Advanced biology最新文献_第7页

FAM136A as a Diagnostic Biomarker in Esophageal Cancer: Insights into Immune Infiltration, m6A Modification, Alternative Splicing, Cuproptosis, and the ceRNA Network 作为食管癌诊断生物标记物的 FAM136A：洞察免疫渗透、m6A 修饰、替代剪接、杯突症和 ceRNA 网络

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-26 DOI: 10.1002/adbi.202400157

Shaowu Sun, Chunyao Huang, Wenbo Fan, Zhulin Wang, Kaiyuan Li, Xu Liu, Zelong Wang, Tianliang Zhao, Guoqing Zhang, Xiangnan Li

{"title":"FAM136A as a Diagnostic Biomarker in Esophageal Cancer: Insights into Immune Infiltration, m6A Modification, Alternative Splicing, Cuproptosis, and the ceRNA Network","authors":"Shaowu Sun, Chunyao Huang, Wenbo Fan, Zhulin Wang, Kaiyuan Li, Xu Liu, Zelong Wang, Tianliang Zhao, Guoqing Zhang, Xiangnan Li","doi":"10.1002/adbi.202400157","DOIUrl":"10.1002/adbi.202400157","url":null,"abstract":"FAM136A promotes the progression and metastasis of various tumors. However, there are few studies on the role of FAM136A in esophageal cancer (ESCA). The TCGA, GTEx, and GEO databases are employed to analyze the expression of FAM136A in ESCA, and qPCR and TMA experiments are performed for validation. Enrichment analyzes are performed to investigate the association of FAM136A expression with immune features, m6A modification, alternative splicing, cuproptosis, and the ceRNA network via bioinformatics analysis. FAM136A is highly expressed in ESCA and correlated with lymph node metastasis and overall survival (OS). Bioinformatics analysis suggested that FAM136A may participate in the following processes to promote ESCA development and progression: 1) Promotion of mast cells infiltration to influence the ESCA immune microenvironment, 2) HNRNPC upregulation to regulate m6A modification, 3) ALYREF upregulation to increase the occurrence of retained intron (RI) events, 4) CDK5RAP1 upregulation to achieve inhibition of tumor cell apoptosis, and 5) promotion of ESCA progression through the lncRNA SNHG15/hsa-miR-29c-3p/FAM136A ceRNA network. FAM136A is a potential biomarker for ESCA diagnosis and treatment response evaluation, and the underlying mechanisms may be associated with immune infiltration, m6A modification, alternative splicing, cuproptosis, and the ceRNA regulatory network.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202400157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Coding RNA in Schwann Cell and Peripheral Nerve Injury: A Review. 许旺细胞和周围神经损伤中的非编码 RNA：综述。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-26 DOI: 10.1002/adbi.202400357

Li-Xin Huang, Tao Sun, Jun Sun, Zhi-Min Wu, Cong Ling, Bao-Yu Zhang, Chuan Chen, Hui Wang

引用次数: 0

"Society Isn't Designed for Us to Win": Trauma and Sexual Healthcare Experiences Among Transgender Women in the Southeastern United States. "社会不是为我们赢而设计的"：美国东南部变性妇女的创伤和性保健经历。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-26 DOI: 10.1002/adbi.202400200

Olivia T Van Gerwen, Christina A Muzny, Bulent Turan, Krishmita Siwakoti, D Scott Batey

{"title":"\"Society Isn't Designed for Us to Win\": Trauma and Sexual Healthcare Experiences Among Transgender Women in the Southeastern United States.","authors":"Olivia T Van Gerwen, Christina A Muzny, Bulent Turan, Krishmita Siwakoti, D Scott Batey","doi":"10.1002/adbi.202400200","DOIUrl":"https://doi.org/10.1002/adbi.202400200","url":null,"abstract":"Transgender women (TGW) are disproportionately affected by sexually transmitted infections (STIs). Experienced trauma threatens TGW's commitment to sexual healthcare. Trauma-informed approaches to sexual healthcare can improve engagement. This study aimed to characterize the trauma experienced by TGW in the Southeastern US, especially related to sexual health. TGW completed in-depth individual interviews guided by the Modified Social Ecological Model (MSEM) and Minority Stress framework. Interviews explored the nature of trauma, sexual health, and their intersection in TGW's lives, and a thematic analysis was performed. Between August 2022 and January 2023, 13 TGW enrolled (69% Black, 31% White). Mental illness was common (77%). Five participants (38%) were HIV+, and seven (54%) reported lifetime STI history. Themes reflected societal (barriers to healthcare, anti-transgender legislation), community (misgendering/deadnaming), network (limited support), and individual (dysphoria, sex work, fear for physical safety, stigma, mental health conditions, race) stressors. The physical/sexual violence and resilience themes pervaded all stressor levels. Medical mistrust was exacerbated by past traumatic experiences within sexual healthcare settings. Resilience and transgender representation in healthcare settings were protective. Various experienced traumas and their cumulative effects were pervasive in the daily lives of TGW. Development of targeted interventions to improve sexual health engagement of TGW must optimize personal strengths and provide holistic support.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400200"},"PeriodicalIF":3.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Arginine Level for Predicting Early Allograft Dysfunction in Liver Transplantation Recipients by Targeted Metabolomics Analysis: A Prospective, Single-Center Cohort Study 通过靶向代谢组学分析预测肝移植受者早期移植物功能障碍的血清精氨酸水平：一项前瞻性单中心队列研究。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-20 DOI: 10.1002/adbi.202400128

Chunmei Geng, Fang Chen, Hanyong Sun, Houwen Lin, Yongbing Qian, Jianjun Zhang, Qiang Xia

{"title":"Serum Arginine Level for Predicting Early Allograft Dysfunction in Liver Transplantation Recipients by Targeted Metabolomics Analysis: A Prospective, Single-Center Cohort Study","authors":"Chunmei Geng, Fang Chen, Hanyong Sun, Houwen Lin, Yongbing Qian, Jianjun Zhang, Qiang Xia","doi":"10.1002/adbi.202400128","DOIUrl":"10.1002/adbi.202400128","url":null,"abstract":"Early allograft dysfunction (EAD) is a frequent phenomenon, leading to increased graft loss and higher mortality after liver transplantation (LT). Despite significant efforts for early diagnosis of EAD, there is no existing approach that can predict EAD on the first post-operative day. The aim is to define a metabolite-based biomarker on the first day after LT complicated with EAD. Ten patients diagnosed with EAD and 26 non-EAD are recruited for the study. A HPLC-MS/MS is used to determine 14 amino acids and 15 bile acids serum concentration. Comparative analyses are conducted between EAD and non-EAD groups. Arginine is identified as the most significant metabolite distinguishing the EAD and non-EAD groups, and therefore, is identified as a potential biomarker of EAD. The optimal cut-off value for arginine is 52.09 µmol L−1, with an AUROC of 0.804 (95% confidence interval: 0.638–0.917, p < 0.001), yielding a sensitivity of 100%, specificity of 53.8%, and Youden index of 0.54, NPVof 100%, and PPV of 45.45%. In summary, the study indicated that targeted metabolomics analysis would be a promising strategy for discovering novel biomarkers to predict EAD. The identified arginine may be helpful in developing an objective diagnostic method for EAD.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectrical Impedance Vectors Analysis of Sarcopenic Older Adults Submitted to a Resistance Training Program. 参加阻力训练计划的肌肉疏松老年人的生物电阻抗向量分析。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-20 DOI: 10.1002/adbi.202400276

Giovanni Henrique Quizzini, Caroline Galan de Souza Pereira, Vanessa Ribeiro Dos Santos, Vitor Cabrera Batista, Bruna Spolador de Alencar Silva, Fábio Santos Lira, Alex Silva Ribeiro, Luís Alberto Gobbo

{"title":"Bioelectrical Impedance Vectors Analysis of Sarcopenic Older Adults Submitted to a Resistance Training Program.","authors":"Giovanni Henrique Quizzini, Caroline Galan de Souza Pereira, Vanessa Ribeiro Dos Santos, Vitor Cabrera Batista, Bruna Spolador de Alencar Silva, Fábio Santos Lira, Alex Silva Ribeiro, Luís Alberto Gobbo","doi":"10.1002/adbi.202400276","DOIUrl":"https://doi.org/10.1002/adbi.202400276","url":null,"abstract":"The objective of the present study is to analyze the changes in bioimpedance vector analysis (BIVA) and phase angle (PhA) in sarcopenic older people submitted to a 12-week resistance training (RT) program according to classic and specific analyses. To this end, 20 sarcopenic older adults of both sexes, invited through media, underwent bioimpedance analysis before and after the RT carried out three times a week, for 12 weeks. The mean impedance vectors of the groups established for the confidence ellipses (95% of the confidence ellipse) are compared using Hotelling's T2 test. The distance D from Mahalanobis is also calculated. Classic and Specific BIVA are presented. The resistance values for the classical analyses (R/H) decreased across all groups (whole group, women and men, p < 0.05), with approximate decreases ranging from 9.4% to 10%, while the classic reactance (Xc/H) decreased (p < 0.05) only for the whole group (5.9%) and men (7.7%). For the specific BIVA, trends are verified for the whole sample, with a decrease in resistance (R.sp) and an increase in reactance (Xc.sp). In conclusion, the RT program in sarcopenic individuals promoted a reduction in resistance values in classical analyses, indicating a possible increase in hydration status and, consequently, musculoskeletal mass.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":" ","pages":"e2400276"},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging Influences Fracture Healing on the Cellular Level and Alters Systemic RANKL and OPG Concentrations in a Murine Model 衰老在细胞水平上影响骨折愈合，并改变小鼠模型中全身 RANKL 和 OPG 的浓度。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-20 DOI: 10.1002/adbi.202300653

Tianqi Zhang, Claudia Neunaber, Weikang Ye, Alessa Wagner, Jasmin Maria Bülow, Borna Relja, Katrin Bundkirchen

{"title":"Aging Influences Fracture Healing on the Cellular Level and Alters Systemic RANKL and OPG Concentrations in a Murine Model","authors":"Tianqi Zhang, Claudia Neunaber, Weikang Ye, Alessa Wagner, Jasmin Maria Bülow, Borna Relja, Katrin Bundkirchen","doi":"10.1002/adbi.202300653","DOIUrl":"10.1002/adbi.202300653","url":null,"abstract":"Clinical complications frequently follow polytrauma and bleeding fractures, increasing the risk of delayed fracture healing and nonunions, especially in aged patients. Therefore, this study examines age's impact on fracture repair with and without severe bleeding in mice. Young (17–26 weeks) and aged (64–72 weeks) male C57BL/6J mice (n = 72 in total, n = 6 per group) are allocated into 3 groups: the fracture group (Fx) undergoes femur osteotomy stabilized via external fixator, the combined trauma group (THFx) additionally receives pressure-controlled trauma hemorrhage (TH) and Sham animals are implanted with catheter and fixator without blood loss or osteotomy. Femoral bones are evaluated histologically 24 h and 3 weeks post-trauma, while RANKL/OPG and β-CTx are measured systemically via ELISA after 3 weeks. Aging results in less mineralized bone and fewer osteoclasts within the fracture of aged mice in contrast to young groups after three weeks. Systemically, aged animals exhibit increased RANKL and OPG levels after fracture compared to their young counterparts. The RANKL/OPG ratio rises in aged Fx animals compared to young mice, with a similar trend in THFx groups. In conclusion, age has an effect during the later course of fracture healing on the cellular and systemic levels.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202300653","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the Role of NEIL1 Gene in DNA Repair and Lifespan: A Literature Review with Bioinformatics Analysis 解码 NEIL1 基因在 DNA 修复和寿命中的作用：文献综述与生物信息学分析。

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-20 DOI: 10.1002/adbi.202300708

Amirhossein Mohajeri Khorasani, Alireza Raghibi, Behzad Haj Mohammad Hassani, Pedram Bolbolizadeh, Arian Amali, Mahboubeh Sadeghi, Narges Farshidi, Aghdas Dehghani, Pegah Mousavi

{"title":"Decoding the Role of NEIL1 Gene in DNA Repair and Lifespan: A Literature Review with Bioinformatics Analysis","authors":"Amirhossein Mohajeri Khorasani, Alireza Raghibi, Behzad Haj Mohammad Hassani, Pedram Bolbolizadeh, Arian Amali, Mahboubeh Sadeghi, Narges Farshidi, Aghdas Dehghani, Pegah Mousavi","doi":"10.1002/adbi.202300708","DOIUrl":"10.1002/adbi.202300708","url":null,"abstract":"Longevity, the length of an organism's lifespan, is impacted by environmental factors, metabolic processes, and genetic determinants. The base excision repair (BER) pathway is crucial for maintaining genomic integrity by repairing oxidatively modified base lesions. Nei-like DNA Glycosylase 1 (NEIL1), part of the BER pathway, is vital in repairing oxidative bases in G-rich DNA regions, such as telomeres and promoters. Hence, in this comprehensive review, it have undertaken a meticulous investigation of the intricate association between NEIL1 and longevity. The analysis delves into the multifaceted aspects of the NEIL1 gene, its various RNA transcripts, and the diverse protein isoforms. In addition, a combination of bioinformatic analysis is conducted to identify NEIL1 mutations, transcription factors, and epigenetic modifications, as well as its lncRNA/pseudogene/circRNA-miRNA-mRNA regulatory network. The findings suggest that the normal function of NEIL1 is a significant factor in human health and longevity, with defects in NEIL1 potentially leading to various cancers and related syndromes, Alzheimer's disease, obesity, and diabetes.","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microphysiological Systems (MPS) for Precision Medicine (Adv. Biology 8/2024) 用于精准医疗的微观生理学系统（MPS）（生物学高级课程 8/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-16 DOI: 10.1002/adbi.202470081

Monty Montano, Venkataramana Sidhaye, Martin Trapecar, Deok-Ho Kim

引用次数: 0

Masthead: (Adv. Biology 8/2024) 刊头：（高级生物学 8/2024）

IF 3.2 3区生物学

Advanced biology Pub Date : 2024-08-16 DOI: 10.1002/adbi.202470082

引用次数: 0

Microphysiological Systems for Cancer Immunotherapy Research and Development (Adv. Biology 8/2024) 癌症免疫疗法研究与开发的微观生理学系统（生物学高级课程 8/2024）

IF 3.2 3区生物学