免疫库分析在甲状腺癌与甲状腺大良性结节鉴别中的应用(ad . Biology 7/2025)

IF 2.6 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Jun Zhu, Xu Zhang, Xiangqing Zhu, Ziran Gao, Zhong Ni, Tiancheng Zhang, Meijin Huang
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引用次数: 0

摘要

免疫库分析的应用本研究分析了早期甲状腺癌(PTC)、大良性结节和健康对照的外周TCR/BCR谱。增强的抗原驱动克隆扩增和疾病特异性的“公共”克隆型具有独特的V-J重排,与甲状腺激素/自身抗体相关。研究结果提供了对免疫病理机制的见解,突出了甲状腺疾病的适应性免疫动力学。更多细节可以在倪忠、张天成、黄美金及其同事的2400760号文章中找到。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Application of Immune Repertoire Analysis in Differentiating Thyroid Cancer and Large Benign Thyroid Nodules (Adv. Biology 7/2025)

Application of Immune Repertoire Analysis in Differentiating Thyroid Cancer and Large Benign Thyroid Nodules (Adv. Biology 7/2025)

Application of Immune Repertoire Analysis in Differentiating Thyroid Cancer and Large Benign Thyroid Nodules (Adv. Biology 7/2025)

Application of Immune Repertoire Analysis in Differentiating Thyroid Cancer and Large Benign Thyroid Nodules (Adv. Biology 7/2025)

Application of Immune Repertoire Analysis in Differentiating Thyroid Cancer and Large Benign Thyroid Nodules (Adv. Biology 7/2025)

Application of Immune Repertoire Analysis

This study analyzes peripheral TCR/BCR profiles in early thyroid cancer (PTC), large benign nodules, and healthy controls. Enhanced antigen-driven clonal expansion and disease-specific “public” clonotypes with unique V-J rearrangements were identified, linked to thyroid hormones/autoantibodies. Findings provide insights into immunopathological mechanisms, highlighting adaptive immune dynamics in thyroid disorders. More details can be found in article number 2400760 by Zhong Ni, Tiancheng Zhang, Meijin Huang, and co-workers.

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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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