Advanced biology最新文献_第10页

The Role and Molecular Pathways of SIRT6 in Senescence and Age-related Diseases SIRT6在衰老和年龄相关疾病中的作用和分子途径

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-02-06 DOI: 10.1002/adbi.202400469

Yi Lu, Junye Yang, Qiuju Wu, Xiaobo Wang

{"title":"The Role and Molecular Pathways of SIRT6 in Senescence and Age-related Diseases","authors":"Yi Lu, Junye Yang, Qiuju Wu, Xiaobo Wang","doi":"10.1002/adbi.202400469","DOIUrl":"10.1002/adbi.202400469","url":null,"abstract":"SIRT6 is a NAD+-dependent histone deacetylase with crucial roles in controlling DNA damage repair, telomere homeostasis, oxidative stress, autophagy, and other cellular processes, and it has long been recognized as a longevity-associated protein. This review details its anti-aging-related mechanisms. First, SIRT6 facilitates DNA repair pathways and maintains genome stability by deacetylating histone H3 at K56, K9, and K18 residues, in addition to participating in DNA damage repair through mono-ADP-ribosylation and other mechanisms. Second, SIRT6 preserves telomere integrity and mitigates cellular senescence by reducing oxidative stress-induced damage through the regulation of reactive oxygen species (ROS), inhibition of inflammation, and other pathways. Furthermore, SIRT6 promotes autophagy, slowing cellular senescence via the modulation of various signaling pathways, including AMPK, IGF-Akt-mTOR, H133Y, IL-1β, and mitochondrial autophagy-related proteins. Finally, SIRT6 regulates multiple signaling pathways, such asNF-κB, FOXO, and AMPK, to counteract the aging process. This review particularly delves into the interplay between SIRT6 and various diseases, including tumors, cardiovascular diseases (e.g., atherosclerosis, heart failure), metabolic diseases (e.g., type 2 diabetes, dyslipidemia, gluconeogenesis, osteoporosis), and neurodegenerative diseases (e.g., Alzheimer's disease). Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ribosomal Proteins as Exosomal Cargo: Random Passengers or Crucial Players in Carcinogenesis? 核糖体蛋白作为外泌体货物：随机乘客还是致癌的关键参与者？

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-02-03 DOI: 10.1002/adbi.202400360

Dmitri Graifer, Alexey Malygin, Aleksei Shefer, Svetlana Tamkovich

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RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer. RhoA和Rac1作为结直肠癌的机械转导介质。

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-30 DOI: 10.1002/adbi.202400626

Sharda Yadav, Sanjaya Kc, Mark A T Blaskovich, Cu-Tai Lu, Alfred K Lam, Nam-Trung Nguyen

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Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome 小鼠模型和人类细胞系模型研究多囊卵巢综合征卵巢卵泡动力学改变。

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-22 DOI: 10.1002/adbi.202400713

Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone

{"title":"Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome","authors":"Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone","doi":"10.1002/adbi.202400713","DOIUrl":"10.1002/adbi.202400713","url":null,"abstract":"Polycystic ovary syndrome is one of the most common endocrine disorders in women of reproductive age, characterized by functional and structural alterations of the female reproductive organs. Due to the unknown underlying molecular mechanisms, in vivo murine models and in vitro human cellular models are developed to study the syndrome. These models are used to analyze various aspects of the pathology by replicating the conditions of the syndrome. Even though the complexity of polycystic ovary syndrome and the challenge of reproducing all its features leave several questions unanswered, studies conducted to date have elucidated some of the alterations in ovarian follicle molecular and cellular mechanisms involved in the syndrome, and do not require the employment of complex and invasive techniques on human patients. This review examines ovarian functions and their alterations in polycystic ovary syndrome, explores preclinical in vivo and in vitro models, and highlights emerging research and medical perspectives. It targets researchers, healthcare professionals, and academics, including endocrinologists, cell biologists, and reproductive medicine specialists, studying the molecular and cellular mechanisms of the syndrome.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 7","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202400713","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatin Marks H3K4me3 and H3K9me3 in Triple-Negative Breast Cancer Cell Lines. 三阴性乳腺癌细胞系H3K4me3和H3K9me3的染色质标记

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-22 DOI: 10.1002/adbi.202400752

Farhan Anjum, Kush Kaushik, Abdul Salam, Chayan Kanti Nandi

{"title":"Chromatin Marks H3K4me3 and H3K9me3 in Triple-Negative Breast Cancer Cell Lines.","authors":"Farhan Anjum, Kush Kaushik, Abdul Salam, Chayan Kanti Nandi","doi":"10.1002/adbi.202400752","DOIUrl":"https://doi.org/10.1002/adbi.202400752","url":null,"abstract":"Triple-negative breast cancer (TNBC) is the most lethal and aggressive breast cancer among all the breast cancer subtypes. Despite several attempts, to date, there is an extensive lack of therapeutic intervention. Hence, there is a dire need for an effective biomarker to timely diagnose TNBC. Here, utilizing super-resolution microscopy, the remodeling structural aspects of euchromatin and heterochromatin in TNBC are studied and the results are compared with non-cancerous and non-TNBC cell lines. The nanoscopic visualization reveals a distinct difference in chromatin remodeling in TNBC in comparison to the other two cell lines. While the euchromatin density is found to increase, the heterochromatin is found to decrease. A complete switching of the heterochromatin-euchromatin ratio is observed in TNBC cells thus proposing that chromatin remodeling and chromatin morphological changes can be pursued as one of the targets for diagnostic purposes. Increased expression of structure specific recognition protein-1(SSRP-1) protein supports the increased rate of chromatin remodeling in breast cancer cell lines. The results may lead to developing a new strategy for diagnosing TNBC patients.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400752"},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of ROS and Its Sources in Tumorigenesis: Friend or Foe? 活性氧及其来源在肿瘤发生中的作用：是敌是友？

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-22 DOI: 10.1002/adbi.202400549

Qin Jiang, Xiang Lin, Mimi Zhai, Yi Gong, Yamin Li, Sushun Liu

引用次数: 0

Light-Triggered Protease-Mediated Release of Actin-Bound Cargo from Synthetic Cells 光触发蛋白酶介导的合成细胞中肌动蛋白结合货物的释放。

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-18 DOI: 10.1002/adbi.202400539

Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu

{"title":"Light-Triggered Protease-Mediated Release of Actin-Bound Cargo from Synthetic Cells","authors":"Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu","doi":"10.1002/adbi.202400539","DOIUrl":"10.1002/adbi.202400539","url":null,"abstract":"Synthetic cells offer a versatile platform for addressing biomedical and environmental challenges, due to their modular design and capability to mimic cellular processes such as biosensing, intercellular communication, and metabolism. Constructing synthetic cells capable of stimuli-responsive secretion is vital for applications in targeted drug delivery and biosensor development. Previous attempts at engineering secretion for synthetic cells have been confined to non-specific cargo release via membrane pores, limiting the spatiotemporal precision and specificity necessary for selective secretion. Here, a protein-based platform termed TEV Protease-mediated Releasable Actin-binding Protein (TRAP) is designed and constructed for selective, rapid, and triggerable secretion in synthetic cells. TRAP is designed to bind tightly to reconstituted actin networks and is proteolytically released from bound actin, followed by secretion via cell-penetrating peptide membrane translocation. TRAP's efficacy in facilitating light-activated secretion of both fluorescent and luminescent proteins is demonstrated. By equipping synthetic cells with a controlled secretion mechanism, TRAP paves the way for the development of stimuli-responsive biomaterials, versatile synthetic cell-based biosensing systems, and therapeutic applications through the integration of synthetic cells with living cells for targeted delivery of protein therapeutics.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 5","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202400539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-12p70 Induces Neuroprotection via the PI3K-AKT-BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction (Adv. Biology 1/2025) IL-12p70通过PI3K-AKT-BCL2轴诱导神经保护介导电针术后认知功能障碍的治疗效果（ad . Biology 1/2025）

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-17 DOI: 10.1002/adbi.202570091

Tingting Huang, Jie Hong, Jia Ling, Lin Zhu, Wei Zhao, Xinlu Zhang, Xinze Yan, Chen Hu, Ruijie Zhang, Chen Gao, Shengzhao Zhang, Chen Chen, Runhuai Yang, Weiwei Wu, Chunhui Wang, Qian Gao

引用次数: 0

β-Catenin/c-Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations β-Catenin/c-Myc轴调节不同氨浓度下的自噬反应

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-11 DOI: 10.1002/adbi.202400408

S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia

{"title":"β-Catenin/c-Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations","authors":"S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia","doi":"10.1002/adbi.202400408","DOIUrl":"10.1002/adbi.202400408","url":null,"abstract":"Ammonia a by-product of nitrogen containing molecules is detoxified by liver into non-toxic urea and glutamine. Impaired ammonia detoxification leads to hyperammonemia. Ammonia has a dual role on autophagy, it acts as inducer at low concentrations and as inhibitor at high concentrations. However, little is known about the mechanisms responsible for this switch. Wnt/β-catenin signalling is emerging for its role in the regulation of ammonia metabolizing enzymes and autophagosome synthesis through c-Myc. Here, using Huh7 cell line, we show a modulation in c-Myc expression under different ammonia concentrations. An increase in c-Myc expression and in its transcriptional regulator β-catenin was detected at low concentrations of ammonia, when autophagy is active, whereas these modifications were lost under high ammonia concentrations. These observations were also recapitulated in the livers of spf-ash mice, a model of constitutive hyperammonaemia due to deficiency in ornithine transcarbamylase enzyme. Moreover, c-Myc-mediated activation of autophagy plays a cytoprotective role in cells under ammonia stress conditions as confirmed through the pharmacological inhibition of c-Myc in Huh7 cells treated with low ammonia concentrations. In conclusion, the unravelled role of c-Myc in modulating ammonia induced autophagy opens new landscapes for the development of novel strategies for the treatment of hyperammonemia.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202400408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant-Like Behavior 人类多能干细胞中TP53的缺失引发恶性样行为。

IF 3.2 3区生物学

Advanced biology Pub Date : 2025-01-06 DOI: 10.1002/adbi.202400538

Joaquin Montilla-Rojo, Thomas F. Eleveld, Marnix van Soest, Sanne Hillenius, Dennis M. Timmerman, Ad J. M. Gillis, Bernard A. J. Roelen, Christine L. Mummery, Leendert H. J. Looijenga, Daniela C. F. Salvatori

{"title":"Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant-Like Behavior","authors":"Joaquin Montilla-Rojo, Thomas F. Eleveld, Marnix van Soest, Sanne Hillenius, Dennis M. Timmerman, Ad J. M. Gillis, Bernard A. J. Roelen, Christine L. Mummery, Leendert H. J. Looijenga, Daniela C. F. Salvatori","doi":"10.1002/adbi.202400538","DOIUrl":"10.1002/adbi.202400538","url":null,"abstract":"Human pluripotent stem cells (hPSCs) tend to acquire genetic aberrations upon culture in vitro. Common aberrations are mutations in the tumor suppressor TP53, suspected to confer a growth-advantage to the mutant cells. However, their full impact in the development of malignant features and safety of hPSCs for downstream applications is yet to be elucidated. Here, TP53 is knocked out in hPSCs using CRISPR-Cas9 and compared them with isogenic wild-type hPSCs and human germ cell tumor lines as models of malignancy. While no major changes in proliferation, pluripotency, and transcriptomic profiles are found, mutant lines display aberrations in some of the main chromosomal hotspots for genetic abnormalities in hPSCs. Additionally, enhanced clonogenic and anchorage-free growth, alongside resistance to chemotherapeutic compounds is observed. The results indicate that common TP53-depleting mutations in hPSCs, although potentially overlooked by standard analyses, can impact their behavior and safety in a clinical setting.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202400538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0