Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Iman Abdelhady Elshnoudy, Abdallah M. Elkhouly, Mira Masoud, Hanin A. Rabea, Fotouh R. Mansour
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引用次数: 0

Abstract

The increase in cases of various cancers, the number of cancer patients, and the serious side effects of current chemical treatments have encouraged researchers to discover novel and more effective drugs from plant sources. In this review, PubMed and Scopus were searched for English-language peer-reviewed articles published since 1994, using the keywords: Medicinal plants, Egypt, and Cancer. The inclusion criteria for this systematic review were English peer-reviewed original research articles. A total of 286 studies were included. Studies have shown that the active compounds in certain plants can have anticancer activities by various mechanisms, such as cell cycle arrest, apoptosis induction, and antioxidant effects. Additionally, it is evident that medicinal plants can act as inhibitors of cancer cells. Plants can also act as immune checkpoint inhibitors, which inhibit proteins such as PD-L1 on tumor cells, PD-1 and CTLA-4 on T cells, and help to regulate immune responses. This review also discusses the efficacy of nanoparticles of these plants against cancer cells. The findings indicate the high potential of investigating the bioactive anticancer components of Egyptian medicinal plants for advancing novel treatments that are more effective in combating cancer. The extracts and active compounds of the medicinal plants detailed in this review could provide the foundation for further clinical trials to be conducted, to develop new anticancer drugs.

Abstract Image

埃及种植的具有抗癌潜力的药用植物;系统综述
各种癌症病例的增加,癌症患者的数量,以及目前化学治疗的严重副作用,促使研究人员从植物中发现新的更有效的药物。在这篇综述中,使用关键词:药用植物、埃及和癌症,检索PubMed和Scopus自1994年以来发表的英文同行评议文章。本系统综述的纳入标准为英文同行评议的原创研究文章。共纳入286项研究。研究表明,某些植物中的活性化合物可通过多种机制发挥抗癌作用,如阻滞细胞周期、诱导细胞凋亡和抗氧化作用。此外,药用植物明显具有抑制癌细胞的作用。植物还可以作为免疫检查点抑制剂,抑制肿瘤细胞上的PD-L1、T细胞上的PD-1和CTLA-4等蛋白,帮助调节免疫反应。本文还对这些植物纳米颗粒的抗癌作用进行了综述。这些发现表明,研究埃及药用植物的生物活性抗癌成分对于推进更有效的抗癌新疗法具有很大的潜力。本文综述了这些药用植物的提取物和活性成分,为进一步开展临床试验,开发新的抗癌药物提供了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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