Advanced biology最新文献_第5页

Masthead: (Adv. Biology 8/2024) 刊头：（高级生物学 8/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-16 DOI: 10.1002/adbi.202470082

引用次数: 0

Microphysiological Systems for Cancer Immunotherapy Research and Development (Adv. Biology 8/2024) 癌症免疫疗法研究与开发的微观生理学系统（生物学高级课程 8/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-16 DOI: 10.1002/adbi.202470083

Yansong Peng, Esak Lee

引用次数: 0

Wavelet Collocation Method for HIV-1/HTLV-I Co-Infection Model Using Hermite Polynomial 使用赫尔墨特多项式的 HIV-1/HTLV-I 协同感染模型小波配位法

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-09 DOI: 10.1002/adbi.202300629

Khushbu Agrawal, Sunil Kumar

{"title":"Wavelet Collocation Method for HIV-1/HTLV-I Co-Infection Model Using Hermite Polynomial","authors":"Khushbu Agrawal, Sunil Kumar","doi":"10.1002/adbi.202300629","DOIUrl":"10.1002/adbi.202300629","url":null,"abstract":"In this study, the dynamic behavior of fractional order co-infection model with human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I) is analyzed using operational matrix of Hermite wavelet collocation method. Also, the uniqueness and existence of solutions are calculated based on the fixed point hypothesis. For the fractional order co-infection model, its positivity and boundedness are demonstrated. Furthermore, different types of Ulam-Hyres stability are also discussed. The numerical solution of the model are obtained by using the operational matrix of the Hermite wavelet approach. This scheme is used to solve the system of nonlinear equations that are very fruitful and easy to implement. Additionally, the stability analysis of the numerical scheme is explained. The mathematical model taken in this work incorporates the biological characteristics of both HIV-1 and HTLV-I. After that all the equilibrium points of the fractional order co-infection model are found and their existence conditions are explored with the help of the Caputo derivative. The global stability of all equilibrium points of this model are determined with the help of Lyapunov functions and the LaSalle invariance principle. Convergence analysis is also discussed. Hermite wavelet operational matrix methods are more accurate and convergent than other numerical methods. Lastly, variations in model dynamics are found when examining different fractional order values. These findings will be valuable to biologists in the treatment of HIV-1/HTLV-I.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryopreservation of Immune Cells: Recent Progress and Challenges Ahead. 免疫细胞的冷冻保存：最新进展与未来挑战》。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-07 DOI: 10.1002/adbi.202400201

Kejun Qi, Danqi Jia, Shengxi Zhou, Kun Zhang, Fangxia Guan, Minghao Yao, Xiaojie Sui

{"title":"Cryopreservation of Immune Cells: Recent Progress and Challenges Ahead.","authors":"Kejun Qi, Danqi Jia, Shengxi Zhou, Kun Zhang, Fangxia Guan, Minghao Yao, Xiaojie Sui","doi":"10.1002/adbi.202400201","DOIUrl":"https://doi.org/10.1002/adbi.202400201","url":null,"abstract":"Cryopreservation of immune cells is considered as a key enabling technology for adoptive cellular immunotherapy. However, current immune cell cryopreservation technologies face the challenges with poor biocompatibility of cryoprotection materials, low efficiency, and impaired post-thaw function, limiting their clinical translation. This review briefly introduces the adoptive cellular immunotherapy and the approved immune cell-based products, which involve T cells, natural killer cells and etc. The cryodamage mechanisms to these immune cells during cryopreservation process are described, including ice formation related mechanical and osmotic injuries, cryoprotectant induced toxic injuries, and other biochemical injuries. Meanwhile, the recent advances in the cryopreservation medium and freeze-thaw protocol for several representative immune cell type are summarized. Furthermore, the remaining challenges regarding on the cryoprotection materials, freeze-thaw protocol, and post-thaw functionality evaluation of current cryopreservation technologies are discussed. Finally, the future perspectives are proposed toward advancing highly efficient cryopreservation of immune cells.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal Cord Injury Associated Disease of the Skeleton, an Unresolved Problem with Need for Multimodal Interventions. 脊髓损伤导致的骨骼疾病，一个需要多模式干预的未决问题。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-07-29 DOI: 10.1002/adbi.202400213

Evelyn Echevarria-Cruz, David W McMillan, Kieran F Reid, Rodrigo J Valderrábano

引用次数: 0

Prefrontal Cortex Oxygenation During Exercise in Older Adults with Motoric Cognitive Risk Syndrome. 患有运动性认知风险综合征的老年人在运动过程中的前额叶皮层氧合。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-07-29 DOI: 10.1002/adbi.202400231

Kell Grandjean da Costa, Eduardo Bodnariuc Fontes, Alekya Menta, Arthur F Kramer, Roger A Fielding, Joe Verghese, Christopher Kowaleski, Nathan Ward, Kieran F Reid

{"title":"Prefrontal Cortex Oxygenation During Exercise in Older Adults with Motoric Cognitive Risk Syndrome.","authors":"Kell Grandjean da Costa, Eduardo Bodnariuc Fontes, Alekya Menta, Arthur F Kramer, Roger A Fielding, Joe Verghese, Christopher Kowaleski, Nathan Ward, Kieran F Reid","doi":"10.1002/adbi.202400231","DOIUrl":"https://doi.org/10.1002/adbi.202400231","url":null,"abstract":"Motoric cognitive risk syndrome (MCR) is a pre-dementia syndrome characterized by subjective memory complaints and gait impairments that may be related to lower prefrontal cortex (PFC) function. Acute bouts of aerobic exercise are shown to improve PFC function, however, the acute effects of exercise on PFC oxygenation have not yet been examined in MCR. This study aims to characterize the PFC oxygenation responses during acute exercise in older adults with MCR. Nineteen older adults with MCR performed a submaximal cycling exercise protocol. Functional near-infrared spectroscopy (fNIRS) is used to measure concentrations of oxygenated (OxyHb) and deoxygenated (DeoxyHb) hemoglobin from the PFC. There is a trend for increased OxyHb concentrations and decreased DeooxyHb concentrations during exercise. Exercise also induced significant increases in ratings of perceived exertion (RPEs) and heart rate. A significant, positive correlation between PFC OxyHb and RPEs during the cycling exercise are also observed. The findings reveal that PFC oxygenation increases during exercise in an intensity-dependent manner and the subjective perception of exertion is associated with the magnitude of PFC oxygenation. These results suggest that moderate-intensity cycling exercise may have beneficial effects on increasing cerebral blood flow in the PFC of older adults with MCR.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qianggu Decoction Alleviated Osteoporosis by Promoting Osteogenesis of BMSCs through Mettl3-Mediated m⁶A Methylation. 羌活煎剂通过Mettl3介导的m6A甲基化促进BMSCs骨生成，从而缓解骨质疏松症

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-07-25 DOI: 10.1002/adbi.202400341

Yuchen Wang, Weizhong Yu, Yuan E, Lining Rui, Chuan Jia, Wenke Zhu

{"title":"Qianggu Decoction Alleviated Osteoporosis by Promoting Osteogenesis of BMSCs through Mettl3-Mediated m6A Methylation.","authors":"Yuchen Wang, Weizhong Yu, Yuan E, Lining Rui, Chuan Jia, Wenke Zhu","doi":"10.1002/adbi.202400341","DOIUrl":"https://doi.org/10.1002/adbi.202400341","url":null,"abstract":"Osteoporosis development is linked to abnormal bone marrow mesenchymal stem cells (BMSCs) differentiation. N6-methyladenosine (m6A), a prevalent mRNA modification, is known to influence BMSCs' osteogenic capacity. Qianggu decoction (QGD), a traditional Chinese medicine for osteoporosis, has unknown effects on BMSCs differentiation. This study investigates QGD's impact on BMSCs and its potential to ameliorate osteoporosis through m6A regulation. Using Sprague-Dawley (SD) rats with ovariectomy-induced osteoporosis, it is evaluated QGD's antiosteoporotic effects through micro-CT, histology, Western blotting, and osteoblastogenesis markers. QGD is found to enhance bone tissue growth and upregulate osteogenic markers Runx2, OPN, and OCN. It also promoted BMSCs osteogenic differentiation, as shown by increased calcium nodules and ALP activity. QGD treatment significantly increased m6A RNA levels and Mettl3 expression in BMSCs. Silencing Mettl3 with siRNA negated QGD's osteogenic effects. Collectively, QGD may improve BMSCs differentiation and mitigate osteoporosis, potentially through Mettl3-mediated m6A modification.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progress in Generation of Inner Ear Organoid 内耳类器官生成的最新进展

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-07-25 DOI: 10.1002/adbi.202400223

Yanjun Zong, Xiaozhou Liu, Yaqi Zhang, Jiahui Zhao, Xinyu Shi, Zhengdong Zhao, Yu Sun

引用次数: 0

Engineering of Erythrocytes as Drug Carriers for Therapeutic Applications. 将红细胞作为药物载体用于治疗。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-07-22 DOI: 10.1002/adbi.202400242

Baoshuo Jia, Yujie Shi, Yuling Yan, Hui Shi, Jing Zheng, Jianbo Liu

{"title":"Engineering of Erythrocytes as Drug Carriers for Therapeutic Applications.","authors":"Baoshuo Jia, Yujie Shi, Yuling Yan, Hui Shi, Jing Zheng, Jianbo Liu","doi":"10.1002/adbi.202400242","DOIUrl":"https://doi.org/10.1002/adbi.202400242","url":null,"abstract":"Erythrocytes, also known as red blood cells (RBCs), have garnered considerable attention as potential carriers for drug delivery, owing to their inherent properties such as biocompatibility, biodegradability, and prolonged circulation half-life. This paper presents a comprehensive overview of the role of erythrocytes in drug delivery, elucidating recent advancements in delivering a diverse array of therapeutic agents, including small molecules, nucleic acids, antibodies, protein enzymes, and nanoparticles. Two primary strategies for encapsulating drugs within erythrocytes are systematically discussed: internal loading and surface loading. Each strategy offers distinct advantages in terms of drug stability and release kinetics. Notably, the utilization of erythrocyte membrane camouflaged nanocarriers holds promise for enhancing the biocompatibility of conventional nanoparticles and facilitating targeted drug delivery. Furthermore, the broad spectrum of biomedical applications of erythrocyte-based drug delivery systems are examined, ranging from cancer treatment to diabetes management, thrombosis prevention, and immunotherapy. This review provides a comprehensive evaluation of current technologies in erythrocyte-loaded drug delivery, highlighting the strengths, weaknesses, and future directions for advancing therapeutic interventions in various disease contexts.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Reactive to Proactive – The Future Life Design to Promote Health and Extend the Human Lifespan 从被动到主动--促进健康和延长人类寿命的未来生活设计。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-07-22 DOI: 10.1002/adbi.202400148

Lan Yao, Chengyuan Yang, J. Carolyn Graff, Guiying Wang, Gang Wang, Weikuan Gu

引用次数: 0