在呼吸循环过程中,用肺芯片追踪吸入颗粒的运输

IF 2.5 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION
Huimin Lv, Jun Dong, Huaying Chen, Yue Yang, Yonggang Zhu
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引用次数: 0

摘要

了解微米级颗粒在呼吸区的运输行为对于评估吸入气溶胶(包括环境污染物和治疗药物)对健康的影响至关重要。然而,通过实验捕捉气溶胶颗粒进入肺泡的详细轨迹并了解颗粒运输的潜在机制仍有待进一步研究。本研究通过实验和数值方法研究了不同雷诺数(Re)条件下肺泡气流输送微粒的详细轨迹。这些轨迹清楚地说明了在吸气和呼气过程中颗粒是如何进入肺泡并被困住的。该研究还强调了流量Re、颗粒直径和初始颗粒位置对颗粒输运行为的关键影响。在较高的Re下,流动倾向于驱动靠近管壁的颗粒沿螺旋路径向肺泡中心深入。较小的颗粒(< 1.5µm)表现出较长时间的悬浮,能够更深地穿透肺部。此外,在低re肺泡区,最初位于肺泡附近的颗粒在进入肺泡并被困方面具有优势。这项研究为提高我们对肺泡区域内颗粒运输行为的理解提供了有价值的数据,并对药物输送应用具有潜在的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tracking the transport of inhaled particles in a lung-on-a-chip during breathing cycles

Understanding the transport behavior of micron-sized particles in the respiratory zone is crucial for assessing health effects of inhaled aerosols, including environmental pollutants and therapeutic drugs. However, experimentally capturing the detailed trajectories of aerosol particles entering the alveoli and understanding the underlying mechanisms of particle transport remain to be further studied. This study experimentally and numerically investigated the detailed trajectories of microparticles transported by alveolar airflows across a range of Reynolds number (Re) conditions. These trajectories clearly illustrate how particles enter and become trapped in the alveoli during both inhalation and exhalation. This study also highlights the critical influence of flow Re, particle diameter, and initial particle position on particle transport behavior. At higher Re, flows tend to drive particles, those near the duct wall, deep towards the alveolar center in spiral paths. Smaller particles (< 1.5 µm) exhibit prolonged suspension, enabling deeper lung penetration. Moreover, in the low-Re alveolar region, particles initially positioned close to the alveoli have an advantage in entering the alveoli and being trapped. This research offers valuable data for improving our understanding of particle transport behavior within the alveolar region, and has potential implications for drug delivery applications.

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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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