Microfluidics and Nanofluidics最新文献

Convective instability analysis of micropolar fluid-saturated horizontal porous layer 微极流体饱和水平多孔层对流不稳定性分析

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-10-06 DOI: 10.1007/s10404-025-02847-y

Pankaj Barman, D. Srinivasacharya

{"title":"Convective instability analysis of micropolar fluid-saturated horizontal porous layer","authors":"Pankaj Barman, D. Srinivasacharya","doi":"10.1007/s10404-025-02847-y","DOIUrl":"10.1007/s10404-025-02847-y","url":null,"abstract":"<div><p>This article investigates the convective instability of a micropolar fluid-saturated horizontal porous layer. An inclined temperature gradient along with the horizontal throughflow is considered during this investigation. The primary aim of this article is to explore the nature of the micropolar fluid parameters on the transverse and longitudinal rolls in the presence of horizontal throughflow. The following parameters, such as coupling number, micropolar parameter, Darcy number, porosity of the medium, horizontal Rayleigh number, and Péclet number, mainly control the flow. The base flow is a combination of horizontally moving mass flow and flow induced by an inclined temperature gradient. This particular flow configuration is known as the Hedley-Prats flow. The eigenvalue problems related to the transverse and longitudinal rolls are numerically solved using the <i>bvp4c</i> routine in MATLAB. A comparison of the numerical results for the Darcy number on the Hadley–Prats flow in the Brinkman model with those of the current problem reveals a high degree of concurrence. It is observed that the direction of the horizontal throughflow does not significantly affect the stability region of micropolar fluids under an inclined temperature gradient. Furthermore, the presence of micropolar fluid parameters (such as <span>(N_text {1})</span> and <i>m</i>) always stabilizes the flow characteristics.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy dissipation mechanisms in droplet dynamics: implications for wetting phenomena 液滴动力学中的能量耗散机制：对润湿现象的影响

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-10-06 DOI: 10.1007/s10404-025-02846-z

Amir Karimdoost Yasuri

引用次数: 0

Characteristics of the travelling speed of droplet flow splitting in bifurcated minichannel networks 分岔小通道网络中液滴流动分裂的传播速度特征

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-10-06 DOI: 10.1007/s10404-025-02848-x

Kui He, Liangzhen Zhang, Yilin Zhan, Ya Ge, Zhaochuan Chen, Si-Min Huang

{"title":"Characteristics of the travelling speed of droplet flow splitting in bifurcated minichannel networks","authors":"Kui He, Liangzhen Zhang, Yilin Zhan, Ya Ge, Zhaochuan Chen, Si-Min Huang","doi":"10.1007/s10404-025-02848-x","DOIUrl":"10.1007/s10404-025-02848-x","url":null,"abstract":"<div><p>The splitting modes of droplet flow in bifurcated minichannel networks are valuable for distributing them in various microfluidics chemical applications and have been widely studied. Previously, predictions of the splitting modes relied on the models of hydraulic flow resistance. This paper presents an experimental study on the correlation between droplet splitting modes and droplet travelling speed characteristics in various minichannel networks. A high-speed camera and machine vision algorithm were used to measure the instantaneous travelling speed of droplets at the inlet and arms of the networks. Five typical splitting modes are identified: bypass splitting, breakup splitting, random splitting, uniform splitting and oscillating splitting. The characteristics of the droplet speed corresponding to different splitting modes are studied and understood by analyzing their varying features and correlations. The results show that splitting modes can be correlated to droplet travelling speed characteristics. This research focuses on how to identify and monitor droplet splitting modes at T-junctions, which relies solely on local visual features of several droplets. It lays the foundation for regulating different splitting modes in the future. </p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrodynamics and mass-transfer properties of alkane-water liquid-liquid system in a microchannel 微通道中烷烃-水-液-液体系的流体力学和传质特性

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-10-06 DOI: 10.1007/s10404-025-02849-w

Shunkai Xia, Jingwei Zhang, Haohong Duan, Zhuo Chen, Jianhong Xu

引用次数: 0

Microfluidic mixing by micropost-driven acoustic microstreaming: effects of micropost shape, actuation voltage, and fluid flow rate 微柱驱动声微流的微流体混合：微柱形状、驱动电压和流体流速的影响

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-09-22 DOI: 10.1007/s10404-025-02845-0

Bahareh Chaichypour, Sinthuran Jegatheeswaran, Alinaghi Salari, Zjardyn L. Hood, Aaron R. Wheeler, Dae Kun Hwang, Michael C. Kolios, Scott S. H. Tsai

{"title":"Microfluidic mixing by micropost-driven acoustic microstreaming: effects of micropost shape, actuation voltage, and fluid flow rate","authors":"Bahareh Chaichypour, Sinthuran Jegatheeswaran, Alinaghi Salari, Zjardyn L. Hood, Aaron R. Wheeler, Dae Kun Hwang, Michael C. Kolios, Scott S. H. Tsai","doi":"10.1007/s10404-025-02845-0","DOIUrl":"10.1007/s10404-025-02845-0","url":null,"abstract":"<div><p>We describe an approach to enhancing microfluidic mixing by generating acoustic microstreaming flows around microposts in a microfluidic device. Specifically, we synthesize microposts with various cross-sectional shapes (i.e., circles, triangles, and stars) using photocrosslinkable polymers, allowing for precise control over their geometry. We also ensure unobstructed micropost vibration via carefully designed gaps between the microposts and the channel ceiling. Experimental findings reveal that the shape of microposts is critical in influencing microstreaming patterns and mixing efficiency. Circular microposts generate semi-symmetrical circular vortices, resulting in superior mixing performance (86.7%). In contrast, star-shaped microposts, despite having sharper edges and forming pairs of microvortices around their vertices, produce the lowest mixing performance (56.5%). This trend correlates with the microposts’ moment of inertia (MOI); circular posts exhibit the lowest MOI and thus oscillate more readily, whereas star-shaped posts are geometrically more resistant to bending, limiting vibration amplitude and reducing streaming strength. Further characterization of the microstreaming flow patterns in a static aqueous solution reveals that the lower mixing performance of star-shaped micropillars is likely due to the impact of the spacing between the microposts and the emergence of counter-rotating pairs of microvortices, leading to destructive interference. Triangular microposts exhibit moderate mixing performance, generating a pair of opposing vortices around each vertex. Increasing the actuation voltage and reducing the flow rates further improves mixing across all micropost shapes. These findings highlight the significance of micropost design and arrangement in enhancing the performance of microfluidic acoustic mixers.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A generalized analytical model for investigating flow dynamics influenced by wall wettability in capillary-driven microfluidics 研究毛细管驱动微流体中壁面润湿性对流动动力学影响的广义分析模型

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-09-05 DOI: 10.1007/s10404-025-02821-8

Sergio Balestrieri, Federica Granata, Mario Iodice, Giuseppe Coppola

{"title":"A generalized analytical model for investigating flow dynamics influenced by wall wettability in capillary-driven microfluidics","authors":"Sergio Balestrieri, Federica Granata, Mario Iodice, Giuseppe Coppola","doi":"10.1007/s10404-025-02821-8","DOIUrl":"10.1007/s10404-025-02821-8","url":null,"abstract":"<div><p>Capillarity is a key mechanism for fluid control in microfluidic devices, enabling, for example, liquid movement without external pumps. This study develops and validates an analytical model to describe the velocity and displacement of the liquid meniscus in three-dimensional microfluidic channels with walls exhibiting different wettability. Particular focus is placed on the transient behavior of the meniscus during the initial phases of channel filling, a critical yet often overlooked aspect for optimizing flow control. This is especially relevant given the growing adoption of capillary pumps and valves in microfluidic systems. To evaluate the validity and reliability of the proposed model under diverse operating conditions, channels with different geometries and dimensional ratios were fabricated using various materials and techniques. Experimental results confirm the model’s accuracy, even in complex configurations, with relative errors ranging from 7<span>(%)</span> to 10<span>(%)</span>.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-025-02821-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular on-chip sensor for flow and monodispersity analysis in droplet-based microfluidics 模块化芯片传感器的流动和单分散性分析在液滴为基础的微流体

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-09-05 DOI: 10.1007/s10404-025-02841-4

Daniel Solano, Sergio Camacho-Leon

{"title":"Modular on-chip sensor for flow and monodispersity analysis in droplet-based microfluidics","authors":"Daniel Solano, Sergio Camacho-Leon","doi":"10.1007/s10404-025-02841-4","DOIUrl":"10.1007/s10404-025-02841-4","url":null,"abstract":"<div><p>Droplet-based microfluidics has emerged as a core technology in developing Lab-On-A-Chip systems thanks to miniaturization, rapid analytical response, and low cross-contamination risk. As a result, detecting and characterizing dispersed phases is crucial across several applications, including biological research, drug development, clinical diagnostics, and the synthesis of micro/nanoparticles. Despite efforts to achieve high sensitivity, specificity, speed, and robustness, current fabrication technologies remain challenging, costly, and complex, which limits broader adoption. Thus, this work presents the design and fabrication of a modular droplet-based sensor system integrating off-the-shelf electronic components and PMMA-based flow-focusing microfluidic chips. The system employs an optical light source and light detector for detection, counting, and characterizing water-in-oil systems, enabling on-chip measurement of droplet length, volume, and monodispersity. Experimental validation demonstrated high accuracy, with a 2.06% error rate and a coefficient of variation of 2.35%, confirming stable and monodisperse droplet generation across multiple channel widths. Furthermore, the proposed sensor system offers an affordable, user-friendly, and easy-to-fabricate modular design, with an easily interchangeable microfluidic module. These findings support the development of an ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end-users) Lab-on-PCB system.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of a finger-actuated quantitative drive module for point-of-care blood typing chips 集成一个手指驱动的定量驱动模块，用于点护理血型芯片

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-09-02 DOI: 10.1007/s10404-025-02844-1

Xiaolong Hu, Yurui Lin, Ling Chen, Lifang Duan, Zhichang Du

{"title":"Integration of a finger-actuated quantitative drive module for point-of-care blood typing chips","authors":"Xiaolong Hu, Yurui Lin, Ling Chen, Lifang Duan, Zhichang Du","doi":"10.1007/s10404-025-02844-1","DOIUrl":"10.1007/s10404-025-02844-1","url":null,"abstract":"<div><p>Although point-of-care testing (POCT) chips offer the advantages of fluid manipulation without external energy and easy portability, they exhibit significant variability in fluid control due to individual operational differences. Therefore, this study developed a finger-actuated quantitative drive module, achieving quantitative fluid driving through its bolt-driven component screwing mechanism, spring return motion, and designed contact point size. The quantitative relationship between its key parameters and fluid-driven volume was elucidated through experiments, providing a theoretical basis for flow control. In addition, we further systematically characterize the consistency of this module’s driving performance. The results indicate that under a single-contact condition, the standard deviation of the single-drive volume for different operators is less than 5%. When using multi-contact parallel control, the maximum volume deviation of each contact is only 0.12 µL, demonstrating good consistency in parallel control. Finally, we integrated the module into our independently developed blood type detection chips and verified its excellent multi-fluid mixing ability through dual color tracing experiments. In double-blind blood type detection experiments, it was able to obtain blood type determination results consistent with traditional test tube methods within 5 min. This work provides an innovative solution for fluid quantitative drive control of POCT chips and demonstrates significant application potential in medical scenarios such as bedside diagnosis and on-site testing.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of a microfluidic chip using mechanical micromilling for flocculant testing 用机械微铣削制造絮凝剂测试用微流控芯片

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-08-30 DOI: 10.1007/s10404-025-02843-2

Parvathi K K, Nithin Tom Mathew

{"title":"Fabrication of a microfluidic chip using mechanical micromilling for flocculant testing","authors":"Parvathi K K, Nithin Tom Mathew","doi":"10.1007/s10404-025-02843-2","DOIUrl":"10.1007/s10404-025-02843-2","url":null,"abstract":"<div><p>The fabrication of microfluidic chips using mechanical micromilling offers a promising method for rapid prototyping. This study investigates the use of mechanical micromilling to produce microchannels in Polymethyl methacrylate for flocculant testing, which requires precision and smooth surfaces to ensure effective fluid flow and mixing. The dimensional accuracy of the fabricated microchannels was evaluated using a coordinate measuring machine, and surface quality was analysed through scanning electron microscopy and confocal microscopy. The coordinate measuring measurements indicated high consistency across most features, but significant deviations were observed in specific regions, suggesting challenges in achieving tight tolerances for certain geometric features. The scanning electron micrographs analysis revealed surface imperfections, including excess burrs and feed marks, which could negatively impact fluid flow in microchannels. Confocal microscopy confirmed the presence of high surface roughness, with pronounced peaks and valleys that could disrupt flow and increase resistance in microfluidic applications. The findings highlight the need to optimise process parameters to improve surface quality. Optimisation of the micromilling parameters and post-processing techniques is necessary to enhance surface quality for the microfluidic device to meet the stringent requirements necessary for effective flocculant testing.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An analysis of ethanol evaporation and flow at triangular capillary ports at different tilt angles 不同倾斜角度下三角形毛细管口乙醇蒸发与流动分析

IF 2.5 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2025-08-29 DOI: 10.1007/s10404-025-02834-3

Aiqiang Chen, Zixu Wang, Jianfei Song, Huiqin Wang

{"title":"An analysis of ethanol evaporation and flow at triangular capillary ports at different tilt angles","authors":"Aiqiang Chen, Zixu Wang, Jianfei Song, Huiqin Wang","doi":"10.1007/s10404-025-02834-3","DOIUrl":"10.1007/s10404-025-02834-3","url":null,"abstract":"<div><p>The use of shaped microchannels has become increasingly prevalent in heat engine and microelectronics industries due to their exceptional heat dissipation efficiency. However, limited research has addressed the evaporation characteristics of special-shaped capillaries under inclined orientations. At the capillary scale, the effects of gravity and surface tension are comparable, making their interplay particularly relevant. This study investigates the combined impact of gravity and capillary driving forces on the ethanol evaporation characteristics at the opening of triangular capillary tubes with different inclination angles. The temperature distribution and morphological changes of the meniscus during evaporation were explored using infrared thermography and video microscopy. Additionally, the internal flow structure of the meniscus was analyzed using particle image velocimetry technique (PIV). Comparisons were made among the evaporation characteristics at the opening of capillary tubes with different inclination angles (0°, 30°, 60°, and 90°) and cross-sectional shapes (circular and triangular). The results show that the inclination angle of triangular capillary tubes significantly influences the liquid level, corner liquid film thickness, temperature distribution, and flow pattern during ethanol evaporation. Increased inclination angle reduces the corner liquid film thickness, enhances heat transfer efficiency, and accelerates the evaporation rate. However, when the corner liquid film becomes excessively thin, liquid supply is impeded, which hinders the overall evaporation process. The fastest evaporation rate is observed at an inclination angle of 60°, accompanied by the lowest and most uniform temperature distribution at the meniscus.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0