{"title":"Apolipoprotein A-I Binding Protein: Functions, Mechanisms, and Therapeutic Targets in Neurological Disorders.","authors":"Zijian Zhang, Yingjun Wang, Hao Yang, Yanhong Jiang, Guyuan Wang, Renfang Mao","doi":"10.1002/adbi.202500012","DOIUrl":null,"url":null,"abstract":"<p><p>Apolipoprotein A-I binding protein (AIBP) interacts with both apolipoprotein A-I and high-density lipoprotein. It modulates lipid raft-related signaling pathways and affects mitochondrial function, oxidative stress, and inflammatory responses, thereby playing an important role in atherosclerosis, neuroinflammation, and neurological disorders. The role of AIBP in cardiovascular diseases has been intensively studied. Nevertheless, recent studies have uncovered correlations between NAD(P)HX differential isomerase variants and various neurological disorders, further highlighting their substantial role in neurological diseases. This review outlines the current investigations on AIBP in neurometabolic diseases, neurodegenerative diseases, and neuropathic pain. The present advances are also updated in the function and regulation of AIBP in cholesterol metabolic and inflammatory signaling and explored the potential of AIBP as a promising strategy and target for neurological disorders.</p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e00012"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/adbi.202500012","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Apolipoprotein A-I binding protein (AIBP) interacts with both apolipoprotein A-I and high-density lipoprotein. It modulates lipid raft-related signaling pathways and affects mitochondrial function, oxidative stress, and inflammatory responses, thereby playing an important role in atherosclerosis, neuroinflammation, and neurological disorders. The role of AIBP in cardiovascular diseases has been intensively studied. Nevertheless, recent studies have uncovered correlations between NAD(P)HX differential isomerase variants and various neurological disorders, further highlighting their substantial role in neurological diseases. This review outlines the current investigations on AIBP in neurometabolic diseases, neurodegenerative diseases, and neuropathic pain. The present advances are also updated in the function and regulation of AIBP in cholesterol metabolic and inflammatory signaling and explored the potential of AIBP as a promising strategy and target for neurological disorders.
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