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IL-12p70 Induces Neuroprotection via the PI3K-AKT-BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction (Adv. Biology 1/2025)

IF 2.6 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Advanced biology Pub Date : 2025-01-17 DOI:10.1002/adbi.202570091
Tingting Huang, Jie Hong, Jia Ling, Lin Zhu, Wei Zhao, Xinlu Zhang, Xinze Yan, Chen Hu, Ruijie Zhang, Chen Gao, Shengzhao Zhang, Chen Chen, Runhuai Yang, Weiwei Wu, Chunhui Wang, Qian Gao
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Abstract

IL-12p70-Induced Neuroprotection

Postoperative cognitive dysfunction (POCD) primarily affects older adults and worsens their prognosis. In article number 2400172, Qian Gao, Chunhui Wang, and co-workers reveal that IL-12p70 up-regulated by electroacupuncture protects hippocampal neurons against POCD-related damage to improve cognitive function.

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IL-12p70通过PI3K-AKT-BCL2轴诱导神经保护介导电针术后认知功能障碍的治疗效果（ad . Biology 1/2025）
il -12p70诱导的术后认知功能障碍（POCD）主要影响老年人，并使其预后恶化。在2400172号文章中，高倩、王春辉等揭示了电针上调IL-12p70可保护海马神经元免受pocd相关损伤，从而改善认知功能。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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