天然产品:对感音神经性听力损失的保护作用

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Wenqi Xu, Mao Huang, Minyan Liao, Shuangshuang Mao, Lei Yang, Rong Chen
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引用次数: 0

摘要

听力损失是世界上主要的公共健康问题之一,给个人和社会带来了巨大的负面影响。大多数听力损失都是由感音神经性听力损失(SNHL)引起的。导致感音神经性听力损失的机制包括活性氧过度积累、炎症因子过度激活、内耳血液微循环受损或 Ca2+ 平衡失调等。天然产物(NPs)在传统医学中的应用历史悠久,且具有良好的安全性,可开发成候选药物库,用于治疗或预防 SNHL。本文从抗凋亡、抗炎、改善微循环和钙拮抗剂作用等方面,总结了 24 种 NPs 对细胞和动物 SNHL 模型的预防或治疗作用,以及目前临床应用的 5 种 NPs。此外,还结合给药系统和网络药理学等先进技术,对 NPs 在预防 SNHL 方面的研究进行了深入探讨。总之,本综述为挖掘和开发预防和治疗SNHL的NPs提供了有力的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural products: protective effects against sensorineural hearing loss

Natural products: protective effects against sensorineural hearing loss

Hearing loss is one of the major public health problems in the world, which brings huge adverse effects to individuals and society. Sensorineural hearing loss (SNHL) is responsible for the majority of hearing loss. Mechanisms contributing to SNHL include excessive accumulation of reactive oxygen species; over-activation of inflammatory factors; impaired blood micro-circulation in the inner ear or Ca2+ homeostasis imbalance, etc. Natural products (NPs), which have a long history of use in traditional medicine and a favorable safety profile, can be developed into a library of drug candidates for the treatment or prevention of SNHL. In this paper, we summarized 24 NPs to exhibit their preventive or therapeutic effects on cellular and animal models of SNHL in terms of their anti-apoptotic, anti-inflammatory, microcirculation-improving, and calcium antagonist effects, as well as 5 NPs in current clinical application. Further, combination with advanced technologies such as drug delivery systems and network pharmacology are applied to improve the research of NPs in the prevention of SNHL. Overall, this review provides a strong reference for the mining and development of NPs in the prevention and treatment of SNHL.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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