Advanced biology最新文献

Amide-Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non-Small Cell Lung Adenocarcinoma. 酰胺连接局部麻醉剂改变非小细胞肺腺癌复杂人体组织模型的肿瘤生物学。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-30 DOI: 10.1002/adbi.202500280

Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta-Carolin Pietsch, Sebastian N Stehr, Sonja Kallendrusch, Tobias Piegeler

{"title":"Amide-Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non-Small Cell Lung Adenocarcinoma.","authors":"Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta-Carolin Pietsch, Sebastian N Stehr, Sonja Kallendrusch, Tobias Piegeler","doi":"10.1002/adbi.202500280","DOIUrl":"https://doi.org/10.1002/adbi.202500280","url":null,"abstract":"Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti-inflammatory properties. However, a translation into clinical evidence is still lacking. Here, effects of LA at clinically relevant concentrations are assessed using a human ex vivo tumor model of patient-derived tumor slice cultures from nine patients with non-small cell lung cancer. Tumors are cultivated for four days and treated with LA in absence/presence of cisplatin. Tumor cell proliferation and apoptosis as well as expression of intercellular adhesion molecule-1 and macrophage polarization are assessed using immunofluorescent imaging. Tumor specimens are considered to be \"Responders\", when a change in proliferation and/or apoptosis by >50% compared to untreated slices occurred. Five of nine samples are \"Responders\", in which the LA exerted effects comparable to cisplatin. Even at clinically relevant concentrations of LA, a strong anti-tumoral effect is observable in patient-derived tumor slice cultures with complex structures of the tumor microenvironment highlighting the LA effect on the tumor itself and its surroundings, without any interference by other leukocytes or neuronal stimulation. The diverse reaction to LA treatment also emphasizes the importance of biomarkers to determine the tumor phenotypes, which may benefit from LA treatment.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00280"},"PeriodicalIF":2.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qianlie Xiaozheng Formula Inhibits Prostate Cancer via the STING/TBK1/IRF3 Pathway by Suppressing CHK1. 千烈消正方通过抑制CHK1通过STING/TBK1/IRF3途径抑制前列腺癌

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-30 DOI: 10.1002/adbi.202500246

Xing Zhang, Guanghui Yuan, Yun Chen, Yan Xu, Tao Liu, Qi Zhao, Shengwei Li

{"title":"Qianlie Xiaozheng Formula Inhibits Prostate Cancer via the STING/TBK1/IRF3 Pathway by Suppressing CHK1.","authors":"Xing Zhang, Guanghui Yuan, Yun Chen, Yan Xu, Tao Liu, Qi Zhao, Shengwei Li","doi":"10.1002/adbi.202500246","DOIUrl":"https://doi.org/10.1002/adbi.202500246","url":null,"abstract":"Qianlie Xiaozheng formula (QLXZF), a multi-herbal TCM prescription, has demonstrated clinical efficacy against prostate cancer (PCa), but its immunomodulatory mechanisms remain elusive. This study aims to explore the molecular mechanisms of QLXZF's inhibitory effects on PCa. Tumor-bearing mouse model and an RM-1 tumor cell model co-cultured with CD8T cells are treated with QLXZF. Mechanistic studies integrated in vivo imaging, IHC, WB, and genetic interventions (CHK1 overexpression). In the mouse model, QLXZF dose-dependently suppressed tumor growth (p<.01) without visceral toxicity. Immunofluorescence experiments showed QLXZF treatment has decreased the expression of CHK1, increased γH2AX foci formation. Western blot experiments confirmed an increase in pSTING/STING, pTBK1/TBK1, and pIRF3/IRF3 ratio. Additionally, the use of QLXZF increased the levels of CCL5 and CXCL10. In vitro cell experiments showed results consistent with those in the in vivo model. Further studies indicated that overexpression of CHK1 abolished the suppressive effects of QLXZF on prostate cancer cells. The study suggests that QLXZF may inhibit CHK1 expression, induce DNA image accumulation, and activate the STING/TBK1/IRF3 pathway to promote CD8+T cell recruitment. These findings provide a new mechanistic basis for the application of QLXZF in the treatment of PCa.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00246"},"PeriodicalIF":2.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glaucocalyxin A Induces Cytotoxicity in Renal Cancer Cells via ROS-Mediated Autophagy by Direct Targeting of Antioxidant Enzymes PRDX1 and PRDX2. 青萼藻素A直接靶向抗氧化酶PRDX1和PRDX2，通过ros介导的自噬诱导肾癌细胞毒性

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-30 DOI: 10.1002/adbi.202500031

Yaping Niu, Jinhuan Ou, Xiaoru Zhong, Piao Luo, Junhui Chen, Ashok Iyaswamy, Haibo Tong, Zhou Zhu, Peng Chen, Xu Wei, Wei Zhang, Hualin Ma, Yulin Feng, Chuanbin Yang, Jigang Wang

{"title":"Glaucocalyxin A Induces Cytotoxicity in Renal Cancer Cells via ROS-Mediated Autophagy by Direct Targeting of Antioxidant Enzymes PRDX1 and PRDX2.","authors":"Yaping Niu, Jinhuan Ou, Xiaoru Zhong, Piao Luo, Junhui Chen, Ashok Iyaswamy, Haibo Tong, Zhou Zhu, Peng Chen, Xu Wei, Wei Zhang, Hualin Ma, Yulin Feng, Chuanbin Yang, Jigang Wang","doi":"10.1002/adbi.202500031","DOIUrl":"https://doi.org/10.1002/adbi.202500031","url":null,"abstract":"Glaucocalyxin A (GLA), a bioactive diterpenoid from the medicinal plant Rabdosia japonica, demonstrates potent antitumor activity, yet its molecular mechanisms in renal cell carcinoma (RCC) remain elusive. Here, GLA is reported to trigger cytotoxicity in RCC cells through reactive oxygen species (ROS) overaccumulation. Mechanistically, ROS surge activates autophagy, and pharmacological or genetic autophagy inhibition significantly rescues GLA-induced cell death, indicating autophagy acts as a pro-death effector in this context. Employing activity-based protein profiling (ABPP) coupled with proteomic analysis, peroxiredoxins PRDX1/2 are identified as direct covalent targets of GLA. Functional validation reveals that PRDX1/2 overexpression mitigates GLA-mediated apoptosis, establishing their role as critical redox sensors governing cell fate. The findings delineate a ROS-autophagy-apoptosis axis driven by PRDX1/2 targeting, positioning GLA as a novel therapeutic scaffold for RCC treatment.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00031"},"PeriodicalIF":2.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

snoRNP RRP9 Promotes Prostate Cancer Cell Proliferation and Migration via SQSTM1. snoRNP RRP9通过SQSTM1促进前列腺癌细胞增殖和迁移

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-24 DOI: 10.1002/adbi.202500182

Butang Li, Lihui Shen, Hui Huang, Kai Shen, Xiaorong Wu, Chenfei Chi, Jiahua Pan

{"title":"snoRNP RRP9 Promotes Prostate Cancer Cell Proliferation and Migration via SQSTM1.","authors":"Butang Li, Lihui Shen, Hui Huang, Kai Shen, Xiaorong Wu, Chenfei Chi, Jiahua Pan","doi":"10.1002/adbi.202500182","DOIUrl":"https://doi.org/10.1002/adbi.202500182","url":null,"abstract":"Small nucleolar RNAs (snoRNAs)-60-300 nucleotide non-coding RNAs are associated with adverse clinical outcomes in cancer patients. However, information on the role of snoRNAs and associated small nuclear ribonucleoprotein (snoRNPs) in prostate cancer (PCa) remains scarce. Here, the contribution of the snoRNP U3 snoRNA-interacting protein 2 (RRP9) in PCa pathogenesis is investigated. A combination of three different shRNAs is employed to knockdown RRP9 in the PCa cell lines DU-145 and PC-3. Cell proliferation is evaluated by seeding cells into a 96-well plates and monitoring daily. Cell migration is evaluated by scratch and Transwell assays. FLAG-RRP9 pull-down, MALDI-TOF/TOF, and co-immunoprecipitation assays are conducted to identify RRP9 binding partners in DU-145 cells. In vitro cell proliferation and migration, as well as in vivo tumor growth, are suppressed following RRP9 knockdown. Pull-down and MALDI-TOF/TOF analyses identified five putative RRP9 binding partners, and co-immunoprecipitation validated that RRP9 interacts with the scaffolding hub protein Sequestome-1 (SQSTM1, p62). Interestingly, SQSTM1 overexpression rescued the anti-growth/migration effects of RRP9 knockdown. This study unveiled a novel oncogenic role for the RRP9-SQSTM1 axis in PCa cells. RRP9 is a snoRNP that binds to SQSTM1, thereby promoting PCa cell proliferation and migration. Targeting the RRP9-SQSTM1 axis may be a viable therapeutic strategy for PCa.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00182"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPARγ. SOX4通过与EBF2和PPARγ的独立复合物调节棕色脂肪组织的产热作用。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-22 DOI: 10.1002/adbi.202500224

Shuai Wang, Ting He, Tong Fu, Yu Zhu, Yixin Wei, Wenlong Xie, Huanming Shen, Ya Luo, Boan Li, Huiling Guo, Weihua Li

{"title":"SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPARγ.","authors":"Shuai Wang, Ting He, Tong Fu, Yu Zhu, Yixin Wei, Wenlong Xie, Huanming Shen, Ya Luo, Boan Li, Huiling Guo, Weihua Li","doi":"10.1002/adbi.202500224","DOIUrl":"https://doi.org/10.1002/adbi.202500224","url":null,"abstract":"Brown adipose tissue (BAT) is crucial for maintaining whole-body metabolic homeostasis and combating obesity and metabolic disorders. SOX4 collaborates with EBF2 to promote the expression of thermogenic genes in BAT, but it is unclear whether there are mechanisms independent of this regulation. However, it is found that SOX4 can directly interact with the promoter regions of thermogenic genes, thereby activating their expression. Simultaneously, early B cell factor 2 (EBF2) and peroxisome proliferator-activated receptor-γ (PPARγ) can independently interact with SOX4, forming two distinct complexes that promote the expression of thermogenic genes. Phenotypically, the deletion of SOX4 in BAT of mice (Ucp1Cre+-Sox4f/f (Sox4-BKO)) leads to the downregulation of thermogenic and oxidative phosphorylation genes, as well as a reduction in mitochondrial numbers. Furthermore, Sox4-BKO mice are more susceptible to obesity, glucose intolerance, and insulin resistance when subjected to a high-fat diet (HFD). Consistently, the loss of SOX4 results in increased cellular triglyceride content and reduced expression levels of thermogenic genes in vitro. Together, a novel mechanism by which SOX4 regulates thermogenesis in BAT is elucidated, offering a promising strategy to address obesity and metabolic disorders.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00224"},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Research on Stress, Resilience, and Aging in Transgender Populations. 跨性别人群的压力、恢复力和老龄化研究进展。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-18 DOI: 10.1002/adbi.202400608

Kylie Madhav, Hannah Yore, Monty A Montano

{"title":"Advancing Research on Stress, Resilience, and Aging in Transgender Populations.","authors":"Kylie Madhav, Hannah Yore, Monty A Montano","doi":"10.1002/adbi.202400608","DOIUrl":"https://doi.org/10.1002/adbi.202400608","url":null,"abstract":"Transgender individuals experience profound health disparities across the life course, shaped by developmental, social, and environmental stressors that accumulate over time. As they age, these disparities manifest in poorer physical and mental health, increased disability, and heightened risks of multimorbidity compared to cisgender peers. This editorial examines the scientific value of integrating life course frameworks, minority stress models, and exposome research to understand the biological and psychosocial mechanisms underlying these disparities. The importance of investigating resilience is highlighted -both physiological and psychosocial-as a key factor in promoting healthy aging, alongside the need to study intersectionality, particularly how race, ethnicity, immigration status, and socioeconomic context interact to influence health outcomes. Additionally, research opportunities are outlined to evaluate the long-term impact of gender-affirming care, advocacy efforts, and macro-level social stressors on health trajectories. It is emphasized how insights gained from transgender-focused research can inform broader health science, including comparative investigations in other high-stress populations, such as military veterans. Together, these lines of inquiry can advance precision health strategies, foster inclusive and person-centered healthcare models, and ultimately improve health equity across diverse aging populations.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00608"},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study. 衰老黑质的空间解析视角：一项探索性蛋白质组学研究。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-18 DOI: 10.1002/adbi.202500358

Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus

{"title":"A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study.","authors":"Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus","doi":"10.1002/adbi.202500358","DOIUrl":"https://doi.org/10.1002/adbi.202500358","url":null,"abstract":"Physiological aging is accompanied by structural and molecular changes in the brain, with varying degrees in different brain areas, and is considered one of the major risk factors for neurodegenerative diseases. Thus, the present study focuses on elucidating age-related changes in the substantia nigra pars compacta (SNpc), a brain region particularly vulnerable in Parkinson's disease. Here, the aim is to gain a spatially resolved view of aging-dependent alterations to conclude early processes potentially involved in neurodegeneration. Neuromelanin granules and SNpc tissue are isolated from tissue samples of young and elderly individuals via laser microdissection and measured by mass spectrometry to ascertain changes in protein expression in response to age. The findings include the identification of reduced levels of proteins involved in dopaminergic neurotransmission, either suggesting a specific loss of dopaminergic neurons or a reduction in metabolic activity. Furthermore, increased neuroinflammation is observed in elderly individuals and alterations in vesicular trafficking as well as mitochondrial proteins. Consequently, this exploratory study suggests that alterations causing known pathomechanisms of Parkinson's disease are already occurring in the physiological aging process. Since aging is still the most important risk factor for neurodegenerative diseases, these findings strengthen the necessity for studying age-related changes.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00358"},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of Stat3 in Prx1⁺ Progenitors Impairs Molar Root Development. Prx1+祖细胞中Stat3的缺失会损害臼齿根的发育。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-12 DOI: 10.1002/adbi.202500329

Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang

{"title":"Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development.","authors":"Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang","doi":"10.1002/adbi.202500329","DOIUrl":"https://doi.org/10.1002/adbi.202500329","url":null,"abstract":"Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating cellular proliferation, survival, apoptosis, vascularization, immune regulation, and migratory processes. Human Stat3 deficiency triggers Hyper-IgE syndrome, associated with immune dysregulation, osseous defects, and dental malformations. This study employs genetically engineered murine models to dissect Stat3's mechanistic role within mesenchymal progenitor cells during molar root formation and periodontal tissue maturation. Conditional Stat3 knockout mice (Prx1-Cre; Stat3f/f) are generated. Comparative assessments of mandibular first molar root development between Stat3 CKO and wild-type cohorts are performed through histomorphometric evaluation, micro-computed tomography, cellular proliferation assays (Ki67/BrdU), and transcriptome sequencing. Stat3 ablation causes marked morphological defects in first molars, featuring reduced root length and elevated crown-root proportion. The periodontal ligament (PDL) at the distal root exhibits diminished width in mutants. Alveolar bone displays suppressed expression of osteogenic markers (Runx2, Col1a1, Ocn), accompanied by decreased Ki67+ and BrdU+ cell populations in the PDL. Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00329"},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1. RRP9通过E2F1转录调控CDK1促进食管鳞状细胞癌进展。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-12 DOI: 10.1002/adbi.202500220

Gang He, Yilong Wan, Yanbo Zhu, Bo Peng, Shengxiang Shao, Xinyi Zou, Zhenyu Han, Jiaxi Li, Sheng Ju, Xin Tong, Jun Zhao, Hansi Liang, Liuqing Zhang, Jiashi Xiong, Dong Jiang

{"title":"RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1.","authors":"Gang He, Yilong Wan, Yanbo Zhu, Bo Peng, Shengxiang Shao, Xinyi Zou, Zhenyu Han, Jiaxi Li, Sheng Ju, Xin Tong, Jun Zhao, Hansi Liang, Liuqing Zhang, Jiashi Xiong, Dong Jiang","doi":"10.1002/adbi.202500220","DOIUrl":"https://doi.org/10.1002/adbi.202500220","url":null,"abstract":"Esophageal cancer is a major disease that seriously threatens human health. Ribosomal RNA biogenesis is implicated in tumorigenesis, while the small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modifications of ribosomal RNAs during biogenesis, which are identified as potential markers of various cancers. The clinical significance, biological behavior, and potential molecular mechanism of the nucleolar small nuclear ribonucleoprotein RRP9 in esophageal squamous cell carcinoma (ESCC), which is a major pathological type of esophageal cancer, are investigated in this study. It is found that RRP9 is abnormally highly expressed in ESCC tissues and is closely associated with poor prognosis. Furthermore, it is found that RRP9 could regulate the cell cycle protein-dependent kinase CDK1 to promote ESCC progression in vitro and in vivo. Mechanistically, RRP9 promotes ESCC progression through enhancing the E2F1-mediated transcriptional regulation of CDK1. Collectively, the results defined RRP9 as an important tumor driver in ESCC that acted by activating oncogenic signaling by the E2F1-CDK1 pathway, and suggested RRP9 as a candidate therapeutic target for ESCC.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00220"},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unrolling of Syngonium podophyllum: Functional Anatomy, Morphology and Modelling of Its Peltate Leaves. 木合根的展开：其盆状叶的功能解剖、形态和造型。

IF 2.6 3区生物学

Advanced biology Pub Date : 2025-09-04 DOI: 10.1002/adbi.202500279

Michelle Modert, Nick Seinsche, Sören Bartels, Tom Masselter, Thomas Speck

引用次数: 0