024-09923-1","url":null,"abstract":"<div><p>A wide range of natural products important for the engineering and drug design of pharmaceuticals comprise largely of nitrogen-based heterocycles. Fungal natural products have proven to be a rich source of the industrially-important molecules, many of which are promising drug leads. Although, natural products containing a phthalimidine core tends not to be given distant classification, but compounds containing these structures exhibit antimicrobial, anthelmintic, antimalarial and insecticidal activities, and are among the potential target for discovering new drug candidates. Intriguingly, these are primarily isolated from fungal sources and to a very lesser extent from plants or bacteria. This review surveys fungal-derived phthalimidine metabolites published until the end of 2022, isolated from both terrestrial and aquatic or marine sources with emphasis on their unique chemistry, bioactivities, biogenesis and taxonomic classification. Their unique chemistry and diverse bioactivities (including antiviral, antiproliferative, antioxidant and antimicrobial) provide a chemical library with high medicinal potential, representing a treasure trove for synthetic chemists.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1271 - 1322"},"PeriodicalIF":7.3,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11101-024-09923-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthocyanins: a comprehensive review on biosynthesis, structural diversity, and industrial applications","authors":"Nitisha Sendri, Pamita Bhandari","doi":"10.1007/s11101-024-09945-9","DOIUrl":"https://doi.org/10.1007/s11101-024-09945-9","url":null,"abstract":"<p>Anthocyanins, a sub-class of polyphenolic secondary metabolites, are the subject of research in numerous pharmacological chemical studies and food industries. These molecules exhibit a wide array of pharmacological benefits own fascinating different molecular architectures and reflect colorful hues, which have made them popular targets for their studies. The potential application of anthocyanins (natural pigment) has attracted numerous widespread industrial interest. The beautiful colorant unveiled by anthocyanins has widened the scope of anthocyanin applications in food. This review summarizes the isolation of more than 200 new anthocyanins during 2010–2023 along with a discussion of their structural diversities, structural elucidation, biosynthetic pathway and more importantly, their industrial relevance in food. These molecules are classified into acylated anthocyanins and non-acylated anthocyanins, which are further divided according to their substitution pattern i.e. <i>O</i>-methylated anthocyanins, 3-deoxyanthocyanins. These are systematized into their derivative viz. pyranoanthocyanins, pyranoanthocyanins dimers, and metalloanthocyanins. The present review also focuses on the structural characterization of anthocyanins by nuclear magnetic resonance spectroscopy.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"35 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycorine as a lead molecule in the treatment of cancer and strategies for its biosynthesis using the in vitro culture technique","authors":"Saikat Sena, Harmeet Kaur, Vijay Kumar","doi":"10.1007/s11101-024-09941-z","DOIUrl":"https://doi.org/10.1007/s11101-024-09941-z","url":null,"abstract":"<p>Medicinal plants are used by many of the global population because they are safe and effective alternative to other treatments. Over the last few decades, using plant cells to produce natural or recombinant chemicals of economic interest has become a great intention. Secondary metabolites are recognized to have a significant role in plant adaptation to their environment and are also a valuable source of medication. The increasing economic importance of secondary metabolites has recently sparked a lot of interest in biotransformation, particularly in using tissue culture techniques to modify the production of bioactive plant metabolites. Plants of the family Amaryllidaceae have been used to extract several different alkaloids, each of which has the potential to be involved in a variety of pharmacological processes. Due to its multiple biological functions and divergent structure, lycorine has received significant interest in the medicinal field. Lycorine and other alkaloids from the Amaryllidaceae family have limited bioavailability by nature. In vitro culture provides an alternate method for producing lycorine sustainably due to the pharmaceutical industries dramatically increasing demand for it and the insufficient availability of natural resources. Many medicinal plants have been reported to produce lycorine in vitro in plant cell suspension cultures, and bioreactors play an effective role in their commercial production. This article focuses on the production of lycorine in in vitro systems from plants and its potential in the treatment of cancer. This study also aims to provide different biotechnological strategies for the production of this important alkaloid using in vitro system.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"10 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}