Microfluidics and Nanofluidics最新文献

筛选
英文 中文
Energy efficiency and thermo-hydraulic performance of MWCNT/water nanofluid in flat and circular tubes MWCNT/水纳米流体在平管和圆管中的能效和热水力性能
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-06-14 DOI: 10.1007/s10404-025-02820-9
Neeti Arora, Himanshu Manchanda, Munish Gupta
{"title":"Energy efficiency and thermo-hydraulic performance of MWCNT/water nanofluid in flat and circular tubes","authors":"Neeti Arora,&nbsp;Himanshu Manchanda,&nbsp;Munish Gupta","doi":"10.1007/s10404-025-02820-9","DOIUrl":"10.1007/s10404-025-02820-9","url":null,"abstract":"<div><p>In this manuscript, heat transfer and flow characteristics (HTFC) of multi-walled carbon nanotubes (MWCNT)/water nanofluids investigated in flat and circular tubes under constant heat flux (CHF) conditions, experimentally. The two-step method was used in preparing nanofluids at various weight fractions of 0.01, 0.05, 0.1 and 0.3 wt.% with the use of cetyl trimethyl ammonium bromide (CTAB) surfactant. The thermo-physical properties (TPP) such as thermal conductivity (TC) and viscosity were studied through instruments. Specific heat and density were calculated through standard theoretical equations. TC enhanced with temperature and particle concentration. The experiments were performed in test rig having both flat and circular tubes connected in parallel. Fluids were flow through tubes at different flow rates 0.15–0.5 L/min. Thermal performance was measured through two parameters such as heat transfer coefficient (HTC) and Nusselt number. Both parameters were increased with increase in nanoparticle concentration and flow rate of nanofluids. Highest enhancement in HTC of 0.3 wt.% nanofluid was 72.13% and 82.82% at flow rate 0.5 L/min compared to that of distilled water in circular and flat tubes, respectively. HTC enhancement of 17% was obtained in flat tube compared to circular tube at similar operating conditions. Pressure drop (PD) for 0.3 wt.% nanofluid was 2.35 times and 2.63 times at 0.5 L/min flow rate in circular and flat tubes, respectively. Energy efficiency ratio (<span>(eta)</span>) was also calculated to be 1.57 and 1.39 for 0.3 wt.% and 0.5 L/min for flat and circular tubes, respectively. Flat tube showed good thermo-hydraulic performance compared to circular tube under similar operating conditions.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an autonomous picoliter droplet array generating device with a centrifugal microfluidic system 离心微流控系统自主皮升液滴阵列产生装置的研制
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-06-04 DOI: 10.1007/s10404-025-02819-2
Shunya Okamoto, Shota Nakamura, Ayumu Oshita, Moeto Nagai, Takayuki Shibata
{"title":"Development of an autonomous picoliter droplet array generating device with a centrifugal microfluidic system","authors":"Shunya Okamoto,&nbsp;Shota Nakamura,&nbsp;Ayumu Oshita,&nbsp;Moeto Nagai,&nbsp;Takayuki Shibata","doi":"10.1007/s10404-025-02819-2","DOIUrl":"10.1007/s10404-025-02819-2","url":null,"abstract":"<div><p>In this study, we propose and develop an autonomous picoliter droplet array-generating device using a centrifugal microfluidic system. Droplet arrays play a crucial role in the advancement of chemical analyses, such as digital quantification and digital PCR. In digital quantification, it is important to standardize the size of the droplets and ensure the ease of analysis of the detection reactions within each droplet. Hence, we developed a device that can form droplets of a predetermined size within pre-arranged cup structures simply by flowing liquid and successfully controlled the flow for generating picoliter droplet arrays. The flow control was conducted simply by rotation, and it was not necessary to customize the centrifuge. By optimizing the cup arrangement and these spaces, the device realized that approximately140 pL of highly uniform droplets with an area concentration as high as 32 pieces per square millimeter. Moreover, by implementing an evaporation-prevention function, it was confirmed that the droplets could be retained for more than 30 min. Owing to its simplicity, it is expected to make a significant contribution to the widespread adoption of digital quantification and advancement of analysis.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-025-02819-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rarefaction slip phenomena within a viscous disk pump with molecular mean free path sized surface roughness elements 具有分子平均自由程大小的表面粗糙度单元的粘性圆盘泵内的稀疏滑移现象
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-06-04 DOI: 10.1007/s10404-025-02813-8
Phil Ligrani, Adrian Pippert, Bernhard Weigand
{"title":"Rarefaction slip phenomena within a viscous disk pump with molecular mean free path sized surface roughness elements","authors":"Phil Ligrani,&nbsp;Adrian Pippert,&nbsp;Bernhard Weigand","doi":"10.1007/s10404-025-02813-8","DOIUrl":"10.1007/s10404-025-02813-8","url":null,"abstract":"<div><p>The present investigation considers roughness elements which are generally very small relative to the principal flow length scale, and about the same order of magnitude as the molecular mean free path of helium. Significantly different rarefaction flow behavior is produced using three roughness arrangements, which have different character and structure in regard to distributions of larger ridges, as well as sizes, shapes, and distributions of smaller roughness elements. Measured distributions of slip velocity and associated tangential momentum accommodation coefficients are provided as they vary with Knudsen number Kn, disk rotation speed ω, and mean roughness height Ra. Results are given for helium and air as working fluids, three different surface roughness types, different disk rotational speeds ω, different volumetric flow rates, and different flow passage heights h. Knudsen number values range from 5.21 × 10<sup>–3</sup> to 2.15 × 10<sup>–2</sup> for helium, and from 1.82 × 10<sup>–3</sup> to 7.53 × 10<sup>–3</sup> for air. The device employed to produce these data is a viscous disk pump (VDP). With smallest mean roughness height, all of the elements on the surface are about the same size, which is about the same as the molecular mean free path of helium, and a larger percentage of molecules are subject to specular reflection resulting in substantial slip velocity magnitudes. With largest mean roughness height, a diversity of roughness element sizes, shapes, and heights is present, and a larger percentage of molecules are subject to diffuse reflection resulting in relatively small slip velocity magnitudes.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a PMMA-based Droplet microfluidic device for high-throughput screening in health care applications 基于pmma的液滴微流控装置在医疗保健中的高通量筛选应用
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-06-04 DOI: 10.1007/s10404-025-02816-5
Kaavya Purushothaman, Ashwin Kumar Narasimhan, S. Gnanavel
{"title":"Development of a PMMA-based Droplet microfluidic device for high-throughput screening in health care applications","authors":"Kaavya Purushothaman,&nbsp;Ashwin Kumar Narasimhan,&nbsp;S. Gnanavel","doi":"10.1007/s10404-025-02816-5","DOIUrl":"10.1007/s10404-025-02816-5","url":null,"abstract":"<p>The research focuses on the development of a novel, cost-effective, three-layer droplet microfluidic device fabricated using Polymethyl methacrylate (PMMA) engineered for high-throughput screening in healthcare applications. PMMA offered improved optical transparency, chemical resistance, low absorption, and high scalability. Here, we evolved a T-junction integrated microchannel with a squeezer mechanism for consistent monodisperse droplet generation. Device fabrication was achieved via a laser ablation technique followed by an ethanol-enhanced UV-irradiation method for strong and leak-free bonding between the PMMA layers. The surface properties of the PMMA layer revealed an increased surface energy and uniform wettability. The tensile strength of fabricated PMMA microfluidic devices demonstrated superior bonding strength and structural integrity compared to the existing fabrication methods. The device reliably generated uniform monodisperse droplets up to a 100 ml/hr flow rate, confirming its robustness and suitability for high-throughput screening. Overall, this PMMA-based Microfluidics platform offers a scalable and reliable solution for droplet generation suitable for applications such as drug delivery, single-cell analysis, and diagnostic assays.</p>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patented technologies of microfluidic devices for targeted drug delivery: a revolution in optimization 靶向药物递送的微流体装置专利技术:优化的革命
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-05-27 DOI: 10.1007/s10404-025-02814-7
Dilpreet Singh
{"title":"Patented technologies of microfluidic devices for targeted drug delivery: a revolution in optimization","authors":"Dilpreet Singh","doi":"10.1007/s10404-025-02814-7","DOIUrl":"10.1007/s10404-025-02814-7","url":null,"abstract":"<div><p>Microfluidic devices have emerged as transformative tools in the field of targeted drug delivery, offering unprecedented precision, efficiency, and control. Patented innovations in microfluidics focus on creating tailored delivery systems capable of overcoming biological barriers, optimizing therapeutic dosing, and minimizing systemic side effects. By integrating advanced materials, microfabrication techniques, and dynamic fluid control, these devices enable localized and sustained release of therapeutics. Applications span oncology, neurology, and chronic disease management, addressing challenges such as drug stability, biodistribution, and cellular targeting. This paper explores patented microfluidic technologies, emphasizing their design principles, functional mechanisms, and their role in revolutionizing drug delivery. Furthermore, we discuss the future prospects and commercialization potential of these devices as key enablers of personalized medicine.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-situ tunable working ranges on microfluidic paper-based analytical devices for cysteine analysis in food 食品中半胱氨酸分析用微流控纸基分析装置的原位可调工作范围
IF 2.5 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-05-27 DOI: 10.1007/s10404-025-02815-6
Jaruwan Mettakoonpitak, Korbua Chaisiwamongkhol, Kanokorn Wechakorn
{"title":"In-situ tunable working ranges on microfluidic paper-based analytical devices for cysteine analysis in food","authors":"Jaruwan Mettakoonpitak,&nbsp;Korbua Chaisiwamongkhol,&nbsp;Kanokorn Wechakorn","doi":"10.1007/s10404-025-02815-6","DOIUrl":"10.1007/s10404-025-02815-6","url":null,"abstract":"<div><p>Colorimetric microfluidic paper-based analytical devices (µPADs) offer a promising platform for point-of-care diagnostics due to their simplicity, portability, and low cost. However, their limited dynamic range, typically restricted by a single reagent concentration, often necessitates sample dilution, increasing analysis time and complexity. This work presents a novel strategy to expand the dynamic range of µPADs by integrating varying reagent concentrations within a single device. This approach was demonstrated for the detection of cysteine (Cys), a biomolecule with a wide concentration range in biological and food samples. Indirect Cys quantification was performed by reacting it with Ag(I) prior to the determination of the remaining Ag(I) using K<sub>2</sub>CrO<sub>4</sub>. Despite the inherent interference from halides in this assay, an integrated online halide removal layer was incorporated into the sensor. Moreover, the interference from other amino acids was not found, indicating high selectivity. A wide linear range of six orders of magnitude (0.0001-10 mg mL<sup>− 1</sup>) with a limit of detection of 0.03 µg mL<sup>− 1</sup> was achieved using the multi-concentration approach. The developed µPADs were successfully applied to the analysis of Cys in food samples, achieving high accuracy with recoveries ranging from 87.0 to 107.8%. This innovative approach holds significant potential for enhancing the analytical capabilities of µPADs for various point-of-care applications.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-time monitoring of Candida albicans biofilm growth and 4-HPA-mediated inhibition using an optoelectrochemical platform 利用光电电化学平台实时监测白色念珠菌生物膜生长和4- hpa介导的抑制作用
IF 2.3 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-05-27 DOI: 10.1007/s10404-025-02810-x
Anmol Kulshrestha, Pratima Gupta, Vivek Kumar Singh, Abhishek Kumar, Sonal Fande, Sanket Goel
{"title":"Real-time monitoring of Candida albicans biofilm growth and 4-HPA-mediated inhibition using an optoelectrochemical platform","authors":"Anmol Kulshrestha,&nbsp;Pratima Gupta,&nbsp;Vivek Kumar Singh,&nbsp;Abhishek Kumar,&nbsp;Sonal Fande,&nbsp;Sanket Goel","doi":"10.1007/s10404-025-02810-x","DOIUrl":"10.1007/s10404-025-02810-x","url":null,"abstract":"<div><p>The opportunistic fungus <i>Candida albicans</i> has become the major cause of hospital-acquired infections due to its ability to develop biofilms that resistance to treatments. his study monitored the real-time growth and inhibition of <i>C. albicans</i> hyphal and biofilm formation using optoelectrochemical approaches, focusing on Secreted Aspartyl Protease 5 (SAP5), a key virulence factor. The natural phenolic compound 4-Hydroxyphenylacetic acid (4-HPA) was computationally screened and demonstrated strong binding affinity to SAP5. In vitro studies indicated a minimum biofilm inhibitory concentration (MBIC) of 4 mg/mL and a minimum biofilm eradication concentration (MBEC) of 16 mg/mL. The 4-HPA exhibited considerable potential as an anti-hyphal and anti-biofilm agent, achieving efficacy &gt; 90% in the Biofilm Infection Simulator System (BISS) platform. Likewise, in microfluidic platform, electrochemical analysis revealed 85–90% biofilm inhibition &amp; reduction on MBIC &amp; MBEC doses, respectively. The correlation of microscopic images with electrochemical data revealed complementarity, introducing a novel approach for monitoring microbial biofilms. This study introduces a novel approach to monitoring and treating biofilms, offering promising insights for anti-biofilm drug development.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of the biocompatibility of polymeric resins processed by 3D printing for applications in manufacturing of devices for short term 3D cultures 3D打印处理的聚合物树脂的生物相容性研究,用于制造短期3D培养设备
IF 2.3 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-05-23 DOI: 10.1007/s10404-025-02809-4
João Paulo de Jesus Vieira, Saulo Soares da Silva, Ilva de Fátima Souza, Marcelo Bráulio Pedras, Bethânia Alves de Avelar Freitas, Libardo Andrés González Torres
{"title":"Study of the biocompatibility of polymeric resins processed by 3D printing for applications in manufacturing of devices for short term 3D cultures","authors":"João Paulo de Jesus Vieira,&nbsp;Saulo Soares da Silva,&nbsp;Ilva de Fátima Souza,&nbsp;Marcelo Bráulio Pedras,&nbsp;Bethânia Alves de Avelar Freitas,&nbsp;Libardo Andrés González Torres","doi":"10.1007/s10404-025-02809-4","DOIUrl":"10.1007/s10404-025-02809-4","url":null,"abstract":"<div><p>The biocompatibility of materials and processes used in the fabrication of three-dimensional (3D) culture devices is crucial for the success of some relevant studies. In this context, 3D printing emerges as a promising technology to be used. This study evaluated three resins as candidates for the production of 3D culture devices: PriZma 3D Bio Splint (resin 1), 3D Prime Premium Cristal (resin 2), and Quanton Spin Skin Opaca (resin 3). Cubic samples of 2 mm and 3 mm were fabricated using a DLP 3D printer, followed by post-processing and sterilization. Biocompatibility was assessed using immortalized BSC-40 cells cultured in 96-well plates using MTT colorimetric assay to estimate cellular viability. A material is considered biocompatible if cell viability is above 70%. Resins 1 and 3 demonstrated high biocompatibility, with cell viability exceeding 80% and no significant differences between sample sizes. In contrast, the cell viability of resin 2 ranged from 60 to 66%. Based on these results, simplified devices for 3D cultures were produced with resin 1, due to its characteristics, particularly its transparency, which facilitates culture protocols and microscopic observations. After 4 days of culture, cells exhibited a three-dimensional morphology with long cellular projections and high viability when evaluated by fluorescence microscopy. We conclude that resins 1 is suitable for device fabrication, while resin 2 and 3 are not recommended because of the low biocompatibility and the opacity. respectively. The chosen materials show great potential for the production of devices for short term 3D cell cultures, an expanding and highly relevant area of scientific research.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An integrated centrifugal microfluidic system for automatic nanozyme ELISA lateral flow immunoassay at point-of-care testing 一个集成的离心微流控系统自动纳米酶ELISA侧流免疫分析在护理点测试
IF 2.3 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-05-20 DOI: 10.1007/s10404-025-02812-9
Yingyi Huang, Lei Wang, Jiaxi Zhou, Guijun Miao, Lulu Zhang, Michael G. Mauk, Lizeng Gao, Xianbo Qiu
{"title":"An integrated centrifugal microfluidic system for automatic nanozyme ELISA lateral flow immunoassay at point-of-care testing","authors":"Yingyi Huang,&nbsp;Lei Wang,&nbsp;Jiaxi Zhou,&nbsp;Guijun Miao,&nbsp;Lulu Zhang,&nbsp;Michael G. Mauk,&nbsp;Lizeng Gao,&nbsp;Xianbo Qiu","doi":"10.1007/s10404-025-02812-9","DOIUrl":"10.1007/s10404-025-02812-9","url":null,"abstract":"<div><p>The accurate and rapid detection of H1N1 viral specific protein is crucial for effective disease control and management. Traditional diagnostic methods based on ELISA immunoassay often require complex manual operations, long incubation times, and lack the integration needed for automated, high-throughput analysis. There is an urgent demand for a portable, sensitive, integrated, and fully automated diagnostic platform to address these challenges in medical diagnostics. We developed an automated diagnostic system that integrates nanozyme-based detection within a centrifugal microfluidic device for rapid H1N1 viral specific protein detection. The system utilizes nanozymes for signal amplification, leveraging nanozymes to reduce assay times. A high-resolution image sensor and image processing algorithm enable precise interrogation of test results, demonstrating significant improvements in sensitivity. The compact centrifugal microfluidic device automates the sequential delivery of samples, reagents, and nanozyme probes, seamlessly implements mixing, incubation, and liquid transfer. The system achieves a 50-fold sensitivity improvement over the conventional method based on colloidal gold lateral flow strips, with a test time of only 15 min. This work develops a fully automated, integrated diagnostic platform by combining nanozyme-enhanced immunoassay with automatic centrifugal microfluidics. The platform eliminates manual intervention, achieving high sensitivity and rapid detection of infectious disease viral specific protein. Its compact and integrated design makes it a versatile tool for point-of-care diagnostics.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gold nanoparticles green production using diethyl carbonate as continuum phase in a dripping regime microfluidic reactor 以碳酸二乙酯为连续相,在滴注式微流控反应器中绿色生产金纳米颗粒
IF 2.3 4区 工程技术
Microfluidics and Nanofluidics Pub Date : 2025-05-17 DOI: 10.1007/s10404-025-02811-w
Mohsen Khorsand, Cavus Falamaki, Leila Zargarzadeh
{"title":"Gold nanoparticles green production using diethyl carbonate as continuum phase in a dripping regime microfluidic reactor","authors":"Mohsen Khorsand,&nbsp;Cavus Falamaki,&nbsp;Leila Zargarzadeh","doi":"10.1007/s10404-025-02811-w","DOIUrl":"10.1007/s10404-025-02811-w","url":null,"abstract":"<div><p>A dripping-regime segmented-flow microfluidic reactor for the continuous production of gold nanoparticles (Au NPs) was designed based on computational fluid dynamics calculations. A flow-focusing junction was applied. Diethyl carbonate (DEC) was used as a green material for the continuous phase. The dispersed aqueous phase consisted of HAuCl<sub>4</sub>, NaBH<sub>4</sub>, and PVA. Experimental dispersed phase droplet diameter as a function of Capillary number (Ca) corroborated with the CFD calculations. The effect of Ca (0.0013,0.0025 and 0.0050) and pH (1,3 and 11) on HAuCl<sub>4</sub> conversion and Au NPs particle size distribution (PSD) was investigated. Based on nanoparticle tracking analysis (NTA), average particle diameters as small as 1.73 nm with a sharp distribution (standard deviation of 0.27 nm) could be achieved. The apparent pseudo-first-order reduction reaction rate constant was found proportional to the average vorticity within the droplets. Particle growth was not dominated by coalescence processes. No leaching of Au<sup>3+</sup> by DEC was detected.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信