Microfluidics and Nanofluidics最新文献_第3页

Shapes of surfactant-laden Taylor bubbles in a square microchannel 方形微通道中含有表面活性剂的泰勒气泡的形状

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-29 DOI: 10.1007/s10404-024-02784-2

Ryota Igarashi, Riku Hachikubo, Ryo Kurimoto, Kosuke Hayashi

引用次数: 0

Envelope boundary conditions for the upper surface of two-dimensional canopy interacting with fluid flow 二维冠层上表面与流体相互作用的包络边界条件

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-26 DOI: 10.1007/s10404-024-02779-z

Shota Akita, Kie Okabayashi, Shintaro Takeuchi

{"title":"Envelope boundary conditions for the upper surface of two-dimensional canopy interacting with fluid flow","authors":"Shota Akita, Kie Okabayashi, Shintaro Takeuchi","doi":"10.1007/s10404-024-02779-z","DOIUrl":"10.1007/s10404-024-02779-z","url":null,"abstract":"<div><p>Boundary conditions at the surface of a layer of flexible fibers (i.e. the canopy envelope) subjected to fluid flow are proposed for uniform and non-uniform motions of the fibers, where the fibers exhibit identical and individual motions, respectively, to understand the mechanisms of the swaying motion of the canopy. By assuming small deflections, the fibers are treated as rigid rods hinged to a flat wall and the effects of the hydrodynamic force on the fibers are expressed with the moment of fluid forces by averaging the Navier–Stokes equations. For the uniformly moving case, displacement of the envelope is represented by a mass-spring-damper system driven by the hydrodynamic force. As the non-uniformity of the canopy behavior enhances, the effects of the diffusion of fiber velocities and fluid inertia along the fiber stems play a more important role in the envelope displacement equation. Numerical simulations of fluid flow are conducted with the envelope displacement models as the boundary conditions at the canopy surface. The validity of the present models is assessed by comparison with the results of fluid–structure interaction (FSI) simulation, which directly solves the interaction between individual fibers and fluid by an immersed boundary method. With the envelope model for non-uniform displacement, the grid convergence of the numerical result is about a first order rate. The comparison of the terms in the envelope model for non-uniform displacement shows that diffusion of fiber velocities dominates the motion of fibers. The applicability of the model is assessed by varying the number density of the fibers.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance analysis of T-shaped micromixers using an innovative bend structure of mixing channel 采用新型弯曲混合通道结构的t型微混合器性能分析

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-26 DOI: 10.1007/s10404-024-02783-3

Kamran Rasheed, Mubashshir Ahmad Ansari, Shahnwaz Alam, Mohammad Nawaz Khan

{"title":"Performance analysis of T-shaped micromixers using an innovative bend structure of mixing channel","authors":"Kamran Rasheed, Mubashshir Ahmad Ansari, Shahnwaz Alam, Mohammad Nawaz Khan","doi":"10.1007/s10404-024-02783-3","DOIUrl":"10.1007/s10404-024-02783-3","url":null,"abstract":"<div><p>Passive micromixers, known for their notable mixing effectiveness and simple manufacturing, are extensively utilized in the lab on chip devices, the bio-medicinal industry, the pharma industry and chemical process. Among the various designs of passive micromixers, the simple T-junction micromixer and the vortex T-junction micromixer are basic designs. In this paper, a comparative study was performed to analyze the influence of bend structural channels on the mixing quality, pressure drop and mixing cost for simple and vortex T micromixers by using numerical simulations. Reynolds numbers (30–120) and angle of bend (θ) ranging from 0° to 180° are the crucial parameters for the investigation. The outcomes suggest that vortex T-junction micromixers with bend structural channels have a greater mixing index than simple T-junction micromixers with bend structural channels, across all the Reynolds values. The findings also suggest that increasing the angle of bend (θ) improves the mixing performance. Additionally, the degree of mixing performance and pressure reduction both exhibit a positive correlation with higher Reynolds numbers.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of pillar shapes on the cell isolation in contactless DEP microfluidic devices 柱形对非接触DEP微流控装置中细胞分离的影响

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-24 DOI: 10.1007/s10404-024-02772-6

Mohsen Mashhadi Keshtiban, Peyman Torky Harchegani, Mahdi Moghimi Zand, Zahra Azizi

引用次数: 0

Computational analysis of Yamada–Ota and Xue models for surface tension gradient impact on radiative 3D flow of trihybrid nanofluid with Soret–Dufour effects 具有Soret-Dufour效应的三杂化纳米流体表面张力梯度对辐射三维流动影响的Yamada-Ota和Xue模型计算分析

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-23 DOI: 10.1007/s10404-024-02777-1

Sayer Obaid Alharbi, Munawar Abbas, Ahmed Babeker Elhag, Abdullah A. Faqihi, Ali Akgül

{"title":"Computational analysis of Yamada–Ota and Xue models for surface tension gradient impact on radiative 3D flow of trihybrid nanofluid with Soret–Dufour effects","authors":"Sayer Obaid Alharbi, Munawar Abbas, Ahmed Babeker Elhag, Abdullah A. Faqihi, Ali Akgül","doi":"10.1007/s10404-024-02777-1","DOIUrl":"10.1007/s10404-024-02777-1","url":null,"abstract":"<div><p>This article discusses the significance of Soret and Dufour, non-uniform heat generation, activation energy on radiative 3D flow of trihybrid nanofluid over a sheet with Marangoni convection. The energy equation takes into consideration the impacts of the heat generation, while the concentration equation takes activation energy into account. This trihybrid nanofluid is based on ethylene glycol and contains nanoparticles of titanium dioxide <span>((Ti{O}_{2}))</span>, cobalt ferrite <span>((CoF{e}_{2}O))</span>, and aluminum oxide <span>((text{A}{l}_{2}{O}_{3}))</span>. For the case of trihybrid nanoparticles, the Yamada–Ota and Xue nanofluid models have been modified. This model is helpful for optimizing heating and cooling systems in fields like energy systems, microelectronics, and aerospace engineering where exact control of thermal properties is essential. By adjusting the characteristics of nanofluids, it also enhances heat transfer rates, which is a critical component in the development of solar collectors and high-efficiency heat exchangers. By using the necessary similarity transformations, non-linear ODEs are obtained from the controlling PDEs. The shooting method (BVP4c) can be utilized to solve this system of highly nonlinear equations numerically. As the surface tension gradient parameter is increased, the velocity distribution, mass transfer, and heat transfer rates all increase but the performance of the thermal and solutal profiles is opposite.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on effects of magnetic fields of different inhomogeneous on the formation mechanism of microdroplets 不同非均匀磁场对微液滴形成机理的影响研究

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-12 DOI: 10.1007/s10404-024-02780-6

Lixiang Lv, Yibiao Chen, Yangyang Jiang, Gulite Wang, Jiacheng Lu

{"title":"Study on effects of magnetic fields of different inhomogeneous on the formation mechanism of microdroplets","authors":"Lixiang Lv, Yibiao Chen, Yangyang Jiang, Gulite Wang, Jiacheng Lu","doi":"10.1007/s10404-024-02780-6","DOIUrl":"10.1007/s10404-024-02780-6","url":null,"abstract":"<div><p>Microfluidic technology is widely applied in biological detection, primarily utilizing microvalves to control and regulate fluid flow. Increasing attention and research have recently been directed toward magnetic droplet valves, which use magnetic fields to control magnetic droplets in microchannels for sealing purposes. A novel droplet formation technique has been proposed, employing a permanent magnet to attract magnetic fluid through a step emulsification process, thus controllably forming the magnetic droplets required for microvalves. However, the current understanding of the generation mechanism of magnetic fluid step emulsification remains insufficiently deep, with inadequate force analysis during the expansion stage of the magnetic fluid. This shortcoming results in an unclear comprehension of the relationship between the magnetic field and step emulsification formation, impeding the accurate prediction and control of droplet size and formation rate, thereby compromising the performance and reliability of magnetic droplet valves. Therefore, the study initially analyzes the forces acting on the magnetic fluid in a non-uniform magnetic field theoretically and systematically explores the step emulsification mechanism of magnetic fluids through a combination of numerical simulations and experimental validations. The magnetic field inhomogeneity degree directly affects the microdroplet formation process. As the lateral distance between the permanent magnet and the channel outlet increases, the magnetic field inhomogeneity degree decreases, resulting in larger droplet volumes and lower formation rates. Through theoretical analysis and experimental validation, this study provides a significant theoretical foundation and practical guidance for forming magnetic fluid in microfluidic systems.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A “Plug-n-Play” permeable brick-based microfluidic pump “即插即用”渗透砖基微流体泵

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-12-02 DOI: 10.1007/s10404-024-02776-2

Zhihao Chen, Jiahao Liu, Shuqiang Min, Tonghuan Zhan, Yange Huang, Xianchang Wu, Jianfeng Chen, Bing Xu

{"title":"A “Plug-n-Play” permeable brick-based microfluidic pump","authors":"Zhihao Chen, Jiahao Liu, Shuqiang Min, Tonghuan Zhan, Yange Huang, Xianchang Wu, Jianfeng Chen, Bing Xu","doi":"10.1007/s10404-024-02776-2","DOIUrl":"10.1007/s10404-024-02776-2","url":null,"abstract":"<div><p>Inexpensive, autonomous, easy to fabricate and portable self-powered microfluidic pumps are urgently required especially in rapid point-of-care testing (POCT). Here, we propose a “Plug-n-Play” permeable brick-based (PB) micropump for autonomous and continuous liquid flow without any external power sources. The key advantage of this pump is that its operation only requires the user to place the PB pump on the outlet of microfluidic devices. The PB pumps are fabricated by simply slicing permeable bricks into predetermined shapes. The microcosmic morphology investigations unveil that their unique porous structures and uneven surface provide outstanding capillary force. For instance, a typical cuboid PB pump (2 × 2 × 2 cm<sup>3</sup>) can produce an average flow rate of more than 100 µL min<sup>− 1</sup>, a working time of 10 min and a maximum liquid absorption volume of ~ 1200 µL. Also, the flow rate and absorption volume can be programmed by using the PB pumps with different shapes. Moreover, we apply hydrophobic reagents (Glaco) treatment on the PB pumps to achieve the control over the liquid flow rates. Finally, through applying the PB pumps, we can perform blood type detection in POC cases. Based on its advantages of low cost, long service life, and adjustable flow rates, brick pump can be easily integrated into microfluidic systems and has great potential for microfluidic applications, especially in developing regions or in resource-limited settings.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of zebrafish sperm activation through microfluidic mixing induced by aquatic microrobots 通过水生微型机器人诱导的微流体混合提高斑马鱼精子活化能力

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-11-28 DOI: 10.1007/s10404-024-02778-0

Kai-Hsiang Yang, Dineshkumar Loganathan, Ming-Lung Chen, Vignesh Sahadevan, Chia-Yun Chen, Chia-Yuan Chen

{"title":"Enhancement of zebrafish sperm activation through microfluidic mixing induced by aquatic microrobots","authors":"Kai-Hsiang Yang, Dineshkumar Loganathan, Ming-Lung Chen, Vignesh Sahadevan, Chia-Yun Chen, Chia-Yuan Chen","doi":"10.1007/s10404-024-02778-0","DOIUrl":"10.1007/s10404-024-02778-0","url":null,"abstract":"<div><p>The activation of zebrafish sperm is essential for advancing vertebrate research, including studies in germplasm physiology and cryopreservation. In this study, a magnetic microrobot-based micromixer is developed to maximize zebrafish sperm activation through uniform micromixing and precise hydrodynamic control. Three distinct configurations of the microfluidic channel, labeled Design I, II, and III, are proposed and employed to activate zebrafish sperm cells. These configurations are distinguished by the number of microrobots utilized and their specific placement within the microfluidic channel. The fluid shear rate induced by the microrobot’s rotational motion is quantified to be 0.2 s⁻¹, falling within the lower range conducive to sperm activation. Meanwhile, zebrafish sperm activation percentage is observed to reach 88% within 10 s in an individual experiment. Additionally, the dynamics of sperm motility parameters, including VSL (straight-line velocity), VCL (curvilinear velocity), and LIN (linearity, VSL/VCL), are quantified to verify these results. The LIN value is observed to be 0.91 for Design III at the actuation time period of 10 s, indicating that the activated sperms are highly efficient and progressively motile. This study underscores the efficacy of microrobotic technologies in live cell manipulation, establishing a promising approach for future research.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic technologies: buffer exchange in bioprocessing, a mini review 微流控技术：生物处理中的缓冲交换，微型综述

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-11-27 DOI: 10.1007/s10404-024-02775-3

Tom Carvell, Paul Burgoyne, Alasdair R. Fraser, Helen Bridle

{"title":"Microfluidic technologies: buffer exchange in bioprocessing, a mini review","authors":"Tom Carvell, Paul Burgoyne, Alasdair R. Fraser, Helen Bridle","doi":"10.1007/s10404-024-02775-3","DOIUrl":"10.1007/s10404-024-02775-3","url":null,"abstract":"<div><p>Buffer exchange is a common process in manufacturing protocols for a wide range of bioprocessing applications, with a variety of technologies available to manipulate biological materials for culture medium exchange, cell washing and buffer removal. Microfluidics is an emerging field for buffer exchange and has shown promising results with both prototype research and commercialised devices which are inexpensive, highly customisable and often have the capacity for scalability to substantially increase throughput. Microfluidic devices are capable of processing biological materials and exchanging solutions without the need for conventional processing techniques like centrifugation, which are time-consuming, unsuitable for large volumes and may be damaging to cells. The use of microfluidic separation devices for cell therapy manufacturing has been under-explored despite some device designs successfully being used for diagnostic enrichment of rare circulating tumour cells from peripheral blood. This mini-review aims to review the current state of microfluidic devices for buffer exchange, provide an insight into the advantages microfluidics offers for buffer exchange and identify future developments key to exploiting the technology for this application.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"28 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-024-02775-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142736926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation system 利用微流体细胞变形系统对细胞对细胞骨架调节的反应进行高通量细胞机械分型

IF 2.3 4区工程技术

Microfluidics and Nanofluidics Pub Date : 2024-11-26 DOI: 10.1007/s10404-024-02774-4

Ian M. Smith, Jeanine A. Ursitti, Sai Pranav Majeti Venkata, Nikka Givpoor, Megan B. Stemberger, Autumn Hengen, Shohini Banerjee, Khaled Hached, Siem van der Laan, Joseph Stains, Stuart S. Martin, Christopher Ward, Kimberly M. Stroka

引用次数: 0