3D机械约束指导肌肉干细胞的命运和功能（Adv. Biology 4/2025）

IF 3.2 3区生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS

Advanced biology Pub Date : 2025-04-16 DOI:10.1002/adbi.202570098

GaYoung Park, Josh A. Grey, Foteini Mourkioti, Woojin M. Han

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引用次数: 0

摘要

3D约束调节肌肉干细胞脂肪在这项研究中，开发了一个3D水凝胶双层平台，通过调节约束和刚度来模拟再生肌肉干细胞（MuSC）生态位。增加的三维约束保留了MuSC的干性，限制了激活、增殖和分化。研究结果表明，机械线索通过核和表观遗传调控对肌生成承诺起“刹车”作用。更多细节可以在Woojin M. Han及其同事的文章编号2400717中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function (Adv. Biology 4/2025)

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3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function (Adv. Biology 4/2025)

3D Confinement Regulates Muscle Stem Cell Fate

In this study a 3D hydrogel bilayer platform is developed that mimics the regenerating muscle stem cell (MuSC) niche by modulating confinement and stiffness. Increased 3D confinement preserves MuSC stemness, limiting activation, proliferation, and differentiation. Findings suggest mechanical cues act as a “brake” on myogenic commitment through nuclear and epigenetic regulation. More details can be found in article number 2400717 by Woojin M. Han and co-workers.

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来源期刊

Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

6.60

自引率

0.00%

发文量

130