Microfluidics and Nanofluidics最新文献_第7页

Transonic, supersonic, and hypersonic flow of rarefied gas into vacuum through channels with a forward- or backward-facing step 稀薄气体以跨音速、超音速和高超音速流经带有前向或后向台阶的通道进入真空

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-25 DOI: 10.1007/s10404-024-02727-x

O. Sazhin, A. Sazhin

引用次数: 0

A 3D printed acoustofluidic nozzle-diffuser microfluidic pump 三维打印声学流体喷嘴-扩散器微流体泵

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-15 DOI: 10.1007/s10404-024-02722-2

Erturan Yetiskin, Sinan Gucluer, Ilayda Erdem, Adem Ozcelik

{"title":"A 3D printed acoustofluidic nozzle-diffuser microfluidic pump","authors":"Erturan Yetiskin, Sinan Gucluer, Ilayda Erdem, Adem Ozcelik","doi":"10.1007/s10404-024-02722-2","DOIUrl":"10.1007/s10404-024-02722-2","url":null,"abstract":"<div><p>Microfluidic flow control systems are critical components for on-chip biomedical applications. This study introduces a new micropump for on-chip sample preparation and analysis by using an acoustic nozzle diffuser mechanism. The micropump implements a commercially available transducer and control board kit with 3D-printed fluid reservoirs. In this micropump, conic-shaped micro-holes on the metal sheet cover of the transducer are employed as oscillating nozzle diffuser micro arrays to achieve directional flow control. The micropump is shown to efficiently pump water and particle mixtures exceeding flow rates of 515 µl/min at a 12-volt input voltage. In addition, owing to the small size of the nozzle hole opening, larger particles can also be filtered out from a sample solution during fluid pumping enabling a new function. Importantly, the micropump can be fabricated and assembled without needing a cleanroom, making it more accessible. This feature is advantageous for researchers and practitioners, eliminating a significant barrier to entry. By combining commercially available components with 3D printing technology, this micropump presents a cost-effective and versatile solution for on-chip applications in biomedical research and analysis.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-024-02722-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Fluid lubrication model over sinusoidal roughness with streamline-based approach 基于流线的正弦粗糙度流体润滑模型

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-15 DOI: 10.1007/s10404-024-02721-3

Haruki Okazaki, Shintaro Takeuchi

{"title":"Fluid lubrication model over sinusoidal roughness with streamline-based approach","authors":"Haruki Okazaki, Shintaro Takeuchi","doi":"10.1007/s10404-024-02721-3","DOIUrl":"10.1007/s10404-024-02721-3","url":null,"abstract":"<div><p>A method is proposed to deterministically obtain steady lubrication pressure for the Stokes flow in a channel bounded by a flat wall and a surface with roughness represented by sinusoidal waves. A streamline sufficiently far away from the rough surface is used to formulate a streamline-based lubrication equation with the velocity on the streamline, and the velocities on the streamline is imposed as a boundary condition. In the solution of the lubrication equation, by virtually moving the streamline towards the flat wall, the pressure on the flat wall is obtained, and then the wall-normal variation of the pressure is recovered from the wall pressure by a lubrication model that considers higher order terms. The proposed method is applied to lubrication flows in channels with roughness represented by a single sinusoidal wave and a superposition of several sinusoidal waves. Through comparison with analytical solutions, the validity of the proposed method is established, and the applicable range of superposition of waves is explained that lowest-wavenumber component in surface profile is sufficiently isolated from higher-wavenumber components. Although the problem setting intrinsically prohibits the application of the conventional Reynolds lubrication equation, this study provides new understandings for the pressure obeying the Reynolds lubrication equation and the role of the higher-order terms.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Merged and alternating droplets generation in double T-junction microchannels using symmetrically inserted capillaries 利用对称插入的毛细管在双 T 型交界微通道中生成合并和交替液滴

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-14 DOI: 10.1007/s10404-024-02725-z

Feng Shen, Yuedong Zhang, Chunyou Li, Yan Pang, Zhaomiao Liu

{"title":"Merged and alternating droplets generation in double T-junction microchannels using symmetrically inserted capillaries","authors":"Feng Shen, Yuedong Zhang, Chunyou Li, Yan Pang, Zhaomiao Liu","doi":"10.1007/s10404-024-02725-z","DOIUrl":"10.1007/s10404-024-02725-z","url":null,"abstract":"<p>In this work, merged and alternating droplets generated in a microfluidic double T-junction are investigated using experiments and numerical simulations. The double T-junction is constructed by symmetrically inserting two capillaries into a microfluidic chip at specific positions. We explore the effects of the two-phase flow rate fraction, capillary tip distance (30 μm, 60 μm, and 200 μm), and fluid properties on droplet formation phenomena. Detailed observations reveal four distinct regimes during the dynamic evolution of the two-phase interface morphology: merged state, stable alternating droplets, droplet pairs, and jetting. Two phase diagrams are obtained to demonstrate that interfacial tension and dispersed phase viscosity significantly influence these regimes. Moreover, we find that as the flow rate fraction increases from 0.054 to 0.286, the length of generated droplets increases from 156 to 789 μm; we provide a theoretical prediction formula for dimensionless droplet length accordingly. Additionally, our simulations show fluctuating pressure in dispersed flows throughout the process of droplet generation. The simulated pressure in the dispersed flows fluctuates during the droplet generation process. The understanding of the underlying physics of the capillary-based double T-junction contributes valuable insights for various related applications.</p>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the stability of single emulsion created by microfluidics and its use in the production of core–shell microparticles 探索微流控技术产生的单一乳液的稳定性及其在核壳微颗粒生产中的应用

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-08 DOI: 10.1007/s10404-024-02723-1

Mehrnaz Oveysi, Vahid Bazargan, Amir Nejat, Marco Marengo

{"title":"Exploring the stability of single emulsion created by microfluidics and its use in the production of core–shell microparticles","authors":"Mehrnaz Oveysi, Vahid Bazargan, Amir Nejat, Marco Marengo","doi":"10.1007/s10404-024-02723-1","DOIUrl":"10.1007/s10404-024-02723-1","url":null,"abstract":"<div><p>This study introduces an innovative method aimed at achieving exceptional stability in emulsions. The primary focus is on re-emulsifying precisely controlled and uniform initial single emulsions, generated by microfluidic devices, to produce single-core double emulsions and core–shell microparticles. Departing from traditional approaches, our method employs a unique combination of advanced Two-level fractional factorial design and numerical simulation. These tools are utilized to discern and optimize critical parameters necessary for the formation of highly monodispersed stable single emulsions and their subsequent transformation into double emulsions. Correlations are established to estimate the size and stability of the primary single emulsion based on immiscible phase flow rate ratio and surfactant concentration. These correlations provide a comprehensive understanding that facilitates the intentional development of desired water-in-oil emulsions. The proposed microfluidic paradigm shows promise for the controlled and efficient production of single-core double emulsions, with broad applications in Pharmaceuticals, Food, and Cosmetics.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized flow control by photothermal actuation of pNIPAAm hydrogel brushes in a macroporous silicon membrane 通过光热驱动大孔硅膜中的 pNIPAAm 水凝胶刷实现局部流量控制

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-04 DOI: 10.1007/s10404-024-02726-y

Youngsik Song, Nafis Mustakim, Mayank Pandey, Sang-Woo Seo

{"title":"Localized flow control by photothermal actuation of pNIPAAm hydrogel brushes in a macroporous silicon membrane","authors":"Youngsik Song, Nafis Mustakim, Mayank Pandey, Sang-Woo Seo","doi":"10.1007/s10404-024-02726-y","DOIUrl":"10.1007/s10404-024-02726-y","url":null,"abstract":"<div><p>We present the control of liquid flow through arrayed micron-sized pores in a macroporous silicon membrane. The pores are coated with about 150 nm polymer N-isopropylacrylamide (pNIPAAm) hydrogel brushes and 200 nm polypyrrole layer, which works as photothermal actuator. The size of pore openings is controlled by utilizing the swelling and de-swelling behavior of temperature-sensitive pNIPAAm brushes, and the temperature on pNIPAAm brushes is changed by 815 nm near infra-red (NIR) illumination to polypyrrole photothermal element layer. The dimension change of the pore openings is investigated by observing the transmitted light and fluorescence signal intensity through the pores in the membrane while changing the ambient temperature. It has shown that the intensity of transmitted light can be controlled by adjusting the ambient temperature across the low critical solution temperature (LCST) of the hydrogel brushes. The localized control of liquid flow through the pores is demonstrated by the diffusion of fluorescein dye from the bottom of the membrane to the surface of the membrane using pulsed NIR light illumination. Fast dynamic response of fluorescein dye diffusion upon the illumination of NIR light suggests that the presented photothermal actuation approach could be applied to diverse biomedical applications such as a localized drug release system.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic chip for synergic drugs assay in 3D breast cancer cell 用于三维乳腺癌细胞协同药物检测的微流控芯片

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-04-02 DOI: 10.1007/s10404-024-02724-0

Franciele Flores Vit, Yu Tzu Wu, Eric Fujiwara, Hernandes F. Carvalho, Lucimara Gaziola de la Torre

{"title":"Microfluidic chip for synergic drugs assay in 3D breast cancer cell","authors":"Franciele Flores Vit, Yu Tzu Wu, Eric Fujiwara, Hernandes F. Carvalho, Lucimara Gaziola de la Torre","doi":"10.1007/s10404-024-02724-0","DOIUrl":"10.1007/s10404-024-02724-0","url":null,"abstract":"<div><p>Some anticancer treatments may cause Multidrug Resistance (MDR). In these cases, cells pump the drug out of the intracellular environment, thereby preventing drug effects. Several strategies have been used to avoid MDR, including using two or more drugs at low concentrations to increase the sensitivity of cells to treatment. We present an effective, cheap, fast microfluidic alternative to test two drugs simultaneously using a reversible sealing and reusable device to determine the optimal concentration. We used the rugs doxorubicin (DOX) and paclitaxel (PXT) as proof of concept. The microdevice allows the testing of two drugs in real time. Furthermore, running two experiments in sextuplicates and control in the same microchip is possible. We used two combinations of drugs, varying the drug concentration (C<sub>1</sub> = 0.010 mg.mL<sup>− 1</sup> DOX and 0.002.mL<sup>− 1</sup> mg PXT, C<sub>2</sub> = 0.010 mg.mL<sup>− 1</sup> DOX and 0.004 mg.mL<sup>− 1</sup> PXT), and evaluated cell death over time. The intermediate drug concentrations were more efficient, reducing the time required to decrease the viability of breast tumor cells, MCF-7 (C<sub>1</sub> = 180 and C<sub>2</sub> = 120). In further analysis, the microdevice also allowed characterization of the effects of the drugs (antagonist, synergic, or additive). This microdevice is a reliable tool for estimating the different combinations of two drug concentrations in a single assay simply and quickly.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the performances of SU-8 microfluidic devices: high liquid water tightness, long-term stability, and vacuum compatibility 量化 SU-8 微流体设备的性能：高液体水密性、长期稳定性和真空兼容性

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-29 DOI: 10.1007/s10404-024-02720-4

Said Pashayev, Romain Lhermerout, Christophe Roblin, Eric Alibert, Jerome Barbat, Rudy Desgarceaux, Remi Jelinek, Edouard Chauveau, Saïd Tahir, Vincent Jourdain, Rasim Jabbarov, Francois Henn, Adrien Noury

{"title":"Quantifying the performances of SU-8 microfluidic devices: high liquid water tightness, long-term stability, and vacuum compatibility","authors":"Said Pashayev, Romain Lhermerout, Christophe Roblin, Eric Alibert, Jerome Barbat, Rudy Desgarceaux, Remi Jelinek, Edouard Chauveau, Saïd Tahir, Vincent Jourdain, Rasim Jabbarov, Francois Henn, Adrien Noury","doi":"10.1007/s10404-024-02720-4","DOIUrl":"10.1007/s10404-024-02720-4","url":null,"abstract":"<div><p>Despite several decades of development, microfluidics lacks a sealing material that can be readily fabricated, leak-tight under high liquid water pressure, stable over a long time, and vacuum compatible. In this paper, we report the performances of a micro-scale processable sealing material for nanofluidic/microfluidics chip fabrication, which enables us to achieve all these requirements. We observed that micrometric walls made of SU-8 photoresist, whose thickness range from 35 to 135 µm, are at least leak-tight to 1.5 bars and up to 5.5 bars, exhibit no water porosity even after 2 months of aging, and are able to sustain under <span>(10^{-5})</span> mbar vacuum. This sealing material is therefore reliable and versatile for building microchips, part of which must be isolated from liquid water under pressure or vacuum. Moreover, the fabrication process we propose does not require the use of either aggressive chemicals or high-temperature or high-energy plasma treatment. It thus opens a new perspective to seal microchips with sensitive surfaces containing nanomaterials.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140325418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behaviors of non-wetting phase snap-off events in two-phase flow: microscopic phenomena and macroscopic effects 两相流中非润湿相卡断事件的行为：微观现象和宏观效应

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-26 DOI: 10.1007/s10404-024-02718-y

Ran Li, Zhaolin Gu, Zhang Li, Weizhen Lu, Guozhu Zhao, Junwei Su

引用次数: 0

Modified capillary number to standardize droplet generation in suction-driven microfluidics 修改毛细管数量，使抽吸驱动微流控技术中的液滴生成标准化

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-03-22 DOI: 10.1007/s10404-024-02714-2

Jatin Panwar, Rahul Roy

{"title":"Modified capillary number to standardize droplet generation in suction-driven microfluidics","authors":"Jatin Panwar, Rahul Roy","doi":"10.1007/s10404-024-02714-2","DOIUrl":"10.1007/s10404-024-02714-2","url":null,"abstract":"<div><p>In droplet microfluidic devices with suction-based flow control, the microchannel geometry and suction pressure at the outlet govern the dynamic properties of the two phases that influence the droplet generation. Therefore, it is critical to understand the role of geometry along with suction pressure in the dynamics of droplet generation to develop a predictive model. We conducted a comprehensive characterization of droplet generation in a flow focusing device with varying control parameters. We used these results to formulate a scaling argument and propose a governing parameter, called as modified capillary number (Ca<sub>L</sub>), that combines normalized droplet volume with geometrical parameters (length of dispersed and continuous phase channels) and flow parameters (interfacial tension, phase viscosity and velocity) in a power law relationship. Ca<sub>L</sub> effectively captures the transition from squeezing to dripping regimes of droplet generation, providing essential insights into the design requirements for suction-driven droplet generation. These findings are key to standardize microfluidic flow-focusing devices that can achieve the desired droplet generation behavior with optimal pressure consumption.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0