Journal of Nanoparticle Research最新文献

{"title":"Suppression of cancer cell growth using nanoparticles containing two different amino acid-degrading enzymes","authors":"Shuhei Murayama,&nbsp;Hiromu Kurase,&nbsp;Kanako Tatsubori,&nbsp;Kyoko Takemura,&nbsp;Takashi Takaki,&nbsp;Masaru Kato","doi":"10.1007/s11051-025-06291-5","DOIUrl":"10.1007/s11051-025-06291-5","url":null,"abstract":"<div><p>Although depleting amino acids is a useful strategy for suppressing tumor growth, the amino acid-degrading enzymes used for this purpose are degraded in vivo, and they must be stabilized and rapidly introduced into target cells. The aim of this study was to explore novel strategies for suppressing cancer cell proliferation while minimizing off-target effects. Specifically, we focused on an amino acid deprivation approach, targeting the essential amino acids arginine and asparagine, which are integral to the proliferation and survival of cancer cells. Here, we report the stabilization and functional expression of amino acid-degrading enzymes using a developed nanoparticle with a network structure, which could be rapidly (in 20 min) introduced into the cell. Using this system, depending on the mesh size, macromolecules (as enzymes) are blocked, whereas small molecules (as amino acids) can freely pass through. This facilitates the introduction of enzymes into cells, along with nanoparticles, to degrade amino acids in a stable state. These results suggest that this system has the potential to be utilized for purposes other than amino acid depletion therapy, as its application enables multiple enzymes to function within cells in a stabilized state.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer potential of chalcones loaded on mesoporous silica nanoparticles","authors":"Guilherme José Schwarzt Sampaio,&nbsp;Rodrigo de Almeida Romagna,&nbsp;Reginaldo Bezerra dos Santos,&nbsp;Rita de Cássia Ribeiro Gonçalves,&nbsp;Edésia Martins Barros de Sousa,&nbsp;Gracielle Ferreira Andrade,&nbsp;Rodrigo Rezende Kitagawa","doi":"10.1007/s11051-025-06292-4","DOIUrl":"10.1007/s11051-025-06292-4","url":null,"abstract":"<div><p>The difficulty in treating cancer has led to several studies on the development of systems that perform targeted drug delivery, with the aim of increasing the effectiveness of treatment and reducing adverse effects. In this study, a series of chalcones were tested for cytotoxic action on gastric adenocarcinoma cells (AGS) and breast cancer cells (MCF-7) using the MTT-tetrazolium method, and significant cytotoxicity was demonstrated for 3-hydroxychalcone (CHO). The synthesis of mesoporous silica nanoparticles (MSNs) and their surface modification with 3-aminopropyltriethoxysilane (APTES) were carried out, and 3-hydroxychalcone was then incorporated into these nanomaterials. Mesoporous silica nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), elemental analysis (CHN), scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta potential, and nitrogen adsorption. In addition, in vitro release tests were carried out to verify the release profile of 3-hydroxychalcone from mesoporous silica samples. The results obtained showed that the mesoporous silica nanoparticles exhibited a gradual and prolonged release profile. In the cytotoxicity test with silica samples incorporated with 3-hydroxychalcone, significant cytotoxic activity was observed against AGS and MCF-7 cells, with the MSN-CHO sample exhibiting a better cytotoxic effect (IC₅₀ of 12.93 to 22.30 μM) than 3-hydroxychalcone (IC₅₀ of 47.58 to 47.97 μM). The results showed that the nanoparticles positively influenced the interaction of 3-hydroxychalcone with tumor cells. This is therefore an unprecedented study on the incorporation of 3-hydroxychalcone into mesoporous silica nanoparticles and its promising results in terms of cytotoxic activity against breast and gastric cancer cells.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of pyrazinamide loaded zeolite imidazole framework (ZIF-8) nanoparticles and effective anticancer effect in breast cancer cells","authors":"Karthick Arumugam,&nbsp;Azar Zochedh,&nbsp;Kaliraj Chandran,&nbsp;Sureba Sukumaran,&nbsp;Karthikeyan Palaniyandi,&nbsp;Asath Bahadur Sultan,&nbsp;Thandavarayan Kathiresan","doi":"10.1007/s11051-025-06289-z","DOIUrl":"10.1007/s11051-025-06289-z","url":null,"abstract":"<div><p>Zeolite imidazole framework (ZIF-8) nanoparticles have gained popularity in medicine delivery due to their distinct features. The goal of the current work was to synthesize ZIF-8 using 2-methylimidazole and zinc nitrate, followed up by loading of pyrazinamide (Py). Imidazole acts as a bridging ligand between the zinc ions in order to form a coordination polymer network. For characterization, these nanoparticles underwent scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersion x-ray spectrum (EDX), zeta potential, particle size measurement, X-ray diffraction (XRD), and Fourier infrared spectroscopy (FTIR) analysis. TEM and SEM investigation revealed rhombic dodecahedron assembly of ZIF-8 and drug-loaded ZIF-8. Variations in elemental compositions of ZIF-8 and Py@ZIF-8 were assessed through EDX spectrum. Particle size analysis revealed the diameter size falls between 70 and 100 nm, and good stability of nanoparticles was signified through zeta potential. The FTIR band of ZIF-8 and Py@ZIF-8 was recorded in the wavenumber between 4000 and 400 cm⁻¹, exhibiting the presence of functional groups. The crystalline nature of ZIF-8 and Py@ZIF-8 was confirmed through XRD analysis. ZIF-8 was exhibited to possess an effective drug-loading potential and a pH-based targeted delivery. Furthermore, cytotoxicity evaluation exhibited MCF-7 cell death at 83.3 µg/mL IC₅₀ dosage of Py@ZIF-8 in 24 h. The apoptotic cell death and ability to permeabilize mitochondrial membrane were investigated based on IC₅₀ dosage. These findings highlight the potential uses of ZIF-8 and Py@ZIF-8 in a variety of therapeutic scenarios, such as drug delivery systems, pH-dependent response, and less toxic and potent therapeutic agent for breast cancer.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air–liquid interfacial tension and foamability of ionic surfactant solutions containing TiO2 nanoparticles","authors":"Farzaneh Hajirasouliha,&nbsp;Daniela Placha,&nbsp;Yong-Qing Fu,&nbsp;Dominika Zabiegaj","doi":"10.1007/s11051-025-06283-5","DOIUrl":"10.1007/s11051-025-06283-5","url":null,"abstract":"<div><p>Presence of TiO₂ nanoparticles in aqueous surfactant solutions affects air–liquid interfacial characteristics of the system in which they have been dispersed. Foam formation, as a comprehensively applied process for new materials and techniques development, is one of the phenomena affected by changes of interfacial properties of solutions containing surfactants. Therefore, finding the relationship between interfacial properties and foamability is of a great importance for predicting and controlling the behaviours of foaming systems. Herein, using interfacial tension and zeta potential measurements, we studied air–liquid interfacial behaviours of negatively charged anatase TiO₂ nanoparticles in two types of ionic surfactant solutions, i.e. cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulphate (SDS), with their concentrations varied from 1e − 6 M to 1e − 1 M. Foamability studies of these surfactant solutions containing nanoparticles showed that the foam formation was dependent on the type and concentration of the surfactant, and the presence of TiO₂ nanoparticles affected the minimum concentration of surfactants required for the foam formation. These nanoparticles were also found to affect the size distribution of bubbles formed in the foam. In case of the CTAB solutions containing TiO₂ nanoparticles, adsorption of TiO₂ nanoparticles at the air–liquid interfaces prevented bubbles’ coalescence and thus resulted in the formation of foams with smaller bubble sizes in comparison to those of SDS solutions. These findings are important for the formulations of foam-forming materials in which the particles are often used for stabilising foams, providing insight into industrial processes where foaming characteristics need to be controlled.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials for enhanced detection of some organophosphate and organochlorine pesticides: a comprehensive review of recent advances","authors":"Ashma Aggarwal,&nbsp;Diya Bose,&nbsp;Dwayne Monteiro,&nbsp;Kyle Meyers,&nbsp;Neha Kapadia,&nbsp;Tanaz Asha","doi":"10.1007/s11051-025-06250-0","DOIUrl":"10.1007/s11051-025-06250-0","url":null,"abstract":"<div><p>Organophosphate and organochlorine pesticides (OPPs and OCPs) have extensively been used for plant protection in agriculture. Being highly persistent and toxic, their indiscriminate use over the years has posed a severe threat to human health and ecological stability. These are labelled as hazardous classes of chemical compounds by the WHO. Though many of these pesticides are slowly phased out in most developed countries, these are still in use in most developing countries amidst a lack of stringent regulations, making it necessary to monitor their concentration levels. Complex matrix coupled with low concentration levels make pesticide monitoring quite challenging. Though sensitive and highly accurate, the currently established detection methods are time-consuming and quite expensive, rendering them inaccessible for wide-scale routine analysis. Nanomaterials (NMs), with their exceptional physicochemical properties, have emerged as promising tools for detecting OPPs and OCPs. Unusual structural manipulations in NMs lead to them exhibiting distinct electrical and optical properties. This review details the hazardous impact of some commonly used OPPs and OCPs. It explores the use of functionalized nanomaterials, including metal nanoparticles, nanozymes, nanocomposites, carbon-based nanostructures and metal–organic frameworks in their detection. The study provides a comprehensive insight into the role of nanomaterials in achieving lower detection limits up to the nanomolar range through enhanced signal responses in spectroscopic, electrochemical and optical techniques and potential for on-site analysis. Challenges associated with these methods and future directions for developing even more robust and practical nanomaterial-based sensors for organophosphate and organochlorine pesticide detection have been discussed.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and wear assessment of Ni–TiN thin films deposited on the surface of Q345 steel","authors":"Yongqiang Hou,&nbsp;Ye Tian,&nbsp;Han Gao","doi":"10.1007/s11051-025-06288-0","DOIUrl":"10.1007/s11051-025-06288-0","url":null,"abstract":"<div><p>To enhance the surface properties of pressure vessels, this study utilized ultrasonic electrodeposition to prefabricate pure Ni and Ni–TiN thin films on the vessel surface using a modified Watts nickel bath. The effects of ultrasonic intensity on phase composition, surface morphology, and microstructure were analyzed through scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning probe microscopy (SPM). Mechanical properties, including Vickers hardness, wear resistance, and friction coefficient, were evaluated. The results indicated that the Ni–TiN thin film fabricated at 30 W/cm² displayed a smooth and uniform surface morphology, with TiN nanoparticles uniformly dispersed within the Ni matrix. This structure resulted in higher hardness (920.6 HV) and improved wear resistance (47.67 µm wear depth) compared to other films. SEM, TEM, and SPM analysis revealed that the NT30 film (synthesized at 30W/cm²) displayed an even, uniform surface morphology. The <i>Ra</i> and <i>Rms</i> values, measured over a 3.98 µm² surface area, were 23.2 nm and 35.6 nm, respectively. The average grain sizes of Ni and TiN were approximately 68.8 nm and 42.6 nm, respectively. Further, the ultrasonic intensity significantly influenced the film's performance, with the optimal intensity (30 W/cm²) achieving the best balance between film smoothness, microstructure, and mechanical properties. XRD analysis indicated that films prepared under different plating parameters displayed identical diffraction angles corresponding to the Ni phase, with variations observed only in diffraction intensity. According to microhardness analysis, the Ni and Ni-TiN films (fabricated at 30 W/cm²) showed the lowest (381.4 HV) and highest (920.6 HV) microhardness values, respectively, while wear analysis indicated the least weight loss and wear depth (approximately 47.67 µm) for the NT30 film, signifying improved wear resistance. Corrosion testing revealed that the NT30 film showed the lowest corrosion current density (<i>I</i>_<i>corr</i> = 4.8 × 10⁻⁶ A/cm²) and the most positive corrosion potential (<i>E</i>_<i>corr</i> = -0.18 V), indicating enhanced corrosion resistance compared to the Ni and NT0 films.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06288-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the silver nanotoxicity: mechanisms, risks, and mitigation strategies","authors":"Muhammad Faran Akhtar,&nbsp;Muhammad Irshad,&nbsp;Shaukat Ali,&nbsp;Muhammad Summer,&nbsp; Noor-ul-ain-Zulfiqar,&nbsp;Muhammad Faizan Akhter,&nbsp;Ghamza Akhtar","doi":"10.1007/s11051-025-06273-7","DOIUrl":"10.1007/s11051-025-06273-7","url":null,"abstract":"<div><p>Silver nanoparticles (AgNPs) are increasingly recognized for their potential in biomedical and environmental applications such as antimicrobial, anticancer, and drug delivery properties. But their widespread use is a source of concern with regard to toxicity. The primary toxicological effects of AgNPs are due to oxidative stress causing cellular damage, DNA damage and mitochondrial dysfunction. The interaction of these AgNPs with cellular membranes generates reactive oxidative species (ROS) and interferes with homeostatic redox balance and induces the apoptotic pathway. AgNPs toxicity is influenced by many factors, including particle size, surface modification and synthesis method. Typically, smaller AgNPs are more toxic; however, surface modifications with biocompatible agents can reduce some of the harmful effects. Possibilities of creating AgNPs with lower toxicities using green synthesis methods through plant extracts and other natural agents are promising. However, while these developments are important, more effort is needed to fully understand how AgNPs exert their toxicity, assess various aspects of their safety and optimize their use for therapeutic or industrial purposes. Environmental impacts and a deeper knowledge of human health risks, in particular, chronic effects, are important future research areas.</p><h3>Graphical Abstract</h3><p>Silver nanoparticles induced cytotoxicity</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic strokes: exploring the challenges of translating nanomedicine into clinical practice","authors":"Thibault de La Taille,&nbsp;Diana Doukhi,&nbsp;Mikael Mazighi,&nbsp;Cédric Chauvierre","doi":"10.1007/s11051-025-06282-6","DOIUrl":"10.1007/s11051-025-06282-6","url":null,"abstract":"<div><p>Acute ischemic strokes (AIS) represent a major health concern with more than 12 million deaths per year. Despite the establishment of intravenous thrombolysis as the main line of treatment three decades ago, and the subsequent advent of endovascular therapy, most patients remain disabled. While nanomedicine has shown considerable promise in the management of strokes over the years, there remains a gap between the numerous preclinical studies and the paucity of related clinical trials. In the last five years, around 250 articles described preclinical nanomedicine-based approaches to tackle AIS. These articles explore multiple directions to alleviate AIS, including firstly neuroprotection, followed by the use of thrombolysis through various approaches. Notably, they show a broad variety in the in vivo model choice as well as key readouts, making comparison across protocols difficult. Moreover, relevant data for clinical translation is often lacking, such as biodistribution and organ toxicity, pharmacokinetics, or stability of the proposed nanomaterials. On the other hand, only a few clinical trials have involved nanoparticles, with mixed results. Thus, it can be proposed that among the obstacles hindering the clinical application of the often-promising nanomaterials, the major challenges are the insufficient characterization of nanomaterials including storage, stability, biodistribution, toxicity, and pharmacokinetics; diversity of in vivo protocols, hyper-focused ischemia–reperfusion damages compared to thrombolysis; and a necessity to acknowledge the complexity of AIS thrombi when designing a therapeutic approach. However, ongoing research considering the speed and feasibility requirements for AIS might result in future improvement in patient care.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple one-pot approach to prepare composites based on bimetallic metal–organic frameworks M, Ni-BTC (M = Cu, Fe) and carbon nanotubes for electrochemical detection of bisphenol A","authors":"Nguyen Ngoc Tien,&nbsp;Nguyen Tien Dat,&nbsp;Nguyen Ba Manh,&nbsp;Nguyen Thi Thanh Ngan,&nbsp;Magdalena Osial,&nbsp;Marcin Pisarek,&nbsp;Olga Chernyayeva,&nbsp;Vu Thi Thu","doi":"10.1007/s11051-025-06287-1","DOIUrl":"10.1007/s11051-025-06287-1","url":null,"abstract":"<div><p>Metal–organic frameworks (MOFs) with large active surface area have recently gained considerable attention due to their potential applications in electrochemical sensing. In this work, composites based on carbon nanotubes and bimetallic metal–organic frameworks are presented as the electrochemical platforms for the detection of emerging water contaminants, such as bisphenol A. The performance of the sensors was optimized and evaluated using differential pulse voltammetry technique. The results show an enhancement of the electrochemical output signals for the electrodes modified with Cu,Ni-BTC/CNT and Fe,Ni-BTC/CNT composites. The results have also demonstrated the important role of nickel ions which are indeed present in the samples at relatively low content (four times less than Cu and Fe ions). The detection limits of bisphenol A sensor based on Cu,Ni-BTC/CNT and Fe,Ni-BTC/CNT were 0.5 and 0.7 µM, respectively. In the same time, the morphological and structural studies have shown a better quality of crystals in Cu,Ni-BTC/CNT and a more porous structure in Fe,Ni-BTC/CNT; which might be responsible for the better sensing performances on the electrode modified with Cu,Ni-BTC/CNT. The proposed method is versatile and can be used to prepare a wide range of composites made of these bimetallic MOF structures with different additives, depending on the target applications.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bismuth vanadate modified glassy carbon electrode for sensitive electrochemical antibiotic detection","authors":"Timmy Unya Anak Nedy,&nbsp;Mohammad Aliff bin Ali Rahman,&nbsp;Ellie Yi Lih Teo,&nbsp;Pang Hung Yiu,&nbsp;Elisha Yiu,&nbsp;Alvin Lim Teik Zheng,&nbsp;Yoshito Andou","doi":"10.1007/s11051-025-06280-8","DOIUrl":"10.1007/s11051-025-06280-8","url":null,"abstract":"<div><p>This study presents the successful synthesis of bismuth vanadate (BiVO₄) using a hydrothermal method and its application as a modifier on glassy carbon electrode (GCE). Fourier-transform infrared (FTIR) spectroscopy confirmed the presence of V–O stretching vibrations, while X-ray diffraction (XRD) analysis verified a pure monoclinic BiVO₄ crystal structure. Morphological analysis revealed spherical BiVO₄ particles, which contributed to enhanced electrochemical performance when integrated into the modified GCE. BiVO₄/GCE exhibited superior electrochemical performance, as confirmed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies, in detecting analytes including hexacyanoferrate, tetracycline (TC), and levofloxacin (LVX). BiVO₄ modification significantly boosted the performance of the electrode in terms of sensitivity, selectivity, and electron transfer kinetics. These enhancements can be attributed to BiVO₄’s efficient electron transport and electrocatalytic activity. Notably, BiVO₄/GCE exhibited the potential for simultaneous detection of multiple antibiotics showing its versatility for diverse electrochemical sensing applications. The limits of detection (LOD) and quantification (LOQ) for TC were 27.9 µM and 83.3 µM, respectively, while for LVX, they were 7.39 µM and 22.3 µM. Overall, these findings position BiVO₄/GCE as a promising platform for advanced electrochemical detection and analysis across various fields.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}