Advanced biologyPub Date : 2026-05-01DOI: 10.1002/adbi.202500513
Lili Tian, Huiyu Liu, Huahao Fan
{"title":"Cross-Species Transmission and Structural Adaptive Evolution: Implications of the FCoV-23 Pandemic for the Evolution of Coronaviruses.","authors":"Lili Tian, Huiyu Liu, Huahao Fan","doi":"10.1002/adbi.202500513","DOIUrl":"10.1002/adbi.202500513","url":null,"abstract":"<p><p>Two recent studies identified feline coronavirus 23 (FCoV-23), a recombinant feline coronavirus responsible for severe feline infectious peritonitis outbreaks in Cyprus. Recombination analysis revealed two breakpoints flanking a region spanning ORF1b and the spike gene, sharing 96.5% identity with the hypervirulent canine coronavirus (CCoV) strain NA/09, with phylogenetic analysis confirming that the FCoV-23 spike gene clusters with CCoV-2 while the genomic backbone clusters with FCoV-1. Structurally, conserved receptor binding domain (RBD) residues (Y549/Q551/W592) enable FCoV-23 to recognize aminopeptidase N (APN) across feline, canine, porcine, and avian hosts, while reduced human APN binding results from loss of N739 glycosylation due to a single substitution at position 741. Deletion of the N-terminal domain 0 (D0), present in over 90% of Cyprus cases, enhances cell entry kinetics and promotes macrophage tropism. Comparative analysis with APN-utilizing CoVs, including CCoV-HuPn-2018 and HCoV-229E, highlights the zoonotic potential of this CoV lineage and underscores the need for enhanced surveillance and pandemic preparedness.</p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 5","pages":"e00513"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RNAi-Loaded Exosomes for the Management of Breast Cancer: Emerging Paradigms in Precision Therapy.","authors":"Jaskiran Kaur, Paras Famta, Saurabh Srivastava, Gurjeet Thakur, Ankit Awasthi, Sachin Kumar Singh","doi":"10.1002/adbi.70127","DOIUrl":"10.1002/adbi.70127","url":null,"abstract":"<p><p>Breast cancer is a heterogeneous disease and is characterized by desmoplastic tumors. Conventional nanocarriers are unable to accumulate in the tumor microenvironment owing to their inability to extravasate through tumor vessels and the high density of the desmoplastic breast tumor. In addition, the exogenous nature of nanocarriers makes them susceptible to recognition by the reticuloendothelial system and therefore leads to short systemic half-life. Exosomes, also known as the body's natural nanocarriers, have an inherent ability to carry nucleic acids. Due to their endogenous nature, they can bypass the macrophages and thus, show prolonged systemic half-life. Exosomes isolated from sources such as macrophages, neutrophils, and mesenchymal stem cells have demonstrated the ability to penetrate and accumulate in breast tumors. Thus, in the present review article, we have highlighted advantages and challenges associated with the delivery of RNAi-loaded exosomes for the precision therapy of breast cancer. Additionally, it reviews various oncogenic targets and the ability of RNAi-loaded exosomes to modulate them. We have also mentioned the common bottlenecks and challenges faced by formulation scientists in the clinical translation of RNAi-loaded exosomes.</p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 5","pages":"e70127"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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