{"title":"Differential diagnosis between low-risk and high-risk thymoma: Comparison of diagnostic performance of radiologists with and without deep learning model.","authors":"Yuriko Yoshida, Masahiro Yanagawa, Yukihisa Sato, Tomo Miyata, Atsushi Kawata, Akinori Hata, Noriyuki Tomiyama","doi":"10.1177/20584601241288509","DOIUrl":"https://doi.org/10.1177/20584601241288509","url":null,"abstract":"<p><strong>Background: </strong>There are few CT-based deep learning (DL) studies on thymoma according to the World Health Organization classification.</p><p><strong>Purpose: </strong>To develop a CT-based DL model to distinguish between low-risk and high-risk thymoma and to compare the diagnostic performance of radiologists with and without the DL model.</p><p><strong>Material and methods: </strong>159 patients with 160 thymomas were included. A fine-tuning VGG16 network model with Adam optimizer was used, followed by k-fold cross validation. The dataset consisted of three axial slices, including the maximum tumor size from the CT volume data. The data were augmented 50 times by rotation, zoom, shear, and horizontal/vertical flip. Three independent networks for the CT dataset were considered, and the result was determined by voting. Three radiologists independently diagnosed thymomas with and without the model. The area under the curve (AUC) of the diagnostic performance was compared using receiver operating characteristic analysis.</p><p><strong>Results: </strong>Accuracy of the DL model was 71.3%. Diagnostic performance of the radiologists was as follows: AUC and accuracy without the DL model, 0.61-0.68 and 61.9%-69.3%; and with the DL model, 0.66-0.69 and 68.1%-70.0%, respectively. AUC of the diagnostic performance showed no significant differences between radiologists with and without the DL model. The DL model tended to increase the diagnostic accuracy, but AUC was not significantly improved.</p><p><strong>Conclusion: </strong>Diagnostic performance of the DL was comparable to that of radiologists. The DL model assistance tended to increase diagnostic accuracy.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cranial nerves bridging the middle ear and cerebellum causing cerebellar peduncle abscess: A case report.","authors":"Prabin Shrestha, Mani Ratnesh S Sandhu, Katherine J Jensen, Satoka Shidoh, Satoshi Yamaguchi","doi":"10.1177/20584601241279337","DOIUrl":"10.1177/20584601241279337","url":null,"abstract":"<p><p>Cerebellar abscess is a reported complication of chronic suppurative otitis media (CSOM) and is life threatening at times. It usually develops by direct spread of CSOM through the bony erosion in the petrous bone or by thrombophlebitis of the sigmoid sinus. However, an alternative pathway of infection transmission from the petrous bone to the cerebellum through the anatomical bridge of the cranial nerves has possibly not been described before. A 63-year-old female patient with CSOM and cholesteatoma developed ataxia and right facial palsy. Computed tomography (CT) showed bone erosion of the right petrous bone suggesting middle ear infection. Post-contrast MRI revealed an enhancement of swollen 7<sup>th</sup>/8<sup>th</sup> nerve complex, suggesting neuritis, and cholesteatoma in the right petrous bone. It also showed ring enhancing lesion in the cerebellar peduncle of the same side suggesting brain abscess. Surgical intervention was performed emergently and pus aspirated. She also underwent mastoidectomy and removal of cholesteatoma later by the otolaryngology team and finally got better. This case illustrates that CSOM can cause cerebellar abscess by spreading infection via anatomical bridge of the cranial nerves without direct invasion from the temporal bone or thrombophlebitis of sinus.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computed tomography patterns and clinical outcomes of radiation pneumonitis in non-small-cell lung cancer patients.","authors":"Ji Hoon Choi, Hee Kang, Ji Su Lim, Ki-Nam Lee","doi":"10.1177/20584601241288502","DOIUrl":"https://doi.org/10.1177/20584601241288502","url":null,"abstract":"<p><strong>Background: </strong>Radiation pneumonitis (RP) is not an uncommon complication in lung cancer patients undergoing radiation therapy (RT) and symptomatic RP can affect their quality of life.</p><p><strong>Purpose: </strong>To investigate the CT findings of RP in non-small cell lung cancer (NSCLC) patients and their relationship with clinical outcomes.</p><p><strong>Materials and methods: </strong>We reviewed data from 240 NSCLC patients who underwent RT between 2014 and 2022. CT findings of RP were evaluated for parenchymal abnormalities and distribution, which were then classified into three patterns: localized pneumonia (LP), cryptogenic organizing pneumonia (COP), and acute interstitial pneumonia (AIP). Clinical outcomes of RP were evaluated based on Common Terminology Criteria for Adverse Events (CTCAE) grade.</p><p><strong>Results: </strong>Of the 153 patients, 135 developed RP. The most common pattern was LP (<i>n</i> = 78), followed by COP (<i>n</i> = 30) and AIP (<i>n</i> = 25). Among the three CT patterns, CTCAE grade and days between the start of RT and the onset of RP (RT-RP days) were statistically significantly different (<i>p</i> < 0.05). The patients with AIP patterns exhibited higher CTCAE grade, and fewer RT-RP days compared to those with non-AIP patterns (<i>p</i> < 0.05). In these patients, lung-to-lung metastasis and underlying interstitial lung abnormality were observed more frequently (<i>p</i> < 0.05). Underlying pulmonary fibrosis, the AIP pattern, and higher CT extent scores were more frequently observed in higher CTCAE grade group (<i>p</i> < 0.001). In multiple regression analysis, age, bilateral distribution, RT-RP days, and CT extent score ≥3 were independent predicting factors for higher CTCAE grade.</p><p><strong>Conclusions: </strong>RP in NSCLC patients can be classified into LP, COP, and AIP patterns and they exhibit different severities in clinical outcomes.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2024-09-09eCollection Date: 2024-09-01DOI: 10.1177/20584601241283780
Rama Krishna Narra, Kavya Are, Parveen Nuzhat
{"title":"Invasive trigeminal ganglioneuroma: A case report and review of the literature.","authors":"Rama Krishna Narra, Kavya Are, Parveen Nuzhat","doi":"10.1177/20584601241283780","DOIUrl":"https://doi.org/10.1177/20584601241283780","url":null,"abstract":"<p><p>Ganglioneuromas are rare tumors arising from retroperitoneal and posterior mediastinal sympathetic nerves. Intracranial trigeminal nerve ganglioneuromas are even more rare, with only seven cases reported to date. We present a case of a 65-year-old male with a right-sided throbbing headache type and blindness in his right eye. Magnetic resonance imaging revealed an ill-defined mass lesion in the middle-cranial fossa, with a few areas having a reduced apparent diffusion coefficient and multiple microhemorrhages. Piecemeal debulking of the tumor was achieved by performing a right-middle craniotomy via the pterionic and sub-temporal approach. The detected histological features matched those of a ganglioneuroma (maturing type) of the trigeminal nerve.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2024-08-30eCollection Date: 2024-09-01DOI: 10.1177/20584601241279134
Kezhou Xing, Guoli Ren, Shuning Liu, Chuanchen Zhang
{"title":"A case of primary osteosarcoma in the occipital bone: A relatively common tumor in an uncommon location.","authors":"Kezhou Xing, Guoli Ren, Shuning Liu, Chuanchen Zhang","doi":"10.1177/20584601241279134","DOIUrl":"10.1177/20584601241279134","url":null,"abstract":"<p><p>Osteosarcomas predominantly manifest in the long bones of the extremities, with rare occurrences in the skull. A case involving of a 53-year-old female who presented to the authors' hospital for examination due to dizziness was incidentally found to have an occipital bone mass, which was initially diagnosed as a benign tumor and did not receive sufficient attention. Two years later, owing to tumor enlargement, the patient underwent further evaluation at the same institution, which revealed evidence of occipital bone destruction. Pathological analysis confirmed the diagnosis of osteosarcoma. The patient underwent surgical resection followed by radiotherapy. Despite its infrequency and uncharacteristic initial presentation, skull osteosarcomas should not be overlooked.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"To biopsy or not to biopsy adrenal mass: is that the question?","authors":"Edouard Purenne, Erika Cornu, Vincent Mezzarobba, Pauline Juttet, Sébastien Cimarelli, Emmanuel Watkin, Anne-Cécile Paepegaey","doi":"10.1177/20584601241269581","DOIUrl":"10.1177/20584601241269581","url":null,"abstract":"<p><p>The European Society of Endocrinology recommends surgical approach for suspicious adrenal mass with a limited role for adrenal biopsy. We report here a case of a patient with a 70 mm adrenal mass in whom adrenal biopsy avoided unnecessary adrenalectomy. An 80-year-old man was explored for a 67 × 41 mm suspect left adrenal tumor. Hormonal explorations were normal. 18F-FDG-PET/CT showed an increase in uptake of the adrenal mass (SUVmax: 44.6). As the diagnostic was uncertain, biopsy was performed. Pathology found T lymphocytic inflammatory infiltrate with CD4 phenotype without malignancy criteria. Simple close monitoring was decided in multidisciplinary meeting and with the patient's consent. At 1 and 3 months, CT and 18F-FDG-PET/CT showed a significant decrease in size and uptake of adrenal mass (40 × 20 mm and 19 × 10 mm and SUVmax 5.9 and 0.0). This report shows the interest of adrenal biopsy for well-selected cases to avoid unnecessary adrenal surgery.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologica openPub Date : 2024-08-08eCollection Date: 2024-08-01DOI: 10.1177/20584601241269608
Maria Correia de Verdier, Elisabeth Ronne-Engström, Ljubisa Borota, Johan Wikström
{"title":"Hemodynamic evaluation of intracranial arteriovenous malformations: Pre- and post-treatment 2D phase-contrast MRI measurements.","authors":"Maria Correia de Verdier, Elisabeth Ronne-Engström, Ljubisa Borota, Johan Wikström","doi":"10.1177/20584601241269608","DOIUrl":"10.1177/20584601241269608","url":null,"abstract":"<p><strong>Background: </strong>Hemodynamic changes are seen in the feeding arteries of arteriovenous malformations (AVMs). Phase-contrast MRI (PC-MRI) enables the acquisition of hemodynamic information from blood vessels. There is insufficient knowledge on which flow or velocity parameter best discriminates AVMs from healthy subjects.</p><p><strong>Purpose: </strong>To evaluate PC-MRI-measured flow and velocity in feeding arteries of AVMs before and, when possible, also after treatment and to compare these measurements to corresponding measurements in healthy controls.</p><p><strong>Materials and methods: </strong>Highest flow (HF), lowest flow (LF), mean flow (MF), peak systolic velocity (PSV), end-diastolic velocity (EDV), and mean velocity (MV) were measured in feeding arteries in patients with intracranial AVMs using 2D PC-MRI at 3 T. Measurements were compared to previously reported values in healthy individuals. Values in patients above the 95th percentile in the healthy cohort were categorized as pathological. Nidus volume was measured using 3D time-of-flight MR angiography.</p><p><strong>Results: </strong>Ten patients with diagnosed AVMs were examined with PC-MRI. Among these, three patients also underwent follow-up PC-MRI after treatment. Pathological velocities (PSV, EDV, and MV) were seen in all five subjects with a nidus larger or equal to 5.7 cm<sup>3</sup>, whereas pathological flow values were not seen in all, that is, pathologic HF in three, pathologic LF in two, and pathologic MF in two. After treatment, there was a decrease in flow and velocity (all measured parameters). After treatment, velocities (PSV, EDV, and MV) were no longer abnormal compared to healthy controls.</p><p><strong>Conclusion: </strong>Patients with a large AVM nidus show pathological velocities, but less consistent flow increases. Following treatment, velocities normalize.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lipomatous pseudohypertrophy of the pancreas mimicking liposarcoma: A case report.","authors":"Tomomi Kamimura, Takashi Katsube, Takeshi Nishi, Yasunari Kawabata, Yoshitsugu Tajima, Asuka Araki, Yasushi Kaji","doi":"10.1177/20584601241259847","DOIUrl":"10.1177/20584601241259847","url":null,"abstract":"<p><p>Lipomatous pseudohypertrophy of the pancreas (LPH) is a rare disease in which the pancreatic parenchyma is replaced with mature adipose tissue. It is an idiopathic condition whose diagnosis is made based on histopathological analyses. Herein, we report the case of a 50-year-old male patient with a lipomatous mass in the head of the pancreas on computed tomography for close examination of a renal tumor. We suspected liposarcoma, and laparotomy was performed. However, histological analyses revealed LPH. Several imaging findings of LPH can enable a noninvasive diagnosis and help its clinical approach.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute on chronic pancreatitis affecting the ectopic pancreas located in the jejunal mesentery: A case report.","authors":"Kazuya Okamura, Emi Ishibashi, Kazumi Araki, Yoshiko Kanasaki, Koji Kodama, Akiyoshi Kanazawa, Hideyuki Onuma","doi":"10.1177/20584601241269617","DOIUrl":"10.1177/20584601241269617","url":null,"abstract":"<p><p>Ectopic pancreas within the mesentery is rare. In this case report, a 61-year-old man with an ectopic pancreas within the jejunal mesentery for over 20 years developed chronic pancreatitis that progressed to acute exacerbation. Our computed tomography (CT) performed for acute abdomen assessment suggested acute appendicitis or Meckel's diverticulitis. However, a CT scan taken 20 years ago revealed a structure indicative of an ectopic pancreas in the mesentery, and further imaging findings taken 10 and 4 years ago confirmed progression to chronic pancreatitis. Furthermore, we found a pancreatic stone confined in the luminal structure that corresponded to the main pancreatic duct; this stone eventually caused acute exacerbation. In summary, we report a case of mesenteric ectopic pancreas that showed typical findings of progression and acute exacerbation of chronic pancreatitis on CT.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of an in-use chest CT protocol in lung cancer screening - A single institutional study","authors":"S. Naimi, M. Tetteh, Haseem Ashraf, S. Johansen","doi":"10.1177/20584601241256005","DOIUrl":"https://doi.org/10.1177/20584601241256005","url":null,"abstract":"Lung cancer is the most common cause of cancer-related death worldwide and therefore there has been a growing demand for low-dose computed tomography (LDCT) protocols. To investigate and evaluate the dose and image quality of patients undergoing lung cancer screening (LCS) using LDCT in Norway. Retrospective dosimetry data, volumetric CT dose index (CTDIvol) and dose-length product (DLP), from 70 average-size and 70 large-size patients who underwent LDCT scan for LCS were included in the survey. Effective dose and size-specific dose were calculated for each examination and were compared with the American Association of Physicists in Medicine (AAPM) requirement. For a quantitative image quality analysis, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were determined for different regions in the chest with two iterative reconstruction techniques, iDose and Iterative Model Reconstruction. Differences in dose and image quality between average-size and large-size patients were evaluated by Independent sample t test, and Wilcoxon signed rank test within the same patient group. The independent sample t test revealed significant differences ( p < .05) in dose values between average-size and large-size patients. Mean CTDIvol and DLP for average-size patients were 2.8 mGy and 115 mGy.cm, respectively, with appropriate increment for the large-size patients. Image quality (image noise, SNR, and CNR) did not significantly differ between patient groups when images were reconstructed with a model based iterative reconstruction algorithm. The screening protocol assessed in this study resulted in CTDIvol values that were compliant with AAPM recommendation. No significant differences in objective image quality were found between patient groups.","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}