Advanced biology最新文献_第4页

o⁸G-miR-6513-5p/BCL2L13 Axis Regulates Mitophagy during Oxidative Stress in the Human Saphenous Vein Endothelial Cells. o8G-miR-6513-5p/BCL2L13 轴调控人隐静脉内皮细胞在氧化应激过程中的有丝分裂。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-09-22 DOI: 10.1002/adbi.202400218

Hao Jia, Le Kang, Ben Huang, Shuyang Lu, Zhiwen Ding, Zhenhang Chen, Chunsheng Wang, Jiangping Song, Yunzeng Zou, Yongxin Sun

引用次数: 0

Adipogenic-Myogenic Signaling in Engineered Human Muscle Grafts used to Treat Volumetric Muscle Loss. 用于治疗体积性肌肉缺失的人造肌肉移植物中的成脂-成肌信号传导。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-09-18 DOI: 10.1002/adbi.202400113

Dallas E Altamirano, Eszter Mihaly, Jalissa D Emmens, Warren L Grayson

{"title":"Adipogenic-Myogenic Signaling in Engineered Human Muscle Grafts used to Treat Volumetric Muscle Loss.","authors":"Dallas E Altamirano, Eszter Mihaly, Jalissa D Emmens, Warren L Grayson","doi":"10.1002/adbi.202400113","DOIUrl":"https://doi.org/10.1002/adbi.202400113","url":null,"abstract":"Tissue-engineered muscle grafts (TEMGs) are a promising treatment for volumetric muscle loss (VML). In this study, human myogenic progenitors (hMPs) cultured on electrospun fibrin microfiber bundles and evaluated the therapeutic potential of engineered hMP TEMGs in the treatment of murine tibialis anterior (TA) VML injuries is employed. In vitro, the hMP TEMGs express mature muscle markers by 21 days. Upon implantation into VML injuries, the hMP TEMGs enable remarkable regeneration. To further promote wound healing and myogenesis, human adipose-derived stem/stromal cells (hASCs) as fibroadipogenic progenitor (FAP)-like cells with the potential to secrete pro-regenerative cytokines are incorporated. The impact of dose and timing of seeding the hASCs on in vitro myogenesis and VML recovery using hMP-hASC TEMGs are investigated. The hASCs increase myogenesis of hMPs when co-cultured at 5% hASCs: 95% hMPs and with delayed seeding. Upon implantation into immunocompromised mice, hMP-hASC TEMGs increase cell survival, collagen IV deposition, and pro-regenerative macrophage recruitment, but result in excessive adipose tissue growth after 28 days. These data demonstrate the interactions of hASCs and hMPs enhance myogenesis in vitro but there remains a need to optimize treatments to minimize adipogenesis and promote full therapeutic recovery following VML treatment.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties (Adv. Biology 9/2024) 乳腺肿瘤细胞在类脑细胞外基质中的存活和形态取决于基质成分和机械特性（生物学进展 9/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-09-15 DOI: 10.1002/adbi.202470091

Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Selma J. Padilla Padilla, Nicoletta Murenu, Philipp Stahlhut, Gregor Lang, Zan Lamberger, Jeanette Weigelt, Natascha Schaefer, Jörg Tessmar, Pamela L. Strissel, Torsten Blunk, Silvia Budday, Reiner Strick, Carmen Villmann

{"title":"Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties (Adv. Biology 9/2024)","authors":"Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Selma J. Padilla Padilla, Nicoletta Murenu, Philipp Stahlhut, Gregor Lang, Zan Lamberger, Jeanette Weigelt, Natascha Schaefer, Jörg Tessmar, Pamela L. Strissel, Torsten Blunk, Silvia Budday, Reiner Strick, Carmen Villmann","doi":"10.1002/adbi.202470091","DOIUrl":"https://doi.org/10.1002/adbi.202470091","url":null,"abstract":"Breast Tumor CellsTriple-negative breast cancer (TNBC) is the most invasive type of breast cancer with a high risk of brain metastasis. In article number 2400184, Carmen Villmann and co-workers systematically set up a 3D cellular system to study TNBC in a biomimetic brain surrounding in terms of cell–cell and cell–matrix interactions. 3D disease model for breast tumor cells (green) attached to collagen (red, confocal image) grown in thiolated hyaluronic acid-based hydrogel (background image black). Icons represent MEW PCL scaffolds, PEGAcr crosslinker, different extracellular matrix (ECM) proteins (collagen, fibronectin, laminin). ECM supplementation is the key regulator of cellular morphology behaviour and survival. The original confocal image was modified using an art filter.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead: (Adv. Biology 9/2024) 刊头：（高级生物学 9/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-09-15 DOI: 10.1002/adbi.202470092

引用次数: 0

Innate Immune Response and Epigenetic Regulation: A Closely Intertwined Tale in Inflammation. 先天免疫反应与表观遗传调控：炎症中紧密交织的故事。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-09-12 DOI: 10.1002/adbi.202400278

Diksha Jawale, Shweta Khandibharad, Shailza Singh

{"title":"Innate Immune Response and Epigenetic Regulation: A Closely Intertwined Tale in Inflammation.","authors":"Diksha Jawale, Shweta Khandibharad, Shailza Singh","doi":"10.1002/adbi.202400278","DOIUrl":"https://doi.org/10.1002/adbi.202400278","url":null,"abstract":"Maintenance of delicate homeostasis is very important in various diseases because it ensures appropriate immune surveillance against pathogens and prevents excessive inflammation. In a disturbed homeostatic condition, hyperactivation of immune cells takes place and interplay between these cells triggers a plethora of signaling pathways, releasing various pro-inflammatory cytokines such as Tumor necrosis factor alpha (TNFα), Interferon-gamma (IFNƴ), Interleukin-6 (IL-6), and Interleukin-1 beta (IL-1β), which marks cytokine storm formation. To be precise, dysregulated balance can impede or increase susceptibility to various pathogens. Pathogens have the ability to hijack the host immune system by interfering with the host's chromatin architecture for their survival and replication in the host cell. Cytokines, particularly IL-6, Interleukin-17 (IL-17), and Interleukin-23 (IL-23), play a key role in orchestrating innate immune responses and shaping adaptive immunity. Understanding the interplay between immune response and the role of epigenetic modification to maintain immune homeostasis and the structural aspects of IL-6, IL-17, and IL-23 can be illuminating for a novel therapeutic regimen to treat various infectious diseases. In this review, the light is shed on how the orchestration of epigenetic regulation facilitates immune homeostasis.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Coding RNA in Schwann Cell and Peripheral Nerve Injury: A Review. 许旺细胞和周围神经损伤中的非编码 RNA：综述。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-26 DOI: 10.1002/adbi.202400357

Li-Xin Huang, Tao Sun, Jun Sun, Zhi-Min Wu, Cong Ling, Bao-Yu Zhang, Chuan Chen, Hui Wang

引用次数: 0

"Society Isn't Designed for Us to Win": Trauma and Sexual Healthcare Experiences Among Transgender Women in the Southeastern United States. "社会不是为我们赢而设计的"：美国东南部变性妇女的创伤和性保健经历。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-26 DOI: 10.1002/adbi.202400200

Olivia T Van Gerwen, Christina A Muzny, Bulent Turan, Krishmita Siwakoti, D Scott Batey

{"title":"\"Society Isn't Designed for Us to Win\": Trauma and Sexual Healthcare Experiences Among Transgender Women in the Southeastern United States.","authors":"Olivia T Van Gerwen, Christina A Muzny, Bulent Turan, Krishmita Siwakoti, D Scott Batey","doi":"10.1002/adbi.202400200","DOIUrl":"https://doi.org/10.1002/adbi.202400200","url":null,"abstract":"Transgender women (TGW) are disproportionately affected by sexually transmitted infections (STIs). Experienced trauma threatens TGW's commitment to sexual healthcare. Trauma-informed approaches to sexual healthcare can improve engagement. This study aimed to characterize the trauma experienced by TGW in the Southeastern US, especially related to sexual health. TGW completed in-depth individual interviews guided by the Modified Social Ecological Model (MSEM) and Minority Stress framework. Interviews explored the nature of trauma, sexual health, and their intersection in TGW's lives, and a thematic analysis was performed. Between August 2022 and January 2023, 13 TGW enrolled (69% Black, 31% White). Mental illness was common (77%). Five participants (38%) were HIV+, and seven (54%) reported lifetime STI history. Themes reflected societal (barriers to healthcare, anti-transgender legislation), community (misgendering/deadnaming), network (limited support), and individual (dysphoria, sex work, fear for physical safety, stigma, mental health conditions, race) stressors. The physical/sexual violence and resilience themes pervaded all stressor levels. Medical mistrust was exacerbated by past traumatic experiences within sexual healthcare settings. Resilience and transgender representation in healthcare settings were protective. Various experienced traumas and their cumulative effects were pervasive in the daily lives of TGW. Development of targeted interventions to improve sexual health engagement of TGW must optimize personal strengths and provide holistic support.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectrical Impedance Vectors Analysis of Sarcopenic Older Adults Submitted to a Resistance Training Program. 参加阻力训练计划的肌肉疏松老年人的生物电阻抗向量分析。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-20 DOI: 10.1002/adbi.202400276

Giovanni Henrique Quizzini, Caroline Galan de Souza Pereira, Vanessa Ribeiro Dos Santos, Vitor Cabrera Batista, Bruna Spolador de Alencar Silva, Fábio Santos Lira, Alex Silva Ribeiro, Luís Alberto Gobbo

{"title":"Bioelectrical Impedance Vectors Analysis of Sarcopenic Older Adults Submitted to a Resistance Training Program.","authors":"Giovanni Henrique Quizzini, Caroline Galan de Souza Pereira, Vanessa Ribeiro Dos Santos, Vitor Cabrera Batista, Bruna Spolador de Alencar Silva, Fábio Santos Lira, Alex Silva Ribeiro, Luís Alberto Gobbo","doi":"10.1002/adbi.202400276","DOIUrl":"https://doi.org/10.1002/adbi.202400276","url":null,"abstract":"The objective of the present study is to analyze the changes in bioimpedance vector analysis (BIVA) and phase angle (PhA) in sarcopenic older people submitted to a 12-week resistance training (RT) program according to classic and specific analyses. To this end, 20 sarcopenic older adults of both sexes, invited through media, underwent bioimpedance analysis before and after the RT carried out three times a week, for 12 weeks. The mean impedance vectors of the groups established for the confidence ellipses (95% of the confidence ellipse) are compared using Hotelling's T2 test. The distance D from Mahalanobis is also calculated. Classic and Specific BIVA are presented. The resistance values for the classical analyses (R/H) decreased across all groups (whole group, women and men, p < 0.05), with approximate decreases ranging from 9.4% to 10%, while the classic reactance (Xc/H) decreased (p < 0.05) only for the whole group (5.9%) and men (7.7%). For the specific BIVA, trends are verified for the whole sample, with a decrease in resistance (R.sp) and an increase in reactance (Xc.sp). In conclusion, the RT program in sarcopenic individuals promoted a reduction in resistance values in classical analyses, indicating a possible increase in hydration status and, consequently, musculoskeletal mass.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Clinical-Grade Partially Decellularized Matrix for Tracheal Replacement: Validation In Vitro and In Vivo in a Porcine Model. 用于气管置换的临床级部分脱细胞基质：猪模型体内外验证

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-20 DOI: 10.1002/adbi.202400208

Lousineh Arakelian, Maëlys Léger, Sabrina Kellouche, Rémy Agniel, Patrick Bruneval, Jean Marc Allain, Valentino Caputo, Nicolas Gendron, Romane Gozlan, Rezlene Bargui, Augustin Vigouroux, Caroline Sansac, Mohamed Jarraya, Françoise Denoyelle, Jérôme Larghero, Briac Thierry

{"title":"A Clinical-Grade Partially Decellularized Matrix for Tracheal Replacement: Validation In Vitro and In Vivo in a Porcine Model.","authors":"Lousineh Arakelian, Maëlys Léger, Sabrina Kellouche, Rémy Agniel, Patrick Bruneval, Jean Marc Allain, Valentino Caputo, Nicolas Gendron, Romane Gozlan, Rezlene Bargui, Augustin Vigouroux, Caroline Sansac, Mohamed Jarraya, Françoise Denoyelle, Jérôme Larghero, Briac Thierry","doi":"10.1002/adbi.202400208","DOIUrl":"https://doi.org/10.1002/adbi.202400208","url":null,"abstract":"The management of extensive tracheal resection followed by circumferential replacement remains a surgical challenge. Numerous techniques are proposed with mixed results. Partial decellularization of the trachea with the removal of the mucosal and submucosal cells is a promising method, reducing immunogenicity while preserving the biomechanical properties of the final matrix. Despite many research protocols and proofs of concept, no standardized clinical grade protocol is described. Furthermore, local and systemic biointegration mechanisms of decellularized trachea are not well known. Therefore, in a translational research perspective, this work set up a partial tracheal decellularization protocol in line with Cell and Tissue Products regulations. Extensive characterization of the final product is performed in vitro and in vivo. The results show that the Partially Decellularized Trachea (PDT) is cell-free in the mucosa and submucosa, while the cartilage structure is preserved, maintaining the biomechanical properties of the trachea. When implanted in the muscle in vivo for 28 days, no systemic inflammation is observed, and locally, the PDT shows an excellent biointegration and vascularization. No signs of graft rejection are observed. These encouraging results confirmed the efficacy of the clinical grade PDT production protocol, which is an important step for future clinical applications.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microphysiological Systems (MPS) for Precision Medicine (Adv. Biology 8/2024) 用于精准医疗的微观生理学系统（MPS）（生物学高级课程 8/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-16 DOI: 10.1002/adbi.202470081

Monty Montano, Venkataramana Sidhaye, Martin Trapecar, Deok-Ho Kim

引用次数: 0