Advanced biology最新文献_第4页

Enhanced BMP Signaling Alters Human β-Cell Identity and Function. 增强的BMP信号改变了人类β细胞的特性和功能

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-11-05 DOI: 10.1002/adbi.202400470

Esmée Dekker, Javier Triñanes, Amadeo Muñoz Garcia, Natascha de Graaf, Eelco de Koning, Françoise Carlotti

{"title":"Enhanced BMP Signaling Alters Human β-Cell Identity and Function.","authors":"Esmée Dekker, Javier Triñanes, Amadeo Muñoz Garcia, Natascha de Graaf, Eelco de Koning, Françoise Carlotti","doi":"10.1002/adbi.202400470","DOIUrl":"https://doi.org/10.1002/adbi.202400470","url":null,"abstract":"Inflammation contributes to the pathophysiology of diabetes. Identifying signaling pathways involved in pancreatic β-cell failure and identity loss can give insight into novel potential treatment strategies to prevent the loss of functional β-cell mass in diabetes. It is reported earlier that the immunosuppressive drug tacrolimus has a detrimental effect on human β-cell identity and function by activating bone morphogenetic protein (BMP) signaling. Here it is hypothesized that enhanced BMP signaling plays a role in inflammation-induced β-cell failure. Single-cell transcriptomics analyses of primary human islets reveal that IL-1β+IFNγ and IFNα treatment activated BMP signaling in β-cells. These findings are validated by qPCR. Furthermore, enhanced BMP signaling with recombinant BMP2 or 4 triggers a reduced expression of key β-cell maturity genes, associated with increased ER stress, and impaired β-cell function. Altogether, these results indicate that inflammation-activated BMP signaling is detrimental to pancreatic β-cells and that BMP-signaling can be a target to preserve β-cell identity and function in a pro-inflammatory environment.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400470"},"PeriodicalIF":3.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-12p70 Induces Neuroprotection via the PI3K-AKT-BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction. IL-12p70通过PI3K-AKT-BCL2轴诱导神经保护，介导电针对术后认知功能障碍的治疗效果

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-30 DOI: 10.1002/adbi.202400172

Tingting Huang, Jie Hong, Jia Ling, Lin Zhu, Wei Zhao, Xinlu Zhang, Xinze Yan, Chen Hu, Ruijie Zhang, Chen Gao, Shengzhao Zhang, Chen Chen, Runhuai Yang, Weiwei Wu, Chunhui Wang, Qian Gao

{"title":"IL-12p70 Induces Neuroprotection via the PI3K-AKT-BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction.","authors":"Tingting Huang, Jie Hong, Jia Ling, Lin Zhu, Wei Zhao, Xinlu Zhang, Xinze Yan, Chen Hu, Ruijie Zhang, Chen Gao, Shengzhao Zhang, Chen Chen, Runhuai Yang, Weiwei Wu, Chunhui Wang, Qian Gao","doi":"10.1002/adbi.202400172","DOIUrl":"https://doi.org/10.1002/adbi.202400172","url":null,"abstract":"Postoperative cognitive dysfunction (POCD), a postsurgical decline in cognitive function, primarily affects older adults and worsens their prognosis. Although elevated interleukin-12p70 (IL-12p70) is closely correlated with slower cognitive decline in older adults, its role in POCD remains unclear. Here, IL-12p70 is identified as a significant mediator of therapeutic effect of electroacupuncture (EA) on POCD. EA at acupoints ST36, GV20, and GV24 significantly enhanced cognitive behaviors of POCD mice. IL-12p70, downregulated in POCD mice but rescued by EA treatment, is the cytokine closely associated with EA's therapeutic effect. Clinically, IL-12p70 is downregulated in older adults' serum post-surgery. Furthermore, IL-12p70 exerts a potent neuroprotective effect in both neuronal cell lines and primary hippocampal neurons. The PI3K-AKT-BCL2 axis enriched by in silico analysis is validated as the signaling mechanism underlying IL-12p70-induced neuroprotection. In vivo, beneficial effects of EA treatment on the activation of PI3K-AKT-BCL2 axis and POCD are reproduced by IL-12p70 administration but attenuated by IL-12p70 knockdown. The findings reveal a novel mechanism underlying the therapeutic effect of EA on POCD, demonstrating that IL-12p70 exerts a neuroprotective effect by activating PI3K-AKT-BCL2 axis in hippocampal neurons. The newly-discovered function and mechanism of IL-12p70 highlight its potential in treating cognitive disorders.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400172"},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on Theoretical and Metrological Aspects of the Surface Hydrophobicity of Virus and Virus-Like Particles. 病毒和类病毒颗粒表面疏水性的理论和计量方面的最新情况。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-22 DOI: 10.1002/adbi.202400221

Guillaume Sautrey

{"title":"An Update on Theoretical and Metrological Aspects of the Surface Hydrophobicity of Virus and Virus-Like Particles.","authors":"Guillaume Sautrey","doi":"10.1002/adbi.202400221","DOIUrl":"https://doi.org/10.1002/adbi.202400221","url":null,"abstract":"Viruses are biological entities embodied in protein-based nanoparticles devoid of metabolic activity. Hence, the colloidal, interfacial, and chemical reactivity of virus particles (VPs) profoundly affects the fate of natural and artificial viruses in biotic or abiotic aqueous systems. These rely on the physical chemistry at the outer surface of VPs. In other words, whether wild or synthetic VPs and regardless of the scientific fields involved, taming viruses implies thus managing the physical chemistry at the VP external surface. The surface hydrophobicity (SH) of VPs is a critical feature that must be looked at. Still, the literature dealing with nanoscale hydrophobic domains at the proteinaceous surface of VPs underlying their global SH is like a fragmented puzzle. This article provides an overview of the topic from the perspective of modern protein biophysics for updating the classic physicochemical picture of outer VP/water interfaces hitherto accepted. Patterns of non-polar and \"false-polar\" patches, expressing variable hydrophobic degrees according to neighboring polar patches, are now drawn. The extensive discussion of reviewed data generates such fresh ideas to explore in the coming years for better modeling the SH of wild virions or engineered virus-based nanoparticles, paving the way for new directions in fundamental virology and virus-based chemistry.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400221"},"PeriodicalIF":3.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation. PAK4是小鼠卵母细胞在减数分裂成熟过程中恢复减数分裂、纺锤体组装和皮质迁移所必需的。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-22 DOI: 10.1002/adbi.202400307

Ke Song, Dandan Chen, Jingyu Li, Jiaqi Zhang, Ying Tian, Xiangning Xu, Bicheng Wang, Ziqi Huang, Shuo Lou, Jingyi Kang, Ningning Zhang, Xiaokui Yang, Wei Ma

{"title":"PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation.","authors":"Ke Song, Dandan Chen, Jingyu Li, Jiaqi Zhang, Ying Tian, Xiangning Xu, Bicheng Wang, Ziqi Huang, Shuo Lou, Jingyi Kang, Ningning Zhang, Xiaokui Yang, Wei Ma","doi":"10.1002/adbi.202400307","DOIUrl":"https://doi.org/10.1002/adbi.202400307","url":null,"abstract":"Oocyte meiotic errors can cause infertility, miscarriage, and birth defects. Here the role and the underlying mechanism of p21 activated kinase 4 (PAK4) in mouse oocyte meiosis is evaluated. It is found that PAK4 expression and its phosphorylation are detected in high level at germinal vesicle (GV) stage, and gradually decreased after meiotic resumption in oocytes. PAK4 has direct physical interaction with both mitogen-activated protein kinases 1/2 (MEK1/2) and Paxillin, they are colocalized on the spindle structure during metaphases I and II. Phospho-PAK4 is distributed beneath the cytoplasmic membrane and on the chromosomes, and colocalized with the microtubule organizing center (MTOC) proteins, Pericentrin and γ-tubulin, as well as phosphor-MEK1/2 and phosphor-Paxillin on spindle poles. PAK4 inhibition by chemical inhibitor LCH-7749944, specific Pak4 morpholino oligo or the dominant negative mutant Pak4K350, 351 M influence the meiotic resumption, spindle assembly and its cortical migration, and associated with the downregulation in the dephosphorylation of cyclin dependent kinase 1 (CDK1) and the levels of Cyclin B1, MEK1/2, Paxillin, g-tubulin, acetylated a-tubulin, Arp3, and Cofilin phosphorylation in oocytes. In sum, PAK4 functions to sustain the rational levels of Cyclin B1, MEK1/2, Paxillin, y-tubulin, acetylated a-tubulin, Arp3, and phosphor-Cofilin in mouse oocytes, thereby promotes the meiotic resumption, spindle assembly, and migration during meiotic maturation.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400307"},"PeriodicalIF":3.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the Supramolecular Interaction of Positively Supercharged Fluorescent Protein with Anionic Phthalocyanines. 阐明带正电荷的荧光蛋白与阴离子酞菁的超分子相互作用。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-16 DOI: 10.1002/adbi.202400308

Sharon Saarinen, Ramsha Khan, Marta Patrian, Juan Pablo Fuenzalida-Werner, Rubén D Costa, Petr Zimcik, Veronika Novakova, Tero-Petri Ruoko, Nikolai V Tkachenko, Eduardo Anaya-Plaza, Mauri A Kostiainen

{"title":"Elucidating the Supramolecular Interaction of Positively Supercharged Fluorescent Protein with Anionic Phthalocyanines.","authors":"Sharon Saarinen, Ramsha Khan, Marta Patrian, Juan Pablo Fuenzalida-Werner, Rubén D Costa, Petr Zimcik, Veronika Novakova, Tero-Petri Ruoko, Nikolai V Tkachenko, Eduardo Anaya-Plaza, Mauri A Kostiainen","doi":"10.1002/adbi.202400308","DOIUrl":"https://doi.org/10.1002/adbi.202400308","url":null,"abstract":"Developing bioinspired materials to convert sunlight into electricity efficiently is paramount for sustainable energy production. Fluorescent proteins are promising candidates as photoactive materials due to their high fluorescence quantum yield and absorption extinction coefficients in aqueous media. However, developing artificial bioinspired photosynthetic systems requires a detailed understanding of molecular interactions and energy transfer mechanisms in the required operating conditions. Here, the supramolecular self-assembly and photophysical properties of fluorescent proteins complexed with organic dyes are investigated in aqueous media. Supercharged mGreenLantern protein, mutated to have a charge of +22, is complexed together with anionic zinc phthalocyanines having 4 or 16 carboxylate groups. The structural characterization reveals a strong electrostatic interaction between the moieties, accompanied by partial conformational distortion of the protein structure, yet without compromising the mGreenLantern chromophore integrity as suggested by the lack of emission features related to the neutral form of the chromophore. The self-assembled biohybrid shows a total quenching of protein fluorescence, in favor of an energy transfer process from the protein to the phthalocyanine, as demonstrated by fluorescence lifetime and ultrafast transient absorption measurements. These results provide insight into the rich photophysics of fluorescent protein-dye complexes, anticipating their applicability as water-based photoactive materials.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400308"},"PeriodicalIF":3.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective Intervention Strategies Between Skeletal Muscle Health and Mitochondrial Changes During Aging. 老化过程中骨骼肌健康与线粒体变化之间的前瞻性干预策略。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-16 DOI: 10.1002/adbi.202400235

Xin Zhang, Suchan Liao, Lingling Huang, Jinhua Wang

{"title":"Prospective Intervention Strategies Between Skeletal Muscle Health and Mitochondrial Changes During Aging.","authors":"Xin Zhang, Suchan Liao, Lingling Huang, Jinhua Wang","doi":"10.1002/adbi.202400235","DOIUrl":"https://doi.org/10.1002/adbi.202400235","url":null,"abstract":"Sarcopenia is a geriatric condition characterized by a decrease in skeletal muscle mass and function, significantly impacting both quality of life and overall health. Mitochondria are the main sites of energy production within the cell, and also produce reactive oxygen species (ROS), which maintain mitochondrial homeostasis-mitophagy (clearing damaged mitochondria); mitochondrial dynamics, which involve fusion and fission to regulate mitochondrial morphology; mitochondrial biogenesis, which ensures the functionality and homeostasis of mitochondria. Sarcopenia is linked to mitochondrial dysfunction, suggesting that muscle mitochondrial function therapy should be investigated. Extrinsic therapies are extensively examined to identify new treatments for muscular illnesses including sarcopenia. Changes in muscle physiology and lifestyle interventions, such as pharmacological treatments and exercise, can modulate mitochondrial activity in older adults. This PubMed review encompasses the most significant mitophagy and sarcopenia research from the past five years. Animal models, cellular models, and human samples are well covered. The review will inform the development of novel mitochondria-targeted therapies aimed at combating age-related muscle atrophy.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400235"},"PeriodicalIF":3.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Anti-Inflammatory and Immunosuppressant Potential of Isotelekin in Lipopolysaccharide (LPS) Stimulated Macrophage (RAW 264.7) and Sheep Red Blood Cells (SRBC) Sensitized Murine Models. 评估异特勒金在脂多糖（LPS）刺激的巨噬细胞（RAW 264.7）和绵羊红细胞（SRBC）致敏小鼠模型中的抗炎和免疫抑制潜力。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-16 DOI: 10.1002/adbi.202400386

Irfan Qasam, Shah Nawaz, Hema Kumari, Narendra Chauhan, Yedukondalu Nalli, Govind Yadav

{"title":"Evaluation of Anti-Inflammatory and Immunosuppressant Potential of Isotelekin in Lipopolysaccharide (LPS) Stimulated Macrophage (RAW 264.7) and Sheep Red Blood Cells (SRBC) Sensitized Murine Models.","authors":"Irfan Qasam, Shah Nawaz, Hema Kumari, Narendra Chauhan, Yedukondalu Nalli, Govind Yadav","doi":"10.1002/adbi.202400386","DOIUrl":"https://doi.org/10.1002/adbi.202400386","url":null,"abstract":"The present study explored the natural compound Isotelekin isolated from Inula racemose against anti-inflammatory and immunomodulatory potential in LPS-induced RAW264.7 cell lines and immune-elevated SRBC-sensitized animal models. Isotelekin in in vitro studies, inhibited the production of Th-1 cytokines Interleukin-6 (IL-6), Tumour necrosis factor (TNF-α), and Interferon-gamma (INF-γ), and increased Th-2 cytokines Interleukin-10 (IL-10). Whereas it inhibited the nitrites and reactive oxygen species (ROS) production by mitigating the effect of LPS significantly. In vivo immunomodulatory activity in Delayed-type hypersensitivity (DTH) and Hemagglutinating antibody (HA), Isotelekin suppressed the cellular as well as humoral immunity in immune-affected and SRBC-sensitized mice. Isotelekin decreased the phagocytic responses against carbon particles and plaque-forming mainly IgG (Immunoglobulin G) production. Additionally, Isotelekin showed immunosuppressive potential through the evaluation of splenocytes, allograft acceptance, and haematological parameters. Molecular studies, including western blot analysis and immunocytochemistry, revealed that Isotelekin reduced the expression of iNOS (Inducible nitric oxide synthase), COX-2 (Cyclo-Oxygenase 2), and p-IkBα (Phospho I-kappa-B-alpha), and significantly inhibited the nuclear translocation of NF-κB/p65. Based on these results, Isotelekin at 10 µm in in vitro and at 30 mg kg-1 in in vivo demonstrated strong anti-inflammatory and immunosuppressive therapeutic potential.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400386"},"PeriodicalIF":3.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Proteomics Approaches for Screening Small Molecule Inhibitors Covalently Binding to SARS-Cov-2 筛选与 SARS-Cov-2 共价结合的小分子抑制剂的化学蛋白质组学方法。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-15 DOI: 10.1002/adbi.202300612

Liuhai Zheng, Qian Zhang, Piao Luo, Fei Shi, Ying Zhang, Xiaoxue He, Yehai An, Guangqing Cheng, Xiaoyan Pan, Zhijie Li, Boping Zhou, Jigang Wang

{"title":"Chemical Proteomics Approaches for Screening Small Molecule Inhibitors Covalently Binding to SARS-Cov-2","authors":"Liuhai Zheng, Qian Zhang, Piao Luo, Fei Shi, Ying Zhang, Xiaoxue He, Yehai An, Guangqing Cheng, Xiaoyan Pan, Zhijie Li, Boping Zhou, Jigang Wang","doi":"10.1002/adbi.202300612","DOIUrl":"10.1002/adbi.202300612","url":null,"abstract":"Although various strategies have been used to prevent and treat SARS-CoV-2, the spread and evolution of SARS-CoV-2 is still progressing rapidly. The emerging variants Omicron and its sublineage have a greater ability to spread and escape nearly all current monoclonal antibodies treatments, highlighting an urgent need to develop therapeutics targeting current and emerging Omicron variants or recombinants with breadth and potency. Here, some small molecule drugs are rapidly identified that could covalently binding to receptor binding domain (RBD) protein of Omicron through the combined application of artificial intelligence (AI) and activity-based protein profiling (ABPP) technology. The surface plasmon resonance (SPR) and pseudo-virus neutralization experiments further reveal that an FDA-approved drug gallic acid has robust neutralization potency against Omicron pseudo-virus with the IC50 values of 23.56 × 10−6 m. Taken together, a platform combining AI intelligence, biochemical, SPR, molecular docking, and pseudo-virus-based screening for rapid identification and evaluation of potential anti-SARS-CoV-2 small molecule drugs is established and the effectiveness of the platform is validated.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead: (Adv. Biology 10/2024) 刊头：（Adv. Biology 10/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-13 DOI: 10.1002/adbi.202470102

引用次数: 0

Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro (Adv. Biology 10/2024) 磁响应同轴纤维传递 TGFβ3 可降低体外脊髓星形胶质细胞的反应性（生物学进展 10/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-10-13 DOI: 10.1002/adbi.202470101

Jessica L. Funnell, Jasper Fougere, Diana Zahn, Silvio Dutz, Ryan J. Gilbert

{"title":"Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro (Adv. Biology 10/2024)","authors":"Jessica L. Funnell, Jasper Fougere, Diana Zahn, Silvio Dutz, Ryan J. Gilbert","doi":"10.1002/adbi.202470101","DOIUrl":"https://doi.org/10.1002/adbi.202470101","url":null,"abstract":"Drug DeliverySpinal cord injury (SCI) is a devastating condition that severely impacts patient quality of life, and there are no available treatments that restore lost function. Biomaterials can provide local, sustained release of therapeutics, but drug-releasing biomaterials do not address variability in injury severity. To tune delivery to a unique injury, Ryan J. Gilbert and co-workers developed a fibrous scaffold that can be stimulated with a magnetic field to alter the release rate of a growth factor. The authors found that sustained release of the growth factor resulted in a greater reduction of spinal cord astrocyte reactivity compared to bolus delivery in vitro. The astrocytes treated with the drug-releasing scaffold supported sensory neuron growth in coculture, shown in the flourescence image. Article number 2300531 provides a foundation for developing biomaterials capable of tunable growth factor release in response to externally applied magnetic fields for SCI treatment.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 10","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0