Advanced biology最新文献_第7页

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead. 细胞外囊泡在纳米医学中的潜力：近期进展和未来挑战的综述。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-31 DOI: 10.1002/adbi.202400623

Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger

{"title":"The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead.","authors":"Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger","doi":"10.1002/adbi.202400623","DOIUrl":"https://doi.org/10.1002/adbi.202400623","url":null,"abstract":"Extracellular vesicles (EVs) have emerged as promising tools in diagnostics and therapy for chronic diseases, including cancer and Alzheimer's. Small EVs, also called exosomes, are lipid-bound particles (≈30-150 nm) that play a role in healthy and pathophysiological interactions, including intercellular communication, by transporting bioactive molecules, including proteins, lipids, and nucleic acids. Their ability to cross biological barriers, such as the blood-brain barrier, makes them ideal candidates for targeted therapeutic interventions. In the context of chronic diseases, exosomes can be engineered to deliver active agents, including small molecules and siRNAs to specific target cells, providing a novel approach to precision medicine. Moreover, exosomes show great promise as repositories for diagnostic biomarkers. Their cargo can reflect the physiological and pathological status of the parent cells, making them valuable indicators of disease progression and response to treatment. This paper presents a comprehensive review of the application of exosomes in four chronic diseases: cancer, cardiovascular disease, neurodegenerative disease, and orthopedic disease, which significantly impact global public health due to their high prevalence and associated morbidity and mortality rates. Furthermore, the potential of exosomes as valuable tools for theranostics and disease management is highlighted. Finally, the challenges associated with exosomes and their demonstrated potential for advancing future nanomedicine applications are discussed.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400623"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysozyme/Tracheal Antimicrobial Peptide-Based Tissue-Specific Expression Antimicrobial Plasmids Show Broad-Spectrum Antibacterial Activities in the Treatment of Mastitis in Mice 基于溶菌酶/气管抗菌肽的组织特异性表达抗菌质粒在治疗小鼠乳腺炎中显示出广谱抗菌活性。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-30 DOI: 10.1002/adbi.202400132

Yi Yang, Yining Meng, Daijie Chen, Ping Hou, Zhipeng Zhang, Wenqiang Cao, Ye Meng, Qianwen Zhang, Runyan Tu, Xiaoli Hao, Aijian Qin, Shaobin Shang, Zhangping Yang

{"title":"Lysozyme/Tracheal Antimicrobial Peptide-Based Tissue-Specific Expression Antimicrobial Plasmids Show Broad-Spectrum Antibacterial Activities in the Treatment of Mastitis in Mice","authors":"Yi Yang, Yining Meng, Daijie Chen, Ping Hou, Zhipeng Zhang, Wenqiang Cao, Ye Meng, Qianwen Zhang, Runyan Tu, Xiaoli Hao, Aijian Qin, Shaobin Shang, Zhangping Yang","doi":"10.1002/adbi.202400132","DOIUrl":"10.1002/adbi.202400132","url":null,"abstract":"The use of antibiotics is the preferred therapy for bacterial diseases. However, overusing antibiotics has led to the development of antibiotic resistance in bacteria, which is now a major public health concern. Therefore, in this study, the performance of lysozyme (LYZ)/tracheal antimicrobial peptide (TAP)–based tissue-specific expression antimicrobial plasmids (TSEAP) have been evaluated in the treatment of mastitis in mice. The results show that LYZ/ and TAP-based TSEAP could effectively reduce the clinical symptoms caused by Staphylococcus sciuri, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa–induced mastitis. In addition, the studies of behavioral tests, parameters of weight growth, blood biochemistry, and organ coefficients comprehensively indicate that the transfection of LYZ/TAP-based TSEAP is safe in mice. Taken together, LYZ/TAP-based TSEAP have broad-spectrum antibacterial activity and may provide new insight for the non-antibiotic treatment of bacterial diseases.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling 肠内分泌细胞通过胰岛素信号感知蔗糖并改变肠神经元的兴奋性。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-20 DOI: 10.1002/adbi.202300566

Jessica R Snyder, Minhal Ahmed, Sukhada Bhave, Ryo Hotta, Ryan A. Koppes, Allan M. Goldstein, Abigail N. Koppes

{"title":"Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling","authors":"Jessica R Snyder, Minhal Ahmed, Sukhada Bhave, Ryo Hotta, Ryan A. Koppes, Allan M. Goldstein, Abigail N. Koppes","doi":"10.1002/adbi.202300566","DOIUrl":"10.1002/adbi.202300566","url":null,"abstract":"Neurosensory circuits of the gastrointestinal tract sense microbial and nutrient changes in the gut; however, studying these circuits in vivo is hindered by invasive techniques and ethical concerns. Here, an in vitro model of enteroendocrine cells (EECs) and calcium reporting enteric neurons (ENs) is established and validated for functional signaling. Both mechanical and sucrose stimulation of co-cultures increased the percentage of neurons undergoing a calcium flux, indicating an action potential. Neuronal activation is blocked with either a piezo or insulin receptor blocker. At baseline, a flow only stimulus elicited 51.9% of neurons to activate in co-culture, which is decreased to 15.1% with a piezo blocker. Piezo blocked and sucrose stimulated EECs increased neuronal activation to 43.9%, and an insulin blocker reduced response to 12.4%. Since a cell line is used to model the EEC in the previous experiments, primary rat duodenal epithelium enriched for EECs are also stimulated and found to produced measurable insulin. This work shows the ability of EECs to produce insulin and for ENs to sense insulin. These results inspire further work on how insulin production outside the pancreas effects diabetes, insulin as a neurotransmitter, and exploration of additional nutritional and microbiotic stimuli on enteroendocrine-to-neuronal signaling.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Potential of Natural Resources-Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies 揭示自然资源衍生疗法改善疟疾管理的潜力：计算到实验研究。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-19 DOI: 10.1002/adbi.202400282

Michael P. Okoh, Maxwell O. Egua, Lukman A. Alli, Damayanthi Dalu, Rohit Gundamaraju, Rajeev K. Singla, Bairong Shen

{"title":"Unveiling the Potential of Natural Resources-Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies","authors":"Michael P. Okoh, Maxwell O. Egua, Lukman A. Alli, Damayanthi Dalu, Rohit Gundamaraju, Rajeev K. Singla, Bairong Shen","doi":"10.1002/adbi.202400282","DOIUrl":"10.1002/adbi.202400282","url":null,"abstract":"Malaria kills millions of people annually, and it is one of the major causes of preventable mortality in the world. Of the different plasmodium species that induce malaria, Plasmodium falciparum and Plasmodium vivax account for the most severe form of malarial disease in humans. This review focuses on understanding preventive measures, mutation-based disease evolution, malaria-related biomarkers, and potential plant bioactive components for the treatment and management of malaria. The burden of malaria drug resistance has made it necessary for scientists to focus on alternative therapeutics, with particular interests in those involving plant-based bioactive components that could mediate biochemical pathways, consisting of metabolic interactions essential for parasitic inhibition. To avoid artefacts or false positives, these bioactive components from plant sources are further filtered using the “pan-assay-interfering compounds” (PAINS) tool. This review discussed the history of malaria treatment, current treatment options, malaria preventive measures, and challenges associated with current treatment strategies. Additionally, this work discusses the barriers while developing drugs from phytochemicals and the steps needed to accelerate the development of new antimalarial from the lead compounds.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis 粒细胞集落刺激因子通过 STAT3/HOXA10 轴增强子宫内膜基质细胞的蜕膜化过程

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-18 DOI: 10.1002/adbi.202400279

Huakun Zhang, Zhengzhong Wu, Ningjie Yang, Shuhua Wu, Jing Fan, Ping Wang, Xuemei Li

{"title":"Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis","authors":"Huakun Zhang, Zhengzhong Wu, Ningjie Yang, Shuhua Wu, Jing Fan, Ping Wang, Xuemei Li","doi":"10.1002/adbi.202400279","DOIUrl":"10.1002/adbi.202400279","url":null,"abstract":"Background: Recurrent implantation failure (RIF) is characterized by the repeated failure of implantation, often linked to impaired endometrial receptivity. This study investigates how granulocyte colony-stimulating factor (G-CSF) promotes endometrial stromal cell decidualization. Methods: THESCs (human telomerase reverse transcriptase-immortalized endometrial stromal cells) were used as an in vitro cell model to induce decidualization. The effects of G-CSF on the expression of decidualization genes and apoptosis during decidualization were examined. Additionally, a chemical inhibitor of signal transducer and activator of transcription 3 (STAT3) and the small interfering RNA (siRNA) targeting Homeobox A10 (Hoxa10) were employed to explore the involvement of the STAT3/HOXA10 axis in the action of G-CSF. Results: G-CSF promoted decidualization markers expression and suppressed apoptosis in THESCs Treatment with G-CSF enhanced STAT3 activation during decidualization induction. STAT3 inhibition diminished the effects of G-CSF on decidualization marker expression and apoptosis suppression. Furthermore, it was demonstrated that G-CSF increased Hoxa10 expression in a STAT3-dependent manner. Silencing Hoxa10 abrogated the effects of G-CSF on promoting decidualization. Conclusion: G-CSF enhances decidualization of endometrial stromal cells via STAT3/HOXA10 axis activation. These findings suggest that optimal G-CSF delivery strategies could improve endometrial receptivity in RIF patients.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post-Assembly Loading. 生物 PISA 中囊泡特性的表征和优化：从粒度分布到组装后装载。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-18 DOI: 10.1002/adbi.202400483

Andrea Belluati, Adrian Bloch, Kaloian Koynov, Mariana Müller Nieva, Mohadeseh Bagherabadi, Annette Andrieu-Brunsen, Harald Kolmar, Nico Bruns

引用次数: 0

Development of a pH-Responsive Antimicrobial and Potent Antioxidant Hydrogel for Accelerated Wound Healing: A Game Changer in Drug Delivery 开发可加速伤口愈合的 pH 值响应型抗菌剂和强效抗氧化剂水凝胶：改变药物输送的游戏规则。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-14 DOI: 10.1002/adbi.202400358

Qixiang Gui, Neng Ding, Haimei Wu, Jinyue Liu, Yingnan Geng, Jie Zhu, Mingyue Gao, Antong Du, Bingbing Yue, Lie Zhu

{"title":"Development of a pH-Responsive Antimicrobial and Potent Antioxidant Hydrogel for Accelerated Wound Healing: A Game Changer in Drug Delivery","authors":"Qixiang Gui, Neng Ding, Haimei Wu, Jinyue Liu, Yingnan Geng, Jie Zhu, Mingyue Gao, Antong Du, Bingbing Yue, Lie Zhu","doi":"10.1002/adbi.202400358","DOIUrl":"10.1002/adbi.202400358","url":null,"abstract":"Stimuli-responsive hydrogels have the capability to alter their state in response to changes in physiological signals within their application environment, providing distinct benefits in drug delivery applications. Here, the acidic pH typically found in acutely infected wounds can be effectively managed by incorporating a pH-responsive Ag+ loaded system within the hydrogel, thereby ensuring efficient drug use and preventing potential toxicity from the sudden release of silver ions. The antimicrobial composite hydrogel HAMA/GelMA-CA/Ag+ provides some tissue adhesion and accelerates wound healing. GelMA-CA is synthesized by modifying gelatin methacryloyl (GelMA) with caffeic acid (CA), while hyaluronic acid methacryloyl (HAMA) is introduced to prepare a double network hydrogel. Silver nitrate is then introduced to make it pH-responsive through the formation of coordination between the polyphenolic structure of caffeic acid and the silver ions. The composite hydrogel exhibited excellent antioxidant properties and strong antimicrobial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the composite hydrogel accelerated the promotion of wound healing in a rat model of S. aureus-infected wounds. In conclusion, the HAMA/GelMA-CA/Ag+ hydrogel is a promising bioactive material that can be used as a wound dressing to promote the healing of acutely infected wounds.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of Intrauterine Adhesion with Platelet-Rich Plasma Double-Network Hydrogel 用富血小板血浆双网水凝胶预防宫内粘连

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-14 DOI: 10.1002/adbi.202400336

Zhuomin Wang, Ying Gu, Yiyuan Qu, Xujia Huang, Tao Sun, Wei Wu, Qianyu Hu, Xiao Chen, Yu Li, Huafei Zhao, Yingying Hu, Bingbing Wu, Jian Xu

{"title":"Prevention of Intrauterine Adhesion with Platelet-Rich Plasma Double-Network Hydrogel","authors":"Zhuomin Wang, Ying Gu, Yiyuan Qu, Xujia Huang, Tao Sun, Wei Wu, Qianyu Hu, Xiao Chen, Yu Li, Huafei Zhao, Yingying Hu, Bingbing Wu, Jian Xu","doi":"10.1002/adbi.202400336","DOIUrl":"10.1002/adbi.202400336","url":null,"abstract":"Intrauterine adhesion (IUA) can negatively impact on pregnancy outcomes, leading to reduced pregnancy rates, secondary infertility, and an increased risk of pregnancy complications. Studies have shown that the application of platelet-rich plasma (PRP) in IUA patients is effective. However, the clinical readhesive rate of IUA after treatment is still high, especially in severe cases. Platelet-rich plasma double-network hydrogel (DN gel) is an engineered PRP double network hydrogel, which is a sodium alginate (SA) based PRP hydrogel with egg carton ion cross-linking and fibrin double network. The results of this study show that intrauterine injection of DN gel has a better effect on promoting endometrial regeneration and enhancing endometrial receptivity than PRP gel. The mechanism is analyzed through single-cell sequencing, which may be achieved by increasing the expression of neutrophils (Neut), natural killer cells (NK), and type I classical dendritic cells (cDC1) in the endometrium and inhibiting the infiltration of M2 macrophages. Overall, based on the good healing efficiency and good biocompatibility of DN gel, it is expected to become a method of treating IUA with better efficacy and faster clinical translation.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"9 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipogenic-Myogenic Signaling in Engineered Human Muscle Grafts used to Treat Volumetric Muscle Loss (Adv. Biology 12/2024) 人造肌肉移植用于治疗体积性肌肉损失的脂肪生成-肌生成信号（Adv. Biology 12/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-13 DOI: 10.1002/adbi.202470121

Dallas E. Altamirano, Eszter Mihaly, Jalissa D. Emmens, Warren L. Grayson

引用次数: 0

Masthead: (Adv. Biology 12/2024) 报头：（Adv. Biology 12/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-12-13 DOI: 10.1002/adbi.202470122

引用次数: 0