{"title":"Phytochemistry and pharmacology of alkaloids from Papaver spp.: a structure–activity based study","authors":"Shekoufeh Aalinezhad, Farid Dabaghian, Aida Namdari, Maryam Akaberi, Seyed Ahmad Emami","doi":"10.1007/s11101-024-09943-x","DOIUrl":null,"url":null,"abstract":"<p>The genus <i>Papaver</i> L. includes 159 annual, biennial, and perennial species divided into 11 sections. Several studies on a few species in this genus have revealed that they have beneficial anti-microbial, anti-inflammatory, anti-cancer, and anti-depressant properties. In addition, they have analgesic and sedative effects to alleviate signs of various disorders such as pain, cough, and neurological problems. These beneficial properties have been shown to be primarily related to their alkaloids content. The majority of the alkaloids in the <i>Papaver</i> genus are aporphines, morphinanes, protoberberines, protopines, and simple benzylisoquinolines. Interestingly, studies on the pharmacological effects of their alkaloids, with focus on the structure–activity relationship, have revealed a number of biological activities, including effects on metabolic syndrome, neurodegenerative and psychiatric disorders. However, findings of literature on the toxic effects and low bioavailability of these bioactivitie alkaloids persuaded researchers to focus on the exact mechanisms of these alkaloids and improve their benefits by alleviating their side effects. In the current study, we aimed to review the chemistry and pharmacology of the <i>Papaver</i> alkaloids in order to assist researchers in their future studies on the genus <i>Papaver</i> to address research gaps. Additionally, we had a complete investigation on the taxonomy of <i>Papaver</i> spp. based on research references.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"161 1","pages":""},"PeriodicalIF":7.3000,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11101-024-09943-x","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The genus Papaver L. includes 159 annual, biennial, and perennial species divided into 11 sections. Several studies on a few species in this genus have revealed that they have beneficial anti-microbial, anti-inflammatory, anti-cancer, and anti-depressant properties. In addition, they have analgesic and sedative effects to alleviate signs of various disorders such as pain, cough, and neurological problems. These beneficial properties have been shown to be primarily related to their alkaloids content. The majority of the alkaloids in the Papaver genus are aporphines, morphinanes, protoberberines, protopines, and simple benzylisoquinolines. Interestingly, studies on the pharmacological effects of their alkaloids, with focus on the structure–activity relationship, have revealed a number of biological activities, including effects on metabolic syndrome, neurodegenerative and psychiatric disorders. However, findings of literature on the toxic effects and low bioavailability of these bioactivitie alkaloids persuaded researchers to focus on the exact mechanisms of these alkaloids and improve their benefits by alleviating their side effects. In the current study, we aimed to review the chemistry and pharmacology of the Papaver alkaloids in order to assist researchers in their future studies on the genus Papaver to address research gaps. Additionally, we had a complete investigation on the taxonomy of Papaver spp. based on research references.
期刊介绍：
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
