Coacervates Composed of Low-Molecular-Weight Compounds– Molecular Design, Stimuli Responsiveness, Confined Reaction

The discovery of coacervation within living cells through liquid–liquid phase separation has inspired scientists to investigate its fundamental principles and significance. Indeed, coacervates composed of low-molecular-weight compounds based on supramolecular strategy can offer valuable models for biomolecular condensates and useful tools. This mini-review highlights recent findings and advances in coacervates (artificial condensates), primarily composed of low-molecular-weight compounds, with focuses on their molecular design, stimuli responsiveness, and controlled reactions within or leading to the coacervates.