Wenqi Xu, Mao Huang, Minyan Liao, Shuangshuang Mao, Lei Yang, Rong Chen
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Natural products: protective effects against sensorineural hearing loss
Hearing loss is one of the major public health problems in the world, which brings huge adverse effects to individuals and society. Sensorineural hearing loss (SNHL) is responsible for the majority of hearing loss. Mechanisms contributing to SNHL include excessive accumulation of reactive oxygen species; over-activation of inflammatory factors; impaired blood micro-circulation in the inner ear or Ca2+ homeostasis imbalance, etc. Natural products (NPs), which have a long history of use in traditional medicine and a favorable safety profile, can be developed into a library of drug candidates for the treatment or prevention of SNHL. In this paper, we summarized 24 NPs to exhibit their preventive or therapeutic effects on cellular and animal models of SNHL in terms of their anti-apoptotic, anti-inflammatory, microcirculation-improving, and calcium antagonist effects, as well as 5 NPs in current clinical application. Further, combination with advanced technologies such as drug delivery systems and network pharmacology are applied to improve the research of NPs in the prevention of SNHL. Overall, this review provides a strong reference for the mining and development of NPs in the prevention and treatment of SNHL.
期刊介绍：
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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