植物载体:输送抗癌草药的重要工具

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Kajal Chaudhary, Anjali Rajora
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引用次数: 0

摘要

植物体是一种类似于脂质体的特殊囊泡结构,将活性植物成分包裹在脂质核心内。许多植物成分(如苷类和类黄酮)具有亲水性,在穿越脂质细胞膜时会遇到困难。然而,植物载体的脂质核心增强了其穿越这些屏障的渗透性,从而提高了封闭植物成分的生物利用率和功效。癌症仍然是导致全球死亡的一个主要原因,给现有的治疗方法带来了巨大挑战,传统的治疗方法如手术、放疗和化疗往往会产生严重的副作用。在探索替代策略的过程中,利用草药活性化合物治疗癌症显示出与传统方法协同增效的巨大前景。虽然天然植物活性成分在体外显示出强大的药理活性,但它们在体内的吸收往往受到限制。为了解决这一制约因素,植物体作为一种新兴的纳米技术应运而生,它通过增强生物活性植物成分在富脂屏障内的适应性提供了一种解决方案。本研究对植物体的理化属性进行了荟萃分析,阐明了其结构的复杂性。此外,综述还讨论了植物体作为草药载体的优缺点,阐明了植物体专利技术和相关临床试验。此外,综述还研究了几种基于植物体、具有显著抗癌特性的草药成分。最后,综述探讨了在癌症治疗中使用植物体所面临的挑战和潜在的未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Phytosomes: a critical tool for delivery of herbal drugs for cancer

Phytosomes: a critical tool for delivery of herbal drugs for cancer

Phytosomes represent specialized vesicular structures akin to liposomes, encapsulating active phytoconstituents within a lipid core. Many phytoconstituents, such as glycosides and flavonoids, exhibit hydrophilic properties and encounter challenges traversing lipid-based cellular membranes. Nevertheless, the lipid core of phytosomes enhances their permeability across these barriers, thereby augmenting the bioavailability and efficacy of enclosed plant components. Cancer remains a prominent global cause of mortality, posing significant challenges for existing treatments, which often entail serious side effects associated with conventional approaches like surgery, radiation therapy, and chemotherapy. In exploring alternative strategies, the utilization of herbal active compounds in cancer treatment shows considerable promise in synergizing with conventional methods. While natural plant-derived active components demonstrate robust in vitro pharmacological activity, their in vivo absorption is often limited. Addressing this constraint, phytosomes emerge as a burgeoning nanotechnology offering a solution by enhancing the adaptability of bioactive phytoconstituents within lipid-rich barriers. This study delves into a meta-analysis of the physicochemical attributes of phytosomes, elucidating their structural intricacies. Furthermore, the review discusses the advantages and disadvantages of phytosomes as carriers for herbal drugs, shedding light on patented phytosome technologies and associated clinical trials. Additionally, it examines several prominent phytosome-based herbal constituents showcasing notable anticancer properties. Lastly, the review addresses the challenges and potential future directions regarding the use of phytosomes in cancer therapy.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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