Morphological and Optical Profiling of Melanocytes and SK-MEL-28 Melanoma Cells Via Digital Holographic Microscopy and Quantitative Phase Imaging (Adv. Biology 2/2025)

Abstract

Advanced Imaging Techniques in Oncology

This study utilizes digital holographic microscopy and quantitative phase imaging to uncover morphological, optical, and behavioral distinctions between melanocytes and SK-MEL-28 melanoma cells. Advanced techniques, including PCA and t-SNE, reveal significant differences in size, shape, optical properties, and migration patterns. These insights support the identification of melanoma biomarkers, enhancing diagnostic precision and therapeutic strategies in melanoma research. More details can be found in article number 2400346 by Besa Xhabija and co-workers.