Advanced biology最新文献_第8页

Therapeutic Potential of Stem Cells From Human Exfoliated Deciduous Teeth and Their Derivatives in Immune-Mediated Inflammatory Diseases: Mechanisms and Perspectives 人脱落乳牙干细胞及其衍生物在免疫介导炎性疾病中的治疗潜力：机制和观点。

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-24 DOI: 10.1002/adbi.202500443

Wenbo Cui, Dandan Zheng, Anqi Liu, Meiling Wu, Qing Liu, Hao Guo, Xiaowei Cai, Zhenlai Zhu

{"title":"Therapeutic Potential of Stem Cells From Human Exfoliated Deciduous Teeth and Their Derivatives in Immune-Mediated Inflammatory Diseases: Mechanisms and Perspectives","authors":"Wenbo Cui, Dandan Zheng, Anqi Liu, Meiling Wu, Qing Liu, Hao Guo, Xiaowei Cai, Zhenlai Zhu","doi":"10.1002/adbi.202500443","DOIUrl":"10.1002/adbi.202500443","url":null,"abstract":"<div>\u0000 \u0000 <p>Stem cells from human exfoliated deciduous teeth (SHED) and their derivatives have emerged as promising therapeutic agents for treating immune-mediated inflammatory diseases (IMIDs). IMIDs are characterized by dysregulated immune responses, leading to chronic inflammation and tissue damage. The current treatment landscape for IMIDs faces challenges, including the complexity of disease mechanisms and the limitations of existing therapies, which frequently fail to achieve long-term remission and are often associated with significant side effects. Consequently, there is a pressing need for innovative therapies that not only alleviate symptoms but also address the underlying immune dysfunction and promote the repair of damaged tissues. In this context, SHED and their derivatives offer a dual therapeutic advantage by harnessing both immunomodulatory and regenerative capacities. Research highlighted in this review demonstrates the therapeutic potential of SHED and their derivatives in multiple IMIDs, such as systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, and rheumatoid arthritis. Critically, the aim of this review is not only to synthesize recent progress in SHED research for IMID treatment but also to highlight the strategic significance of innovative therapies emerging from the intersection of regenerative medicine and immunology.</p>\u0000 </div>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

iMSCs vs MSCs: Comparative Features and Therapeutic Potential in Wound Healing 间充质干细胞与间充质干细胞：伤口愈合的比较特征和治疗潜力。

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-24 DOI: 10.1002/adbi.202500623

Avinash Sanap, Akshaya Ashok, Kaustubh Raundal, Supriya Kheur, Ravindra Badhe, Ramesh Bhonde

{"title":"iMSCs vs MSCs: Comparative Features and Therapeutic Potential in Wound Healing","authors":"Avinash Sanap, Akshaya Ashok, Kaustubh Raundal, Supriya Kheur, Ravindra Badhe, Ramesh Bhonde","doi":"10.1002/adbi.202500623","DOIUrl":"10.1002/adbi.202500623","url":null,"abstract":"<div>\u0000 \u0000 <p>Regenerative medicine is evolving exponentially due to the wide range of therapeutic applications of mesenchymal stromal cells (MSCs), including wound healing. Although the translation of tissue-derived primary MSCs (tMSCs) into clinical practice remains scarce despite preclinical success. The primary causes are donor-associated and batch-to-batch variations, replicative senescence, and the inability of large-scale manufacturing. Recent studies show that the induced MSCs (iMSCs) derived from reprogrammed induced pluripotent stem cells (iPSCs) offer distinct advantages over conventional tMSCs. This review aims to provide a comprehensive comparative analysis of the cellular characteristics, secretome composition (including growth factors, cytokines, and exosome cargo), regenerative capacities, and therapeutic potentials of tMSCs and iMSCs, with a specific focus on their applications in wound healing and tissue regeneration. The iMSCs surpass tMSCs by providing superior regenerative, immunomodulatory, and angiogenic benefits, along with unmatched consistency and scalability. iMSCs and their derivatives have exhibited remarkable capacities to promote angiogenesis, ECM production, re-epithelialization, tissue regeneration, and scarless wound healing in diabetic, cutaneous, mucosal, and burn wounds. These advantages position iMSCs as a next-generation cell therapy for managing both acute and chronic wounds, promising improved clinical outcomes and broader applicability.</p>\u0000 </div>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-24

引用次数: 0

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-24

引用次数: 0

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-24

引用次数: 0

Application and Research Progress of Carbonated Hydroxyapatite in Bone Tissue Regeneration 碳酸羟基磷灰石在骨组织再生中的应用与研究进展。

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-24 DOI: 10.1002/adbi.202500451

Yifu Bian, Xinliang Duan, Sichen Han, Yao Yuan, Jiayu Shen, Zilin Wang, Bing Han

{"title":"Application and Research Progress of Carbonated Hydroxyapatite in Bone Tissue Regeneration","authors":"Yifu Bian, Xinliang Duan, Sichen Han, Yao Yuan, Jiayu Shen, Zilin Wang, Bing Han","doi":"10.1002/adbi.202500451","DOIUrl":"10.1002/adbi.202500451","url":null,"abstract":"<div>\u0000 \u0000 <p>Carbonated Hydroxyapatite (CHA) has attracted widespread attention in bone tissue regeneration due to its chemical composition and crystal structure, which are similar to natural bone tissue. This review summarizes the basic characteristics of CHA, preparation methods, and advances in its application in bone repair. First, the crystal structure, chemical composition, and the effect of carbonate doping on its physicochemical properties are discussed, focusing on how preparation techniques such as the wet chemical method, sol–gel method, and hydrothermal synthesis regulate CHA's properties. Second, the biological mechanisms of CHA in bone tissue regeneration are outlined, including its role in promoting osteoblast proliferation and differentiation, regulating the bone repair microenvironment, and mediating related signaling pathways (e.g., Wnt/β-catenin and bone morphogenetic protein (BMP)/Smad). Furthermore, the research progress of CHA in repairing cranial, alveolar, and long bone defects is systematically reviewed through animal models and clinical studies to evaluate its bone repair capacity and biocompatibility. In addition, the composite application of CHA with polymers and bioactive glass and its potential development in frontier technologies such as 3D printing and smart drug delivery are discussed. Finally, the challenges in mechanical properties, degradation rate, and preparation processes are analyzed, and the future application prospects of CHA as an intelligent, multifunctional bone repair material are envisaged. This review aims to provide theoretical support and research insights to optimize the design and application of CHA in bone tissue engineering.</p>\u0000 </div>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-09

引用次数: 0

Tumor-Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance 肿瘤浸润性伤害感受器神经元在卵巢癌治疗抵抗中的作用。

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-09 DOI: 10.1002/adbi.202500404

Allison Jorgensen, Daniel W. Vermeer, Euihye Jung, Caitlin S. Williamson, Dalia K. Omran, Lauren E. Schwartz, Ju-Yoon Yoon, Jeffrey Barr, Ashley L. Tetlow, Camille V. Trinidad, Ronny Drapkin, Andrew K. Godwin, Paola D. Vermeer

{"title":"Tumor-Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance","authors":"Allison Jorgensen, Daniel W. Vermeer, Euihye Jung, Caitlin S. Williamson, Dalia K. Omran, Lauren E. Schwartz, Ju-Yoon Yoon, Jeffrey Barr, Ashley L. Tetlow, Camille V. Trinidad, Ronny Drapkin, Andrew K. Godwin, Paola D. Vermeer","doi":"10.1002/adbi.202500404","DOIUrl":"10.1002/adbi.202500404","url":null,"abstract":"<p>Patients with densely innervated tumors suffer with poor outcomes, thus identifying them could define a cohort that could benefit from aggressive treatments. Most cases and deaths from ovarian cancer are associated with high-grade serous ovarian carcinoma (HGSOC). We immunohistochemically analyzed the histological subtypes of ovarian cancer (high-grade serous, low-grade serous, clear cell, mucinous, and endometrioid) for nerves; only HGSOCs were densely innervated. We previously defined that tumor-released small extracellular vesicles (sEVs) recruit nerves to the tumor bed and thus tested whether the difference in nerve infiltration amongst ovarian cancers was associated with sEVs. Using an in vitro neurite outgrowth assay, we found that HGSOC sEVs harbored robust neurite outgrowth activity. Importantly, sEVs from fallopian tube cell lines (the primary cell of origin of HGSOC) predominantly lacked this activity. Implantation of a syngeneic mouse model of HGSOC into transgenic mice lacking tumor-infiltrating nerves slowed tumor growth, sensitized disease to carboplatin, and improved survival. Consistent with this, we show that recurrent, treatment-resistant disease in patients is significantly more innervated than its matched naïve (untreated) malignancy. Taken together, these data identify dense nerve infiltration of HGSOCs and show that innervation contributes to treatment resistance.</p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Responses of Amyloid-β 42 Aggregates to Resveratrol 淀粉样蛋白-β 42聚集体对白藜芦醇的差异反应。

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-04 DOI: 10.1002/adbi.202500586

Nghia D. Nguyen, Peter G. Vekilov

{"title":"Differential Responses of Amyloid-β 42 Aggregates to Resveratrol","authors":"Nghia D. Nguyen, Peter G. Vekilov","doi":"10.1002/adbi.202500586","DOIUrl":"10.1002/adbi.202500586","url":null,"abstract":"<div>\u0000 \u0000 <p>Amyloid-β (Aβ) aggregation is targeted with small molecules as a pathway toward developing potential Alzheimer's disease (AD) therapies. Resveratrol, a natural polyphenol, has been proposed as an inhibitor of Aβ aggregation, but its mechanistic effects across distinct Aβ42 aggregates remain unresolved. To better evaluate resveratrol's potential to treat AD, here we focus on molecular-level insights into the mechanisms that underlie its interaction with several distinct classes of Aβ42 aggregates. In contrast to published approaches that are based on monitoring the evolution of the total fibrillar mass, we employ time-resolved in situ atomic force microscopy to explore the effects of resveratrol on Aβ42 amyloid and non-amyloid assemblies. While data suggest a weak interaction between resveratrol and low-molecular-weight Aβ42 species, we also observe a concentration-dependent reduction in fibrillization. In the presence of resveratrol, we observe a decrease in fibril thickness and end-dependent slowing of elongation; furthermore, the fibrils exhibit reduced mechanical integrity and fragment under minimal scanning stress. Importantly, resveratrol does not affect the formation or morphology of oligomers and amorphous aggregates. These findings suggest that resveratrol selectively targets the fibril pathway while leaving oligomeric assemblies unaltered. The results provide mechanistic insights into the differential effects of small molecules on Aβ42 assemblies and establish a framework for evaluating inhibitors of aggregation with single-aggregate resolution.</p>\u0000 </div>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"10 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 3区生物学

Advanced biology Pub Date : 2026-03-04

引用次数: 0