Microfluidics and Nanofluidics最新文献_第2页

Boron nitride quantum dot-enabled paper microfluidic platform for non-invasive kidney disease detection 氮化硼量子点纸微流控平台用于无创肾脏疾病检测

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-18 DOI: 10.1007/s10404-026-02929-5

Melahat Sevgül Bakay, Frank A. Gomez, Petr Vozka, Brenda Andrade Rounds

{"title":"Boron nitride quantum dot-enabled paper microfluidic platform for non-invasive kidney disease detection","authors":"Melahat Sevgül Bakay, Frank A. Gomez, Petr Vozka, Brenda Andrade Rounds","doi":"10.1007/s10404-026-02929-5","DOIUrl":"10.1007/s10404-026-02929-5","url":null,"abstract":"<div><p>Chronic kidney disease (CKD) is a significant disorder that requires reliable and non-invasive tracking of key urinary biomarkers like creatinine, albumin, and urea for early diagnosis and disease management. In the present work, a microfluidic paper-based analytical device integrated with boron nitride quantum dots (BNQDs) was developed for the detection of these biomarkers according to fluorescence response. The fluorescence response of BNQDs was optimized at pH 8, BNQD concentration of 3.6 mM, and an incubation time of 10 min. Under these optimized conditions, concentration-dependent fluorescence quenching was observed with no emission peak shift at ~498 nm. On the other hand, linear detection ranges of 1.0 to 5.0 mg/mL for creatinine (R<sup>2</sup> = 0.9626), 0.06 to 0.20 mg/mL for albumin (R<sup>2</sup> = 0.974), and 0.2 to 1.0 mg/mL for urea (R<sup>2</sup> = 0.9844) were obtained. The developed system in this study was successfully tested using the artificial urine samples, providing recoveries of 95–105%. The proposed BNQD-enabled microfluidic paper-based platform provides the simultaneous fluorescence detection of creatinine, albumin, and urea, three clinically relevant biomarkers associated with CKD, demonstrating its potential as a simple, low-cost, and multiplex point-of-care (POC) sensing platform.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vacuum-induced droplet generation and transport in parallel microchannels 平行微通道中真空诱导液滴的产生和输运

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-18 DOI: 10.1007/s10404-026-02932-w

Prasad Nikhil, R. Rahul, B. Indulakshmi, R. S. Mini, S. Kumar Ranjith

{"title":"Vacuum-induced droplet generation and transport in parallel microchannels","authors":"Prasad Nikhil, R. Rahul, B. Indulakshmi, R. S. Mini, S. Kumar Ranjith","doi":"10.1007/s10404-026-02932-w","DOIUrl":"10.1007/s10404-026-02932-w","url":null,"abstract":"<div><p>Despite the widespread use of droplet microfluidics, achieving simultaneous, uniform, and controllable droplet generation across multiple channels remains a challenge, especially without relying on complex pressure controllers or individual channel actuation. This study introduces a simplified yet powerful multichannel vacuum-driven droplet microfluidic platform that enables synchronised droplet production using a single shared vacuum source. Through experiments, we demonstrated robust control over droplet size and generation frequency by tuning the hydrostatic head of the continuous phase and the outlet vacuum strength. Parallel droplet formation is investigated in 3, 5, and 7-channel chips, revealing excellent inter-channel uniformity over a wide pressure range. Additionally, a novel strategy for generating distinct droplet sizes simultaneously within the same chip by modulating the channel hydraulic resistance is introduced, enabling multiplexed operations without added complexity. To further enhance scalability, a 3D chip design featuring a common-inlet architecture for the dispersed and continuous phases is introduced and analyzed for droplet generation in parallel microchannels, enabling the splitting of a single sample into multiple droplets across parallel channels. This work establishes vacuum-driven multichannel droplet systems as a compact, cost-effective, and scalable solution for high-throughput lab-on-a-chip applications, including multiplexed diagnostics and parallelized chemical or biological assays, particularly in resource-limited settings.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study to investigate the impact of sensing area and sample volume on the sensitivity of Circular InterDigital Capacitor-based Analyzer 实验研究了传感面积和样本量对圆形数字电容分析仪灵敏度的影响

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-17 DOI: 10.1007/s10404-026-02934-8

Swati Todi, Poonam Agarwal

{"title":"Experimental study to investigate the impact of sensing area and sample volume on the sensitivity of Circular InterDigital Capacitor-based Analyzer","authors":"Swati Todi, Poonam Agarwal","doi":"10.1007/s10404-026-02934-8","DOIUrl":"10.1007/s10404-026-02934-8","url":null,"abstract":"<div><p>In this work, an experimental study is presented to explore the effect of sensing area and sample volume on the sensor performance, without altering the sensor design. Here, a 50<span>(Omega)</span> coplanar waveguide-fed Circular InterDigital Capacitor-based Analyzer (CIDCA) is demonstrated, where a circular interdigital capacitor serves as the sensing area. The CIDCA prototype is experimentally tested with aqueous solutions of varying glucose concentrations in the range 0-0.5g/ml with 0.1g/ml step intervals, serving as the sample under test (SUT). As the sample is in a liquid state, a circular cavity made of polydimethylsiloxane (PDMS) polymer is utilized to confine the SUT. The performance of the analyzer has been evaluated using a configuration of six distinct circular cavities made of PDMS, with a constant height of 3mm and varying diameters: 3mm, 4mm, 5mm, 6mm, 7mm, and 8mm, respectively. The CIDCA prototypes are experimentally analyzed for RF performance in the 1-3GHz frequency range, with the SUT volume varying with cavity diameter. The experimental results reveal the sensitivity for CIDCA prototypes with circular cavity of varying diameters from 3mm to 8mm are 5.644, 9.257, 9.203, 11.099, 11.421, and 8.893 in dB/g/ml in terms of <span>(S_{11})</span> magnitude and 33, 79.643, 71.68, 75.454, 121.668, and 138.64 in MHz/g/ml in terms of peak frequency, respectively.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geometric asymmetry as a design parameter for flow control and thrust characteristics of micronozzles 几何不对称作为微喷嘴流动控制和推力特性的设计参数

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-11 DOI: 10.1007/s10404-026-02930-y

MohammadTaha Zahraeipour, Elyas Lekzian, Moslem Sabouri

{"title":"Geometric asymmetry as a design parameter for flow control and thrust characteristics of micronozzles","authors":"MohammadTaha Zahraeipour, Elyas Lekzian, Moslem Sabouri","doi":"10.1007/s10404-026-02930-y","DOIUrl":"10.1007/s10404-026-02930-y","url":null,"abstract":"<div><p>Micronozzle performance is highly sensitive to the geometric design, particularly in rarefied flow regimes (<span>(Kn = 0.01-0.1)</span>). Geometric asymmetry in this study is considered a deliberate design parameter for specialised micro-propulsion conditions. A parametric investigation of planar converging-diverging micronozzles with controlled wall-angle asymmetry is conducted using the Direct Simulation Monte Carlo (DSMC) method. The symmetric nozzle (<span>(theta _{1} =theta _{2}'= 18.43^{circ })</span>) is considered the benchmark (Case 1). The impacts on rarefied flow fields, exit velocity direction, and thrust performance are characterised. Results indicate that higher asymmetric divergence angles induce exhaust plume deflection, as the velocity profile deflects toward the wall with greater expansion, with deflection angles ranging from <span>(-5.5^circ)</span> to <span>(+3^circ)</span> depending on the asymmetry configuration. The asymmetric nozzle (case 2, <span>(theta _{2}''= 26.5^{circ })</span>), which has a higher divergence angle than the benchmark case, elevates local Knudsen number by approximately 19.8% (from <span>(Kn = 0.086)</span> to 0.103), reducing wall shear stress and viscous interaction. Under the vacuum back pressure, a thrust increase of up to 4% is observed for the selected asymmetric configuration (case 2), attributed to a higher effective expansion ratio. Additionally, the average exit Mach number increases by 6.1% for case 2. Furthermore, under externally imposed non-uniform exit pressure conditions (pressure asymmetry ratio <span>(Pi = 0)</span>–0.2), the asymmetric geometry acts as a passive flow-reorientation mechanism within the range of conditions studied. It mitigates plume deflection and promotes an approximately axial exhaust direction. This benefit comes at the expense of an unavoidable thrust reduction of less than 4%.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superior mixing efficiency in inertial sunflower microfluidics 惯性葵花籽微流体中优越的混合效率

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-11 DOI: 10.1007/s10404-026-02922-y

D. Akyıldız, Y. E. Aldı, İ. B. Gül, R. Taşkın, T. Y. Kaya, L. Trabzon

{"title":"Superior mixing efficiency in inertial sunflower microfluidics","authors":"D. Akyıldız, Y. E. Aldı, İ. B. Gül, R. Taşkın, T. Y. Kaya, L. Trabzon","doi":"10.1007/s10404-026-02922-y","DOIUrl":"10.1007/s10404-026-02922-y","url":null,"abstract":"<div><p>Micromixing has emerged as a promising approach due to its advantages, including accelerated mixing times, reduced sample volumes, and cost-effectiveness. In biological applications, where intricate living systems are studied, the degree of mixing, signifying the homogeneity of the mixture, assumes paramount importance. Micromixers, integral components of MEMS (Micro-Electro-Mechanical Systems), harness microscale mechanical and electro-mechanical elements to achieve efficient mixing. These micromixers are broadly classified into passive and active categories based on the presence of external driving forces. Passive micromixers exploit inertial forces arising from geometric channel configurations to induce mixing. The efficacy of passive micromixers is assessed based on the mixing index, a critical parameter central to this investigation that quantifies the extent of intermixing between two fluids. This study explores Sunflower geometry as a passive micromixer by mixing simulations conducted at 10 ≤ Re ≤ 100 and experiments conducted at 10 ≤ Re ≤ 60, aiming to understand how the performance of the Sunflower geometry changes. Sunflower geometry was examined through comparisons with spiral micromixers to assess the extent of its distinctiveness. The study’s findings demonstrated how well-suited sunflower micromixers are for producing complete mixing. In particular, the sunflower micromixer outperformed the spiral micromixer, producing a noteworthy 99% mixing ratio at its exit when tested under a flow with a Reynolds number of 100 in the simulation analysis. Similarly, experimental analysis at Re 60 reveals a ⁓99% mixing ratio even at a shorter distance. Analysis of simulated and experimental data also revealed a strong correlation between mixing quality and higher Reynolds numbers.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel wavy-like-structured dielectrophoretic microchip for single cell-bead pairing and mRNA extraction 用于单细胞头配对和mRNA提取的新型波状结构介电泳微芯片

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-10 DOI: 10.1007/s10404-026-02925-9

Yingzhe Piao, Chunhui Wu, Qionghua Zhu, Ying Tan, Zhaoan Huang, Yu Liu, Liang Fang, Yuan Lin, Wei Chen, Xing Cheng

{"title":"Novel wavy-like-structured dielectrophoretic microchip for single cell-bead pairing and mRNA extraction","authors":"Yingzhe Piao, Chunhui Wu, Qionghua Zhu, Ying Tan, Zhaoan Huang, Yu Liu, Liang Fang, Yuan Lin, Wei Chen, Xing Cheng","doi":"10.1007/s10404-026-02925-9","DOIUrl":"10.1007/s10404-026-02925-9","url":null,"abstract":"<div><p>With the rapid growth of microfluidic technologies, various microchips are capable of generating high-throughput parallel reaction systems for accurate single-cell analysis. Here, a novel dielectrophoretic microchip with a wavy-like surface, which enables a large-scale single cell-bead pairing with over 9000 cell-bead pairs in a single run within 1 × 1.8 cm<sup>2</sup> working area and on-chip electrical lysis for mRNA extraction, was proposed as proof-of-principle for the high-throughput single cell analysis applications. The throughput could be increased to tens of thousands by scaling up the microwell count in the microchip during identical microfabrication steps within the same timeframe. Notably, the design and fabrication of the wavy-like surface of the microchip accounts for cell-bead size-differences to improve the generality and flexibility of the microchip in practical applications. An “encapsulation-first, disruption-later” mode incorporated with an on-chip electrical lysis was proposed for scRNA release and the operability of the present microchip for mRNA extraction was verified by qPCR testing. The present microchip demonstrates potential utility for high-throughput single analysis to promote various biomedical studies with single cell resolution.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidics and biosensors-driven detection of exosomes: advances in aptamers, peptides and POC devices for next-generation diagnostics 微流体和生物传感器驱动的外泌体检测：用于下一代诊断的适体、肽和POC设备的进展

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-08 DOI: 10.1007/s10404-026-02935-7

P. Priyanka, S. Hemalatha

{"title":"Microfluidics and biosensors-driven detection of exosomes: advances in aptamers, peptides and POC devices for next-generation diagnostics","authors":"P. Priyanka, S. Hemalatha","doi":"10.1007/s10404-026-02935-7","DOIUrl":"10.1007/s10404-026-02935-7","url":null,"abstract":"<div><p>Cancer remains one of the leading causes of mortality worldwide, early detection is essential for improving cancer patient survival. Although advanced imaging techniques and point-of-care (POC) devices have emerged, they are often invasive, costly and insufficiently sensitive for detecting cancers at their earliest stages. Exosomes are nanoscale extracellular vesicles (EVs) (30–150 nm) released by tumor cells that contain proteins, lipids, RNA, and DNA. Because they represent the molecular status of their parent cells, exosomes can be used as biomarkers. However, the practical translation of traditional isolation techniques, such as ultracentrifugation, precipitation, and immunoaffinity capture, is limited due to their time-consuming nature, high sample volume requirements, and tendency to produce heterogeneous preparations. While nanomaterials excel in tunability and controlled engineering, exosomes provide a biologically informed and physiologically relevant alternative. Microfluidic platforms coupled with biosensors, such as lab-on-a-chip (LOC) devices, paper-based platforms, and other tiny systems, provide for rapid, sensitive, and portable exosome analysis in POC testing. The use of aptamers and peptides as biorecognition elements improves these systems by providing greater reproducibility, lower cost, sensitivity and specificity than antibodies, increasing clinical feasibility. This review discusses current breakthroughs in aptamer and peptide functionalized microfluidic biosensors for exosome-based cancer diagnostics, focusing on their translation into POC applications. Finally, we highlight present challenges, such as repeatability, clinical validation, and scalable production, as well as potential future prospects, such as smartphone-based readouts and artificial intelligence (AI) integration for next-generation cancer diagnostics.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic geometry design of inlet-boundary confinement for two-phase displacement in heterogeneous porous media 非均质多孔介质中两相驱的入口边界约束微流控几何设计

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-07 DOI: 10.1007/s10404-026-02928-6

Mingbao Zhang, Xukang Lu, Yuedi Wang, Rui Li, Moran Wang

{"title":"Microfluidic geometry design of inlet-boundary confinement for two-phase displacement in heterogeneous porous media","authors":"Mingbao Zhang, Xukang Lu, Yuedi Wang, Rui Li, Moran Wang","doi":"10.1007/s10404-026-02928-6","DOIUrl":"10.1007/s10404-026-02928-6","url":null,"abstract":"<div><p>Visual experiments on a microfluidic chip provide a powerful platform for mechanism studies on multiphase flow and displacements in subsurface porous media. Generally, the inlet-outlet conditions and injection confinement naturally inherit those from microfluidics for microsystems, which can influence the flow behavior and displacement stages strongly, yet may not be appropriate for subsurface scenarios. In this work, inspired by field-scale injection processes, a capillary-number-mapped inlet-boundary design is developed and tested for heterogeneous micromodels, in which point injection is combined with variable boundary confinement to introduce a progressive along-path capillary number evolution and reduce inlet-induced discontinuities. Compared with two common configurations: a uniform injection with constant confinement and a point injection with constant confinement, experiments spanning multiple orders of magnitude in the capillary number identify three representative stages with the corresponding capillary number ranges highly sensitive to inlet–boundary designs. The proposed geometry design suppresses rapid early-stage transverse invasion at the inlet and enables a progressive expansion of matrix mobilization as capillary number increases, thereby alleviating the abrupt mobilization transition observed in conventional point-injection layouts while reducing the experimental fluctuation caused by stochastic pathway selection under uniform injection. Interface-evolution metrics, pressure-drop responses, and skeleton-based topology analyses support these findings consistently, suggesting that the proposed design helps improve the physical consistency of quasi-two-dimensional micromodel displacement experiments for interpreting in-plane preferential flow and matrix mobilization.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic model for reproducing wall shear stress on endothelial cell surface at arteriovenous fistula anastomosis site 动静脉瘘吻合处内皮细胞表面壁剪应力重现的微流控模型

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-07 DOI: 10.1007/s10404-026-02933-9

Shu-Xin Liu, Hong-Han Wang, Jing-Tong Na, Chun-Dong Xue, Yong-Jiang Li, Hai-Yang Sun, Yu-Lin Wu, Shuang Zhang, Qing-Mei Meng, Kai-Rong Qin

{"title":"Microfluidic model for reproducing wall shear stress on endothelial cell surface at arteriovenous fistula anastomosis site","authors":"Shu-Xin Liu, Hong-Han Wang, Jing-Tong Na, Chun-Dong Xue, Yong-Jiang Li, Hai-Yang Sun, Yu-Lin Wu, Shuang Zhang, Qing-Mei Meng, Kai-Rong Qin","doi":"10.1007/s10404-026-02933-9","DOIUrl":"10.1007/s10404-026-02933-9","url":null,"abstract":"<div><p>To prevent arteriovenous fistula (AVF) stenosis, elucidating the functional regulation mechanism of endothelial cells by wall shear stress (WSS) at the AVF site was crucial. In this study, we proposed a novel microfluidic model to reproduce the WSS within the AVF region and revealed the associated mechanobiology mechanism. The computed tomography angiography (CTA) and computational fluid dynamics (CFD) simulation techniques were used to obtain the WSS with different characteristics on endothelial cell surface at AVF site. The constructed microfluidic model was employed to perform hemodynamics and cell experiments. The hemodynamic experiment results demonstrated that the AVF-specific WSS were successfully reproduced by the proposed model. Our cell-based experiments revealed that the pulsatile WSS promoted cell migration. Conversely, low intensity WSS and oscillatory pathological WSS were observed to significantly reduce endothelial cell migration, with oscillatory WSS resulting in the most severe damage to cell function. The neointimal hyperplasia (NIH) progression of AVF was accelerated by WSS-mediated endothelial injury. The proposed microfluidic model provided an in vitro research platform for clarifying AVF stenosis mechanisms, and the findings indicated that optimizing hemodynamic conditions at the AVF site was a potential strategy for maintaining patency of AVF.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing sustainable nanomanufacturing through continuous-flow microfluidic synthesis for scalable applications: a review 通过可扩展应用的连续流微流体合成推进可持续纳米制造：综述

IF 2.9 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2026-09-07 DOI: 10.1007/s10404-026-02931-x

Abdulrazak Jinadu Otaru, Isaac Alhamdu Baba, Omoniyi Babajide Awe, Manase Auta, Sami F. Khalil, Mohammed Al-Yaari

{"title":"Advancing sustainable nanomanufacturing through continuous-flow microfluidic synthesis for scalable applications: a review","authors":"Abdulrazak Jinadu Otaru, Isaac Alhamdu Baba, Omoniyi Babajide Awe, Manase Auta, Sami F. Khalil, Mohammed Al-Yaari","doi":"10.1007/s10404-026-02931-x","DOIUrl":"10.1007/s10404-026-02931-x","url":null,"abstract":"<div><p>Continuous-flow microfluidics presents a scalable, consistent, and eco-friendly alternative to conventional batch nanomanufacturing for applications in energy, medicine, and the environment. This review examines how channel designs, laminar flow, and droplet formation allow for precise control over the dimensions and shapes of metallic, polymeric, and hybrid nanostructures. It emphasizes the “green” benefits, such as decreased reagent use and the employment of bio-based solvents, and evaluates scale-up methods like numbering-up and parallelization for industrial feasibility. Additionally, emerging applications, including image-guided drug delivery, diagnostics, photocatalysis, energy storage, and antimicrobial systems, are explored to demonstrate the translational and interdisciplinary potential of this technology. The review also identifies key challenges, such as clogging, fouling, a lack of standardization, and the necessity for strong industrial adoption, while suggesting future directions in AI-optimized process development and automated nanomanufacturing. This review positions continuous-flow microfluidic synthesis as a scalable and sustainable method for the industrial production of advanced nanomaterials.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"30 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0