Phytochemistry Reviews最新文献

{"title":"Unlocking the therapeutic potential of cinchonains: a comprehensive review","authors":"Nidal Fahsi, Ismail Mahdi, Hassan Annaz, Gabin Thierry M. Bitchagno, Mona F. Mahmoud, Mansour Sobeh","doi":"10.1007/s11101-024-09949-5","DOIUrl":"https://doi.org/10.1007/s11101-024-09949-5","url":null,"abstract":"<p>Cinchonains are a group of naturally occurring flavonolignans that exhibit a plethora of biological activities. This comprehensive review provides a critical analysis of the research on cinchonains and their related compounds, aiming to describe their various biological activities, including but not limited to, cytotoxicity, antioxidant, anti-inflammatory, antimicrobial, neuroprotective, antidiabetic, and anticancer activities. The occurrence and distribution of cinchonains in plants, their biosynthesis pathways, bioavailability, toxicity, and clinical investigations are also discussed. By synthesizing information from scientific literature, we present an informative and accessible overview of cinchonains' potential as a source of new therapeutics and highlight the importance of continued research on cinchonains and their related compounds to unlock their possible therapeutic merits.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"43 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products: protective effects against sensorineural hearing loss","authors":"Wenqi Xu,&nbsp;Mao Huang,&nbsp;Minyan Liao,&nbsp;Shuangshuang Mao,&nbsp;Lei Yang,&nbsp;Rong Chen","doi":"10.1007/s11101-024-09924-0","DOIUrl":"10.1007/s11101-024-09924-0","url":null,"abstract":"<div><p>Hearing loss is one of the major public health problems in the world, which brings huge adverse effects to individuals and society. Sensorineural hearing loss (SNHL) is responsible for the majority of hearing loss. Mechanisms contributing to SNHL include excessive accumulation of reactive oxygen species; over-activation of inflammatory factors; impaired blood micro-circulation in the inner ear or Ca²⁺ homeostasis imbalance, etc. Natural products (NPs), which have a long history of use in traditional medicine and a favorable safety profile, can be developed into a library of drug candidates for the treatment or prevention of SNHL. In this paper, we summarized 24 NPs to exhibit their preventive or therapeutic effects on cellular and animal models of SNHL in terms of their anti-apoptotic, anti-inflammatory, microcirculation-improving, and calcium antagonist effects, as well as 5 NPs in current clinical application. Further, combination with advanced technologies such as drug delivery systems and network pharmacology are applied to improve the research of NPs in the prevention of SNHL. Overall, this review provides a strong reference for the mining and development of NPs in the prevention and treatment of SNHL.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1323 - 1349"},"PeriodicalIF":7.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosomes: a critical tool for delivery of herbal drugs for cancer","authors":"Kajal Chaudhary, Anjali Rajora","doi":"10.1007/s11101-024-09947-7","DOIUrl":"https://doi.org/10.1007/s11101-024-09947-7","url":null,"abstract":"<p>Phytosomes represent specialized vesicular structures akin to liposomes, encapsulating active phytoconstituents within a lipid core. Many phytoconstituents, such as glycosides and flavonoids, exhibit hydrophilic properties and encounter challenges traversing lipid-based cellular membranes. Nevertheless, the lipid core of phytosomes enhances their permeability across these barriers, thereby augmenting the bioavailability and efficacy of enclosed plant components. Cancer remains a prominent global cause of mortality, posing significant challenges for existing treatments, which often entail serious side effects associated with conventional approaches like surgery, radiation therapy, and chemotherapy. In exploring alternative strategies, the utilization of herbal active compounds in cancer treatment shows considerable promise in synergizing with conventional methods. While natural plant-derived active components demonstrate robust in vitro pharmacological activity, their in vivo absorption is often limited. Addressing this constraint, phytosomes emerge as a burgeoning nanotechnology offering a solution by enhancing the adaptability of bioactive phytoconstituents within lipid-rich barriers. This study delves into a meta-analysis of the physicochemical attributes of phytosomes, elucidating their structural intricacies. Furthermore, the review discusses the advantages and disadvantages of phytosomes as carriers for herbal drugs, shedding light on patented phytosome technologies and associated clinical trials. Additionally, it examines several prominent phytosome-based herbal constituents showcasing notable anticancer properties. Lastly, the review addresses the challenges and potential future directions regarding the use of phytosomes in cancer therapy.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"47 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme-mediated adaptation of herbivorous\u0000 insects to host phytochemicals","authors":"Showket Ahmad Dar,&nbsp;Wajid Hasan,&nbsp;Yendrembam K. Devi,&nbsp;Ivana Tlak Gajger,&nbsp;James John","doi":"10.1007/s11101-024-09933-z","DOIUrl":"10.1007/s11101-024-09933-z","url":null,"abstract":"<p>The review comprehensively explores factors influencing enzyme\u0000 activities in insects and their implications in defense against toxicants. It\u0000 encompasses a diverse array of enzymes involved in metabolizing synthetic chemicals,\u0000 emphasizing their dynamic regulation. Key factors affecting enzyme activities, such\u0000 as external and internal influences, are discussed, shedding light on the intricate\u0000 regulatory mechanisms. The inhibitory effects of various compounds on insect GST\u0000 activity are thoroughly examined, providing insights into potential avenues for\u0000 insect control. The implications of insect defenses against toxicants are elucidated,\u0000 emphasizing the complexity of plant–insect interactions. The review delves into the\u0000 evolutionary adaptations of insects to plant defense mechanisms, highlighting the\u0000 role of enzymes like thioglucosidase and myrosinase in detoxifying glucosinolates.\u0000 The co-evolutionary dynamics between insects and plants, particularly in the\u0000 Brassicaceae family, are explored, underscoring the intricate biochemical strategies\u0000 employed by both parties. Additionally, the review addresses the challenges\u0000 associated with developing pest-resistant crop plants through traditional breeding or\u0000 genetic engineering. It discusses the need for a nuanced approach, considering the\u0000 adaptability of insects to various toxicants and the potential drawbacks of repeated\u0000 exposures. The success of chemical plant defenses, particularly monoterpene synthesis\u0000 in pine trees, is noted, along with the distinctive biodegradability of plant\u0000 metabolites. The review provides a thorough examination of the mechanisms underlying\u0000 insect responses to toxic plant metabolites, offering valuable insights into the\u0000 dynamic interplay between insects and plants. It suggests potential targets for\u0000 insect control programs and highlights the importance of understanding the\u0000 co-evolutionary processes that shape these interactions.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 5","pages":"1 - 24"},"PeriodicalIF":7.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uneven molecular distribution: a connection with plant functioning and stress resilience","authors":"Saumya Jaiswal, Durgesh Kumar Tripathi, Ravi Gupta, Francisco J. Corpas, Vijay Pratap Singh","doi":"10.1007/s11101-024-09953-9","DOIUrl":"https://doi.org/10.1007/s11101-024-09953-9","url":null,"abstract":"<p>The current global population is approximately 8 billion. So from a socio-economic point of view, governmental policies are intended to secure at least a minimum of the natural resources like food to the global population to minimize their uneven distribution. However, in the case of plants, the scenario seems different where an uneven distribution of resources seems to be required for the optimized growth. Therefore, a better understanding of this uneven distribution in plants is needed to generate stress-resilient plants with improved yield. It is known that all necessary functions in plants are governed by the efflux and influx of molecules/chemical species and their distribution make plants capable of performing crucial physiological processes as well as acclimating under stress conditions. In this review, we have discussed the role of uneven distribution of different molecules/chemical species in sustaining plant life in the surrounding environment with a few examples of physiological processes.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"23 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clerodendrum inerme (L.) Gaertn.: a critical review on current progress in traditional uses, phytochemistry, pharmacological aspects and toxicity","authors":"Manabendu Barman, Anuva Barman, Sanjib Ray","doi":"10.1007/s11101-024-09934-y","DOIUrl":"https://doi.org/10.1007/s11101-024-09934-y","url":null,"abstract":"<p><i>Clerodendrum inerme</i> (L.) Gaertn., commonly known as garden quinine, is a perennial shrub that belongs to the <i>Lamiaceae</i> family. It has been extensively used in various traditional medicinal practices to treat ailments such as rheumatic pain, arthritis, scrofulous, venereal disease, skin diseases, wounds, fever, cough, dysentery, and more. This review aims to critically examine a comprehensive compilation of recent research on <i>C. inerme</i>, encompassing its botanical characteristics, ethnomedical applications, phytochemicals, pharmacological activity, and toxicological data, in order to provide insights and inspiration for future research, promote further development, and facilitate the rational application of <i>C. inerme.</i> Nearly 95 chemical constituents belonging to different classes have been isolated from <i>C. inerme</i>, including diterpenoids, triterpenoids, steroids, flavonoids, phenolic glycosides, lignans, iridoid and megastigmane glycosides. Notably, diterpenoids, triterpenoids, steroids, and flavonoids are the main bioactive substances that have been extensively studied and demonstrated the most significant bioactivity. Pharmacological studies demonstrated that the extract of <i>C. inerme</i> exhibits a wide range of biological activities, such as antioxidant, antimicrobial, anticancer, antiinflammatory, insecticidal, antifeedant, neuroprotective, anti-motor tic, and so on, which are closely connected to its numerous ethnomedicinal applications. Nevertheless, some literature have reported the toxicity of <i>C. inerme</i>. Therefore, it is imperative to conduct further in-depth studies encompassing toxicology, as well as preclinical and clinical research, to ascertain the safety and efficacy of <i>C. inerme</i> for medicinal purposes.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"5 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on phytochemistry, pharmacology, preclinical, and clinical trials of Cydonia oblonga","authors":"Tuba, Muhammad Ajaz Hussain, Gulzar Muhammad, Muhammad Arshad Raza, Adnan Ashraf, Muhammad Tahir Haseeb, Muhammad Mushtaq, Zahid Shafiq","doi":"10.1007/s11101-024-09946-8","DOIUrl":"https://doi.org/10.1007/s11101-024-09946-8","url":null,"abstract":"<p><i>Cydonia oblonga</i> M. (Quince), a deciduous shrub from the family <i>Rosaceae</i>, has been recognized in the last decade mainly because of its potential to prevent/cure cancer, high cholesterol, blood sugar, chronic stress, peptic ulcer, liver injuries, asthma, and various fertility disorders. Several metabolites, including flavonoids, phenolic acids, polyphenols, carotenoids, lignans, stilbenes, triterpenoids, procyanidins, glycosides, and organic acids, have been identified as the major phytochemical components. Different parts of <i>C. oblonga</i> are known to demonstrate a broad spectrum of biological activities against numerous microbial infections, free radicals-mediated damages, cancer cells proliferation, lipid profile dysfunction, glucose metabolism disorder, lethal oxalocalcic kidney stones, hydatid cysts of protoscolices, and inflammatory diseases. In preclinical trials, neuro-protective, anti-hyperglycemic, anti-hyperlipidemic, anti-inflammatory, and wound healing activities and protective effects on hepatocellular carcinoma, testicular tissue alteration, endocrine disruption, cardiotoxicity, depression, and blood pressure have been investigated for the valuable plant. The clinical studies explore the plant's potential to treat reproductive, respiratory, and gastrointestinal disorders and support using <i>C. oblonga</i> as a new herbal medicine. However, additional research is needed to unravel its intricate action mechanisms, evaluate safe dosing strategies, identify any adverse effects, and validate its pharmacological effects in a broad population over a longer timeframe before approving it as a new herbal treatment. In conclusion, the review presents detailed analyses of the phytochemistry, pharmacology, preclinical, and clinical trials of <i>C</i>. <i>oblonga</i>.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"45 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular targeting of constituents of commonly used spices and its molecular interactions in endothelial dysfunction: A review","authors":"Pronay Mandal, S. K. Kanthlal","doi":"10.1007/s11101-024-09939-7","DOIUrl":"https://doi.org/10.1007/s11101-024-09939-7","url":null,"abstract":"<p>Endothelial dysfunction, characterized by impaired endothelial function, is critical in developing cardiovascular diseases. Emerging evidence suggests that certain constituents of commonly used spices potentially mitigate endothelial dysfunction. This review summarizes the current literature on the constituents of commonly used spices and their molecular interactions in endothelial system. We first provide an overview of physiological significance as well as dysfunction of endothelium and its role in cardiovascular diseases, including the mechanisms like oxidative stress, inflammation, atherosclerosis, hypertension, thrombosis, and impaired nitric oxide (NO) bioavailability. The physiological significance such as, regulation of thrombosis and fibrinolysis, preventing atherosclerosis and neo-angiogenesis, were discussed. Various spices reported to possess vascular-targeting properties, including curcumin from turmeric, allicin from garlic, gingerol from ginger, piperine from black pepper, quercetin from onion, 2-methoxycinnamaldehyde from cinnamon etc. were discussed. We highlight the molecular interactions of these spice constituents with endothelial cells, including their effects on oxidative stress, inflammation, atherosclerosis, thrombosis, and NO bioavailability. Evidence from in vitro, animal, and human studies reveals that, spice constituents modulate various signaling pathways and enhance NO bioavailability, which collectively contribute to their potential beneficial effects on endothelial function. Furthermore, we discuss the potential mechanisms including reduced expression of ICAM, VCAM, and selectin, inhibition of NF-κB activation and translocation, and decreased ROS and H₂O₂ levels. In conclusion, the constituents of commonly used spices, such as (allicin, curcumin, quercetin, gingerol etc.) promises a novel approach for modulating endothelial function in vascular disorders. Further research in this area may provide valuable insights into the potential use of these spice constituents as complementary or alternative therapies for cardiovascular diseases.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"45 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140325127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in natural compounds for cancer therapy and prevention","authors":"R. Pavithra, Mohammad Rashid Khan, Mohd Shahanbaj Khan","doi":"10.1007/s11101-024-09940-0","DOIUrl":"https://doi.org/10.1007/s11101-024-09940-0","url":null,"abstract":"<p>Even after a century of substantial advancements in oncology medicines, cancer still ranks as one of the top causes of death worldwide. As a result, there is an ongoing and pressing need for the development of new cancer drugs. Natural compounds and their semi-synthetic derivatives continue to show promise as potential therapeutic leads, due to their high chemical diversity, biochemical specificity, significant molecular activities, and pharmacological properties. They serve as excellent starting points for the discovery of new drugs, inspiring new breakthroughs in biology, chemistry, and medicine. In recent years, scientists have made significant advancements in the development of naturally occurring or partly synthesized analogues with improved bioactivity, simpler synthetic targets and reduced toxicity. This review aims to summarize the importance and biological actions of natural compounds identified form plants and their role in prevention of cancer treatment.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"15 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140325129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucosinolates, isothiocyanates, and their role in the regulation of autophagy and cellular function","authors":"Paola Maycotte, Marcelo Illanes, Diego A. Moreno","doi":"10.1007/s11101-024-09944-w","DOIUrl":"https://doi.org/10.1007/s11101-024-09944-w","url":null,"abstract":"<p>Autophagy is a cellular degradation process important for the maintenance of cytoplasmic integrity which can be upregulated in response to stress which is active in eukaryotic cells. Promotion of autophagy has been related to lifespan expansion, tumor suppression and the maintenance of metabolic health. Also, alterations in this pathway have been related to human diseases or pathological states including neurodegenerative diseases, stroke, metabolic alterations, or cancer. Extensive research on the effects of natural products on autophagy has been made, with a particular focus on phenolic compounds. However, plant nitrogen-containing specialized metabolites have recently acquired great importance due to their potential therapeutic uses. Among these, glucosinolates (GSL), a group of thioglucosides and their bioactive metabolites, isothiocyanates (ITC) and indoles, are known to modulate cellular processes important for disease treatment and prevention. These compounds are almost exclusive of cruciferous foods (Brassicas), including broccoli, cabbages, radishes, kale, mustards, rocket salad or arugula, wasabi, and so on. The cruciferous vegetables are widely distributed worldwide and highly consumed in Europe, Asia and the Americas. Due to the important role of autophagy as a cellular homeostatic maintenance process, and its alterations in pathological states, we reviewed the recent evidence relating the effects of GSL metabolites and their role as modulators of autophagy. The potential to modulate this process is crucial for the maintenance of human health and to treat highly prevalent diseases where autophagy is involved, such as neurodegenerative, metabolic disorders, or cancer.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"15 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}