Nidal Fahsi, Ismail Mahdi, Hassan Annaz, Gabin Thierry M. Bitchagno, Mona F. Mahmoud, Mansour Sobeh
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Unlocking the therapeutic potential of cinchonains: a comprehensive review
Cinchonains are a group of naturally occurring flavonolignans that exhibit a plethora of biological activities. This comprehensive review provides a critical analysis of the research on cinchonains and their related compounds, aiming to describe their various biological activities, including but not limited to, cytotoxicity, antioxidant, anti-inflammatory, antimicrobial, neuroprotective, antidiabetic, and anticancer activities. The occurrence and distribution of cinchonains in plants, their biosynthesis pathways, bioavailability, toxicity, and clinical investigations are also discussed. By synthesizing information from scientific literature, we present an informative and accessible overview of cinchonains' potential as a source of new therapeutics and highlight the importance of continued research on cinchonains and their related compounds to unlock their possible therapeutic merits.
期刊介绍：
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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