Current advances in biocompatibility assessment for MEMS in biomedical applications

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION
Ahmad Razin Zainal Abidin, Nor Syafirah Zambry, Fatimah Ibrahim, Nurshamimi Nor Rashid, Nurul Fauzani Jamaluddin, Wan Safwani Wan Kamarul Zaman
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引用次数: 0

Abstract

Microelectromechanical systems (MEMS) have significantly advanced biomedical applications, enabling precise control in cell culture, tissue engineering, and drug delivery by creating highly controlled microenvironments that mimic biological systems. Traditional approaches to diagnostics and tissue fabrication face challenges in precision and scalability, driving interest in MEMS-based biosensors and microfluidic devices. These technologies offer high-throughput analysis and cellular manipulation, essential for developing complex three-dimensional (3D) tissue constructs. This paper reviews advancements in MEMS biocompatibility assessment over the past 14 years (2011–2024), focusing on material selection and device design to meet regulatory and performance standards. It also evaluates in vitro and in vivo testing methods, addressing unique challenges posed by MEMS-specific characteristics such as micro-scale structures and mixed materials. Finally, this paper highlights future directions for enhancing biocompatibility, safety, and performance, paving the way for the integration of MEMS into clinical applications to address critical challenges in biomedical fields.

生物医学应用中MEMS生物相容性评价研究进展
微机电系统(MEMS)具有显著先进的生物医学应用,通过创建模拟生物系统的高度可控微环境,可以精确控制细胞培养、组织工程和药物输送。传统的诊断和组织制造方法在精度和可扩展性方面面临挑战,这推动了对基于mems的生物传感器和微流体器件的兴趣。这些技术提供高通量分析和细胞操作,对于开发复杂的三维(3D)组织结构至关重要。本文回顾了过去14年(2011-2024)MEMS生物相容性评估的进展,重点是材料选择和器件设计,以满足法规和性能标准。它还评估了体外和体内测试方法,解决了mems特定特性(如微尺度结构和混合材料)带来的独特挑战。最后,本文强调了提高生物相容性、安全性和性能的未来方向,为将MEMS集成到临床应用中以应对生物医学领域的关键挑战铺平了道路。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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