Microfluidics and Nanofluidics最新文献_第6页

Quantifying the performances of SU-8 microfluidic devices: high liquid water tightness, long-term stability, and vacuum compatibility 量化 SU-8 微流体设备的性能：高液体水密性、长期稳定性和真空兼容性

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-29 DOI: 10.1007/s10404-024-02720-4

Said Pashayev, Romain Lhermerout, Christophe Roblin, Eric Alibert, Jerome Barbat, Rudy Desgarceaux, Remi Jelinek, Edouard Chauveau, Saïd Tahir, Vincent Jourdain, Rasim Jabbarov, Francois Henn, Adrien Noury

{"title":"Quantifying the performances of SU-8 microfluidic devices: high liquid water tightness, long-term stability, and vacuum compatibility","authors":"Said Pashayev, Romain Lhermerout, Christophe Roblin, Eric Alibert, Jerome Barbat, Rudy Desgarceaux, Remi Jelinek, Edouard Chauveau, Saïd Tahir, Vincent Jourdain, Rasim Jabbarov, Francois Henn, Adrien Noury","doi":"10.1007/s10404-024-02720-4","DOIUrl":"10.1007/s10404-024-02720-4","url":null,"abstract":"<div><p>Despite several decades of development, microfluidics lacks a sealing material that can be readily fabricated, leak-tight under high liquid water pressure, stable over a long time, and vacuum compatible. In this paper, we report the performances of a micro-scale processable sealing material for nanofluidic/microfluidics chip fabrication, which enables us to achieve all these requirements. We observed that micrometric walls made of SU-8 photoresist, whose thickness range from 35 to 135 µm, are at least leak-tight to 1.5 bars and up to 5.5 bars, exhibit no water porosity even after 2 months of aging, and are able to sustain under <span>(10^{-5})</span> mbar vacuum. This sealing material is therefore reliable and versatile for building microchips, part of which must be isolated from liquid water under pressure or vacuum. Moreover, the fabrication process we propose does not require the use of either aggressive chemicals or high-temperature or high-energy plasma treatment. It thus opens a new perspective to seal microchips with sensitive surfaces containing nanomaterials.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140325418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behaviors of non-wetting phase snap-off events in two-phase flow: microscopic phenomena and macroscopic effects 两相流中非润湿相卡断事件的行为：微观现象和宏观效应

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-26 DOI: 10.1007/s10404-024-02718-y

Ran Li, Zhaolin Gu, Zhang Li, Weizhen Lu, Guozhu Zhao, Junwei Su

引用次数: 0

Modified capillary number to standardize droplet generation in suction-driven microfluidics 修改毛细管数量，使抽吸驱动微流控技术中的液滴生成标准化

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-22 DOI: 10.1007/s10404-024-02714-2

Jatin Panwar, Rahul Roy

{"title":"Modified capillary number to standardize droplet generation in suction-driven microfluidics","authors":"Jatin Panwar, Rahul Roy","doi":"10.1007/s10404-024-02714-2","DOIUrl":"10.1007/s10404-024-02714-2","url":null,"abstract":"<div><p>In droplet microfluidic devices with suction-based flow control, the microchannel geometry and suction pressure at the outlet govern the dynamic properties of the two phases that influence the droplet generation. Therefore, it is critical to understand the role of geometry along with suction pressure in the dynamics of droplet generation to develop a predictive model. We conducted a comprehensive characterization of droplet generation in a flow focusing device with varying control parameters. We used these results to formulate a scaling argument and propose a governing parameter, called as modified capillary number (Ca<sub>L</sub>), that combines normalized droplet volume with geometrical parameters (length of dispersed and continuous phase channels) and flow parameters (interfacial tension, phase viscosity and velocity) in a power law relationship. Ca<sub>L</sub> effectively captures the transition from squeezing to dripping regimes of droplet generation, providing essential insights into the design requirements for suction-driven droplet generation. These findings are key to standardize microfluidic flow-focusing devices that can achieve the desired droplet generation behavior with optimal pressure consumption.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hybrid Gaussian mixture/DSMC approach to study the Fourier thermal problem 研究傅立叶热问题的混合高斯混合物/DSMC 方法

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-20 DOI: 10.1007/s10404-024-02719-x

Shahin Mohammad Nejad, Frank A. Peters, Silvia V. Nedea, Arjan J. H. Frijns, David M. J. Smeulders

{"title":"A hybrid Gaussian mixture/DSMC approach to study the Fourier thermal problem","authors":"Shahin Mohammad Nejad, Frank A. Peters, Silvia V. Nedea, Arjan J. H. Frijns, David M. J. Smeulders","doi":"10.1007/s10404-024-02719-x","DOIUrl":"10.1007/s10404-024-02719-x","url":null,"abstract":"<div><p>In rarefied gas dynamics scattering kernels deserve special attention since they contain all the essential information about the effects of physical and chemical properties of the gas–solid surface interface on the gas scattering process. However, to study the impact of the gas–surface interactions on the large-scale behavior of fluid flows, these scattering kernels need to be integrated in larger-scale models like Direct Simulation Monte Carlo (DSMC). In this work, the Gaussian mixture (GM) model, an unsupervised machine learning approach, is utilized to establish a scattering kernel for monoatomic (Ar) and diatomic (<span>(hbox {H}_{2})</span>) gases directly from Molecular Dynamics (MD) simulations data. The GM scattering kernel is coupled to a pure DSMC solver to study isothermal and non-isothermal rarefied gas flows in a system with two parallel walls. To fully examine the coupling mechanism between the GM scattering kernel and the DSMC approach, a one-to-one correspondence between MD and DSMC particles is considered here. Benchmarked by MD results, the performance of the GM-DSMC is assessed against the Cercignani–Lampis–Lord (CLL) kernel incorporated into DSMC simulation (CLL-DSMC). The comparison of various physical and stochastic parameters shows the better performance of the GM-DSMC approach. Especially for the diatomic system, the GM-DSMC outperforms the CLL-DSMC approach. The fundamental superiority of the GM-DSMC approach confirms its potential as a multi-scale simulation approach for accurately measuring flow field properties in systems with highly nonequilibrium conditions.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-024-02719-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation of avascular tumor growth and drug response in a microfluidic device with a cellular automaton model 利用细胞自动机模型模拟微流控装置中血管瘤的生长和药物反应

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-16 DOI: 10.1007/s10404-024-02717-z

Sijia Liu, Yuewu Li, Chunxiao Chen, Zhiyu Qian, Hongjun Wang, Yamin Yang

{"title":"Simulation of avascular tumor growth and drug response in a microfluidic device with a cellular automaton model","authors":"Sijia Liu, Yuewu Li, Chunxiao Chen, Zhiyu Qian, Hongjun Wang, Yamin Yang","doi":"10.1007/s10404-024-02717-z","DOIUrl":"10.1007/s10404-024-02717-z","url":null,"abstract":"<div><p>The microfluidic system is capable of recapitulating key attributes of in vivo circumstances and, therefore, becomes a valuable platform for better understanding tumor growth dynamics and evaluating drug efficiency. While numerical simulations have been envisioned as powerful tools for validating versatile performance of advanced microfluidic platforms, cell growth within these microchannels has not yet been theoretically modeled. In this paper, we developed an experimental data-driven cellular automaton model, which was adopted for simulating cell behaviors and drug responses in a microfluidic system. The boundaries of the cellular automata lattices and prohibited zones for simulation were directly converted from microscopic images of cell morphology and the microchamber configuration. The dynamic progression of tumor growth at the avascular stage was predicted by incorporating the biophysical and molecular characteristics of cells and their interactions with surrounding environment. The simulated proliferation rate of tumor cells over time demonstrated its dependency on nutrient delivery, aligning well with experimental observations in the microfluidic culture. The spatiotemporal efficacy of the chemotherapeutic compound doxorubicin (DOX) on the microfluidic culture was also simulated. The similarity between in silico simulations and in vitro tumor response upon drug interaction highlighted the potential of the computational models as complementary tools for predicting the drug treatment efficacy with acceptable accuracy before practical applications.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140155819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curved microchannels with inner wall expansion–contraction array for particle focusing 用于粒子聚焦的带内壁膨胀-收缩阵列的弯曲微通道

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-15 DOI: 10.1007/s10404-024-02715-1

Ruihan Zhuang, Kaixin Song, Zhibin Wang, Gang Chen, Ying Chen, Lisi Jia

{"title":"Curved microchannels with inner wall expansion–contraction array for particle focusing","authors":"Ruihan Zhuang, Kaixin Song, Zhibin Wang, Gang Chen, Ying Chen, Lisi Jia","doi":"10.1007/s10404-024-02715-1","DOIUrl":"10.1007/s10404-024-02715-1","url":null,"abstract":"<div><p>To enhance focusing performance, we proposed an integrated microchannel with expansion–contraction arrays (ECA) on the inner wall of the curved microchannel (CIECA) and compared it with a straight microchannel with ECA (SECA) as well as the traditional integrated microchannel of ECA on the outer wall of the curved channel (COECA). We investigated the particle-focusing mechanisms in these microchannels through a combination of experiments and numerical simulations. The proposed integrated microchannel demonstrates significant improvements in focusing performance compared to SECA and COECA, which is attributed to its consistent Dean flow. In contrast, COECA shows the poorest performance because of inconsistent Dean flow. The focusing width in the proposed integrated microchannel is reduced to 1/3 of that in COECA and 1/2 of that in SECA. Furthermore, the focusing performance of CIECA improves as the Reynolds number increases, eventually forming a single trajectory when the Reynolds number (at contraction) reaches 83.33. Finally, the impact of particle size on focusing performance was investigated through numerical simulations. The focusing performance of the CIECA is the best in these three microchannels. In CIECA, as the particle size increases, the focusing width initially decreases and then increases. Among them, 8 and 10 μm particles can achieve complete focusing. This study serves as a crucial reference for comprehending and enhancing particle focusing through the synergy of multi-Dean flow.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140155683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A thermally actuated biocompatible flexible micropump for surface adaptable mounting 用于表面适应性安装的热致动生物兼容柔性微型泵

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-09 DOI: 10.1007/s10404-024-02708-0

Victor Bradley Bednar, Kenichi Takahata

{"title":"A thermally actuated biocompatible flexible micropump for surface adaptable mounting","authors":"Victor Bradley Bednar, Kenichi Takahata","doi":"10.1007/s10404-024-02708-0","DOIUrl":"10.1007/s10404-024-02708-0","url":null,"abstract":"<div><p>Pulsed thermal energy causes piecewise actuation of a nitinol cantilever providing the mechanical force required to evacuate a chamber constructed of parylene C. This proof-of-principle micropump demonstrates an alternative to typical evacuation and rectification methods utilized in most micropumps. The chamber and normally closed channels that serve as valves are all of parylene C construction, leading to the flexibility of the device. The nitinol cantilever functions as an actuator capable of yielding successive partial chamber evacuations until achieving complete evacuation. Piecewise shape recovery of the actuator was made viable by implementing a Peltier device, providing the means for supplying responsive and controlled thermal energy. Experiments delivered measurements of consecutive advancement of shape recovery using a laser displacement sensor while monitoring the temperature with fiber-optic sensors. The release of a saturated lithium chloride solution from the pump was monitored by observing conductivity changes in the experimental area. Theoretically predicting a release amount used calculations for the expected recovery of the actuator based on displacement characterization via a logistic curve fit against actuator temperature data. The measured release amounts correlated well with the theoretically predicted values made using the temperature values obtained near the device during the release. These works provide novel approaches to micropump fabrication and implementation and new strategies for predicting the recovery of shape memory alloys. The micropump concepts are viable in many fields, such as biomedical applications: in vivo drug delivery, organ-on-chip, and lab-on-chip devices, to name a few. Likewise, a simple prediction for nitinol recovery has vast potential.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140097288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of microfluidic trap and mixer module for rapid fluorescent tagging of microplastics 用于快速荧光标记微塑料的微流体捕集器和混合器模块的特性分析

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-06 DOI: 10.1007/s10404-024-02716-0

Seongcheol Shin, Boeun Jeon, Wonkyu Kang, Cholong Kim, Jonghoon Choi, Sung Chul Hong, Hyun Ho Lee

{"title":"Characterization of microfluidic trap and mixer module for rapid fluorescent tagging of microplastics","authors":"Seongcheol Shin, Boeun Jeon, Wonkyu Kang, Cholong Kim, Jonghoon Choi, Sung Chul Hong, Hyun Ho Lee","doi":"10.1007/s10404-024-02716-0","DOIUrl":"10.1007/s10404-024-02716-0","url":null,"abstract":"<div><p>This study introduces a practical approach utilizing microfluidic trap and mixer modules fabricated with polydimethylsiloxane (PDMS) microfluidic devices. These modules were employed to capture and fluorescently label various randomly shaped microplastics (MPs) like polyethylene (PE), polypropylene (PP), and polystyrene (PS). Within the MPs trap module, grooves were incorporated into a straight-lined channel using SU-8 photolithography. This design induced turbulence effectively trapping and gathering the MPs within aqueous phases at 15 groove spaces, which achieved a trapping efficiency of up to 69% for PS MPs sized at a flow rate of 2 mL/min. Additionally, a mixer module featuring two flow inlets was designed to create a serpentine microfluidic channel, whose design significantly reduced sample and reagent (Nile Red) consumption during MP fluorescence staining at 80 °C. Furthermore, 2 nm gold nanoparticles (Au NPs), conjugated with a PS binding peptide (PSBP), were examined as an alternative fluorescent agent at room temperature. Photoluminescence (PL) and Fourier transform infrared (FT-IR) showcased efficiency of mixer module in labeling 30 mL MP solutions within a short time of 15 min. Moreover, a combined platform integrating trap and mixer devices was devised, incorporating a disposable heating pad and filter paper unit, which offers a simplified and compact MPs staining tool including spherical PE nanoplastics (200 nm–99 μm). This study aims to propose a preliminary concept for a lab-on-a-chip, facilitating the simultaneous collection and fluorescent labeling, which can be instrumentally implemented in future MPs monitoring.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140054519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the impact of liquid presence on the acoustic streaming generated by a vibrating sharp tip capillary 研究液体存在对振动尖头毛细管产生的声流的影响

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-05 DOI: 10.1007/s10404-024-02713-3

Chong Li, Balapuwaduge Lihini Mendis, Lisa Holland, Peng Li

{"title":"Investigation of the impact of liquid presence on the acoustic streaming generated by a vibrating sharp tip capillary","authors":"Chong Li, Balapuwaduge Lihini Mendis, Lisa Holland, Peng Li","doi":"10.1007/s10404-024-02713-3","DOIUrl":"10.1007/s10404-024-02713-3","url":null,"abstract":"<div><p>Sharp edge structures have been demonstrated as an efficient way of generating acoustic streaming in microfluidic devices, which finds numerous applications in fluid mixing, pumping, particle actuation, and cell lysis. A sharp tip capillary is widely available means of generating sharp structures without the need of microfabrication, which has been used for studying enzyme kinetics, droplet digital PCR, and mass spectrometry analysis. In this work, we studied the influence of liquid inside the vibrating glass capillary on its efficiency of generating acoustic streaming. Using fluorescence microscopy and fluorescent particles, we observed that adding liquid to the inside of the vibrating glass capillary changed the streaming patterns as well as led to increased streaming velocity. Based on the observed streaming patterns, we hypothesized the liquid present in the capillary changed vibration mode of the capillary, which is matched with COMSOL simulations. Finally, the utility of the liquid filled vibrating capillary was demonstrated for higher energy efficiency for fluid mixing and mass spectrometry experiments. This study will provide useful guidance when optimizing the efficiency of vibrating sharp tip capillary systems.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140033942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Model order reduction for the 1D Boltzmann-BGK equation: identifying intrinsic variables using neural networks 减少一维波兹曼-BGK方程的模型阶次：利用神经网络识别内在变量

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-02-28 DOI: 10.1007/s10404-024-02711-5

Julian Koellermeier, Philipp Krah, Julius Reiss, Zachary Schellin

引用次数: 0