Acta radiologica openPub Date : 2026-04-27eCollection Date: 2026-04-01DOI: 10.1177/20584601261443992
Tero Korhonen, Antti Kemppainen, Tuukka Kananen, Mika T Nevalainen
{"title":"Age predicts therapeutic outcome of imaging-guided sacroiliac joint injections, whereas osteoarthritis grade does not: A retrospective single-center study.","authors":"Tero Korhonen, Antti Kemppainen, Tuukka Kananen, Mika T Nevalainen","doi":"10.1177/20584601261443992","DOIUrl":"https://doi.org/10.1177/20584601261443992","url":null,"abstract":"<p><strong>Background: </strong>Sacroiliac joint (SIJ) disorders are among the most common causes of chronic low back pain. Imaging-guided SIJ injections are widely used as an early diagnostic tool, with corticosteroid often added to provide a therapeutic component. Evidence of factors predicting the therapeutic outcome of these injections remains scarce.</p><p><strong>Purpose: </strong>To evaluate the effect of SIJ osteoarthritis and other potentially relevant demographic, imaging, and procedural factors on the patient-reported therapeutic outcome of imaging-guided SIJ injection.</p><p><strong>Material and methods: </strong>This retrospective single-center study included 101 patients who underwent specialist-referred imaging-guided SIJ injection between 2010 and 2023. Medical records and procedural reports were reviewed to collect relevant patient information, and associated SIJ MRIs and CT scans were reanalyzed for osteoarthritis, sacroiliitis, and bone marrow edema by an experienced musculoskeletal radiologist. The association of demographic, imaging, and procedural factors with the therapeutic injection outcome was assessed using logistic regression modeling.</p><p><strong>Results: </strong>Of 101 patients who underwent an imaging-guided SIJ injection, 72 (71.3%) met the inclusion criteria. The mean age was 52.2 (SD 14.2) years, and 30 patients (41.7%) achieved a positive therapeutic response. Increasing age was significantly associated with a lower likelihood of a positive outcome, with the probability decreasing on average by 9.4% for each additional year of age (OR 0.91 [95% CI 0.84-0.99]). Neither SIJ osteoarthritis grade nor other demographic, imaging, or procedural factors showed a significant association with injection outcome.</p><p><strong>Conclusion: </strong>Increasing age was significantly associated with a lower likelihood of achieving a positive therapeutic SIJ injection outcome, while SIJ osteoarthritis grade showed no association.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 4","pages":"20584601261443992"},"PeriodicalIF":1.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-03-06eCollection Date: 2026-03-01DOI: 10.1177/20584601261424494
Louise Harder, Ole Graumann, Noa Larsen Ohana, Josefine Axelsen, Maria Tækker, Flemming Kromann Nielsen
{"title":"A retrospective study on diagnostic yield, tumor types, and complications of CT-guided bone biopsies.","authors":"Louise Harder, Ole Graumann, Noa Larsen Ohana, Josefine Axelsen, Maria Tækker, Flemming Kromann Nielsen","doi":"10.1177/20584601261424494","DOIUrl":"10.1177/20584601261424494","url":null,"abstract":"<p><strong>Background: </strong>CT-guided percutaneous bone biopsy is a minimally invasive and effective procedure for evaluating and diagnosing bone lesions.</p><p><strong>Purpose: </strong>To evaluate the diagnostic yield, tumor types, and complication rates of CT-guided percutaneous bone biopsy procedures at a single tertiary institution.</p><p><strong>Materials and methods: </strong>This retrospective study analyzed 508 biopsy procedures performed on 473 patients between March 2019 and March 2024. Patients were identified through the RIS/PACS system at Aarhus University Hospital. Data on diagnostic yield, tumor types, and complications were retrospectively reviewed and collected from electronic health and histopathology records. Complications were classified according to the Society of Interventional Radiology (SIR) and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) classification systems.</p><p><strong>Results: </strong>The most common findings were metastatic lesions (<i>n</i> = 234), with breast cancer being the most frequent primary tumor. The procedures resulted in an overall diagnostic yield of 88.7% and a total complication rate of 5.5%.</p><p><strong>Conclusion: </strong>This study demonstrates that CT-guided percutaneous bone biopsy is a reliable method with a high diagnostic yield and a low complication rate. These findings support its continued role as a key diagnostic tool in the clinical management of bone lesions.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 3","pages":"20584601261424494"},"PeriodicalIF":1.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-03-05eCollection Date: 2026-03-01DOI: 10.1177/20584601261431608
Johannes Halkoaho, Oskari Niiranen, Tuomas Kaseva, Arttu Ruohola, Eero Salli, Sauli Savolainen, Harri Hakovirta, Marko Kangasniemi
{"title":"Neural network assessment of aortic, iliac, renal, and mesenteric artery calcification in CTA: Normalized scoring framework and comparison to threshold-based method.","authors":"Johannes Halkoaho, Oskari Niiranen, Tuomas Kaseva, Arttu Ruohola, Eero Salli, Sauli Savolainen, Harri Hakovirta, Marko Kangasniemi","doi":"10.1177/20584601261431608","DOIUrl":"10.1177/20584601261431608","url":null,"abstract":"<p><strong>Background: </strong>Calcification of abdominal arteries is an important risk marker in vascular disease. Automated, objective quantification methods could improve reproducibility and reduce observer dependency in clinical practice.</p><p><strong>Purpose: </strong>To develop and evaluate a deep learning method for quantifying abdominal arterial calcification from contrast-enhanced CT angiography (CTA).</p><p><strong>Material and methods: </strong>We retrospectively collected 223 CTA volumes, divided into 147 training and 76 test cases. Ground truth calcification segmentations were manually annotated, while vessel segmentations were generated by a previously trained neural network and manually refined. Two nnU-Net models were trained, one for artery segmentation and one for calcification segmentation. Renal, mesenteric, and common iliac arteries were shortened algorithmically. Performance of the models was evaluated using Dice score, volumetric similarity, sensitivity, precision, and Jaccard index. Calcification burden was defined as the ratio of calcified volume to artery volume. The amount and the average size of calcification clusters were investigated. The performance of the method was benchmarked against an idealized threshold-based approach and a more clinically realistic approach.</p><p><strong>Results: </strong>The neural network achieved performance comparable to the optimized threshold-based method, with slight improvements across several segmentation metrics. Dice scores and volumetric similarity demonstrated reliable vessel and calcification detection. The predicted calcification burden score showed high correlation with the ground truth calcification burden score.</p><p><strong>Conclusion: </strong>The proposed deep learning tool enables fast, reproducible, and observer-independent quantification of calcification in major abdominal vessels, offering a practical alternative to manual or threshold-based scoring methods.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 3","pages":"20584601261431608"},"PeriodicalIF":1.0,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-02-24eCollection Date: 2026-02-01DOI: 10.1177/20584601261427005
Shinya Fujii, Yuko Iraha, Kanae Ozaki
{"title":"Diffusion lacunae and T2 dark bands in placenta accreta spectrum: MR-pathologic correlation.","authors":"Shinya Fujii, Yuko Iraha, Kanae Ozaki","doi":"10.1177/20584601261427005","DOIUrl":"https://doi.org/10.1177/20584601261427005","url":null,"abstract":"<p><p>A 41-year-old woman with placenta previa and a prior cesarean delivery presented with placenta accreta spectrum (PAS). MRI at 26 weeks of gestation demonstrated an intraplacental hypointense region on diffusion-weighted imaging corresponding to diffusion lacunae (DL). Additionally, irregular hypointense areas on T2-weighted imaging corresponding to T2 dark bands were observed. The entire placenta and uterine wall were sectioned through close collaboration between pathologists and radiologists to match the axial MRI slice plane. MR-pathologic correlation was performed using representative axial MRI and histopathologic findings. Histopathology revealed that DL corresponded to villous-devoid areas suggesting placental lacunae with recent thrombi, whereas T2 dark bands predominantly represented thrombi with lines of Zahn, reflecting the gradual development of thrombi under conditions of blood stasis with residual blood flow. These two MRI findings may therefore represent sequential stages within the same pathological process in PAS.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 2","pages":"20584601261427005"},"PeriodicalIF":1.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-02-21eCollection Date: 2026-02-01DOI: 10.1177/20584601261428675
Shweta Kataria, Girish Gandikota, Cody J Schwartz, Michael M Cunningham
{"title":"Case report: Pancreatitis-associated polyarthritis, panniculitis, and bone infarcts in a patient with alcohol use disorder.","authors":"Shweta Kataria, Girish Gandikota, Cody J Schwartz, Michael M Cunningham","doi":"10.1177/20584601261428675","DOIUrl":"https://doi.org/10.1177/20584601261428675","url":null,"abstract":"<p><p>Musculoskeletal complications secondary to pancreatitis, including polyarthritis, panniculitis, and bone infarction (Pancreatitis Panniculitis Polyarthritis syndrome), are rare and under-recognized. We report a case of a 31-year-old man with alcohol use disorder who initially presented with acute pancreatitis. Two months later, he developed migratory polyarthritis and subcutaneous nodules. Radiographs revealed permeative bone lesions, and MRI demonstrated multiple bone infarcts. Subcutaneous biopsy confirmed panniculitis. His clinical course was complicated by infected pancreatic necrosis and splanchnic vein thromboses. Joint symptoms improved with aggressive treatment of pancreatitis. Early imaging evaluation is essential in patients with pancreatitis and musculoskeletal symptoms. Recognition of bone infarctions and panniculitis should prompt consideration of systemic pancreatic complications.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 2","pages":"20584601261428675"},"PeriodicalIF":1.0,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12925010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-01-30eCollection Date: 2026-01-01DOI: 10.1177/20584601261422371
Taisuke Furuta, Tomohiko Sakuda, Nobuo Adachi
{"title":"Intraoperative MRI for giant cell tumor of bone after denosumab and other selected tumors: A pilot study.","authors":"Taisuke Furuta, Tomohiko Sakuda, Nobuo Adachi","doi":"10.1177/20584601261422371","DOIUrl":"10.1177/20584601261422371","url":null,"abstract":"<p><strong>Background: </strong>Although intraoperative magnetic resonance imaging (iMRI) is well established in neurosurgery, its role in musculoskeletal oncology remains unclear.</p><p><strong>Purpose: </strong>To assess the feasibility and safety of iMRI in bone and soft tissue tumor surgery, focusing on giant cell tumor of bone (GCTB) after denosumab.</p><p><strong>Material and methods: </strong>Fourteen patients (12 GCTB, 1 undifferentiated pleomorphic sarcoma [UPS], 1 chondroblastoma) underwent tumor resection with intraoperative 0.4 T MRI between 2017 and 2024. Outcomes included residual tumor detection, recurrence, and safety.</p><p><strong>Results: </strong>iMRI identified residual tumor in 7 of 12 GCTB patients (58.3%), all histologically confirmed. At a median follow-up of 42 months, recurrence occurred in one GCTB case (8.3%). iMRI guided complete resection in a femoral head chondroblastoma, enabling full functional recovery. Soft tissue assessment was limited in the UPS case. No iMRI-related complications occurred.</p><p><strong>Conclusion: </strong>iMRI is a feasible and safe adjunct in bone tumor surgery, enhancing detection of residual tumor and supporting joint-preserving procedures, particularly in GCTB after denosumab.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 1","pages":"20584601261422371"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-01-25eCollection Date: 2026-01-01DOI: 10.1177/20584601261419037
Kantheera Leesmidt, Amanda Liu, Liina Poder, Rachelle Durand, Orit Glenn, Yi Li, Jesse Courtier
{"title":"3D steady-state free precession in fetal body MR imaging: A useful adjunctive sequence.","authors":"Kantheera Leesmidt, Amanda Liu, Liina Poder, Rachelle Durand, Orit Glenn, Yi Li, Jesse Courtier","doi":"10.1177/20584601261419037","DOIUrl":"10.1177/20584601261419037","url":null,"abstract":"<p><p>Fetal magnetic resonance imaging (MRI) has become a valuable noninvasive method for evaluating congenital anomalies of the fetus and can serve as an important adjunct to the prenatal ultrasound, particularly where the ultrasound is unable to exclude or detect fetal abnormalities. This pictorial review will describe the utilization of three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) in various clinical entities, specifically at 3T, and how to generate clinically valuable information.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 1","pages":"20584601261419037"},"PeriodicalIF":1.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-01-24eCollection Date: 2026-01-01DOI: 10.1177/20584601261418668
Li He Shaun Lim, Shuyi Guo, P Chandra Mohan, Su Chong Albert Low, Zhuyi Rebekah Lee
{"title":"Hidden in plain sight: Extrapulmonary manifestations of tuberculosis in Asia.","authors":"Li He Shaun Lim, Shuyi Guo, P Chandra Mohan, Su Chong Albert Low, Zhuyi Rebekah Lee","doi":"10.1177/20584601261418668","DOIUrl":"10.1177/20584601261418668","url":null,"abstract":"<p><p>Extrapulmonary tuberculosis represents 15-20% of all tuberculosis infections and can involve nearly any organ, earning tuberculosis a reputation as one of the great mimickers in medicine. Imaging plays a critical role in diagnosing extrapulmonary tuberculosis, which presents with a wide range of manifestations. We present a pictorial essay comprising cases from Asia, where tuberculosis remains endemic, illustrating the imaging characteristics of extrapulmonary tuberculosis with a focus on thoracoabdominal pathology. Differential diagnoses that exhibit similar imaging findings are also discussed. We aim to raise awareness among radiologists about the importance of considering extrapulmonary tuberculosis for accurate diagnosis and timely management.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 1","pages":"20584601261418668"},"PeriodicalIF":1.0,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2026-01-21eCollection Date: 2026-01-01DOI: 10.1177/20584601261418629
Mimmi K Liukkonen, Miska Jämsä, Suvi Hartikainen, Minna Husso, Marja Hedman, Heikki Hietanen, Martin Ugander, Saara Sillanmäki, Elias Ylä-Herttuala
{"title":"The effect of age and sex on T1, T2, and T2* relaxation time constants in cardiac MRI in healthy Finnish population.","authors":"Mimmi K Liukkonen, Miska Jämsä, Suvi Hartikainen, Minna Husso, Marja Hedman, Heikki Hietanen, Martin Ugander, Saara Sillanmäki, Elias Ylä-Herttuala","doi":"10.1177/20584601261418629","DOIUrl":"https://doi.org/10.1177/20584601261418629","url":null,"abstract":"<p><strong>Background: </strong>Magnetic resonance imaging (MRI) enables the non-invasive assessment of myocardial tissue properties through the T1, T2, and T2* relaxation mapping. Establishing population-specific normal reference values enhances diagnostic accuracy.</p><p><strong>Purpose: </strong>To study the effect of sex and age on the T1, T2, and T2* relaxation time constants in a healthy Finnish population.</p><p><strong>Methods: </strong>We recruited 47 healthy volunteers aged 18-60 years from Eastern Finland from 2023 to 2024 and categorised them by sex and age (18-30 years, 31-41 years, and 42-60 years). The participants underwent a comprehensive screening process to eliminate the possibility of cardiac disease. MRI scans were conducted on 40 participants at 1.5 T. The T1, T2, and T2* relaxation time constants were calculated for basal, mid-ventricular, and apical short-axis slices.</p><p><strong>Results: </strong>The T1 and T2 relaxation time constants were higher in females than males (T1: 1040 ± 29 vs 1020 ± 17 ms, <i>p</i> < .01; T2: 51 ± 4 vs 48 ± 3 ms, <i>p</i> < .001). The 95% normal T1 range was 981-1098 ms for females and 985-1054 ms for males. The normal T2 range was 44-58 ms for females and 43-53 ms for males. No sex differences were found in the T2* relaxation times. The septal T2* across the whole population was 36 ± 7 ms (95% normal limit: 22-49 ms).</p><p><strong>Conclusion: </strong>This study established age-independent and sex-specific reference values for the native myocardial T1, T2, and T2* relaxation time constants at 1.5 T. Females had higher T1 and T2 values than males, and age did not affect these values.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"15 1","pages":"20584601261418629"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12831919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2025-12-24eCollection Date: 2025-12-01DOI: 10.1177/20584601251412850
Adil Aytaç, Kâmil Gürel, Yunus Yılmazsoy, Mustafa Hızal, Selma Erdoğan Düzcü, Oya Kalaycıoğlu
{"title":"Comparison of low- and standard-dose CT-guided transthoracic core needle biopsies: Feasibility, safety, diagnostic yield, and radiation dose.","authors":"Adil Aytaç, Kâmil Gürel, Yunus Yılmazsoy, Mustafa Hızal, Selma Erdoğan Düzcü, Oya Kalaycıoğlu","doi":"10.1177/20584601251412850","DOIUrl":"10.1177/20584601251412850","url":null,"abstract":"<p><strong>Background: </strong>Computed tomography (CT)-guided transthoracic biopsy is essential for diagnosing pulmonary lesions but exposes patients to considerable radiation from repeated image acquisitions. With the growing emphasis on radiation safety, applying validated low-dose CT protocols to interventional procedures has become a key clinical priority.</p><p><strong>Purpose: </strong>To assess the feasibility, safety, diagnostic yield, and radiation dose of low-dose computed tomography-guided transthoracic biopsies using an 80 kVp protocol compared with standard 120 kVp protocols.</p><p><strong>Methods: </strong>A retrospective review was performed on 183 consecutive computed tomography-guided transthoracic biopsies of lung nodules or masses, including 143 procedures with the standard 120 kVp protocol and 40 procedures with a low-dose 80 kVp protocol at 30 mAs. Procedural characteristics, image quality, histopathological adequacy, radiation exposure, and complications were analyzed. Both subjective and objective image quality assessments, including signal-to-noise and contrast-to-noise ratios, and cellular analyses of specimens were compared.</p><p><strong>Results: </strong>The low-dose protocol reduced mean effective radiation dose from 5.89 ± 2.88 millisieverts to 0.19 ± 0.06 millisieverts, a 96.8% reduction. Biopsy specimen adequacy was 85% in the low-dose group versus 79% in the standard-dose group. Complication rates were comparable, 45% versus 43.4%. Subjective image quality was lower in the low-dose group, but objective signal-to-noise and contrast-to-noise ratios remained sufficient for accurate diagnosis.</p><p><strong>Conclusion: </strong>Computed tomography-guided transthoracic biopsies with an 80 kVp and 30 mAs protocol significantly reduce radiation exposure without compromising diagnostic yield or safety. This low-dose approach is a viable alternative to conventional protocols and can be adopted in routine interventional radiology practice.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"14 12","pages":"20584601251412850"},"PeriodicalIF":1.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}