Microfluidics and Nanofluidics最新文献

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Effect of obstruction on the dynamics of compound droplets in microchannels 阻塞对微通道中复合液滴动力学的影响
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-06-10 DOI: 10.1007/s10404-026-02906-y
Adarsh Malodia, Rishi Dhiman, Sreeja Sadasivan, Bibin John
{"title":"Effect of obstruction on the dynamics of compound droplets in microchannels","authors":"Adarsh Malodia,&nbsp;Rishi Dhiman,&nbsp;Sreeja Sadasivan,&nbsp;Bibin John","doi":"10.1007/s10404-026-02906-y","DOIUrl":"10.1007/s10404-026-02906-y","url":null,"abstract":"<div><p>This paper examines deformation and transport behavior of compound droplets when transported through microchannels with different geometries, including sinusoidal, sawtooth, diffuser, nozzle obstructions. The effect of capillary number (varying between 0.025 and 1) and obstruction size (0.4 Ro -0.8 Ro) on transition behaviour of compound droplets is studied systematically. The results indicate that capillary number is significant factor in deformation and stability of droplets. One of the values tested gave reliable outcomes with capillary number of 0.1 and even more accurate with 0.025. This implies that lower capillary numbers result in more accurate simulations, as they are precise in capturing interface dynamics and droplet-obstruction interactions. Transit time of outer and inner droplets decreases with obstruction ratio of 0.4–0.8, which means that obstructions of higher size facilitate faster droplet passage. This suggests that a lower capillary number enhances the precision of simulations by better capturing interface dynamics and droplet–obstruction interactions. The transit time for both outer and inner droplets decreases with increasing obstruction ratio from 0.4 to 0.8, indicating that larger obstructions facilitate faster droplet passage.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148236809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic inductors designed via topology optimization 基于拓扑优化的微流控电感器设计
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-06-09 DOI: 10.1007/s10404-026-02904-0
Zhengdong Yu, Siyuan Huang, Hanzhe Chen, Qiucheng Liu, Zhenyu Liu, Jun Deng, Jiucheng Zhao
{"title":"Microfluidic inductors designed via topology optimization","authors":"Zhengdong Yu,&nbsp;Siyuan Huang,&nbsp;Hanzhe Chen,&nbsp;Qiucheng Liu,&nbsp;Zhenyu Liu,&nbsp;Jun Deng,&nbsp;Jiucheng Zhao","doi":"10.1007/s10404-026-02904-0","DOIUrl":"10.1007/s10404-026-02904-0","url":null,"abstract":"<div><p>The equivalent circuit design method has evolved into a relatively mature technique for designing microfluidic devices. This approach simplifies microfluidic device design by approximating fluid behavior within the devices as analogous to electron behavior in electrical circuits, thereby leveraging the analogy between microfluidic hydraulics and electrical circuits. Based on this technique, scientists have developed microfluidic devices with various functionalities, such as multi-concentration mixing, cell capture, flow distribution, concentration gradient generation, and droplet generation. However, due to the disparity in physical properties between microfluidic systems and electrical circuits, the impedance effect experienced by fluids during the analogical design process is not pronounced—specifically, when mapping fluidic characteristics like high and low Reynolds numbers to circuit properties such as high and low current frequencies. This gap has resulted in a lack of microchannel design methods analogous to inductive components in electrical circuits when applying the equivalent circuit approach to microfluidic chip design. Here, we propose a design strategy for microfluidic valves with inductive properties and their topological optimization. The valve structures designed by this method exhibit high flow resistance under high Reynolds number conditions and low resistance under low Reynolds number conditions. Consequently, this work enriches the equivalent circuit design methodology by introducing the equivalent inductive microfluidic module—Microfluidic inductor as a new available module, along with its corresponding design method.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic synthesis of alumina particle-laden beads via capillary number tuning for varying particle concentrations 微流控合成的氧化铝颗粒负载珠通过毛细管数调整为不同的颗粒浓度
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-06-01 DOI: 10.1007/s10404-026-02905-z
Tao Zhang, Sebastien Jiguet, Arnaud Bertsch, Juergen Brugger
{"title":"Microfluidic synthesis of alumina particle-laden beads via capillary number tuning for varying particle concentrations","authors":"Tao Zhang,&nbsp;Sebastien Jiguet,&nbsp;Arnaud Bertsch,&nbsp;Juergen Brugger","doi":"10.1007/s10404-026-02905-z","DOIUrl":"10.1007/s10404-026-02905-z","url":null,"abstract":"<div><p>Colloidal particle-laden inks are increasingly used in additive manufacturing to produce functional components with tailored properties, and droplet-based microfluidics enables precise generation of high-viscosity, particle-rich droplets. Despite extensive studies on particle-free shear-thinning fluids, the coupled influence of particle concentration on both flow regimes and droplet size in microfluidic systems remains insufficiently understood. Here, we showed that particle concentration in shear-thinning, alumina-laden inks governs droplet formation dynamics through a dual effect on viscosity and interfacial tension. We investigated the droplet formation of a solvent-free, alumina-laden acrylate ink dispersed in a continuous aqueous phase using a flow-focusing microfluidic device. Inks containing 10%, 20%, and 30% (w/w) alumina particles (500 nm) were characterized in terms of rheology and interfacial tension. By adjusting flow rates of both phases and particle concentrations, we modulated the capillary number and mapped the resulting droplet formation regimes. Unlike polymer-only shear-thinning systems, where interfacial tension remains nearly constant, alumina particles modified both viscosity and interfacial tension of alumina particle-laden inks, shifting flow regimes and droplet size. Higher particle concentrations promoted jetting and altered droplet size, whereas dripping produced highly uniform droplets (&lt; 100 μm). Downstream UV polymerization produced solid beads, and sequential exposure enabled assembly into two-dimensional structures. These results provided quantitative insight into how alumina particle concentration governs droplet generation through coupled rheological and interfacial effects, and demonstrated a bead-based assembly route for microfluidic particle-laden inks.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148172472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bovine serum albumin@AuNCs synthesized by microfluidic droplet system for Cu(II) detection in zebrafish embryos 微流控液滴系统合成牛血清albumin@AuNCs用于斑马鱼胚胎中Cu(II)的检测
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-19 DOI: 10.1007/s10404-026-02901-3
Xiaotong Zhu, Shufan Ge, Deyu Wu, Zhengkun Qiao, Talanati Tuerdan, Peng Sun, Juan Qiao
{"title":"Bovine serum albumin@AuNCs synthesized by microfluidic droplet system for Cu(II) detection in zebrafish embryos","authors":"Xiaotong Zhu,&nbsp;Shufan Ge,&nbsp;Deyu Wu,&nbsp;Zhengkun Qiao,&nbsp;Talanati Tuerdan,&nbsp;Peng Sun,&nbsp;Juan Qiao","doi":"10.1007/s10404-026-02901-3","DOIUrl":"10.1007/s10404-026-02901-3","url":null,"abstract":"<div><p>In this study, bovine serum albumin-stabilized gold nanoclusters (BSA@AuNCs) were synthesized using a microfluidic droplet system. Compared with traditional flask-based synthesis methods, the microfluidic droplet system yielded AuNCs with uniform nucleation, enhanced fluorescence properties, improved stability, and a significantly shortened preparation time (24 min). Selectivity analysis demonstrated that BSA@AuNCs exhibit high specificity toward Cu(II), and a linear relationship was observed between the Cu(II) concentration (0–5000.0 µM) and the fluorescence intensity of BSA@AuNCs, with a detection limit of 20.0 µM. Upon the addition of Cu(II), the binding of Cu(II) to BSA@AuNCs led to increased particle size and aggregation, which was macroscopically manifested as fluorescence quenching. Finally, BSA@AuNCs were innovatively applied to the detection of Cu(II) levels in zebrafish embryos. Confocal laser scanning microscopy (CLSM) imaging revealed a gradual decrease in fluorescence intensity within BSA@AuNC-incubated zebrafish embryos as the Cu(II) concentration increased. This method provides a viable strategy for detecting metal ions in living organisms and lays an experimental foundation for investigating the effects of Cu(II) and their related mechanisms <i>in vivo</i>.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of the generalized Knudsen theory for diverse gas flow in nanochannels 纳米通道中不同气体流动的广义Knudsen理论的验证
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-19 DOI: 10.1007/s10404-026-02903-1
HaoKe Peng, HengAn Wu, FengChao Wang
{"title":"Validation of the generalized Knudsen theory for diverse gas flow in nanochannels","authors":"HaoKe Peng,&nbsp;HengAn Wu,&nbsp;FengChao Wang","doi":"10.1007/s10404-026-02903-1","DOIUrl":"10.1007/s10404-026-02903-1","url":null,"abstract":"<div><p>Gas transport through nanochannels is critical to applications ranging from gas separation to shale gas extraction. Accurately predicting flow rates under non-adsorbing or weak-physisorption conditions requires the generalized Knudsen theory, which accounts for the full spectrum of gas-wall scattering mechanisms. However, its broad validation across diverse gases and surfaces remains incomplete, largely because the key parameter quantifying scattering, the diffuse reflection fraction (<i>f</i>) or tangential momentum accommodation coefficient (TMAC), is notoriously difficult to determine. Here, we employ molecular dynamics (MD) simulations to develop a robust approach for calculating <i>f</i>. Using this method, we systematically validate the generalized Knudsen theory for a wide range of gases, including all noble gases and common polyatomic species (H<sub>2</sub>, O<sub>2</sub>, H<sub>2</sub>O, CO<sub>2</sub> and CH<sub>4</sub>). Our results show that <i>f</i> or TMAC is predominantly a surface property: it clusters around 0.1 for graphene and 0.8 for SiO<sub>2</sub>, with only weak dependence on the gas species. By incorporating these <i>f</i> values, the theory achieves remarkable accuracy in predicting flow rates, as confirmed by direct MD simulations across all tested gas-channel combinations. This work establishes a general and predictive framework for gas transport in nanochannels, paving the way for the rational design of nanofluidic devices and advanced separation membranes.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spreading behavior of oil droplets on solid surfaces under various temperature fields 不同温度场下油滴在固体表面的扩散行为
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-19 DOI: 10.1007/s10404-026-02902-2
Rixian Li, Zhihai Jia, Yaxin Zhang, Bing Han, Di Song
{"title":"Spreading behavior of oil droplets on solid surfaces under various temperature fields","authors":"Rixian Li,&nbsp;Zhihai Jia,&nbsp;Yaxin Zhang,&nbsp;Bing Han,&nbsp;Di Song","doi":"10.1007/s10404-026-02902-2","DOIUrl":"10.1007/s10404-026-02902-2","url":null,"abstract":"<div><p>An infrared thermal imager and a digital microscope are employed to observe the spreading behavior of oil droplets that are subject to various temperature fields in this study. The spreading characteristics of oil droplets are analyzed by adjusting the temperature field, temperature gradient, liquid viscosity and volume. Experimental results show that when an oil droplet is placed on a solid surface that is subject to a temperature field, the oil droplet always spreads forward in the opposite direction of the temperature gradient. During the spreading process, the front end of the droplet advances while the rear end remains fixed, forming an oil film whose shape is constrained by the temperature field. Moreover, when the temperature field keeps unchanged, a larger temperature gradient will cause the droplet to spread more rapidly, expand the oil film area and promote the morphological evolution. Furthermore, as the viscosity increases, the spreading velocity decreases, and the response of the droplet to the temperature field weakens, resulting in a reduction in the oil film area and suppression of the shape evolution. Finally, the spreading velocity rises with the increase of droplet volumes, and the oil film area expands while preserving morphological similarity. A theoretical model for the spreading speed is established based on the force analysis, and the theoretical results agree well with the experimental values. These findings contribute to the understanding of wear mechanisms caused by lubricant depletion or starvation in mechanical equipment and provide a guide for preventing lubricant accumulation.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the rarefied flow at micro-step using a DeepONet surrogate model with a physics-guided zonal loss function 利用带物理导向层间损失函数的DeepONet代理模型分析微步稀薄流动
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-11 DOI: 10.1007/s10404-026-02899-8
Ehsan Roohi, Amirmehran Mahdavi
{"title":"Analysis of the rarefied flow at micro-step using a DeepONet surrogate model with a physics-guided zonal loss function","authors":"Ehsan Roohi,&nbsp;Amirmehran Mahdavi","doi":"10.1007/s10404-026-02899-8","DOIUrl":"10.1007/s10404-026-02899-8","url":null,"abstract":"<div><p>Rarefied gas flow over a micro backward-facing step (BFS) is a canonical non-equilibrium benchmark featuring separation, recirculation and strong Knudsen-layer effects that are highly sensitive to both the Knudsen number and the step-height ratio. High-fidelity Direct Simulation Monte Carlo (DSMC) simulations resolve these phenomena but are prohibitively expensive for parametric studies, uncertainty quantification and design exploration. In this work, we develop a Deep Operator Network (DeepONet) surrogate for rarefied step flows that maps the Knudsen number (<span>(textrm{Kn})</span>) and the geometric ratio (<i>h</i>/<i>H</i>) to the full two-dimensional velocity field in a micro-step geometry. The architecture is augmented with a physics-guided zonal loss that assigns higher weights to errors in the recirculation region (<span>(U &lt; 0)</span>), thereby enforcing accurate prediction of separation and reattachment. Systematic comparisons with DSMC data in the slip and early transition regimes show that the surrogate reproduces key physical trends, including the shortening and eventual disappearance of the separation bubble with increasing <span>(textrm{Kn})</span> and the non-monotonic variation of the reattachment length with <i>h</i>/<i>H</i>. A low-data study (reported in the supplementary material) demonstrates that the model attains more than <span>(90%)</span> of its asymptotic accuracy using only about 40–<span>(50%)</span> of the available high-fidelity simulations, substantially mitigating the cost of data generation. Furthermore, stochastic weight averaging Gaussian (SWAG) provides epistemic uncertainty estimates that are naturally localized near the shear layer and separation point, i.e. in the most non-equilibrium regions of the flow. The resulting framework offers a fast, robust and data-efficient tool for exploring rarefied micro-step flows, enabling many-query analyses in regimes where direct DSMC sampling is computationally intractable.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147937960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SERS-assisted toxicity profiling of nitrofurantoin photodegradation towards sustainable water treatment sers辅助下呋喃妥英光降解对可持续水处理的毒性分析
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-11 DOI: 10.1007/s10404-026-02900-4
Tadi Sai Ratnakar, Kapil Sadani, Chiranjay Mukhopadhyay, Pooja Nag
{"title":"SERS-assisted toxicity profiling of nitrofurantoin photodegradation towards sustainable water treatment","authors":"Tadi Sai Ratnakar,&nbsp;Kapil Sadani,&nbsp;Chiranjay Mukhopadhyay,&nbsp;Pooja Nag","doi":"10.1007/s10404-026-02900-4","DOIUrl":"10.1007/s10404-026-02900-4","url":null,"abstract":"<div><p>Nitrofurantoin, a broad-spectrum nitrofuran-class antibiotic, persists in food and aquatic environments, posing risks of hepatotoxicity and contributing to antibiotic resistance. Although LC-MS/MS and HPLC-based provide exceptional sensitivity, they are incompatible for rapid and on-site analysis. Beyond trace on-site detection, effective management of antibiotic load requires scalable and efficient remediation strategies to prevent indirect entry and minimize secondary toxicity. While conventional UV-photodegradation is extensively studied for antibiotic removal, it often leads to formation of toxic intermediates raising concerns about environmental safety. Thus, exists a need for alternate photodegradation approach with less toxic intermediates. This study comprehensively investigates the Near-infrared (NIR) light-based degradation of nitrofurantoin (NFT) coupled with surface-enhanced Raman spectroscopy (SERS)-based toxicity profiling. To ensure rigorous comparison, identical power of 37 W was used with UV and NIR irradiations for constant exposure duration. To investigate the field deployability of this strategy, we developed a low-cost paper-based microfluidic platform integrated with silver nanorods for simultaneous degradation and SERS-based detection of the non-toxic intermediates. SERS fingerprint of the UV degraded samples corresponded to 1-aminohydantoin (AHD), a toxic and carcinogenic metabolite, while NIR irradiation favours the formation of a less toxic 5-nitro-2-furaldehyde (NFA). Time-resolved Raman analysis demonstrated systematic degradation of NFT with R<sup>2</sup> &gt; 0.95 upon NIR irradiation. These results establish NIR-assisted degradation as a safer alternative to UV degradation and signify the potential of SERS-based paper microfluidics as a field-deployable device for Sustainable Development Goals 3 and 6 through sustainable water management and improved public health safety.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-026-02900-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147937961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioluminescence detection of intracellular ATP in porcine sperm cells using paper-based devices 利用纸基装置生物发光检测猪精细胞内ATP
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-05 DOI: 10.1007/s10404-026-02894-z
Koji Matsuura, Zheyi Chen, Shuyu Hu, Yuka Asano, Chao-Min Cheng
{"title":"Bioluminescence detection of intracellular ATP in porcine sperm cells using paper-based devices","authors":"Koji Matsuura,&nbsp;Zheyi Chen,&nbsp;Shuyu Hu,&nbsp;Yuka Asano,&nbsp;Chao-Min Cheng","doi":"10.1007/s10404-026-02894-z","DOIUrl":"10.1007/s10404-026-02894-z","url":null,"abstract":"<div><p>Mammalian sperm motion relies on adenosine triphosphate (ATP) to produce energy for dynein slide-motion via hydrolysis. To clarify the relationship between mammalian sperm motility and ATP production/consumption, semen ATP concentration was examined using a paper-based bioluminescence assay (luciferase) due to its higher sensitivity, reduced detection time, and minimal reagent requirements compared to fluorometry or colorimetry. ATP concentration in the form of sperm sample signal intensity was then correlated to motile sperm count and sperm motility, with higher ATP concentrations indicating the presence of lower-motility sperm and lower ATP concentrations indicating higher ATP consumption and higher-motility sperm. Employing the described paper-based bioluminescence methodology and selective inhibition of glycolysis and oxidative phosphorylation (OXPHOS), porcine sperm was found to produce more ATP through OXPHOS than glycolysis. The results of our analyses support the notion that bioluminescence-based ATP detection on a paper-based device can be employed to examine the contribution of these two metabolic systems to sperm motility and fertilization.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of the hydrophilic structural parameters of titanium alloy bioinspired Nepenthes on droplet flow characteristics 钛合金仿生蜈蚣草亲水结构参数对液滴流动特性的影响
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2026-05-05 DOI: 10.1007/s10404-026-02898-9
Dongya Zhang, Wenjing Li, Minhua Deng, Weiming Yuan, Enxiu Shi, Zhaoyang Zhai
{"title":"Influence of the hydrophilic structural parameters of titanium alloy bioinspired Nepenthes on droplet flow characteristics","authors":"Dongya Zhang,&nbsp;Wenjing Li,&nbsp;Minhua Deng,&nbsp;Weiming Yuan,&nbsp;Enxiu Shi,&nbsp;Zhaoyang Zhai","doi":"10.1007/s10404-026-02898-9","DOIUrl":"10.1007/s10404-026-02898-9","url":null,"abstract":"<div><p>A bioinspired Nepenthes-inspired hydrophilic track was prepared on a Ti4Al6V substrate, and droplet flow behavior was explored under different texture widths (<i>B</i>), texture orientation angles (<i>α</i>), and texture spacings (<i>L</i>).Simulation indicated that the droplet migration distance decreased with increasing <i>B</i>. The optimal droplet migration performance was achieved at <i>B</i><sup>*</sup> = <span>(:frac{text{B}}{text{W}})</span> = 0.1, <i>α</i> = 45°, and <i>L</i><sup>*</sup> = <span>(:frac{text{L}}{text{W}})</span> = 0.5, with a migration distance of 14.85 mm, The migration efficiency <i>η</i> = 99%. At <i>B</i>* = 0.1, <i>L</i>* = 1, <i>α</i> = 45°, the migration distance is 13.35 mm, <i>η</i> = 89%, which was 4.6% larger than at <i>B</i>* = 0.1, <i>L</i>* = 1,<i>α</i> = 90°. When <i>B</i> and <i>α</i> were fixed, the migration distance decreased with increasing <i>L</i>. Specifically, at <i>B</i>* = 0.1 and <i>α</i> = 45° and <i>L</i>* = 0.5, the migration distance was 33.8% longer than that at <i>L</i>* = 2. Experimental results on the flow of droplets along the hydrophilic track demonstrated the migration efficiency under parameters of: <i>η</i> = 76% at α = 30°, <i>L</i>* = 1.0, <i>B</i>* = 0.4, <i>η</i> = 86% at α = 45°, <i>L</i>* = 1.0, <i>B</i>* = 0.1, and <i>η</i> = 94% at α = 45°, <i>L</i>* = 0.5, <i>B</i>* = 0.1. Mechanistically, increasing <i>L</i> reduced hydrophilic unit density, weakened the capillary force gradient, and thus shortened migration distance. Texture width B regulated the balance between capillary and viscous forces, while orientation angle <i>α</i> modified the capillary force vector and its components, collectively governing the droplet flow behavior.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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