Lycorine as a lead molecule in the treatment of cancer and strategies for its biosynthesis using the in vitro culture technique

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Saikat Sena, Harmeet Kaur, Vijay Kumar
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Abstract

Medicinal plants are used by many of the global population because they are safe and effective alternative to other treatments. Over the last few decades, using plant cells to produce natural or recombinant chemicals of economic interest has become a great intention. Secondary metabolites are recognized to have a significant role in plant adaptation to their environment and are also a valuable source of medication. The increasing economic importance of secondary metabolites has recently sparked a lot of interest in biotransformation, particularly in using tissue culture techniques to modify the production of bioactive plant metabolites. Plants of the family Amaryllidaceae have been used to extract several different alkaloids, each of which has the potential to be involved in a variety of pharmacological processes. Due to its multiple biological functions and divergent structure, lycorine has received significant interest in the medicinal field. Lycorine and other alkaloids from the Amaryllidaceae family have limited bioavailability by nature. In vitro culture provides an alternate method for producing lycorine sustainably due to the pharmaceutical industries dramatically increasing demand for it and the insufficient availability of natural resources. Many medicinal plants have been reported to produce lycorine in vitro in plant cell suspension cultures, and bioreactors play an effective role in their commercial production. This article focuses on the production of lycorine in in vitro systems from plants and its potential in the treatment of cancer. This study also aims to provide different biotechnological strategies for the production of this important alkaloid using in vitro system.

Abstract Image

作为治疗癌症先导分子的番茄红素及其利用体外培养技术进行生物合成的策略
药用植物是安全有效的替代疗法,因此被全球许多人所使用。在过去几十年中,利用植物细胞生产具有经济价值的天然或重组化学物质已成为人们的一大意图。次生代谢物被认为在植物适应环境方面发挥着重要作用,同时也是一种宝贵的药物来源。次生代谢物的经济重要性与日俱增,最近引发了人们对生物转化的浓厚兴趣,特别是利用组织培养技术改造生物活性植物代谢物的生产。天南星科植物被用来提取多种生物碱,每种生物碱都有可能参与多种药理过程。由于具有多种生物功能和不同的结构,番荔枝碱在医药领域受到了极大的关注。番荔枝碱和其他来自金盏花科的生物碱在自然界中的生物利用度有限。由于制药业对番茄红素的需求急剧增加,而自然资源又不足,因此体外培养为可持续生产番茄红素提供了另一种方法。据报道,许多药用植物都能通过植物细胞悬浮培养体外生产番茄红素,生物反应器在其商业化生产中发挥了有效作用。本文主要介绍在体外系统中利用植物生产番茄红素及其在治疗癌症方面的潜力。本研究还旨在为利用体外系统生产这种重要生物碱提供不同的生物技术策略。
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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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