Clerodendrum inerme (L.) Gaertn.:传统用途、植物化学、药理和毒性方面的最新进展综述

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Manabendu Barman, Anuva Barman, Sanjib Ray
{"title":"Clerodendrum inerme (L.) Gaertn.:传统用途、植物化学、药理和毒性方面的最新进展综述","authors":"Manabendu Barman, Anuva Barman, Sanjib Ray","doi":"10.1007/s11101-024-09934-y","DOIUrl":null,"url":null,"abstract":"<p><i>Clerodendrum inerme</i> (L.) Gaertn., commonly known as garden quinine, is a perennial shrub that belongs to the <i>Lamiaceae</i> family. It has been extensively used in various traditional medicinal practices to treat ailments such as rheumatic pain, arthritis, scrofulous, venereal disease, skin diseases, wounds, fever, cough, dysentery, and more. This review aims to critically examine a comprehensive compilation of recent research on <i>C. inerme</i>, encompassing its botanical characteristics, ethnomedical applications, phytochemicals, pharmacological activity, and toxicological data, in order to provide insights and inspiration for future research, promote further development, and facilitate the rational application of <i>C. inerme.</i> Nearly 95 chemical constituents belonging to different classes have been isolated from <i>C. inerme</i>, including diterpenoids, triterpenoids, steroids, flavonoids, phenolic glycosides, lignans, iridoid and megastigmane glycosides. Notably, diterpenoids, triterpenoids, steroids, and flavonoids are the main bioactive substances that have been extensively studied and demonstrated the most significant bioactivity. Pharmacological studies demonstrated that the extract of <i>C. inerme</i> exhibits a wide range of biological activities, such as antioxidant, antimicrobial, anticancer, antiinflammatory, insecticidal, antifeedant, neuroprotective, anti-motor tic, and so on, which are closely connected to its numerous ethnomedicinal applications. Nevertheless, some literature have reported the toxicity of <i>C. inerme</i>. Therefore, it is imperative to conduct further in-depth studies encompassing toxicology, as well as preclinical and clinical research, to ascertain the safety and efficacy of <i>C. inerme</i> for medicinal purposes.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clerodendrum inerme (L.) Gaertn.: a critical review on current progress in traditional uses, phytochemistry, pharmacological aspects and toxicity\",\"authors\":\"Manabendu Barman, Anuva Barman, Sanjib Ray\",\"doi\":\"10.1007/s11101-024-09934-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><i>Clerodendrum inerme</i> (L.) Gaertn., commonly known as garden quinine, is a perennial shrub that belongs to the <i>Lamiaceae</i> family. It has been extensively used in various traditional medicinal practices to treat ailments such as rheumatic pain, arthritis, scrofulous, venereal disease, skin diseases, wounds, fever, cough, dysentery, and more. This review aims to critically examine a comprehensive compilation of recent research on <i>C. inerme</i>, encompassing its botanical characteristics, ethnomedical applications, phytochemicals, pharmacological activity, and toxicological data, in order to provide insights and inspiration for future research, promote further development, and facilitate the rational application of <i>C. inerme.</i> Nearly 95 chemical constituents belonging to different classes have been isolated from <i>C. inerme</i>, including diterpenoids, triterpenoids, steroids, flavonoids, phenolic glycosides, lignans, iridoid and megastigmane glycosides. Notably, diterpenoids, triterpenoids, steroids, and flavonoids are the main bioactive substances that have been extensively studied and demonstrated the most significant bioactivity. Pharmacological studies demonstrated that the extract of <i>C. inerme</i> exhibits a wide range of biological activities, such as antioxidant, antimicrobial, anticancer, antiinflammatory, insecticidal, antifeedant, neuroprotective, anti-motor tic, and so on, which are closely connected to its numerous ethnomedicinal applications. Nevertheless, some literature have reported the toxicity of <i>C. inerme</i>. Therefore, it is imperative to conduct further in-depth studies encompassing toxicology, as well as preclinical and clinical research, to ascertain the safety and efficacy of <i>C. inerme</i> for medicinal purposes.</p><h3 data-test=\\\"abstract-sub-heading\\\">Graphical abstract</h3>\\n\",\"PeriodicalId\":733,\"journal\":{\"name\":\"Phytochemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Reviews\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11101-024-09934-y\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11101-024-09934-y","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

Clerodendrum inerme (L.) Gaertn.俗称 "花园奎宁",是一种多年生灌木,属于唇形科。在各种传统医学中,它被广泛用于治疗风湿痛、关节炎、瘰疬、性病、皮肤病、伤口、发烧、咳嗽、痢疾等疾病。这篇综述旨在批判性地全面梳理近年来关于茵陈的研究,包括其植物学特征、民族医药应用、植物化学成分、药理活性和毒理学数据,以期为今后的研究提供见解和启发,促进茵陈的进一步开发和合理应用。目前已从茵陈中分离出近 95 种不同类别的化学成分,包括二萜类、三萜类、甾体类、黄酮类、酚苷类、木脂素类、鸢尾苷类和巨黄酮苷类。值得注意的是,二萜类、三萜类、甾体类和黄酮类是主要的生物活性物质,这些物质已被广泛研究,并被证明具有最显著的生物活性。药理学研究表明,C. inerme 的提取物具有广泛的生物活性,如抗氧化、抗菌、抗癌、抗炎、杀虫、抗辐射、神经保护、抗运动性抽搐等,这与其众多的民族医药应用密切相关。然而,一些文献报道了 C. inerme 的毒性。因此,必须进一步开展包括毒理学、临床前研究和临床研究在内的深入研究,以确定 C. inerme 的药用安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clerodendrum inerme (L.) Gaertn.: a critical review on current progress in traditional uses, phytochemistry, pharmacological aspects and toxicity

Clerodendrum inerme (L.) Gaertn., commonly known as garden quinine, is a perennial shrub that belongs to the Lamiaceae family. It has been extensively used in various traditional medicinal practices to treat ailments such as rheumatic pain, arthritis, scrofulous, venereal disease, skin diseases, wounds, fever, cough, dysentery, and more. This review aims to critically examine a comprehensive compilation of recent research on C. inerme, encompassing its botanical characteristics, ethnomedical applications, phytochemicals, pharmacological activity, and toxicological data, in order to provide insights and inspiration for future research, promote further development, and facilitate the rational application of C. inerme. Nearly 95 chemical constituents belonging to different classes have been isolated from C. inerme, including diterpenoids, triterpenoids, steroids, flavonoids, phenolic glycosides, lignans, iridoid and megastigmane glycosides. Notably, diterpenoids, triterpenoids, steroids, and flavonoids are the main bioactive substances that have been extensively studied and demonstrated the most significant bioactivity. Pharmacological studies demonstrated that the extract of C. inerme exhibits a wide range of biological activities, such as antioxidant, antimicrobial, anticancer, antiinflammatory, insecticidal, antifeedant, neuroprotective, anti-motor tic, and so on, which are closely connected to its numerous ethnomedicinal applications. Nevertheless, some literature have reported the toxicity of C. inerme. Therefore, it is imperative to conduct further in-depth studies encompassing toxicology, as well as preclinical and clinical research, to ascertain the safety and efficacy of C. inerme for medicinal purposes.

Graphical abstract

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信