{"title":"Application of Immune Repertoire Analysis in Differentiating Thyroid Cancer and Large Benign Thyroid Nodules (Adv. Biology 7/2025)","authors":"Jun Zhu, Xu Zhang, Xiangqing Zhu, Ziran Gao, Zhong Ni, Tiancheng Zhang, Meijin Huang","doi":"10.1002/adbi.70027","DOIUrl":null,"url":null,"abstract":"<p><b>Application of Immune Repertoire Analysis</b></p><p>This study analyzes peripheral TCR/BCR profiles in early thyroid cancer (PTC), large benign nodules, and healthy controls. Enhanced antigen-driven clonal expansion and disease-specific “public” clonotypes with unique V-J rearrangements were identified, linked to thyroid hormones/autoantibodies. Findings provide insights into immunopathological mechanisms, highlighting adaptive immune dynamics in thyroid disorders. More details can be found in article number 2400760 by Zhong Ni, Tiancheng Zhang, Meijin Huang, and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 7","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.70027","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced biology","FirstCategoryId":"99","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.70027","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
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Abstract
Application of Immune Repertoire Analysis
This study analyzes peripheral TCR/BCR profiles in early thyroid cancer (PTC), large benign nodules, and healthy controls. Enhanced antigen-driven clonal expansion and disease-specific “public” clonotypes with unique V-J rearrangements were identified, linked to thyroid hormones/autoantibodies. Findings provide insights into immunopathological mechanisms, highlighting adaptive immune dynamics in thyroid disorders. More details can be found in article number 2400760 by Zhong Ni, Tiancheng Zhang, Meijin Huang, and co-workers.
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