液滴聚结按需控制及乳状液稳定性测试的混合微流控装置

IF 2.5 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION
Max G. A. Wolf, Kalpit J. Bakal, Xavier Casadevall i Solvas, Hans M. Wyss
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引用次数: 0

摘要

我们提出了一种新的微流控方法来表征微流控制滴装置内乳液抗聚结的稳定性。在我们的装置中,液滴的合并可以在广泛的流动条件下主动控制,使用简单的结构。新方法结合了已有的被动方法和主动方法的特点,因此我们称之为“混合”方法。我们的混合方法允许相对容易地集成在任何PDMS(聚二甲基硅氧烷)为基础的微流控装置,包括一个液滴制造结构,因为它采用了简单的单层PDMS几何结构。主装置结构包括2个压力室,沿局部扩展的主通道对称放置,液滴通过该通道流动。通过在压力室中诱导超压,使主通道的横截面积发生变化,从而影响液滴的速度和相互距离,从而影响聚并速率。为了验证我们对设备工作原理的假设并测试其性能,我们在不同的流量和施加压力下进行了系统的实验。这些实验证实了该装置的假设工作原理,表明该方法适用于乳液稳定性的表征。此外,我们表明混合方法能够主动控制按需聚结模式的创建,甚至触发特定的单个聚结事件。这表明,当将混合方法集成到液滴制造装置中时,可以为表征乳剂的稳定性和控制按需液滴聚结提供一种有前途的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hybrid microfluidic device for on-demand control of droplet coalescence and testing of emulsion stability

We present a new microfluidic method for the characterization of emulsion stability against coalescence within a microfluidic droplet-making device. In our device, the merging of droplets can be actively controlled under a wide range of flow conditions, using a simple structure. The new method combines features of already existing passive and active methods, hence we refer to it as a “hybrid” method. Our hybrid method allows for a relatively easy integration within any PDMS (polydimethysiloxane)-based microfluidic device comprising a droplet-making structure, since it employs a simple single-layer PDMS geometry. The main device structure comprises 2 pressure chambers, placed symmetrically along a locally expanded main channel, through which the droplets are flowing. By inducing an overpressure in the pressure chambers, a change of the cross-sectional area of the main channel is reached, which influences the droplets’ velocities and their mutual distance, and thus the coalescence rate. To test our hypotheses on the working principle of the device and to test its performance, we carry out systematic experiments at varying flow rates and applied pressures. These experiments confirm the hypothesized working principle of the device and indicate that the method is suitable for characterizing emulsion stability. Moreover, we show that the hybrid method is capable of actively controlling the creation of on-demand coalescence patterns and even of triggering specific single coalescence events. This indicates that the hybrid method, when integrated into a droplet-making device, can offer a promising approach both for characterizing the stability of emulsions and for controlling on-demand droplet coalescence.

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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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